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Displacement of [3H]-colchicine from tubulin (unknown origin) at 5 uM after 10 mins relative to control
Assay data:34 Tested
SummaryPubMed Citation
Inhibition of colchicine binding to tubulin (unknown origin) at 100 uM
Assay data:1 Tested
Inhibition of colchicine binding to tubulin (unknown origin) at 50 uM
Inhibition of colchicine binding to tubulin (unknown origin) at 25 uM
Inhibition of tubulin polymerization in human HeLa cells assessed as insoluble form of tubulin at 10 uM (Rvb = 61.5%)
Inhibition of tubulin polymerization in human HeLa cells assessed as insoluble form of tubulin at 100 uM (Rvb = 61.5%)
Binding affinity to tubulin (unknown origin) by fluorescence assay
Assay data:2 Tested
Inhibition of MAPs-rich tubulin (unknown origin) polymerization at 50 uM
Assay data:3 Tested
Binding affinity to tubulin in human HepG2 cells at 5 uM after 4 hrs by EBI competition assay
Assay data:1 Active, 5 Tested
SummaryCompounds, ActivePubMed Citation
Inhibition of tubulin (unknown origin) assembly preincubated for 15 mins followed by GTP addition measured for 20 mins by spectrophotometric analysis
Assay data:35 Active, 2 Activity ≤ 1 µM, 42 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Inhibition of tubulin polymerization in human HeLa cells assessed as polymeric tubulin level at 100 uM
Inhibition of MAP-rich tubulin (unknown origin) assembly measured every 30 secs for 30 mins by turbidimetric analysis
Assay data:2 Active, 2 Tested
Inhibition of brain tubulin (unknown origin) polymerization at 5 uM measured up to 15 to 30 mins
Inhibition of brain tubulin (unknown origin) polymerization measured up to 15 to 30 mins
Assay data:4 Active, 4 Tested
Displacement of [3H]-colchicine from tubulin (unknown origin) preincubated with protein for 1 hr followed by [3H]-colchicine addition measured after 3 hrs by scintillation counting analysis
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Inhibition of tubulin (unknown origin) assembly pre-incubated for 15 mins before GTP addition measured after 20 mins by turbidimetry
Assay data:7 Active, 1 Activity ≤ 1 µM, 8 Tested
Displacement of [3H]-colchicine from tubulin (unknown origin) at 5 uM after 10 mins
Assay data:8 Tested
Displacement of [3H]-colchicine from tubulin (unknown origin) at 1 uM after 10 mins
Inhibition of tubulin (unknown origin) assembly
Assay data:4 Tested
Inhibition of colchicine binding to tubulin (unknown origin)
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