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Protac activity at VHL/HDAC4 in Q175 KI mouse cortical neuron assessed as induction of HDAC4 degradation preincubated with elacridar for 1 hr followed by compound addition and measured after 4 to 72 hrs by MSD assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Protac activity at VHL/HDAC4 in Q175 KI mouse cortical neuron assessed as induction of HDAC4 degradation incubated for 4 to 72 hrs in absence of elacridar by MSD assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Protac activity at VHL/HDAC4 in mouse Neuro2a cells assessed as induction of HDAC4 degradation preincubated with elacridar for 1 hr followed by compound addition and measured after 24 hrs by Western blot analysis
Protac activity at VHL/HDAC4 in mouse Neuro2a cells assessed as induction of HDAC4 degradation incubated for 24 hrs in absence of elacridar by Western blot analysis
Protac activity at VHL/HDAC6 in mouse 4935 cells assessed as HDAC6 degradation after 6 hrs by ELISA relative to control
Protac activity at VHL/HDAC6 in mouse 4935 cells assessed as HDAC6 degradation after 6 hrs by Western blot analysis
Protac activity at VHL/HDAC6 in mouse 4935 cells assessed as HDAC6 degradation after 6 hrs by ELISA
Protac activity at VHL/HDAC6 in mouse 4935 cells assessed as tubulin acetylation at 10 nM to 10 uM after 6 hrs by Western blot analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Protac activity at VHL/HDAC6 in mouse 4935 cells assessed as HDAC6 degradation at 10 nM to 10 uM after 6 hrs by Western blot analysis
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout
Assay data:762 Active, 16821 Tested
SummaryRelated BioAssays by Same Project
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout
Assay data:1106 Active, 16821 Tested
A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen
Assay data:788 Active, 16789 Tested
SummaryPubMed Citation
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