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HSF-1 induced GFP reporter and Doxycycline induced RFP reporter Measured in Cell-Based System Using Plate Reader - 2038-03_Inhibitor_Dose_DryPowder_Activity
Assay data:5 Active, 1 Activity ≤ 1 µM, 7 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Luminescence Cell-Based Primary HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1).
Assay data:2328 Active, 301406 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Identifying Small Molecules To Probe the Role of Heat Shock Factor 1 in Cancer
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1)
Assay data:523 Active, 150 Activity ≤ 1 µM, 2448 Tested
Induction of HSF1-mediated heat-shock protein 72 expression in mouse fibroblast with plasmid EGFP at 2 uM after overnight incubation by micro plate fluorometer
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1)
Assay data:514 Active, 7 Activity ≤ 1 µM, 1953 Tested
HSF-1 induced GFP reporter and Doxycycline induced RFP reporter Measured in Cell-Based System Using Plate Reader - 2038-03_Inhibitor_DoseNoFile_CherryPick_Activity_Set3
Assay data:94 Active, 5 Activity ≤ 1 µM, 2448 Tested
HSF-1 induced GFP reporter and Doxycycline induced RFP reporter Measured in Cell-Based System Using Plate Reader - 2038-03_Inhibitor_DoseNoFile_CherryPick_Internal-Standard_Set3
Assay data:362 Active, 20 Activity ≤ 1 µM, 2448 Tested
Luminescence Cell-Based Primary HTS to Identify Activators of Heat Shock Factor 1 (HSF1)
SummaryRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
HSF-1 induced GFP reporter and Doxycycline induced RFP reporter Measured in Cell-Based System Using Plate Reader - 2038-03_Inhibitor_Dose_CherryPick_Activity_Set4
Assay data:19 Active, 2 Activity ≤ 1 µM, 2448 Tested
Quantitative-PCR analysis for transcription inhibition of HSF-1 target gene Hsp90aa Measured in Cell-Based System Using RT-PCR - 2038-08_Inhibitor_Dose_CherryPick_Activity
Assay data:1 Active, 30 Tested
Heat Shock Factor-1 (HSF-1) Luciferase Reporter Measured in Cell-Based System Using Plate Reader - 2038-01_Inhibitor_Dose_DryPowder_Activity
Activation of HSF1 in MEF assessed as protection against IR-induced caspase3 cleavage at 3 uM pretreated for 1 hr followed by 10 Gy irradiation measured after 48 hrs by immunoblotting analysis
Assay data:2 Active, 2 Tested
Sustained Induction of HSF-1 Measured in Cell-Based System Using Plate Reader - 2038-07_Activator_Dose_CherryPick_Activity
Assay data:194 Active, 2 Activity ≤ 1 µM, 1953 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen
Assay data:788 Active, 16789 Tested
SummaryPubMed Citation
Inhibition of HSP1 activity in mouse MEF assessed as reduction of hsp25 promoter activity at 5 to 100 uM after 12 hrs by luciferase reporter gene assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of HSP1 activity in mouse MEF assessed as reduction of hsp70 promoter activity at 5 to 100 uM after 12 hrs by luciferase reporter gene assay
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout
Assay data:1106 Active, 16821 Tested
SummaryRelated BioAssays by Same Project
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout
Assay data:762 Active, 16821 Tested
Activation of HSF1 in MEF assessed as protection against paclitaxel-induced PARP cleavage at 3 uM pretreated for 1 hr followed by paclitaxel addition measured after 24 hrs by immunoblotting analysis
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