BioAssay by Target (List) for Gene (Select 15484) - PubChem BioAssay - NCBI

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Select item 5907871.

Inhibition of mouse 11beta-HSD2 expressed in CHO-K1 cells assessed as conversion of [3H]-cortisol to [3H]-cortisone by scintillation proximity assay

Source:: ChEMBL

Protein Target:: Corticosteroid 11-beta-dehydrogenase isozyme 2

Assay data:2 Active, 1 Activity ≤ 1 µM, 35 Tested

AID:: 590787

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 2573732.

Inhibitory activity against mouse 11beta-HSD2

Source:: ChEMBL

Protein Target:: Corticosteroid 11-beta-dehydrogenase isozyme 2

Assay data:2 Active, 5 Tested

AID:: 257373

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 2742493.

Inhibition of mouse 11beta-HSD2

Source:: ChEMBL

Protein Target:: Corticosteroid 11-beta-dehydrogenase isozyme 2

Assay data:1 Active, 17 Tested

AID:: 274249

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 2742614.

Inhibition of mouse 11beta-HSD2

Source:: ChEMBL

Protein Target:: Corticosteroid 11-beta-dehydrogenase isozyme 2

Assay data:2 Active, 17 Tested

AID:: 274261

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 2753345.

Inhibitory activity against mouse 11beta-HSD2 by SPA

Source:: ChEMBL

Protein Target:: Corticosteroid 11-beta-dehydrogenase isozyme 2

Assay data:13 Tested

AID:: 275334

Summary PubMed Citation Related BioAssays by Target

Select item 2760786.

Inhibition of mouse 11beta-HSD2

Source:: ChEMBL

Protein Target:: Corticosteroid 11-beta-dehydrogenase isozyme 2

Assay data:3 Active, 12 Tested

AID:: 276078

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 2768237.

Inhibition of mouse 11beta-HSD2 assessed as cortisol disappearance by SPA

Source:: ChEMBL

Protein Target:: Corticosteroid 11-beta-dehydrogenase isozyme 2

Assay data:9 Active, 1 Activity ≤ 1 µM, 19 Tested

AID:: 276823

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 3051828.

Inhibition of mouse HSD2 assessed as interconversion of cortisone to cortisol

Source:: ChEMBL

Protein Target:: Corticosteroid 11-beta-dehydrogenase isozyme 2

Assay data:21 Tested

AID:: 305182

Summary PubMed Citation Related BioAssays by Target

Select item 3053399.

Inhibition of mouse 11beta-HSD2 by SPA

Source:: ChEMBL

Protein Target:: Corticosteroid 11-beta-dehydrogenase isozyme 2

Assay data:9 Active, 2 Activity ≤ 1 µM, 20 Tested

AID:: 305339

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 31605110.

Inhibition of mouse 11beta-HSD2 at 10 uM

Source:: ChEMBL

Protein Target:: Corticosteroid 11-beta-dehydrogenase isozyme 2

Assay data:6 Tested

AID:: 316051

Summary PubMed Citation Related BioAssays by Target

Select item 33206511.

Inhibition of mouse 11-beta-HSD2 by SPA assay

Source:: ChEMBL

Protein Target:: Corticosteroid 11-beta-dehydrogenase isozyme 2

Assay data:29 Tested

AID:: 332065

Summary PubMed Citation Related BioAssays by Target

Select item 35231612.

Inhibition of mouse 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol at 100 uM by scintillation proximity assay in presence of NADPH

Source:: ChEMBL

Protein Target:: Corticosteroid 11-beta-dehydrogenase isozyme 2

Assay data:11 Tested

AID:: 352316

Summary PubMed Citation Related BioAssays by Target

Select item 40422813.

Inhibition of mouse 11beta HSD2

Source:: ChEMBL

Protein Target:: Corticosteroid 11-beta-dehydrogenase isozyme 2

Assay data:51 Tested

AID:: 404228

Summary PubMed Citation Related BioAssays by Target

Select item 43314014.

Inhibition of mouse microsomal 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay

Source:: ChEMBL

Protein Target:: Corticosteroid 11-beta-dehydrogenase isozyme 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 6 Tested

AID:: 433140

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 59041515.

Inhibition of mouse 11beta-HSD2

Source:: ChEMBL

Protein Target:: Corticosteroid 11-beta-dehydrogenase isozyme 2

Assay data:42 Tested

AID:: 590415

Summary PubMed Citation Related BioAssays by Target

Select item 179708216.

Human and Mouse 11beta-HSD1 SPA Assay from Article 10.1016/j.bmcl.2006.10.074: "Discovery of adamantane ethers as inhibitors of 11beta-HSD-1: Synthesis and biological evaluation."

Source:: BindingDB

Protein Targets:: Corticosteroid 11-beta-dehydrogenase isozyme 1; ...
Total:: 4

Assay data:20 Active, 20 Activity ≤ 1 µM, 20 Tested

AID:: 1797082

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 62588317.

Inhibition of mouse 11beta-HSD-2

Source:: ChEMBL

Protein Target:: Corticosteroid 11-beta-dehydrogenase isozyme 2

Assay data:28 Tested

AID:: 625883

Summary PubMed Citation Related BioAssays by Target

Select item 65795118.

Inhibition of mouse 11beta-HSD2 expressed in HEK293 cells assessed as [3H]cortisol production after 60 mins by SPA

Source:: ChEMBL

Protein Target:: Corticosteroid 11-beta-dehydrogenase isozyme 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 4 Tested

AID:: 657951

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 66459319.

Inhibition of mouse 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [3H]cortisone into [3H]cortisol by scintillation proximity assay

Source:: ChEMBL

Protein Target:: Corticosteroid 11-beta-dehydrogenase isozyme 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 3 Tested

AID:: 664593

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 66459720.

Inhibition of mouse 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [3H]cortisone into [3H]cortisol at 1 uM by scintillation proximity assay

Source:: ChEMBL

Protein Target:: Corticosteroid 11-beta-dehydrogenase isozyme 2

Assay data:5 Tested

AID:: 664597

Summary PubMed Citation Related BioAssays by Target

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BioActivity

Active Compounds (12)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 µM (7)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (2)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (21)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (1)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (26)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (3)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (2)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (26)
BioAssays extracted from the literature
Other (3)
BioAssays deposited by other experimentalists

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BioAssay by Target (List) for Gene (Select 15484) (29)
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