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Potency index, ratio of genistein EC50 to test compound EC50 for potentiation of CFTR F508del mutant in rat FRT cells assessed as increase in iodide influx in presence of forskolin
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Potentiation of CFTR F508del mutant in rat FRT cells assessed as increase in iodide influx in presence of forskolin
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Induction of CFTR channel function restoration in FRT cells assessed as effect on forskolin induced transepithelial CFTR-mediated Cl- current by measuring basal short circuit current at 12 uM measured after 24 hrs by voltage clamp method
Assay data:2 Tested
Vmax (maximal I influx) of compound against CFTR (cystic fibrosis transmembrane conductance regulator) in rat was determined
Assay data:18 Tested
Kd (half effective concentration) of compound against CFTR (cystic fibrosis transmembrane conductance regulator) in rat was determined
Assay data:22 Tested
Percent activity against CFTR (cystic fibrosis transmembrane conductance regulator) in rat relative to UCCF-152(50 uM)
Assay data:27 Tested
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