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Percent inhibition (high) of [3H](R)-QNB binding to Muscarinic acetylcholine receptor M3 expressed in A9 L cell line
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by Target
Increase in phosphoinositide (PI) metabolism in A9L-cholinergic receptor, muscarinic 3 expressing cells was measured at 100 uMolar
Assay data:28 Tested
Analgesic activity as percentage analgesic efficacy on male albino swiss-webster mice with the hotplate test
Assay data:25 Tested
Analgesic activity after subcutaneous administration in male albino Swiss-Webster mice with the hotplate test
Ability to inhibit binding of [3H]QNB to Muscarinic acetylcholine receptor in cultured N4TG1 neuroblastoma cells at 1e-8 to 1e-3 M
Assay data:4 Tested
Ability (10 ug/kg) to inhibit binding of [125I]iododexetimide to muscarinic receptor in mice
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of the specific binding of [3H]QNB to Muscarinic acetylcholine receptor
Assay data:8 Tested
Hill coefficient for binding of [3H]QNB to Muscarinic acetylcholine receptor
Assay data:2 Tested
Compound was tested for the binding affinity towards muscarinic acetylcholine receptor in mouse brain membrane
Assay data:1 Tested
Compound was tested for the binding affinity towards muscarinic receptor in mouse brain membrane
Dissociation constant towards Muscarinic acetylcholine receptor was determined by using [3H]4NMPB as radioligand
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Tested against Muscarinic acetylcholine receptor M3 expressed in A9 L cell line
Assay data:6 Active, 14 Tested
Antagonist activity at muscarinic receptor in BALB/c mouse MSC assessed as inhibition of carbachol-induced increase in cell viability at 10'-10M incubated for 24 hrs by Cell-titer 96 aqueous one solution reagent based assay
Percent inhibition (low) of [3H](R)-QNB binding to Muscarinic acetylcholine receptor M3 expressed in A9 L cell line
Binding affinity (high) of [3H](R)-QNB binding to Muscarinic acetylcholine receptor M3 expressed in A9 L cell line
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Binding affinity (low) of [3H](R)-QNB binding to Muscarinic acetylcholine receptor M3 expressed in A9 L cell line
Assay data:5 Active, 3 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 5 Tested
Maximum stimulation at Muscarinic acetylcholine receptor M3 expressed in A9 L cells
Assay data:13 Tested
Percent inhibition of radioligand [3H]QNB binding to muscarinic receptor at 10 uM concentration
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