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Homo sapiens transcription factor 7 (T-cell specific, HMG-box) (TCF7), transcript variant 1, mRNA

NCBI Reference Sequence: NM_003202.3

FASTA Graphics 

LOCUS       NM_003202               3277 bp    mRNA    linear   PRI 16-SEP-2016
DEFINITION  Homo sapiens transcription factor 7 (T-cell specific, HMG-box)
            (TCF7), transcript variant 1, mRNA.
ACCESSION   NM_003202
VERSION     NM_003202.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3277)
  AUTHORS   Campbell JE, Ussher JR, Mulvihill EE, Kolic J, Baggio LL, Cao X,
            Liu Y, Lamont BJ, Morii T, Streutker CJ, Tamarina N, Philipson LH,
            Wrana JL, MacDonald PE and Drucker DJ.
  TITLE     TCF1 links GIPR signaling to the control of beta cell function and
            survival
  JOURNAL   Nat. Med. 22 (1), 84-90 (2016)
   PUBMED   26642437
  REMARK    GeneRIF: Tcf7 levels are lower in islets taken from patients with
            type 2 diabetes. Knockdown of TCF7 in islets impairs the
            cytoprotective responsiveness to GIP and enhances the magnitude of
            apoptotic injury.
REFERENCE   2  (bases 1 to 3277)
  AUTHORS   Park J, Schlederer M, Schreiber M, Ice R, Merkel O, Bilban M,
            Hofbauer S, Kim S, Addison J, Zou J, Ji C, Bunting ST, Wang Z,
            Shoham M, Huang G, Bago-Horvath Z, Gibson LF, Rojanasakul Y, Remick
            S, Ivanov A, Pugacheva E, Bunting KD, Moriggl R, Kenner L and Tse
            W.
  TITLE     AF1q is a novel TCF7 co-factor which activates CD44 and promotes
            breast cancer metastasis
  JOURNAL   Oncotarget 6 (24), 20697-20710 (2015)
   PUBMED   26079538
  REMARK    GeneRIF: Findings indicate that breast cancer cells with a
            hyperactive AF1q/TCF7/CD44 regulatory axis in the primary sites may
            represent 'metastatic founder cells' which have invasive
            properties.
REFERENCE   3  (bases 1 to 3277)
  AUTHORS   Pramanik KC, Fofaria NM, Gupta P, Ranjan A, Kim SH and Srivastava
            SK.
  TITLE     Inhibition of beta-catenin signaling suppresses pancreatic tumor
            growth by disrupting nuclear beta-catenin/TCF-1 complex: critical
            role of STAT-3
  JOURNAL   Oncotarget 6 (13), 11561-11574 (2015)
   PUBMED   25869100
  REMARK    GeneRIF: Capsaicin-induced apoptosis in pancreatic cancer cells was
            associated with inhibition of beta-catenin signaling due to the
            dissociation of beta-catenin/TCF-1 complex and the process was
            orchestrated by STAT-3.
REFERENCE   4  (bases 1 to 3277)
  AUTHORS   Wang Y, He L, Du Y, Zhu P, Huang G, Luo J, Yan X, Ye B, Li C, Xia
            P, Zhang G, Tian Y, Chen R and Fan Z.
  TITLE     The long noncoding RNA lncTCF7 promotes self-renewal of human liver
            cancer stem cells through activation of Wnt signaling
  JOURNAL   Cell Stem Cell 16 (4), 413-425 (2015)
   PUBMED   25842979
  REMARK    GeneRIF: induction of expression activates the Wnt signaling
            pathway, leading to priming of liver cancer stem cells self-renewal
            and tumor propagation
REFERENCE   5  (bases 1 to 3277)
  AUTHORS   Zhu Y, Wang W and Wang X.
  TITLE     Roles of transcriptional factor 7 in production of inflammatory
            factors for lung diseases
  JOURNAL   J Transl Med 13, 273 (2015)
   PUBMED   26289446
  REMARK    GeneRIF: TCF7 plays critical roles in lung diseases [review]
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3277)
  AUTHORS   Van de Wetering M, Castrop J, Korinek V and Clevers H.
  TITLE     Extensive alternative splicing and dual promoter usage generate
            Tcf-1 protein isoforms with differential transcription control
            properties
  JOURNAL   Mol. Cell. Biol. 16 (3), 745-752 (1996)
   PUBMED   8622675
REFERENCE   7  (bases 1 to 3277)
  AUTHORS   Castrop J, van Wichen D, Koomans-Bitter M, van de Wetering M, de
            Weger R, van Dongen J and Clevers H.
  TITLE     The human TCF-1 gene encodes a nuclear DNA-binding protein uniquely
            expressed in normal and neoplastic T-lineage lymphocytes
  JOURNAL   Blood 86 (8), 3050-3059 (1995)
   PUBMED   7579399
REFERENCE   8  (bases 1 to 3277)
  AUTHORS   Mayer K, Wolff E, Clevers H and Ballhausen WG.
  TITLE     The human high mobility group (HMG)-box transcription factor TCF-1:
            novel isoforms due to alternative splicing and usage of a new exon
            IXA
  JOURNAL   Biochim. Biophys. Acta 1263 (2), 169-172 (1995)
   PUBMED   7640309
REFERENCE   9  (bases 1 to 3277)
  AUTHORS   van de Wetering M, Oosterwegel M, Holstege F, Dooyes D,
            Suijkerbuijk R, Geurts van Kessel A and Clevers H.
  TITLE     The human T cell transcription factor-1 gene. Structure,
            localization, and promoter characterization
  JOURNAL   J. Biol. Chem. 267 (12), 8530-8536 (1992)
   PUBMED   1569101
REFERENCE   10 (bases 1 to 3277)
  AUTHORS   van de Wetering M, Oosterwegel M, Dooijes D and Clevers H.
  TITLE     Identification and cloning of TCF-1, a T lymphocyte-specific
            transcription factor containing a sequence-specific HMG box
  JOURNAL   EMBO J. 10 (1), 123-132 (1991)
   PUBMED   1989880
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC048769.1, AC011336.5 and
            AK131428.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            [WARNING] On Oct 14, 2016 this sequence was replaced by
            NM_003202.4.
            
            On Sep 19, 2008 this sequence version replaced NM_003202.2.
            
            Summary: The protein encoded by this gene is a transcriptional
            activator that plays an important role in lymphocyte
            differentiation. This gene is expressed predominantly in T-cells.
            The encoded protein can bind an enhancer element and activate the
            CD3E gene, and it also may repress the CTNNB1 and TCF7L2 genes
            through a feedback mechanism. Several transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Oct 2011].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC048769.1, BC072023.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1704              BC048769.1         1-1704
            1705-2999           AC011336.5         16994-18288
            3000-3277           AK131428.1         3082-3359
FEATURES             Location/Qualifiers
     source          1..3277
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.1"
     gene            1..3277
                     /gene="TCF7"
                     /gene_synonym="TCF-1"
                     /note="transcription factor 7 (T-cell specific, HMG-box)"
                     /db_xref="GeneID:6932"
                     /db_xref="HGNC:HGNC:11639"
                     /db_xref="MIM:189908"
     CDS             197..1351
                     /gene="TCF7"
                     /gene_synonym="TCF-1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     T-cell-specific transcription factor 1"
                     /codon_start=1
                     /product="transcription factor 7 isoform 1"
                     /protein_id="NP_003193.2"
                     /db_xref="CCDS:CCDS4169.1"
                     /db_xref="GeneID:6932"
                     /db_xref="HGNC:HGNC:11639"
                     /db_xref="MIM:189908"
                     /translation="MPQLDSGGGGAGGGDDLGAPDELLAFQDEGEEQDDKSRDSAAGP
                     ERDLAELKSSLVNESEGAAGGAGIPGVPGAGAGARGEAEALGREHAAQRLFPDKLPEP
                     LEDGLKAPECTSGMYKETVYSAFNLLMHYPPPSGAGQHPQPQPPLHKANQPPHGVPQL
                     SLYEHFNSPHPTPAPADISQKQVHRPLQTPDLSGFYSLTSGSMGQLPHTVSWFTHPSL
                     MLGSGVPGHPAAIPHPAIVPPSGKQELQPFDRNLKTQAESKAEKEAKKPTIKKPLNAF
                     MLYMKEMRAKVIAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYP
                     GWSARDNYGKKKRRSREKHQESTTGGKRNAFGTYPEKAAAPAPFLPMTVL"
     misc_feature    197..373
                     /gene="TCF7"
                     /gene_synonym="TCF-1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P36402.3);
                     Region: CTNNB1-binding"
     misc_feature    1226..1240
                     /gene="TCF7"
                     /gene_synonym="TCF-1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P36402.3);
                     Region: Nuclear localization signal. {ECO:0000255}"
     polyA_site      1806
                     /gene="TCF7"
                     /gene_synonym="TCF-1"
     regulatory      3237..3242
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TCF7"
                     /gene_synonym="TCF-1"
     polyA_site      3277
                     /gene="TCF7"
                     /gene_synonym="TCF-1"
ORIGIN      
        1 cccgccagct cgcggagccg ctctgccccg cgccctagcc cgcgcctgca gcccgcccag
       61 gcggagtcag cccgcgctcc gcccgccgcg atccgagctc ggaggttcgg actccgggct
      121 cgccgccccc cgggccggct ccgcgccccg cactcccggc gcccagcgcc ccgcgccccg
      181 gcgggcggag cgcaccatgc cgcagctgga ctccggcggg ggcggcgcgg gcggcggcga
      241 cgacctcggc gcgccggacg agctgctggc cttccaggat gaaggcgagg agcaggacga
      301 caagagccgc gacagcgccg ccggtcccga gcgcgacctg gccgagctca agtcgtcgct
      361 cgtgaacgag tccgagggcg cggccggcgg cgcagggatc ccgggggtcc cgggggccgg
      421 cgccggggcc cgcggcgagg ccgaggctct cgggcgggaa cacgctgcgc agagactctt
      481 cccggacaaa cttccagagc ccctggagga cggcctgaag gccccggagt gcaccagcgg
      541 catgtacaaa gagaccgtct actccgcctt caatctgctc atgcattacc cacccccctc
      601 gggagcaggg cagcaccccc agccgcagcc cccgctgcac aaggccaatc agccccccca
      661 cggtgtcccc caactctctc tctacgaaca tttcaacagc ccacatccca cccctgcacc
      721 tgcggacatc agccagaagc aagttcacag gcctctgcag acccctgacc tctctggctt
      781 ctactccctg acctcaggca gcatggggca gctcccccac actgtgagct ggttcaccca
      841 cccatccttg atgctaggtt ctggtgtacc tggtcaccca gcagccatcc cccacccggc
      901 cattgtgccc ccctcaggga agcaggagct gcagcccttc gaccgcaacc tgaagacaca
      961 agcagagtcc aaggcagaga aggaggccaa gaagccaacc atcaagaagc ccctcaatgc
     1021 cttcatgctg tacatgaagg agatgagagc caaggtcatt gcagagtgca cacttaagga
     1081 gagcgctgcc atcaaccaga tcctgggccg caggtggcac gcgctgtcgc gagaagagca
     1141 ggccaagtac tatgagctgg cccgcaagga gaggcagctg cacatgcagc tatacccagg
     1201 ctggtcagcg cgggacaact acgggaagaa gaagaggcgg tcgagggaaa agcaccaaga
     1261 atccaccaca ggaggaaaaa gaaatgcatt cggtacttac ccggagaagg ccgctgcccc
     1321 agccccgttc cttccgatga cagtgctcta ggctgccccg ggtccccagc tccccaggac
     1381 tcaccctcat accatctgct gccccgcttc cccacagaac tgcttactag ccctgcggag
     1441 ccggcaccta catccccagg tctctccact gctctcagcc tcccaacccc agggccccca
     1501 caggcccccc gcagcaccct gcagagcaca caggtacagc aacaggaatc tcagagacag
     1561 gtggcctagc aggcacagga cacctggccg cctccaggag cctaccccct gaaagtgaca
     1621 gagacccaga tctcatggaa actggccagg ggtcctgtta acgtcatctc agggtccaga
     1681 ccctgaagat ttcagaggct gcaggacttc tgcctgaacc tggggtcatc gattcaaact
     1741 gctccaagtg gtgggaatca gatctgtctt gatgtgtcat ctaattaagg gaatcccttg
     1801 tacctatggc tgcctgcatc tattctttgt accatctgtc ttgccagcca gaagcctctg
     1861 cctccctagc ttttctgcta taggtcagag atgggctgaa ctgagcctag ctaccttctc
     1921 tacccatctc ccccatcccc cactgccaca ccctccccat tcagacactt catggaccaa
     1981 gaatgagctg gtttgtcaaa caacatgtga gcatggtcac aagcacaaag ctcaagatga
     2041 cagctcttct aaggaaatgg agaagctctg tttataaaaa caaaaacaaa accagctgct
     2101 actcataagt tggaccagag gaagcccctt actatgatct caggagcttg caagaagcag
     2161 gaaggggaat ggaataggtt aagtttaggc ctatcaacct aagcaacaga aataatctga
     2221 cactacctta tcaggcaaat tggggagggg agggtgtatc tagctctagt tcaaattatt
     2281 tggaagtgtt ccctgagaaa cccaccagcc taagaagctc tggccccagg cttgtcacta
     2341 gcagctgcag tcaacagttc aaagaagtca tggcccaaat ccagtgtgca cccctcccca
     2401 ttcacagagc ctttttcaca attccatttc cagttcatct atggcagtcc agccagctcc
     2461 tgggcagctt gagagggcaa acccaaaacc tcatgacagc cagagcctgt ctttcagcat
     2521 tcagtccgcc tggccggctc cagtttcccc atggggctgc gggacagagg accattacaa
     2581 ctagatcaag gagcccagaa aacctccagt agtggacaac aggttttcac catagcctac
     2641 gttaacccat ttttgagcca agcttcaacc ctcagccttg aaaaacaagt ctttaattta
     2701 atttttgttt tttgcctaaa tccaaagaaa aagggctgcc gggccaggcg cggtggctca
     2761 cgcctgtaat cccagcactt tggcaggccg aggcaggtgg atcacctgac gtcagtagtt
     2821 tgagaccagc ctggccaaca tggtgaaacc ctgtatctac taaaaataca aaaattagcc
     2881 ggacgtggtg gtgcgcgcat gtaatcccag ctactcggga ggctgaggcg gaagaatcac
     2941 ttgaacccgg gaggcggagg ttccagtgag ccgagatggc gctattgcac tccagtctgg
     3001 gtaacaggga gactgcatct caaaaaaaaa aaaaaaaaaa aaaaagggct gtccatgtat
     3061 tcacacaccc ctcaaaaaaa gcctttagtt cctactttag ccactggttt ctcagaatcc
     3121 aaagatcaca tattctagtg taacactgca agaagtcttg agaaaaagat tattgtagtg
     3181 ttcaaaatat ttttgtattg ttaatgcatc atcatagaaa aacttttaaa catgagaata
     3241 aagatacttt ttactgggtt tgtttttcaa agcctga
//
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