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Inhibition of JAK2 V617F mutant in mouse BaF3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Assay data:40 Active, 31 Activity ≤ 1 µM, 40 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of IL-6-induced JAK2 phosphorylation in mouse embryonic stem cells at 20 uM by Western blotting
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of JAK1/JAK2/TYK2 in C57BL/6 mouse whole blood assessed as inhibition of IL-6-stimulated STAT3 phosphorylation after 30 mins by flow cytometric analysis
Assay data:3 Active, 3 Tested
Inhibition of JAK2/JAK1 in C57BL/6 mouse whole blood assessed as inhibition of IFN-gamma-stimulated STAT1 phosphorylation after 30 mins by flow cytometric analysis
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of JAK2 in C57BL/6 mouse whole blood assessed as inhibition of GM-CSF-stimulated STAT5a phosphorylation after 30 mins by flow cytometric analysis
Assay data:3 Active, 1 Activity ≤ 1 µM, 3 Tested
A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen
Assay data:788 Active, 16789 Tested
SummaryPubMed Citation
Inhibition of Jak2 in mouse BA/F3 cells expressing TEL-Jak2 assessed as inhibition of STAT5 phosphorylation by Western blotting analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of JAK2 V617F mutant in mouse BAF3 cells
SummaryCompounds, ActiveRelated BioAssays by Target
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout
Assay data:1106 Active, 16821 Tested
SummaryRelated BioAssays by Same Project
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout
Assay data:762 Active, 16821 Tested
Inhibition of JAK2 in mouse BMDM assessed as inhibition of GM-CSF-induced STAT5 phosphorylation at 5 uM preincubated for 3 hrs followed by GM-CSF induction measured after 30 mins by immunoblotting
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of JAK2 in mouse BAF3 cells assessed as reduction in STAT5 phosphorylation incubated for 2 hrs by Western blot method
Inhibition of JAK1/JAK2 in C57BL/6 mouse CD4-positive T cell assessed as reduction in IFNgamma-induced STAT1 phosphorylation at 1 to 10 uM pretreated for 1 hr followed by IFNgamma addition after 15 mins by Western blot analysis
Inhibition of JAK1/JAK2 in C57BL/6 mouse CD4-positive T cell assessed as reduction in IFNgamma-induced STAT3 phosphorylation at 1 to 10 uM pretreated for 1 hr followed by IFNgamma addition after 15 mins by Western blot analysis
Inhibition of JAK2 V617F mutant in BAF3 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Inhibition of JAK2 V617F mutant expressed in mouse BaF3 cells cells assessed as reduction in cell viability
Inhibition of IL-3 stimulated wild type JAK2-mediated signalling in mouse BaF3 cells preincubated with compound for 5 hrs followed by IL-3 stimulation and measured after 20 mins by Alphascreen SureFire assay
Inhibition of JAK2 V617F mutant in mouse BAF3 cells assessed as decrease in STAT5 phosphorylation at 50 nM after 2 hrs by Western blot analysis
Inhibition of JAK2 signaling pathway in C57 mouse assessed as reduction in GM-CSF induced STAT3 phosphorylation in spleen at 3 to 50 mg/kg, po preincubated for 30 mins followed by GM-CSF addition and measured after 30 mins by ELISA
Inhibition of JAK2 signaling pathway in C57 mouse assessed as reduction in GM-CSF induced STAT5 phosphorylation in spleen at 3 to 50 mg/kg, po preincubated for 30 mins followed by GM-CSF addition and measured after 30 mins by ELISA
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