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SAR analysis of small molecule antagonists of the CXCR6 receptor in a screening panel assay
Assay data:1 Active, 6 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Inhibition of CXCR6 (unknown origin) at 10 uM relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
RNAi screen for vorinostat resistance genes - Primary Screen
Assay data:450 Active, 18118 Tested
SummaryPubMed Citation
Druggable Genome siRNA Screen for Enhancers of Camptothecin in MDA-MB-231 Breast Cancer Cells
Assay data:167 Active, 26449 Tested
Summary
Binding affinity to CXCR6 (unknown origin) at 10 uM by radioligand displacement assay
Antagonist activity at CXCR6 (unknown origin) assessed as inhibition of calcium flux at 10 uM
Antagonist activity at CXCR6 (unknown origin) assessed as inhibition of chemotaxis at 10 uM
SAR analysis of small molecule antagonists of the CXCR6 receptor in a screening panel assay - 4
Assay data:8 Active, 36 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Ambion Library)
Assay data:9227 Active, 64752 Tested
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Dharmacon Library)
Assay data:826 Active, 18119 Tested
SAR analysis of small molecule antagonists of the CXCR6 receptor in a screening panel assay - 3
Assay data:8 Active, 2 Activity ≤ 1 µM, 35 Tested
A whole genome RNAi screen highlights components of the ER/Golgi as a prominent source of resistance to immunotoxin-mediated cytotoxicity
Assay data:555 Active, 64752 Tested
SAR analysis of small molecule antagonists of the CXCR6 receptor in an APJ-DiscoveRx counter screen panel assay
Activity at human CXCR6 receptor at 10 uM
Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay
Assay data:390 Active, 610 Tested
An siRNA screen for human genes that are involved in human papilloma virus (HPV) E2 transcriptional repression of the E6 and E7 oncogenes
Assay data:497 Active, 21019 Tested
Single concentration confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor via a luminescent beta-arrestin assay
Assay data:458 Active, 704 Tested
Summary assay for small molecule Inhibitors of CXCR6
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
uHTS identification of CXCR6 Inhibitors in a B-arrestin luminescence assay
Assay data:1305 Active, 362388 Tested
Inhibition of CXCR6 upto 1 uM
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