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Potency index, ratio of retigabine EC50 to test compound EC50 for agonist activity at rat KCNQ2/3 channel expressed in CHO cells by patch clamp method
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Agonist activity at rat KCNQ2/3 channel expressed in CHO cells by patch clamp method
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at rat KCNQ2/3 channel expressed in CHO cells assessed as amplitude change of outward current at 10 uM by patch clamp method
Agonist activity at rat KCNQ2/3 channel expressed in CHO cells assessed as shift of half voltage of maximal activation at 10 uM by patch clamp method
Agonist activity at rat KCNQ2/3 channel expressed in CHO cells assessed as amplitude change of outward current at 0.1 uM by patch clamp method
Agonist activity at rat KCNQ2/3 channel expressed in CHO cells assessed as shift of half voltage of maximal activation at 0.1 uM by patch clamp method
Agonist activity at rat KCNQ3 expressed in CHOK1 cells assessed as increase in amplitude of outward current at 10 uM by whole cell patch clamp assay relative to control
Activity at rat KCNQ3 expressed in CHOK1 cells assessed as ratio of amplitude of outward current in presence of test compound to amplitude of outward current in absence of test compound at 10 uM at +60 mV by whole cell patch clamp assay
Activity at rat KCNQ3 expressed in CHOK1 cells assessed as ratio of amplitude of outward current in presence of test compound to amplitude of outward current in absence of test compound at 10 uM at -10 mV by whole cell patch clamp assay
Rat Kv7.3 (Voltage-gated potassium channels)
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Activation of rat Kv7.2/7.3 expressed in CHOK1 cells assessed as increase in current amplitude relative to control
Activation of rat Kv7.2/7.3 expressed in CHOK1 cells
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Mode of action assay-Specificity test for the KCNQ2 activators in the KCNQ3 expressing cells
Assay data:5 Tested
SummaryRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Mode of action assay-Dose response assay for KCNQ2 activators in the KCNQ2/KCNQ3 co-expressing cells on automated patch clamp
Assay data:5 Active, 3 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Mode of Action - subtype specificity assay for ztz240, a potentiator of KCNQ2 potassium channels
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
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