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Inverse agonist activity at PPARbeta/delta in mouse C2C12 cells assessed as inhibition of Angptl4 expression after 24 hrs by RT-qPCR analysis
Assay data:3 Active, 4 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at mouse PPARdelta by FRET assay relative to GW-501516
Assay data:18 Tested
SummaryPubMed CitationRelated BioAssays by Target
Agonist activity at Gal4-fused mouse PPARdelta
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Transactivation of mouse PPARdelta expressed in CV1 cells
Assay data:1 Active, 4 Tested
Agonist activity at mouse PPAR-delta expressed in african green monkey CV-1 cells after 24 hrs by luciferase reporter gene assay
Assay data:1 Active, 2 Activity ≤ 1 µM, 2 Tested
Binding affinity to mouse PPAR-delta after 1 hr by TR-FRET assay
Assay data:1 Active, 1 Tested
Agonist activity at mouse PPARdelta expressed in CV1 cells co-expressing tk-PPRE-luciferase vector assessed as transient transactivation at 20 uM after 24 hrs by luciferase reporter gene transactivation assay relative to GW0742
Assay data:17 Tested
Agonist activity at mouse PPARdelta
Displacement of fluormone Pan-PPAR Green from mouse recombinant GST-tagged PPARbeta/delta LBD at 1 uM after 60 mins by TR-FRET assay
Assay data:32 Active, 36 Tested
Antagonist activity at PPARbeta/delta in mouse NIH3T3 cells coexpressing LexA assessed as decrease in L165,041-induced transcriptional activation at 1 uM after 48 hrs by luciferase reporter gene assay relative to control
Assay data:3 Active, 3 Tested
Displacement of fluormone Pan-PPAR Green from mouse recombinant GST-tagged PPARbeta/delta LBD after 60 mins by TR-FRET assay
Assay data:2 Active, 3 Activity ≤ 1 µM, 3 Tested
Inverse agonist activity at GST-tagged recombinant mouse PPARbeta/delta assessed as increase in corepressor peptide SMRT-ID2 interaction after 60 mins by TR-FRET assay
Agonist activity at mouse PPARdelta by FRET assay
Assay data:18 Active, 18 Activity ≤ 1 µM, 18 Tested
Inhibition of wild type PPARD-mediated downregulation of Angptl expression in mouse macrophages at 1 uM after 6 hrs by RT-qPCR analysis
Agonist activity at mouse PPARdelta assessed as maximum activation at 10 uM by in vitro functional transactivation assay relative to 0.1 uM GW0742
Assay data:9 Tested
Agonist activity at PPARdelta in mouse C2C12 cells assessed as upregulation of TFAM gene expression after 4 days by real time PCR analysis
Agonist activity at PPARdelta in mouse C2C12 cells assessed as upregulation of NRF1 gene expression after 4 days by real time PCR analysis
Agonist activity at PPARdelta in mouse C2C12 cells assessed as upregulation of COX4-2 gene expression after 4 days by real time PCR analysis
Agonist activity at PPARdelta in mouse C2C12 cells assessed as upregulation of COX4-1 gene expression after 4 days by real time PCR analysis
Agonist activity at PPARdelta in mouse 3T3L1 cells assessed as upregulation of PDK4 mRNA level at 10 uM after 6 days by oil red-O staining-based spectrophotometric analysis relative to control
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