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Blocking of NMDA receptor in mouse fibroblast assessed as inhibition of NMDA-induced excitotoxicity by LDH release assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Positive allosteric modulation of C57BL/6 mouse NMDA receptor assessed as fold change in compound potentiated NMDA-induced current relative to NMDA current alone in presence of saturating glutamate by patch-clamp method
Assay data:6 Tested
Positive allosteric modulation of C57BL/6 mouse NMDA receptor assessed as potentiation of NMDA-induced current in presence of saturating glutamate by patch-clamp method
Assay data:5 Active, 6 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Positive allosteric modulation of of ICR mouse primary cortical neuron NMDA receptor assessed as potentiation of glycine-induced current in presence of 100 uM NMDA by whole-cell patch clamp method
Positive allosteric modulation of of ICR mouse primary cortical neuron NMDA receptor assessed as potentiation of NMDA-induced maximum current by whole-cell patch clamp method
Positive allosteric modulation of of ICR mouse primary cortical neuron NMDA receptor assessed as potentiation of NMDA-induced current in presence of 30 uM exogenous glycine by whole-cell patch clamp method (Rvb = 23.9 +/- 1.3 uM)
Positive allosteric modulation of of ICR mouse primary cortical neuron NMDA receptor assessed as potentiation of NMDA-induced current at 10 uM in presence of 30 uM exogenous glycine by whole-cell patch clamp method
Positive allosteric modulation of ICR mouse primary cortical neuron NMDA receptor assessed as potentiation of NMDA-induced current at 10 uM in absence of exogenous glycine/D-serine by whole-cell patch clamp method
Positive allosteric modulation of C57BL/6 mouse NMDA receptor assessed as fold change in compound potentiated NMDA-induced current relative to NMDA current alone at 30 uM measured after 15 to 30 mins by patch-clamp method
Assay data:61 Tested
Positive allosteric modulation of C57BL/6 mouse NMDA receptor assessed as potentiation of NMDA-induced current by measuring peak current amplitude at 30 uM measured after 15 to 30 mins by patch-clamp method (Rvb = 54.6 +/- 4.6 pA)
Assay data:2 Tested
Inhibition of NMDA receptor in mouse cortical neurons assessed as effect on NMDA currents
SummaryRelated BioAssays by Target
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout
Assay data:762 Active, 16821 Tested
SummaryRelated BioAssays by Same Project
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout
Assay data:1106 Active, 16821 Tested
A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen
Assay data:788 Active, 16789 Tested
SummaryPubMed Citation
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