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Agonist activity at rat pancreas P2Y1 receptor assessed as enhancement of insulin secretion
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at rat P2Y1R assessed as glucose-dependent insulin secretion
Agonist activity at rat P2Y1R expressed in HEK293 cells assessed as release of intracellular calcium by fluorescence based assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
ML353 Eurofin Panel Assay for mGlu5 SAM Inhibitor (Probe Compound)
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
ML354 Eurofin Panel Assay for PAR4 Antagonists Inhibitor (Probe Compound)
ML352 Eurofin Panel Assay for Choline Transporter Inhibitor (Probe Compound)
Assay data:1 Tested
SummaryRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
ML347 Eurofin Panel Assay for BMP Inhibitor (Probe Compound)
Late stage results from the probe development effort to identify inhibitors of Hepatitis C Virus (HCV) core protein dimerization: Cell-based radioligand binding assay to determine the binding affinities for selected transporters, receptors, and GPCRs
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Late stage results from the probe development efforts to identify dual inhibitors of signal transducer and activator of transcription 3 (STAT3) and nuclear factor NF-kappa-B (NF-kB): Cell-based radioligand binding assay to determine the binding affinities for selected transporters, receptors, and GPCRs
Agonist activity at rat P2Y1R assessed as glucose-dependent insulin secretion relative to control
SummaryPubMed CitationRelated BioAssays by Target
Agonist activity at rat pancreas P2Y1 receptor assessed as enhancement of insulin secretion relative to basal level
Activity against rat P2Y1-GFP transfected in HEK293 cells by intracellular calcium increase
Assay data:4 Active, 4 Activity ≤ 1 µM, 6 Tested
Concentration required for calcium mobilization at rat purinergic 2Y1 receptor expressed in HEK 293 cells
Assay data:9 Active, 2 Activity ≤ 1 nM, 9 Activity ≤ 1 µM, 9 Tested
Agonists activity was evaluated by release of [Ca2+] release of HEK 293 cells stably transfected with rat-brain P2Y purinoceptor 1 (P2Y1-R)
Assay data:6 Active, 1 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 6 Tested
High throughput discovery of novel modulators of ROMK K+ channel activity: Ancillary Activity
Discovery of a Highly Selective in vitro and in vivo M4 Positive Allosteric Modulator: Ancillary Activity
Assay data:2 Tested
Identification of Novel Modulators of Cl- dependent Transport Process via HTS: Antagonist Ancillary Profile
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Ancillary Activity
Development of inhibitors for Menin-MLL Receptor(Eurofin Panel Assay Results)
SummaryCompounds, ActiveRelated BioAssays by Target
P2Y/RAT Eurofins SafetyScreen44 (BI)
SummaryRelated BioAssays by Target
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