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Kinase Inhibition Assay from Article 10.1021/jm970124v: "Use of a pharmacophore model for the design of EGF-R tyrosine kinase inhibitors: 4-(phenylamino)pyrazolo[3,4-d]pyrimidines."
Assay data:28 Active, 1 Activity ≤ 1 nM, 28 Activity ≤ 1 µM, 30 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Tested for ability to displace [20e3] phorbol 12,13- dibutyrate binding from recombinant bovine Protein kinase C alpha in presence of [Ca2+]
Assay data:19 Active, 17 Activity ≤ 1 µM, 19 Tested
Displacement of [3H-20]-phorbol-12-13-dibutyrate from bovine brain protein kinase C alpha
Assay data:5 Active, 3 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Ability to displace bound [20-3H]-PDBU from a recombinant single isozyme (PKCalpha) in the presence of phosphatidylserine
Assay data:21 Active, 1 Activity ≤ 1 nM, 17 Activity ≤ 1 µM, 21 Tested
Inhibition of PKCalpha kinase
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
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