BioAssay by Target (List) for Gene (Select 5148) - PubChem BioAssay - NCBI

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Select item 3495701.

Inhibition of human recombinant PDE6 expressed in baculovirus-infected insect Sf9 cells at 10 uM by modified two-step method

Source:: ChEMBL

Protein Targets:: Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'; ...
Total:: 6

Assay data:1 Tested

AID:: 349570

Summary PubMed Citation Related BioAssays by Target

Select item 7434582.

RNAi screen for vorinostat resistance genes - Secondary Deconvolution Screen

Source:: Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre

Assay data:732 Active, 1804 Tested

AID:: 743458

Summary PubMed Citation

Select item 7434543.

RNAi screen for vorinostat resistance genes - Primary Screen

Source:: Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre

Assay data:450 Active, 18118 Tested

AID:: 743454

Summary PubMed Citation

Select item 7431214.

Druggable Genome siRNA Screen for Enhancers of Camptothecin in MDA-MB-231 Breast Cancer Cells

Source:: National Center for Advancing Translational Sciences (NCATS)

Assay data:167 Active, 26449 Tested

AID:: 743121

Select item 7354835.

Inhibition of PDE6 (unknown origin) using FAM-cGMP as substrate after 60 mins by fluorescence assay

Source:: ChEMBL

Protein Targets:: Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'; ...
Total:: 6

Assay data:5 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 5 Tested

AID:: 735483

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 7242556.

Inhibition of human recombinant PDE6AB expressed in Sf9 cells by scintillation proximity assay

Source:: ChEMBL

Protein Targets:: Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'; ...
Total:: 6

Assay data:1 Active, 1 Tested

AID:: 724255

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 7142517.

Inhibition of human PDE6 at 10 uM by CEREP assay

Source:: ChEMBL

Protein Targets:: Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'; ...
Total:: 6

Assay data:1 Tested

AID:: 714251

Summary PubMed Citation Related BioAssays by Target

Select item 6786358.

Inhibition of PDE6

Source:: ChEMBL

Protein Targets:: Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'; ...
Total:: 6

Assay data:24 Active, 15 Activity ≤ 1 µM, 35 Tested

AID:: 678635

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 6561259.

Inhibition of human recombinant PDE6 assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assay

Source:: ChEMBL

Protein Targets:: Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'; ...
Total:: 6

Assay data:5 Tested

AID:: 656125

Summary PubMed Citation Related BioAssays by Target

Select item 65181110.

Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Ambion Library)

Source:: National Center for Advancing Translational Sciences (NCATS)

Assay data:9227 Active, 64752 Tested

AID:: 651811

Summary PubMed Citation

Select item 65181011.

Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Dharmacon Library)

Source:: National Center for Advancing Translational Sciences (NCATS)

Assay data:826 Active, 18119 Tested

AID:: 651810

Summary PubMed Citation

Select item 64067712.

Inhibition of recombinant human PDE6 using [3H]cAMP as substrate at 1 uM by scintillation proximity assay

Source:: ChEMBL

Protein Targets:: Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'; ...
Total:: 6

Assay data:1 Tested

AID:: 640677

Summary PubMed Citation Related BioAssays by Target

Select item 64067613.

Inhibition of recombinant human PDE6 using [3H]cAMP as substrate at 3.6 uM by scintillation proximity assay

Source:: ChEMBL

Protein Targets:: Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'; ...
Total:: 6

Assay data:1 Tested

AID:: 640676

Summary PubMed Citation Related BioAssays by Target

Select item 64065814.

Inhibition of recombinant human PDE6 using [3H]cAMP as substrate by scintillation proximity assay

Source:: ChEMBL

Protein Targets:: Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'; ...
Total:: 6

Assay data:7 Active, 6 Activity ≤ 1 µM, 10 Tested

AID:: 640658

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 62409915.

An siRNA screen for human genes that are involved in human papilloma virus (HPV) E2 transcriptional repression of the E6 and E7 oncogenes

Source:: ICCB-Longwood Screening Facility, Harvard Medical School

Assay data:497 Active, 21019 Tested

AID:: 624099

Summary PubMed Citation

Select item 74883316.

Inhibition of PDE6 (unknown origin)

Source:: ChEMBL

Protein Targets:: Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'; ...
Total:: 6

Assay data:1 Tested

AID:: 748833

Summary PubMed Citation Related BioAssays by Target

Select item 27446617.

Activity at PDE6 at 10 uM

Source:: ChEMBL

Protein Targets:: Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'; ...
Total:: 6

Assay data:2 Tested

AID:: 274466

Summary PubMed Citation Related BioAssays by Target

Select item 26969618.

Inhibition of PDE6 at 0.2 uM

Source:: ChEMBL

Protein Targets:: Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'; ...
Total:: 6

Assay data:4 Tested

AID:: 269696

Summary PubMed Citation Related BioAssays by Target

Select item 26969519.

Inhibition of PDE6 at 2 uM

Source:: ChEMBL

Protein Targets:: Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'; ...
Total:: 6

Assay data:16 Tested

AID:: 269695

Summary PubMed Citation Related BioAssays by Target

Select item 26969420.

Inhibition of PDE6

Source:: ChEMBL

Protein Targets:: Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'; ...
Total:: 6

Assay data:12 Active, 9 Activity ≤ 1 µM, 14 Tested

AID:: 269694

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

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Target

RNAi Target, Active (7)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (21)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (3)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (17)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (32)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (10)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (44)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (14)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (1)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (43)
BioAssays extracted from the literature
NIH MLP (1)
BioAssays deposited by the NIH Molecular Libraries Program
Other (14)
BioAssays deposited by other experimentalists

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