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Inhibition of NIK in NIK adenovirus infected C57BL/6 mouse primary hepatocytes assessed as reduction in TNFalpha mRNA expression measured after 16 hrs by SYBR staining based RT-qPCR analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen
Assay data:788 Active, 16789 Tested
SummaryPubMed Citation
TLR-pathway-mouse_P3C ligand_NFkB readout
Assay data:128 Active, 756 Tested
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same Project
TLR-pathway-mouse_R848 ligand_TNF readout
Assay data:130 Active, 756 Tested
TLR-pathway-mouse_R848 ligand_NFkB readout
Assay data:147 Active, 756 Tested
TLR-pathway-mouse_LPS ligand_NFkB readout
Assay data:137 Active, 756 Tested
TLR-pathway-mouse_P3C ligand_TNF readout
Assay data:115 Active, 756 Tested
TLR-pathway-mouse_LPS ligand_TNF readout
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout
Assay data:1106 Active, 16821 Tested
SummaryRelated BioAssays by Same Project
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout
Assay data:762 Active, 16821 Tested
Inhibition of NIK in NIK/p100 adenoviruses infected C57BL/6 mouse primary hepatocytes assessed as suppression of NIK-mediated proteolysis of p100 to p52 by measuring reduction in p52 level measured after 16 hrs by Western blot analysis
Inhibition of NIK in NIK/p100 adenoviruses infected C57BL/6 mouse primary hepatocytes assessed as suppression of NIK-mediated proteolysis of p100 to p52 by measuring reduction in p52 level at 5 uM measured after 16 hrs by Western blot analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
In vivo inhibition of NIK in C57 mouse model of IMQ-induced psoriasis assessed as reduction in NF-kappaB signalling in back skin by measuring decrease in mRNA IL-12 level at 60 to 120 mg/kg, po administered starting from day 3 post IMQ-challenge and measured 2 days post-last dose of IMQ by qPCR analysis
Inhibition of NIK in NIK adenovirus infected C57BL/6 mouse primary hepatocytes assessed as reduction in CCL2 mRNA expression measured after 16 hrs by SYBR staining based RT-qPCR analysis
Inhibition of NIK in NIK adenovirus infected C57BL/6 mouse primary hepatocytes assessed as reduction in CCL5 mRNA expression measured after 16 hrs by SYBR staining based RT-qPCR analysis
Inhibition of NIK in NIK adenovirus infected C57BL/6 mouse primary hepatocytes assessed as reduction in CXCL5 mRNA expression measured after 16 hrs by SYBR staining based RT-qPCR analysis
Inhibition of NIK in NIK adenovirus infected C57BL/6 mouse primary hepatocytes assessed as reduction in NOS2 mRNA expression measured after 16 hrs by SYBR staining based RT-qPCR analysis
Inhibition of NIK in mouse J774 cells assessed as reduction in LPS-induced TNFalpha mRNA level by SYBR green dye-based quantitative PCR analysis
Inhibition of NIK in mouse J774 cells assessed as reduction in LPS-induced IL6 mRNA level by SYBR green dye-based quantitative PCR analysis
In vivo inhibition of NIK in po dosed C57 mouse model of IMQ-induced psoriasis assessed as reduction in P52 expression in back skin administered starting from day 3 post IMQ-challenge and measured 2 days post-last dose of IMQ by Western blot analysis
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