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The compound was tested for binding affinity against Kainate binding site using [3H]kainate as radioligand
Assay data:8 Active, 1 Activity ≤ 1 µM, 8 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Compound was tested for binding affinity against Ionotropic glutamate receptor ionotropic kainate 1 in HK293 cells using [3H]kainate as radioligand; value according to table 4
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]kainate as radioligand
Assay data:46 Active, 39 Activity ≤ 1 µM, 47 Tested
Whole-cell voltage clamp recordings made from HEK293 cells stably transfected with Ionotropic glutamate receptor ionotropic kainate 1.Results are expressed as % of maximum inward current evoked
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Assay data:4 Tested
Binding affinity of compound was determined against Ionotropic glutamate receptor ionotropic kainate 1 using cell membranes prepared from HEK293 cells
Binding affinity of compound was determined towards cloned Ionotropic glutamate receptor ionotropic kainate 1 (GluR5) expressed in Sf 9 insect cells
Assay data:3 Active, 1 Activity ≤ 1 µM, 3 Tested
Compound has been evaluated for its binding affinity towards kainate by displacing the radioligand [3H]kainate
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of binding of [3H]kainate to kainate at 10 uM compound concentration
Ability to displace [3H]kainate from kainate receptor
Assay data:9 Active, 3 Activity ≤ 1 µM, 10 Tested
Compound was tested for binding affinity against Ionotropic glutamate receptor ionotropic kainate 1 in HK293 cells using [3H]kainate as radioligand; value according to table 1
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
The compound was tested for binding affinity against Kainate binding site using [3H]kainate as radioligand.
SummaryCompounds, ActiveRelated BioAssays by Target
The compound was tested for binding affinity against Kainate binding site using [3H]kainate as radioligand; Not tested
SummaryRelated BioAssays by Target
Effective concentration required for evoking response in HEK293 cell
Whole-cell voltage clamp recordings made from HEK293 cells stably transfected with hGluR5. Results are expressed as % of maximum inward current evoked
Inhibitory activity against kainic acid receptor using [3H]-kainic acid as radioligand
Binding affinity for kainate Glutamate receptor GluR5 expressed in Sf9 cells
Assay data:4 Active, 1 Activity ≤ 1 µM, 5 Tested
Inhibition of [3H]-KA binding to iontropic glutamate receptor 5
Assay data:4 Active, 7 Tested
Percent inhibition against Kainate receptor at a compound concentration of 1 uM
Assay data:1 Active, 1 Activity ≤ 1 µM, 3 Tested
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