BioAssay by Target (List) for Gene (Select 24626) - PubChem BioAssay - NCBI

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Select item 1599621.

Inhibition of rolipram binding to PDE4 in rat brain

Source:: ChEMBL

Protein Targets:: cAMP-specific 3',5'-cyclic phosphodiesterase 4A; ...
Total:: 4

Assay data:9 Active, 8 Activity ≤ 1 µM, 9 Tested

AID:: 159962

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 1599522.

Affinity for the high affinity rolipram binding site of phosphodiesterase (PDE IV) by [3H]rolipram displacement.

Source:: ChEMBL

Protein Targets:: cAMP-specific 3',5'-cyclic phosphodiesterase 4A; ...
Total:: 4

Assay data:23 Active, 10 Activity ≤ 1 µM, 23 Tested

AID:: 159952

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 1599533.

Displacement of [3H]rolipram from Phosphodiesterase 4 in rat brain membranes (Not tested)

Source:: ChEMBL

Protein Targets:: cAMP-specific 3',5'-cyclic phosphodiesterase 4A; ...
Total:: 4

Assay data:1 Tested

AID:: 159953

Summary PubMed Citation Related BioAssays by Target

Select item 1599544.

Displacement of [3H]rolipram from Phosphodiesterase 4 in rat brain membranes (not tested)

Source:: ChEMBL

Protein Targets:: cAMP-specific 3',5'-cyclic phosphodiesterase 4A; ...
Total:: 4

Assay data:4 Tested

AID:: 159954

Summary PubMed Citation Related BioAssays by Target

Select item 1599555.

Displacement of [3H]-rolipram from Phosphodiesterase 4 in rat brain membranes (Not tested)

Source:: ChEMBL

Protein Targets:: cAMP-specific 3',5'-cyclic phosphodiesterase 4A; ...
Total:: 4

Assay data:2 Tested

AID:: 159955

Summary PubMed Citation Related BioAssays by Target

Select item 1599566.

Displacement of [3H]rolipram from rat brain membranes (not tested)

Source:: ChEMBL

Protein Targets:: cAMP-specific 3',5'-cyclic phosphodiesterase 4A; ...
Total:: 4

Assay data:1 Tested

AID:: 159956

Summary PubMed Citation Related BioAssays by Target

Select item 1599577.

Inhibition of rolipram binding in rat brain

Source:: ChEMBL

Protein Targets:: cAMP-specific 3',5'-cyclic phosphodiesterase 4A; ...
Total:: 4

Assay data:8 Active, 7 Activity ≤ 1 µM, 8 Tested

AID:: 159957

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 1599588.

Inhibition of rolipram binding in rat brain (not tested)

Source:: ChEMBL

Protein Targets:: cAMP-specific 3',5'-cyclic phosphodiesterase 4A; ...
Total:: 4

Assay data:1 Tested

AID:: 159958

Summary PubMed Citation Related BioAssays by Target

Select item 1599599.

Evaluated for the inhibition of [3H]rolipram binding to membrane-bound PDE4.

Source:: ChEMBL

Protein Targets:: cAMP-specific 3',5'-cyclic phosphodiesterase 4A; ...
Total:: 4

Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested

AID:: 159959

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 15996010.

Inhibition of calcium-independent Phosphodiesterase 4

Source:: ChEMBL

Protein Targets:: cAMP-specific 3',5'-cyclic phosphodiesterase 4A; ...
Total:: 4

Assay data:8 Active, 4 Activity ≤ 1 µM, 9 Tested

AID:: 159960

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 15996111.

Inhibition of [3H]- rolipram binding to phosphodiesterase 4 of rat cerebral cortex membranes.

Source:: ChEMBL

Protein Targets:: cAMP-specific 3',5'-cyclic phosphodiesterase 4A; ...
Total:: 4

Assay data:3 Active, 4 Activity ≤ 1 µM, 4 Tested

AID:: 159961

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 15995112.

Displacement of [3H]rolipram binding to Phosphodiesterase 4 in rat brain

Source:: ChEMBL

Protein Targets:: cAMP-specific 3',5'-cyclic phosphodiesterase 4A; ...
Total:: 4

Assay data:6 Active, 7 Activity ≤ 1 µM, 7 Tested

AID:: 159951

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 15996313.

Inhibition of [3H]rolipram binding to rat brain membranes

Source:: ChEMBL

Protein Targets:: cAMP-specific 3',5'-cyclic phosphodiesterase 4A; ...
Total:: 4

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 159963

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 15996414.

Concentration for inhibitory activity against phosphodiesterase 4 from rat liver

Source:: ChEMBL

Protein Targets:: cAMP-specific 3',5'-cyclic phosphodiesterase 4A; ...
Total:: 4

Assay data:15 Active, 6 Activity ≤ 1 µM, 24 Tested

AID:: 159964

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 15996515.

Inhibition of phosphodiesterase 4 from rat liver at 0.3 uM (not determined)

Source:: ChEMBL

Protein Targets:: cAMP-specific 3',5'-cyclic phosphodiesterase 4A; ...
Total:: 4

Assay data:1 Tested

AID:: 159965

Summary PubMed Citation Related BioAssays by Target

Select item 15996616.

Inhibition of rolipram binding to rat brain

Source:: ChEMBL

Protein Targets:: cAMP-specific 3',5'-cyclic phosphodiesterase 4A; ...
Total:: 4

Assay data:13 Active, 12 Activity ≤ 1 µM, 13 Tested

AID:: 159966

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 15996717.

Inhibition of rolipram binding to rat brain (not tested)

Source:: ChEMBL

Protein Targets:: cAMP-specific 3',5'-cyclic phosphodiesterase 4A; ...
Total:: 4

Assay data:1 Tested

AID:: 159967

Summary PubMed Citation Related BioAssays by Target

Select item 15996818.

Inhibition of rat kidney Phosphodiesterase 4

Source:: ChEMBL

Protein Targets:: cAMP-specific 3',5'-cyclic phosphodiesterase 4A; ...
Total:: 4

Assay data:6 Active, 10 Tested

AID:: 159968

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 15996919.

Inhibitory activity against purified rat liver phosphodiesterase 4

Source:: ChEMBL

Protein Targets:: cAMP-specific 3',5'-cyclic phosphodiesterase 4A; ...
Total:: 4

Assay data:10 Active, 3 Activity ≤ 1 nM, 14 Activity ≤ 1 µM, 14 Tested

AID:: 159969

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 15997020.

Inhibition of purified rat liver phosphodiesterase 4 (not determined)

Source:: ChEMBL

Protein Targets:: cAMP-specific 3',5'-cyclic phosphodiesterase 4A; ...
Total:: 4

Assay data:1 Tested

AID:: 159970

Summary PubMed Citation Related BioAssays by Target

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BioActivity

Active Compounds (45)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (3)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (39)
BioAssays with the active concentration of tested reagents less than 1 micromolar

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Confirmatory (57)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations

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Literature Extraction (83)
BioAssays extracted from the literature
Other (2)
BioAssays deposited by other experimentalists

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