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Agonist activity at human recombinant PAC1 receptor expressed in CHO cells assessed as PACAP38-induced calcium mobilization at 1 uM by FLIPR assay
Assay data:12 Tested
SummaryPubMed CitationRelated BioAssays by Target
Druggable Genome siRNA Screen for Enhancers of Camptothecin in MDA-MB-231 Breast Cancer Cells
Assay data:167 Active, 26449 Tested
Summary
Displacement of [125I]PACAP1-27 from human recombinant PAC1 receptor expressed in CHO cells at 10 uM after 120 mins
Assay data:1 Tested
Inhibition of human PAC1 receptor at 10 uM by CEREP assay
Inhibition of PACAP receptor at 5 uM by cell based assay
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Ambion Library)
Assay data:9227 Active, 64752 Tested
SummaryPubMed Citation
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Dharmacon Library)
Assay data:826 Active, 18119 Tested
An siRNA screen for human genes that are involved in human papilloma virus (HPV) E2 transcriptional repression of the E6 and E7 oncogenes
Assay data:497 Active, 21019 Tested
Antagonist activity at human PACAPR1 expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation
Displacement of [125I]PACAP1-27 from human recombinant PAC1 receptor expressed in CHO cells at 10 uM after 120 mins by scintillation counting
Antagonist activity at human recombinant PAC1 receptor expressed in CHO cells assessed as reduction in PACAP38-induced calcium mobilization at 10 uM by FLIPR assay
Antagonist activity at human recombinant PAC1 receptor expressed in CHO cells assessed as reduction in PACAP38-induced calcium mobilization by FLIPR assay
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at human recombinant PAC1 receptor expressed in CHO cells assessed as PACAP38-induced calcium mobilization at 1 uM by FLIPR assay relative to PACAP38
RNAi screen for vorinostat resistance genes - Primary Screen
Assay data:450 Active, 18118 Tested
Agonist activity at human recombinant PAC1 receptor expressed in CHO cells assessed as PACAP38-induced calcium mobilization by FLIPR assay relative to PACAP38
Assay data:68 Tested
Agonist activity at human recombinant PAC1 receptor expressed in CHO cells assessed as calcium mobilization by FLIPR assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Agonist activity at human recombinant PAC1 receptor expressed in CHO cells assessed as PACAP38-induced calcium mobilization by FLIPR assay
Assay data:67 Active, 4 Activity ≤ 1 nM, 59 Activity ≤ 1 µM, 67 Tested
Displacement of [125I]Ac-PACAP27 from human recombinant PAC1 receptor expressed in CHO cells by gamma- counter
Assay data:80 Active, 64 Activity ≤ 1 µM, 80 Tested
Displacement of radiolabeled PACAP1-38 from human PACAP
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Binding affinity to human PACAP at 10 uM relative to control
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