LOCUS NM_003202 3277 bp mRNA linear PRI 16-SEP-2016
DEFINITION Homo sapiens transcription factor 7 (T-cell specific, HMG-box)
(TCF7), transcript variant 1, mRNA.
ACCESSION NM_003202
VERSION NM_003202.3
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3277)
AUTHORS Campbell JE, Ussher JR, Mulvihill EE, Kolic J, Baggio LL, Cao X,
Liu Y, Lamont BJ, Morii T, Streutker CJ, Tamarina N, Philipson LH,
Wrana JL, MacDonald PE and Drucker DJ.
TITLE TCF1 links GIPR signaling to the control of beta cell function and
survival
JOURNAL Nat. Med. 22 (1), 84-90 (2016)
PUBMED 26642437
REMARK GeneRIF: Tcf7 levels are lower in islets taken from patients with
type 2 diabetes. Knockdown of TCF7 in islets impairs the
cytoprotective responsiveness to GIP and enhances the magnitude of
apoptotic injury.
REFERENCE 2 (bases 1 to 3277)
AUTHORS Park J, Schlederer M, Schreiber M, Ice R, Merkel O, Bilban M,
Hofbauer S, Kim S, Addison J, Zou J, Ji C, Bunting ST, Wang Z,
Shoham M, Huang G, Bago-Horvath Z, Gibson LF, Rojanasakul Y, Remick
S, Ivanov A, Pugacheva E, Bunting KD, Moriggl R, Kenner L and Tse
W.
TITLE AF1q is a novel TCF7 co-factor which activates CD44 and promotes
breast cancer metastasis
JOURNAL Oncotarget 6 (24), 20697-20710 (2015)
PUBMED 26079538
REMARK GeneRIF: Findings indicate that breast cancer cells with a
hyperactive AF1q/TCF7/CD44 regulatory axis in the primary sites may
represent 'metastatic founder cells' which have invasive
properties.
REFERENCE 3 (bases 1 to 3277)
AUTHORS Pramanik KC, Fofaria NM, Gupta P, Ranjan A, Kim SH and Srivastava
SK.
TITLE Inhibition of beta-catenin signaling suppresses pancreatic tumor
growth by disrupting nuclear beta-catenin/TCF-1 complex: critical
role of STAT-3
JOURNAL Oncotarget 6 (13), 11561-11574 (2015)
PUBMED 25869100
REMARK GeneRIF: Capsaicin-induced apoptosis in pancreatic cancer cells was
associated with inhibition of beta-catenin signaling due to the
dissociation of beta-catenin/TCF-1 complex and the process was
orchestrated by STAT-3.
REFERENCE 4 (bases 1 to 3277)
AUTHORS Wang Y, He L, Du Y, Zhu P, Huang G, Luo J, Yan X, Ye B, Li C, Xia
P, Zhang G, Tian Y, Chen R and Fan Z.
TITLE The long noncoding RNA lncTCF7 promotes self-renewal of human liver
cancer stem cells through activation of Wnt signaling
JOURNAL Cell Stem Cell 16 (4), 413-425 (2015)
PUBMED 25842979
REMARK GeneRIF: induction of expression activates the Wnt signaling
pathway, leading to priming of liver cancer stem cells self-renewal
and tumor propagation
REFERENCE 5 (bases 1 to 3277)
AUTHORS Zhu Y, Wang W and Wang X.
TITLE Roles of transcriptional factor 7 in production of inflammatory
factors for lung diseases
JOURNAL J Transl Med 13, 273 (2015)
PUBMED 26289446
REMARK GeneRIF: TCF7 plays critical roles in lung diseases [review]
Review article
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 3277)
AUTHORS Van de Wetering M, Castrop J, Korinek V and Clevers H.
TITLE Extensive alternative splicing and dual promoter usage generate
Tcf-1 protein isoforms with differential transcription control
properties
JOURNAL Mol. Cell. Biol. 16 (3), 745-752 (1996)
PUBMED 8622675
REFERENCE 7 (bases 1 to 3277)
AUTHORS Castrop J, van Wichen D, Koomans-Bitter M, van de Wetering M, de
Weger R, van Dongen J and Clevers H.
TITLE The human TCF-1 gene encodes a nuclear DNA-binding protein uniquely
expressed in normal and neoplastic T-lineage lymphocytes
JOURNAL Blood 86 (8), 3050-3059 (1995)
PUBMED 7579399
REFERENCE 8 (bases 1 to 3277)
AUTHORS Mayer K, Wolff E, Clevers H and Ballhausen WG.
TITLE The human high mobility group (HMG)-box transcription factor TCF-1:
novel isoforms due to alternative splicing and usage of a new exon
IXA
JOURNAL Biochim. Biophys. Acta 1263 (2), 169-172 (1995)
PUBMED 7640309
REFERENCE 9 (bases 1 to 3277)
AUTHORS van de Wetering M, Oosterwegel M, Holstege F, Dooyes D,
Suijkerbuijk R, Geurts van Kessel A and Clevers H.
TITLE The human T cell transcription factor-1 gene. Structure,
localization, and promoter characterization
JOURNAL J. Biol. Chem. 267 (12), 8530-8536 (1992)
PUBMED 1569101
REFERENCE 10 (bases 1 to 3277)
AUTHORS van de Wetering M, Oosterwegel M, Dooijes D and Clevers H.
TITLE Identification and cloning of TCF-1, a T lymphocyte-specific
transcription factor containing a sequence-specific HMG box
JOURNAL EMBO J. 10 (1), 123-132 (1991)
PUBMED 1989880
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BC048769.1, AC011336.5 and
AK131428.1.
This sequence is a reference standard in the RefSeqGene project.
[WARNING] On Oct 14, 2016 this sequence was replaced by
NM_003202.4.
On Sep 19, 2008 this sequence version replaced NM_003202.2.
Summary: The protein encoded by this gene is a transcriptional
activator that plays an important role in lymphocyte
differentiation. This gene is expressed predominantly in T-cells.
The encoded protein can bind an enhancer element and activate the
CD3E gene, and it also may repress the CTNNB1 and TCF7L2 genes
through a feedback mechanism. Several transcript variants encoding
different isoforms have been found for this gene. [provided by
RefSeq, Oct 2011].
Transcript Variant: This variant (1) encodes the longest isoform
(1).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC048769.1, BC072023.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA1965299, SAMEA1968540
[ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-1704 BC048769.1 1-1704
1705-2999 AC011336.5 16994-18288
3000-3277 AK131428.1 3082-3359
FEATURES Location/Qualifiers
source 1..3277
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="5"
/map="5q31.1"
gene 1..3277
/gene="TCF7"
/gene_synonym="TCF-1"
/note="transcription factor 7 (T-cell specific, HMG-box)"
/db_xref="GeneID:6932"
/db_xref="HGNC:HGNC:11639"
/db_xref="MIM:189908"
CDS 197..1351
/gene="TCF7"
/gene_synonym="TCF-1"
/note="isoform 1 is encoded by transcript variant 1;
T-cell-specific transcription factor 1"
/codon_start=1
/product="transcription factor 7 isoform 1"
/protein_id="NP_003193.2"
/db_xref="CCDS:CCDS4169.1"
/db_xref="GeneID:6932"
/db_xref="HGNC:HGNC:11639"
/db_xref="MIM:189908"
/translation="MPQLDSGGGGAGGGDDLGAPDELLAFQDEGEEQDDKSRDSAAGP
ERDLAELKSSLVNESEGAAGGAGIPGVPGAGAGARGEAEALGREHAAQRLFPDKLPEP
LEDGLKAPECTSGMYKETVYSAFNLLMHYPPPSGAGQHPQPQPPLHKANQPPHGVPQL
SLYEHFNSPHPTPAPADISQKQVHRPLQTPDLSGFYSLTSGSMGQLPHTVSWFTHPSL
MLGSGVPGHPAAIPHPAIVPPSGKQELQPFDRNLKTQAESKAEKEAKKPTIKKPLNAF
MLYMKEMRAKVIAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYP
GWSARDNYGKKKRRSREKHQESTTGGKRNAFGTYPEKAAAPAPFLPMTVL"
misc_feature 197..373
/gene="TCF7"
/gene_synonym="TCF-1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P36402.3);
Region: CTNNB1-binding"
misc_feature 1226..1240
/gene="TCF7"
/gene_synonym="TCF-1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P36402.3);
Region: Nuclear localization signal. {ECO:0000255}"
polyA_site 1806
/gene="TCF7"
/gene_synonym="TCF-1"
regulatory 3237..3242
/regulatory_class="polyA_signal_sequence"
/gene="TCF7"
/gene_synonym="TCF-1"
polyA_site 3277
/gene="TCF7"
/gene_synonym="TCF-1"
ORIGIN
1 cccgccagct cgcggagccg ctctgccccg cgccctagcc cgcgcctgca gcccgcccag
61 gcggagtcag cccgcgctcc gcccgccgcg atccgagctc ggaggttcgg actccgggct
121 cgccgccccc cgggccggct ccgcgccccg cactcccggc gcccagcgcc ccgcgccccg
181 gcgggcggag cgcaccatgc cgcagctgga ctccggcggg ggcggcgcgg gcggcggcga
241 cgacctcggc gcgccggacg agctgctggc cttccaggat gaaggcgagg agcaggacga
301 caagagccgc gacagcgccg ccggtcccga gcgcgacctg gccgagctca agtcgtcgct
361 cgtgaacgag tccgagggcg cggccggcgg cgcagggatc ccgggggtcc cgggggccgg
421 cgccggggcc cgcggcgagg ccgaggctct cgggcgggaa cacgctgcgc agagactctt
481 cccggacaaa cttccagagc ccctggagga cggcctgaag gccccggagt gcaccagcgg
541 catgtacaaa gagaccgtct actccgcctt caatctgctc atgcattacc cacccccctc
601 gggagcaggg cagcaccccc agccgcagcc cccgctgcac aaggccaatc agccccccca
661 cggtgtcccc caactctctc tctacgaaca tttcaacagc ccacatccca cccctgcacc
721 tgcggacatc agccagaagc aagttcacag gcctctgcag acccctgacc tctctggctt
781 ctactccctg acctcaggca gcatggggca gctcccccac actgtgagct ggttcaccca
841 cccatccttg atgctaggtt ctggtgtacc tggtcaccca gcagccatcc cccacccggc
901 cattgtgccc ccctcaggga agcaggagct gcagcccttc gaccgcaacc tgaagacaca
961 agcagagtcc aaggcagaga aggaggccaa gaagccaacc atcaagaagc ccctcaatgc
1021 cttcatgctg tacatgaagg agatgagagc caaggtcatt gcagagtgca cacttaagga
1081 gagcgctgcc atcaaccaga tcctgggccg caggtggcac gcgctgtcgc gagaagagca
1141 ggccaagtac tatgagctgg cccgcaagga gaggcagctg cacatgcagc tatacccagg
1201 ctggtcagcg cgggacaact acgggaagaa gaagaggcgg tcgagggaaa agcaccaaga
1261 atccaccaca ggaggaaaaa gaaatgcatt cggtacttac ccggagaagg ccgctgcccc
1321 agccccgttc cttccgatga cagtgctcta ggctgccccg ggtccccagc tccccaggac
1381 tcaccctcat accatctgct gccccgcttc cccacagaac tgcttactag ccctgcggag
1441 ccggcaccta catccccagg tctctccact gctctcagcc tcccaacccc agggccccca
1501 caggcccccc gcagcaccct gcagagcaca caggtacagc aacaggaatc tcagagacag
1561 gtggcctagc aggcacagga cacctggccg cctccaggag cctaccccct gaaagtgaca
1621 gagacccaga tctcatggaa actggccagg ggtcctgtta acgtcatctc agggtccaga
1681 ccctgaagat ttcagaggct gcaggacttc tgcctgaacc tggggtcatc gattcaaact
1741 gctccaagtg gtgggaatca gatctgtctt gatgtgtcat ctaattaagg gaatcccttg
1801 tacctatggc tgcctgcatc tattctttgt accatctgtc ttgccagcca gaagcctctg
1861 cctccctagc ttttctgcta taggtcagag atgggctgaa ctgagcctag ctaccttctc
1921 tacccatctc ccccatcccc cactgccaca ccctccccat tcagacactt catggaccaa
1981 gaatgagctg gtttgtcaaa caacatgtga gcatggtcac aagcacaaag ctcaagatga
2041 cagctcttct aaggaaatgg agaagctctg tttataaaaa caaaaacaaa accagctgct
2101 actcataagt tggaccagag gaagcccctt actatgatct caggagcttg caagaagcag
2161 gaaggggaat ggaataggtt aagtttaggc ctatcaacct aagcaacaga aataatctga
2221 cactacctta tcaggcaaat tggggagggg agggtgtatc tagctctagt tcaaattatt
2281 tggaagtgtt ccctgagaaa cccaccagcc taagaagctc tggccccagg cttgtcacta
2341 gcagctgcag tcaacagttc aaagaagtca tggcccaaat ccagtgtgca cccctcccca
2401 ttcacagagc ctttttcaca attccatttc cagttcatct atggcagtcc agccagctcc
2461 tgggcagctt gagagggcaa acccaaaacc tcatgacagc cagagcctgt ctttcagcat
2521 tcagtccgcc tggccggctc cagtttcccc atggggctgc gggacagagg accattacaa
2581 ctagatcaag gagcccagaa aacctccagt agtggacaac aggttttcac catagcctac
2641 gttaacccat ttttgagcca agcttcaacc ctcagccttg aaaaacaagt ctttaattta
2701 atttttgttt tttgcctaaa tccaaagaaa aagggctgcc gggccaggcg cggtggctca
2761 cgcctgtaat cccagcactt tggcaggccg aggcaggtgg atcacctgac gtcagtagtt
2821 tgagaccagc ctggccaaca tggtgaaacc ctgtatctac taaaaataca aaaattagcc
2881 ggacgtggtg gtgcgcgcat gtaatcccag ctactcggga ggctgaggcg gaagaatcac
2941 ttgaacccgg gaggcggagg ttccagtgag ccgagatggc gctattgcac tccagtctgg
3001 gtaacaggga gactgcatct caaaaaaaaa aaaaaaaaaa aaaaagggct gtccatgtat
3061 tcacacaccc ctcaaaaaaa gcctttagtt cctactttag ccactggttt ctcagaatcc
3121 aaagatcaca tattctagtg taacactgca agaagtcttg agaaaaagat tattgtagtg
3181 ttcaaaatat ttttgtattg ttaatgcatc atcatagaaa aacttttaaa catgagaata
3241 aagatacttt ttactgggtt tgtttttcaa agcctga
//