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Partial agonist activity at mouse adenosine A1 receptor expressed in HEK293 cell membranes assessed as inhibition of forskolin-stimulated cAMP production preincubated for 30 mins prior to forskolin-treatment measured after 15 mins by ELISA relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Antagonist activity at adenosine A1 receptor in BALB/C mouse ileum assessed as reversal of 1 uM CCPA-induced reduction in rhythmic spontaneous contractions by measuring tissue response at 1 uM after 1 hr (Rvb = 20%)
Mouse A1 receptor (Adenosine receptors)
Assay data:4 Active, 4 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout
Assay data:762 Active, 16821 Tested
SummaryRelated BioAssays by Same Project
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout
Assay data:1106 Active, 16821 Tested
Displacement of [3H]R-PIA from mouse A1 adenosine receptor expressed in CHO cells at 10 uM after 60 mins by liquid scintillation counting
Assay data:6 Tested
Inhibition of binding of wild type mBIMBH3 peptide to mouse adenosine A1 receptor by surface plasmon resonance competition experiment
Assay data:2 Tested
A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen
Assay data:788 Active, 16789 Tested
SummaryPubMed Citation
Agonist activity at mouse adenosine A1 receptor expressed in HEK293 cell membranes assessed as inhibition of forskolin-stimulated cAMP production up to 10 uM preincubated for 30 mins prior to forskolin-treatment measured after 15 mins by ELISA
Partial agonist activity at mouse adenosine A1 receptor expressed in HEK293 cell membranes assessed as inhibition of forskolin-stimulated cAMP production preincubated for 30 mins prior to forskolin-treatment measured after 15 mins by ELISA
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Antagonist activity at adenosine A1 receptor in BALB/C mouse ileum assessed as reversal of 0.1 uM CCPA-induced reduction in rhythmic spontaneous contractions by measuring tissue response at 1 uM after 1 hr (Rvb = 65%)
Partial agonist activity at mouse adenosine A1 receptor expressed in HEK293 cell membranes assessed as inhibition of forskolin-stimulated cAMP production preincubated for 30 mins prior to forskolin-treatment measured after 15 mins by ELISA relative to 2-chloro-N6-cyclopentyladenosine
Agonist activity at mouse adenosine A1 receptor expressed in HEK293 cell membranes assessed as inhibition of forskolin-stimulated cAMP production preincubated for 30 mins prior to forskolin-treatment measured after 15 mins by ELISA
Agonist activity at mouse adenosine A1 receptor expressed in HEK293 cell membranes assessed as inhibition of forskolin-stimulated cAMP production preincubated for 30 mins prior to forskolin-treatment measured after 15 mins by ELISA relative to control
Displacement of [125I]N6-(4-amino-3-iodobenzyl)adenosine-5'-N-methyluronamide from mouse adenosine A1 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting analysis
Assay data:3 Active, 1 Activity ≤ 1 µM, 3 Tested
Displacement of [125I]N6-(4-amino-3-iodobenzyl)adenosine-5'-N-methyluronamide from mouse adenosine A1 receptor expressed in HEK293 cell membranes at 10 uM after 60 mins by liquid scintillation counting analysis relative to control
Assay data:9 Tested
Displacement of [3H]CGS21680 from mouse adenosine A1 receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting
Displacement of [3H]CGS21680 from mouse adenosine A1 receptor expressed in HEK293 cells at 10 uM after 60 mins by liquid scintillation counting
Assay data:10 Tested
Binding affinity to mouse adenosine A1 receptor
Assay data:3 Active, 2 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
Displacement of [125I]N6-(4-amino-3-iodobenzyl)adenosine-5'-N-methyl-uronamide from mouse recombinant adenosine A1 receptor expressed in HEK293 cells
Assay data:22 Active, 19 Activity ≤ 1 µM, 23 Tested
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