BioAssay by Target (List) for Gene (Select 5031) - PubChem BioAssay - NCBI

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Select item 6518101.

Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Dharmacon Library)

Source:: National Center for Advancing Translational Sciences (NCATS)

Assay data:826 Active, 18119 Tested

AID:: 651810

Summary PubMed Citation

Select item 7431212.

Druggable Genome siRNA Screen for Enhancers of Camptothecin in MDA-MB-231 Breast Cancer Cells

Source:: National Center for Advancing Translational Sciences (NCATS)

Assay data:167 Active, 26449 Tested

AID:: 743121

Select item 7326523.

Inhibition of human P2Y6 receptor

Source:: ChEMBL

Protein Target:: P2Y purinoceptor 6

Assay data:5 Tested

AID:: 732652

Summary PubMed Citation Related BioAssays by Target

Select item 7059324.

Agonist activity at P2Y6R

Source:: ChEMBL

Protein Target:: P2Y purinoceptor 6

Assay data:3 Tested

AID:: 705932

Summary PubMed Citation Related BioAssays by Target

Select item 6824165.

Ratio of UDP EC50 to compound EC50 for human GFP-tagged P2Y6 receptor

Source:: ChEMBL

Protein Target:: P2Y purinoceptor 6

Assay data:2 Tested

AID:: 682416

Summary PubMed Citation Related BioAssays by Target

Select item 6824156.

Agonist activity at human GFP-tagged P2Y6 receptor expressed in human 1321N1 cells assessed as intracellular calcium mobilization by fura2/AM-based fluorescence spectrophotometry

Source:: ChEMBL

Protein Target:: P2Y purinoceptor 6

Assay data:6 Active, 4 Activity ≤ 1 µM, 9 Tested

AID:: 682415

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 6824127.

Agonist activity at human P2Y6 receptor

Source:: ChEMBL

Protein Target:: P2Y purinoceptor 6

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 682412

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 6824118.

Agonist activity at P2Y6 receptor expressed in human 1321N1 cells assessed as inositol phosphate accumulation

Source:: ChEMBL

Protein Target:: P2Y purinoceptor 6

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 682411

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 6518119.

Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Ambion Library)

Source:: National Center for Advancing Translational Sciences (NCATS)

Assay data:9227 Active, 64752 Tested

AID:: 651811

Summary PubMed Citation

Select item 74345410.

RNAi screen for vorinostat resistance genes - Primary Screen

Source:: Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre

Assay data:450 Active, 18118 Tested

AID:: 743454

Summary PubMed Citation

Select item 64818511.

Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as stimulation of PLC-induced [3H]inositol phosphate production at 100 uM after 30 mins by scintillation counting

Source:: ChEMBL

Protein Target:: P2Y purinoceptor 6

Assay data:12 Tested

AID:: 648185

Summary PubMed Citation Related BioAssays by Target

Select item 62409912.

An siRNA screen for human genes that are involved in human papilloma virus (HPV) E2 transcriptional repression of the E6 and E7 oncogenes

Source:: ICCB-Longwood Screening Facility, Harvard Medical School

Assay data:497 Active, 21019 Tested

AID:: 624099

Summary PubMed Citation

Select item 60086713.

Agonist activity at human recombinant P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate production at 10 uM after 30 mins by scintillation proximity assay

Source:: ChEMBL

Protein Target:: P2Y purinoceptor 6

Assay data:10 Tested

AID:: 600867

Summary PubMed Citation Related BioAssays by Target

Select item 60086414.

Agonist activity at human recombinant P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate production after 30 mins by scintillation proximity assay

Source:: ChEMBL

Protein Target:: P2Y purinoceptor 6

Assay data:18 Active, 5 Activity ≤ 1 µM, 23 Tested

AID:: 600864

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 59313615.

Agonist activity at P2Y6 receptor

Source:: ChEMBL

Protein Target:: P2Y purinoceptor 6

Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested

AID:: 593136

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 59312616.

Agonist activity at human recombinant P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate intracellular accumulation by scintillation proximity assay

Source:: ChEMBL

Protein Target:: P2Y purinoceptor 6

Assay data:16 Active, 2 Activity ≤ 1 µM, 27 Tested

AID:: 593126

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 57013017.

Antagonist activity against human P2Y6 receptor expressed in 1321N1 astrocytoma cells by calcium mobilization assay

Source:: ChEMBL

Protein Target:: P2Y purinoceptor 6

Assay data:6 Active, 14 Tested

AID:: 570130

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 48478418.

Agonist activity at human recombinant P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate production by scintillation proximity assay

Source:: ChEMBL

Protein Target:: P2Y purinoceptor 6

Assay data:23 Active, 13 Activity ≤ 1 µM, 28 Tested

AID:: 484784

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 112196819.

Binding affinity to human recombinant P2Y6 receptor expressed in human 1321N1 cells assessed as surface bound fraction at 400 nM after 60 mins by flow cytometry in sucrose containing media

Source:: ChEMBL

Protein Target:: P2Y purinoceptor 6

Assay data:1 Tested

AID:: 1121968

Summary PubMed Citation Related BioAssays by Target

Select item 112198420.

Binding affinity to human recombinant P2Y6 receptor expressed in human 1321N1 cells after 2 mins by flow cytometry in presence of MRS2578

Source:: ChEMBL

Protein Target:: P2Y purinoceptor 6

Assay data:1 Tested

AID:: 1121984

Summary PubMed Citation Related BioAssays by Target

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Target

Proteins (1)
BioAssays with protein sequences specified as targets
RNAi Target, Active (6)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (60)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 µM (36)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (48)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (9)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (125)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (13)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (1)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (120)
BioAssays extracted from the literature
NIH MLP (1)
BioAssays deposited by the NIH Molecular Libraries Program
Other (17)
BioAssays deposited by other experimentalists

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