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Agonist activity at GLP1 receptor in mouse BetaTC6 cells assessed as increase in insulin secretion at 10'-15 to 10'-9 M after 120 mins by sandwich ELISA
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Agonist activity at mouse GLP1R expressed in CHO cells assessed as stimulation of intracellular [3H]cAMP accumulation by scintillation proximity assay
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen
Assay data:788 Active, 16789 Tested
SummaryPubMed Citation
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout
Assay data:1106 Active, 16821 Tested
SummaryRelated BioAssays by Same Project
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout
Assay data:762 Active, 16821 Tested
Agonist activity at GLP1 receptor in mouse BetaTC6 cells assessed as increase in insulin release at 20 ug/ml incubated for 2 hrs by ELISA
Assay data:2 Tested
SummaryRelated BioAssays by Target
Agonist activity at mouse GLP1 receptor expressed in CHO cells assessed as increase in cAMP level by TR-FRET assay
Antagonist activity at GLP-1R in C57BL/6J mouse primary islets assessed as inhibition of exendin-4-induced increase in glucose-stimulated insulin secretion at 1 uM after 60 mins by radio-immunoassay
Assay data:2 Active, 2 Tested
Agonist activity at GLP1 receptor in mouse BetaTC6 cells assessed as increase in insulin secretion at 10'-12 to 10'-5 M after 120 mins by sandwich ELISA
Agonist activity at GLP1 receptor in mouse BetaTC6 cells assessed as increase in glucose-dependent insulin secretion at 10'-12 to 10'-5 M after 120 mins by sandwich ELISA
Agonist activity at GLP1 receptor in mouse BetaTC6 cells assessed as increase in insulin secretion at 10'-15 to 10'-12 M after 120 mins by sandwich ELISA
Agonist activity at GLP1 receptor in mouse BetaTC6 cells assessed as increase in glucose-dependent insulin secretion at 10'-15 M after 120 mins by sandwich ELISA
Agonist activity at GLP1 receptor in mouse BetaTC6 cells assessed as increase in glucose-dependent insulin secretion at 10'-15 to 10'-9 M after 120 mins by sandwich ELISA
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Agonist activity at mouse GLP-1R expressed in CHO cells assessed as increase in cAMP accumulation relative to GLP-1
Assay data:10 Tested
Agonist activity at GLP1 receptor in mouse BetaTC6 cells assessed as increase in glucose-dependent insulin secretion after 120 mins by sandwich ELISA
Agonist activity at mouse GLP-1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay
Assay data:5 Active, 5 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 5 Tested
Positive allosteric modulator activity at GLP-1R in mouse MIN6-c4 cells assessed as effect on glucose-mediated increase in intracellular Ca2+ level by FLIPR assay relative to control
Assay data:3 Tested
Positive allosteric modulator activity at mouse GLP-1R expressed in PSC-HEK293 cells in presence of EC20 level of GLP1(9-36)NH2 incubated for 30 mins by HTRF cAMP assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Positive allosteric modulator activity at mouse GLP-1R expressed in PSC-HEK293 cells in presence of EC20 level of GLP1(9-36)NH2 incubated for 30 mins by HTRF cAMP assay relative to control
Inhibition of 15 mM glucose-mediated increase in intracellular Ca2+ level in mouse MIN6-c4 cells at 0.12 to 30 uM by FLIPR assay relative to control
Assay data:1 Active, 2 Tested
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