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Antagonistic potency against N/OFQ in electrically evoked contraction of mouse vas deferens at 0.1 uM
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Agonist activity at NOP receptor in Swiss mouse vas deferens assessed as effect on electrically stimulated contractions
Assay data:23 Active, 23 Activity ≤ 1 µM, 23 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of electrically evoked contraction of mouse vas deferens; Effect evident only in some tissues
Assay data:5 Active, 5 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of electrically evoked contraction of mouse vas deferens at 10 uM
Assay data:1 Tested
Inhibition of electrically evoked contraction of mouse vas deferens
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Assay data:4 Active, 2 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 5 Tested
Maximal inhibition of electrically evoked contraction of mouse vas deferens; Effect evident only in some tissues
Maximal inhibition of electrically evoked contraction of mouse vas deferens at 10 uM
Maximal inhibition of electrically evoked contraction of mouse vas deferens
Assay data:5 Tested
Agonist activity at NOP receptor in Swiss mouse vas deferens by [35S]GTP-gamma-S binding assay
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 3 Tested
Antagonistic potency against N/OFQ in electrically evoked contraction of mouse vas deferens at 10 uM
Antagonistic potency against N/OFQ in electrically evoked contraction of mouse vas deferens at 1 uM
Antagonistic potency against N/OFQ in electrically evoked contraction of mouse vas deferens
Assay data:4 Tested
Binding affinity towards Orphanin FQ receptor on mouse forebrain membranes was determined using [3H]-NC-NH2 as radioligand
Assay data:1 Active, 1 Tested
Affinity to nociceptin receptors on mouse forebrain membranes by [3H]NC-NH2 displacement.
Assay data:23 Active, 3 Activity ≤ 1 nM, 16 Activity ≤ 1 µM, 23 Tested
Inhibition of [3H]NC-NH2 binding to mouse forebrain membranes
Assay data:14 Active, 7 Activity ≤ 1 nM, 13 Activity ≤ 1 µM, 14 Tested
Maximum receptor binding in the electrically stimulated mouse vas deferens
Assay data:12 Tested
Antagonist activity at NOR in mouse Neuro-2a cells assessed as inhibition of nociceptin-induced ERK phosphorylation administered for 15 mins before nociceptin challenge by Alphascreen Surefire assay
Assay data:5 Active, 9 Activity ≤ 1 µM, 9 Tested
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout
Assay data:762 Active, 16821 Tested
SummaryRelated BioAssays by Same Project
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