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Drug metabolism in human liver microsome S9 fraction assessed as UGT-mediated metabolism by measuring compound remaining at 5 uM pretreated with UDPGA and measured after 15 mins by UPLC-MS/MS analysis
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by Target
Drug metabolism in human liver S9 fraction assessed as UGT-mediated metabolism by measuring parent compound remaining at 5 uM measured immediately in presence of UDPGA by UPLC analysis
Assay data:1 Tested
Drug metabolism in human liver S9 fraction assessed as UGT-mediated metabolism by measuring compound remaining at 5 uM incubated for 60 mins in presence of UDPGA by UPLC-MS analysis
Drug metabolism in human liver S9 fraction assessed as UGT-mediated metabolism by measuring compound remaining at 5 uM incubated for 30 mins in presence of UDPGA by UPLC-MS analysis
Drug metabolism in human liver S9 fraction assessed as UGT-mediated metabolism by measuring compound remaining at 5 uM incubated for 15 mins in presence of UDPGA by UPLC-MS analysis
Drug metabolism in human liver S9 fraction assessed as UGT-mediated metabolism by measuring compound remaining at 5 uM measured immediately in presence of UDPGA by UPLC-MS analysis
Drug metabolism in human liver S9 fractions assessed as assessed as UGT-mediated phase 2 metabolism at 1 mM preincubated for 5 mins followed by NADPH addition and measured after 60 mins by RP-UHPLC-DAD analysis relative to control
Assay data:2 Tested
Drug metabolism in human liver microsome S9 fraction assessed as UGT-mediated metabolism by measuring compound remaining at 5 uM pretreated with UDPGA and measured after 60 mins by UPLC-MS/MS analysis
Drug metabolism in human liver microsome S9 fraction assessed as UGT-mediated metabolism by measuring compound remaining at 5 uM pretreated with UDPGA and measured after 30 mins by UPLC-MS/MS analysis
Drug metabolism in human liver S9 fraction assessed as UGT-mediated metabolism by measuring parent compound remaining at 5 uM measured after 15 mins in presence of UDPGA by UPLC analysis
Drug metabolism assessed as human UGT-mediated metabolism by measuring intrinsic clearance
Drug metabolism assessed as human UGT-mediated metabolism by measuring half life for DHD3 formation
Drug metabolism assessed as human UGT-mediated metabolism by measuring half life for DHD1 formation
Microsomal stability in human liver microsomes assessed as UGT-mediated metabolism by measuring compound remaining at 5 uM and measured for 60 mins in presence of UDPGA by UPLC-MS/MS analysis (Rvb = 100%)
Assay data:7 Tested
Microsomal stability in human liver microsomes assessed as UGT-mediated metabolism by measuring compound remaining at 5 uM and measured for 30 mins in presence of UDPGA by UPLC-MS/MS analysis (Rvb = 100%)
Microsomal stability in human liver microsomes assessed as UGT-mediated metabolism by measuring compound remaining at 5 uM and measured for 15 mins in presence of UDPGA by UPLC-MS/MS analysis (Rvb = 100%)
Drug metabolism in human hepatocytes assessed as UGT-mediated glucuronidation by measuring O-glucuronide formation at 10 uM measured after 4 hrs by LC-MS analysis
Metabolic stability in human liver microsomes assessed as UGT-mediated N-glucuronidation by measuring intrinsic clearance at 3 uM measured up to 45 mins by LC-MS/MS analysis
Metabolic stability in human liver microsomes S9 fraction assessed as UGT-mediated metabolism by measuring parent compound remaining measured after 30 mins in presence of NADPH
Metabolic stability in human liver microsomes S9 fraction assessed as UGT-mediated metabolism by measuring parent compound remaining measured after 15 mins in presence of NADPH
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