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Inhibition of Beta-Lactamase Enzymes from US Patent US10800778: "Beta-lactamase inhibitor compounds"
Assay data:39 Active, 1 Activity ≤ 1 nM, 38 Activity ≤ 1 µM, 40 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Test for beta-lactamase Inhibitory Activity from US Patent US10544146: "Bicyclic compounds and their use as antibacterial agents and β-lactamase inhibitors"
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Kinetic Assay from Article 10.1074/jbc.M113.533562: "The different inhibition mechanisms of OXA-1 and OXA-24 -lactamases are determined by the stability of active site carboxylated lysine."
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Cell Free Inhibition Assay from US Patent US9120808: "Substituted clavulanic acid"
Assay data:38 Active, 3 Activity ≤ 1 nM, 30 Activity ≤ 1 µM, 42 Tested
Inhibition Assay from Article 10.1016/S1074-5521(01)00034-5: "Structure-based design and in-parallel synthesis of inhibitors of AmpC beta-lactamase."
Assay data:33 Active, 17 Activity ≤ 1 µM, 41 Tested
Beta-lactamase CTX-M Inhibition Assay from Article 10.1038/nchembio.155: "Molecular docking and ligand specificity in fragment-based inhibitor discovery."
Assay data:14 Tested
SummaryPubMed CitationRelated BioAssays by Depositor
The drug is tested on Escherichia coli strain: BW25113 for biotransformation. The drug concentrations were measured before and after a 12-h incubation by liquid-chromatography-coupled mass spectrometry (LC?MS)
Assay data:205 Tested
SummaryPubMed Citation
Antibacterial activity against Escherichia coli incubated for 24 hrs by disc diffusion method
Assay data:16 Tested
Antimicrobial activity against Escherichia coli assessed as inhibition of bacterial growth
Assay data:1 Tested
Antibacterial activity against Escherichia coli assessed as inhibition of bacterial growth
Assay data:3 Tested
Potency index, ratio of ampicillin MIC to compound MIC for Escherichia coli by agar dilution method
Antibacterial activity against Escherichia coli by agar dilution method
Assay data:4 Tested
Antibacterial activity against Escherichia coli assessed as inhibition of microbial growth
Antimicrobial activity against Escherichia coli
Antibacterial activity against Escherichia coli ATCC 25922 by plate dilution method
Antibacterial activity against Escherichia coli
Antibacterial activity against Escherichia coli assessed as zone of inhibition at 100 ppm
Assay data:10 Tested
Antimicrobial activity against Escherichia coli assessed as bacterial growth inhibition
Antibacterial activity against Escherichia coli assessed as bacterial growth inhibition by microdilution assay
Assay data:2 Tested
Antibacterial activity against Escherichia coli ATCC 11229 assessed as inhibition zone
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