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Inhibition of FtsZ in Escherichia coli ATCC 25922 assessed as decrease in cell division by measuring lowest compound concentration at which bacterial filamentation is observed after 5 hrs by phase-contrast light microscopy
Assay data:32 Tested
SummaryPubMed Citation
Induction of inner membrane permeabilization in Escherichia coli ATCC 25922 assessed as increase in absorbance at 420 nm in presence of ONPG by absorbance based assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed Citation
Induction of outer membrane permeabilization in Escherichia coli ATCC 25922 assessed as increase in NPN uptake at 10 to 40 uM by NPN-dye based fluorescence analysis
Assay data:1 Tested
Induction of cell membrane disruption in Escherichia coli ATCC25922 at 5 uM preincubated for 15 mins followed by irradiated with 81 J/cm^2 light for 15 mins by DAPI staining based confocal laser scanning microscopic analysis
Induction of cell membrane permeabilization in Escherichia coli ATCC 25922 assessed as cell morphology distortion by measuring modifications on bacillary structure at 0.23 uM by Atomic force microscopy analysis
Induction of cell membrane permeabilization in Escherichia coli ATCC 25922 assessed as cell morphology distortion by measuring modifications on bacillary structure at 0.12 uM by Atomic force microscopy analysis
Induction of cell membrane permeabilization in Escherichia coli ATCC 25922 assessed as cell morphology distortion by measuring alterations in cell shape at 0.47 uM by Atomic force microscopy analysis
Induction of cell membrane permeabilization in Escherichia coli ATCC 25922 assessed as cell morphology distortion by measuring circular depressions along the bacterial surface at 0.47 uM by Atomic force microscopy analysis
Inhibition of LspA in wild type Escherichia coli 25922 assessed as inhibition of bacterial growth
Inhibition of Escherichia coli ATCC 25922 DNA gyrase A assessed as reduction in enzyme-mediated supercoiling of relaxed pBR322 DNA by ethidium bromide staining based gel electrophoresis method
Assay data:32 Active, 10 Activity ≤ 1 µM, 40 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of LpxC in Escherichia coli isolate 35 ATCC 25922
Assay data:35 Active, 6 Activity ≤ 1 nM, 35 Activity ≤ 1 µM, 35 Tested
Inhibition of Escherichia coli ATCC 25922 topoisomerase-4 ParC at 100 uM using kinetoplast DNA as substrate after 60 mins relative to control
Assay data:1 Active, 3 Tested
Inhibition of DNA gyrase-A in Escherichia coli ATCC 25922 using relaxed pBR322 DNA as substrate after 30 mins by ethidium bromide staining based agarose gel electrophoresis method
Assay data:1 Active, 1 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Binding affinity to Escherichia coli ATCC 25922 DNA gyrase B by surface plasmon resonance assay
Assay data:4 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of Escherichia coli ATCC 25922 DNA gyrase B using relaxed pNO1 DNA as substrate incubated for 30 mins and measured by sybrGOLD staining based fluorescence assay
Assay data:7 Active, 2 Activity ≤ 1 µM, 24 Tested
Inhibition of His tagged Escherichia coli ATCC 25922 DNA gyrase A expressed in Escherichia coli BL21 (DE3) pLysS cells assessed as reduction in enzyme-mediated supercoiling of relaxed plasmid DNA pNO1 after 30 mins in presence of biotinylated TFO1 by fluorescence assay
Assay data:7 Active, 7 Activity ≤ 1 µM, 9 Tested
Inhibition of His tagged Escherichia coli ATCC 25922 DNA gyrase A SD-LY mutant expressed in Escherichia coli BL21 (DE3) pLysS cells assessed as reduction in enzyme-mediated supercoiling of relaxed plasmid DNA pNO1 after 30 mins in presence of biotinylated TFO1 by fluorescence assay
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Drug uptake in Escherichia coli ATCC 25922 at 100 uM by LC-MS/Ms analysis
Assay data:2 Tested
Inhibition of DNA gyrase in Escherichia coli ATCC 25922 assessed as elongation of bacterial cells at 2 ug/ml measured after 1.5 hrs by DAPI/FM 4-64 staining based confocal fluorescence microscopic analysis
Inhibition of DNA gyrase in Escherichia coli ATCC 25922 assessed as change in DNA morphology at 2.5 ug/ml measured after 1.5 hrs by DAPI/FM 4-64 staining based confocal fluorescence microscopic analysis
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