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Inhibition of PTP1B in differentiated mouse C2C12 cells assessed as upregulation of AMPKalpha phosphorylation at Thr-172 residue by Western blot assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Ability to decrease plasma insulin levels in mouse at a dose 100 mg/kg/day
Assay data:27 Tested
In vivo ability to decrease plasma glucose levels in diabetic C57BL/KsJ ob/ob mouse at a dose 100 mg/kg/day
Binding affinity for mouse protein-tyrosine phosphatase 1B (PTP1B) expressed in COS 7 cells
Assay data:3 Active, 1 Activity ≤ 1 µM, 8 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
In vitro inhibitory activity against PTP1B at 100 uM 10 min incubation
Assay data:23 Tested
Inhibition of PTP1B in mouse C2C12 cells assessed as increase in insulin receptor beta tyrosine phosphorylation at 25 uM
Assay data:6 Active, 7 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of PTP1B in mouse C2C12 cells assessed as increase in intracellular 2-deoxyglucose uptake using [3H]glucose as substrate at 25 uM after 90 mins by scintillation counting
Assay data:4 Active, 8 Tested
A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen
Assay data:788 Active, 16789 Tested
SummaryPubMed Citation
Inhibition of PTP1B in mouse C2C12 cells assessed as increase of 2-deoxy-D-1,2-[3H]-glucose at 25 uM after 90 mins by beta-scintillation counting
Assay data:3 Active, 5 Tested
Inhibition of PTP1B in mouse C2C12 cells assessed as increase of insulin receptor beta phosphorylation at 25 uM after 90 mins
Assay data:9 Active, 9 Tested
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout
Assay data:1106 Active, 16821 Tested
SummaryRelated BioAssays by Same Project
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout
Assay data:762 Active, 16821 Tested
Inhibition of PTP1B in mouse 3T3L1 cells assessed as stimulation of 2-NBDG uptake preincubated for 24 hrs followed by 2-NBDG addition measured after 30 mins by fluorescence reader analysis
Assay data:7 Tested
Inhibition of PTP1B in mouse 3T3L1 cells assessed as stimulation of 2-NBDG uptake at 10 uM preincubated for 24 hrs followed by 2-NBDG addition measured after 30 mins by fluorescence reader analysis relative to control
Assay data:3 Tested
Inhibition of PTP1B in mouse C2C12 cells assessed as increase in phosphorylation of IRbeta at Tyr1162/1163 residues at 50 uM after 30 mins by Western blot method
Assay data:6 Active, 6 Tested
Inhibition of PTP1B in mouse C2C12 cells assessed as increase in phosphorylation of Akt at Ser473 residue at 50 uM after 30 mins by Western blot method
Assay data:2 Active, 6 Tested
Inhibition of PTP1B in mouse PA-induced insulin-resistance C2C12 cells assessed as increase in glucose consumption at 1 ug/ml in presence of insulin after 16 hrs
Assay data:8 Active, 8 Tested
Inhibition of PTP1B in differentiated mouse C2C12 cells assessed as upregulation of ACC phosphorylation at Ser-79 residue at 20 uM after 30 mins by Western blot assay
Assay data:1 Active, 1 Tested
Inhibition of PTP1B in differentiated mouse C2C12 cells assessed as upregulation of ACC phosphorylation at Ser-79 residue at 0.2 mM after 30 mins by Western blot assay
Inhibition of PTP1B in differentiated mouse C2C12 cells assessed as upregulation of AMPKalpha phosphorylation at Thr-172 residue at 20 uM after 3 hrs by Western blot assay
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