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Antagonist activity at KCC2 expressed in human HEK293 cells assessed as decrease in Tl-stimulated fluorescence increase at 2 uM after 8 mins by fluorescence analysis
Assay data:10 Tested
SummaryPubMed CitationRelated BioAssays by Target
Identification of Novel Modulators of Cl- dependent Transport Process via HTS: Primary Screen
Assay data:4127 Active, 189275 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Identification of Novel Modulators of Cl- dependent Transport Process via HTS: Secondary Assay with KCC2 cells
Assay data:546 Active, 3695 Tested
Identification of Novel Modulators of Cl- dependent Transport Process via HTS: Secondary Assay 3 with KCC2 cells
Assay data:1815 Active, 3695 Tested
Identification of Novel Modulators of Cl- dependent Transport Process via HTS: Secondary Assay 2 with KCC2 cells
Assay data:867 Active, 3695 Tested
Identification of Novel Modulators of Cl- dependent Transport Process via HTS: Dose-Dependent Assay 2 with KCC2
Assay data:8 Active, 3 Activity ≤ 1 µM, 62 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Identification of Novel Modulators of Cl- dependent Transport Process via HTS: Rubidium Flux
Assay data:22 Active, 3 Activity ≤ 1 µM, 26 Tested
Identification of Novel Modulators of Cl- dependent Transport Process via HTS; Dose-dependent Assay with KCC2
Assay data:92 Active, 29 Activity ≤ 1 µM, 609 Tested
Identification of Novel Modulators of Cl- dependent Transport Process via HTS: Dose-dependent Assay 3 with KCC2
Assay data:3 Active, 7 Activity ≤ 1 µM, 62 Tested
Identification of Novel Modulators of Cl- dependent Transport Process via HTS: Antagonist Probe Summary
Assay data:1 Active, 1 Tested
siRNA Circadian Assay
Assay data:527 Active, 33364 Tested
SummaryPubMed CitationRelated BioAssays by Depositor
An siRNA screen for human genes that are involved in human papilloma virus (HPV) E2 transcriptional repression of the E6 and E7 oncogenes
Assay data:497 Active, 21019 Tested
SummaryPubMed Citation
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Dharmacon Library)
Assay data:826 Active, 18119 Tested
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Ambion Library)
Assay data:9227 Active, 64752 Tested
Inhibition of KCC2 (unknown origin) transfected in HEK293 cells assessed a reduction in TI influx at 10 uM incubated for 1 hr by fluorescence based analysis relative to control
Assay data:1 Tested
Antagonist activity at KCC2 expressed in human HEK293 cells assessed as decrease in Tl-stimulated fluorescence increase after 8 mins by fluorescence analysis
Assay data:11 Active, 7 Activity ≤ 1 µM, 15 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Antagonist activity at KCC2 expressed in human HEK293 cells assessed as [86Rb] uptake after 30 mins by scintillation counting
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Ratio of IC50 for ML077 to compound IC50 for KCC2 expressed in human HEK293 cells assessed as decrease in Tl-stimulated fluorescence increase at 2 uM after 8 mins by fluorescence analysis
RNAi screen for vorinostat resistance genes - Primary Screen
Assay data:450 Active, 18118 Tested
A whole genome RNAi screen highlights components of the ER/Golgi as a prominent source of resistance to immunotoxin-mediated cytotoxicity
Assay data:555 Active, 64752 Tested
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