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A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen
Assay data:788 Active, 16789 Tested
SummaryPubMed Citation
In vitro antagonist potency in transactivation assay in NIH3T3 cells expressing glucocorticoid receptor
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
In vitro agonist potency in transactivation assay in NIH3T3 cells expressing glucocorticoid receptor; NE=no effect
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
In vitro agonist potency in transactivation assay in NIH3T3 cells expressing glucocorticoid receptor
Inhibition of mouse glutamine synthetase by GR-mediated transactivation in C2C12 cells
Assay data:8 Active, 7 Activity ≤ 1 µM, 8 Tested
GR-mediated transrepression of IL-6 in peritoneal exudate cells harvested from C57BI/6 mice
Assay data:15 Active, 15 Activity ≤ 1 µM, 15 Tested
Inhibition of mouse glutamine synthetase by GR-mediated transactivation in C2C12 cells; nd=not determined
Assay data:7 Tested
Percent absolute inhibition of LPS-induced tumor necrosis factor alpha release in mice at 3 mg/kg dose
Percent absolute inhibition of LPS-induced tumor necrosis factor alpha release in mice at 30 mg/kg dose
Assay data:3 Tested
Percent inhibition of LPS-induced tumor necrosis factor alpha release in mice relative to prednisolone at 3 mg/kg dose
Percent inhibition of LPS-induced tumor necrosis factor alpha release in mice relative to prednisolone at 30 mg/kg dose
Percent absolute inhibition of LPS-induced tumor necrosis factor alpha release in mice at 30 mg/kg dose; ne = Not effective
Activity at glucocorticoid receptor in mouse ATT20 cells assessed as repression of POMC gene expression after 24 hrs by RT-PCR
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Induction of glucocorticoid receptor nuclear translocation in mouse C2C12 cells at 1 x 10'-5 to 1.69 x 10'-10 M by chemiluminescence assay relative to control
Assay data:20 Tested
Mouse Glucocorticoid receptor (3C. 3-Ketosteroid receptors)
Binding affinity to glucocorticoid receptor in soluble fraction of mouse L929 cells assessed as dissociation half life
Displacement of 1 x 10'-8 M of [1,2,3-3H]-triamcinolone acetonide from glucocorticoid receptor in soluble fraction of mouse L929 cells after 20 hrs
Assay data:3 Active, 2 Activity ≤ 1 µM, 4 Tested
Displacement of 2 x 10'-8 M of [1,2,3-3H]-triamcinolone acetonide from glucocorticoid receptor in soluble fraction of mouse L929 cells after 20 hrs
Assay data:2 Active, 2 Activity ≤ 1 µM, 3 Tested
Binding affinity to glucocorticoid receptor in soluble fraction of mouse L929 cells at 10'-7 M at 0 degC
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