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Inhibitory activity against Gamma-aminobutyric acid A (GABA-A) receptor from rat cultured cortical neuron RNA expressed in Xenopus oocytes
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity against the BZD site of the Gamma-aminobutyric acid A receptor in rat cerebral cortex using radioligand ([3H]flunitrazepam) assay in the presence of Gamma-aminobutyric acid
Assay data:24 Active, 21 Activity ≤ 1 µM, 26 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Binding affinity against the BZD site of the Gamma-aminobutyric acid A receptor in rat cerebral cortex using radioligand ([3H]flunitrazepam) assay in the absence of Gamma-aminobutyric acid
Assay data:25 Active, 21 Activity ≤ 1 µM, 27 Tested
Binding affinity against benzodiazepine site of gamma-aminobutyric-acid A receptor of rat cerebral cortex by using [3H]flunitrazepam in the presence of GABA 1 mM.
Assay data:25 Active, 2 Activity ≤ 1 nM, 24 Activity ≤ 1 µM, 26 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity against benzodiazepine site of gamma-aminobutyric-acid A receptor of rat cerebral cortex by using [3H]flunitrazepam in the absence of GABA.
Binding affinity against Gamma-aminobutyric acid A receptor in rat brain synaptosomes after 30 minutes (inactive)
SummaryRelated BioAssays by Target
Binding affinity against Gamma-aminobutyric acid A receptor in rat brain synaptosomes after 30 minutes
Assay data:6 Active, 5 Activity ≤ 1 µM, 6 Tested
Binding affinity against Gamma-aminobutyric acid A receptor in rat cerebral cortex
Assay data:6 Active, 3 Activity ≤ 1 µM, 12 Tested
Binding affinity against Diazepam sensitive (DS) Gamma-aminobutyric acid A receptor
Assay data:3 Active, 12 Activity ≤ 1 µM, 12 Tested
Allosteric modulation of [35S]TBPS binding to Gamma-aminobutyric acid A receptor in rat brain cortical P2 membranes (inhibits binding with two components)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Ability to allosterically modulate the binding of [35S]TBPS to gamma-aminobutyric-acid A receptor in rat brain cortical P2 membranes.
Assay data:32 Active, 30 Activity ≤ 1 µM, 35 Tested
Non-competitive inhibitory activity against recombinant Gamma-aminobutyric acid A (GABA-A) receptor
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity for Gamma-aminobutyric acid A receptor from rat brain in the presence of radioligand [35S]- TBPS
Assay data:14 Tested
Antagonist activity against Gamma-aminobutyric acid A (GABA-A) receptor
Displacement of [3H]flunitrazepam from GABA-A receptor of rat forebrain
Assay data:8 Tested
Displacement of [3H]flunitrazepam from GABA-A receptor of rat cerebellum
In vitro displacement of [3H]muscimol from Gamma-aminobutyric acid A receptor of rat brain membranes, slight stimulation activity
Assay data:3 Tested
In vitro displacement of [3H]muscimol from Gamma-aminobutyric acid A receptor of rat brain membranes, range 5-10% stimulation
In vitro displacement of [3H]muscimol from Gamma-aminobutyric acid A receptor of rat brain membranes (No data)
In vitro displacement of [3H]muscimol from Gamma-aminobutyric acid A receptor of rat brain membranes (15% stimulation)
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