LOCUS NM_200497 2013 bp mRNA linear VRT 20-OCT-2024
DEFINITION Danio rerio GDP-mannose pyrophosphorylase Ab (gmppab), mRNA.
ACCESSION NM_200497 XM_697197
VERSION NM_200497.1
KEYWORDS RefSeq.
SOURCE Danio rerio (zebrafish)
ORGANISM Danio rerio
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE 1 (bases 1 to 2013)
AUTHORS Zheng,L., Liu,Z., Wang,Y., Yang,F., Wang,J., Huang,W., Qin,J.,
Tian,M., Cai,X., Liu,X., Mo,X., Gao,N. and Jia,D.
TITLE Cryo-EM structures of human GMPPA-GMPPB complex reveal how cells
maintain GDP-mannose homeostasis
JOURNAL Nat Struct Mol Biol 28 (5), 1-12 (2021)
PUBMED 33986552
REFERENCE 2 (bases 1 to 2013)
AUTHORS Pasquier,J., Cabau,C., Nguyen,T., Jouanno,E., Severac,D.,
Braasch,I., Journot,L., Pontarotti,P., Klopp,C., Postlethwait,J.H.,
Guiguen,Y. and Bobe,J.
TITLE Gene evolution and gene expression after whole genome duplication
in fish: the PhyloFish database
JOURNAL BMC Genomics 17, 368 (2016)
PUBMED 27189481
REMARK Publication Status: Online-Only
REFERENCE 3 (bases 1 to 2013)
AUTHORS Elkon,R., Milon,B., Morrison,L., Shah,M., Vijayakumar,S.,
Racherla,M., Leitch,C.C., Silipino,L., Hadi,S., Weiss-Gayet,M.,
Barras,E., Schmid,C.D., Ait-Lounis,A., Barnes,A., Song,Y.,
Eisenman,D.J., Eliyahu,E., Frolenkov,G.I., Strome,S.E., Durand,B.,
Zaghloul,N.A., Jones,S.M., Reith,W. and Hertzano,R.
TITLE RFX transcription factors are essential for hearing in mice
JOURNAL Nat Commun 6, 8549 (2015)
PUBMED 26469318
REMARK Publication Status: Online-Only
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from BC055506.1.
On Jul 6, 2005 this sequence version replaced XM_697197.1.
##Evidence-Data-START##
Transcript exon combination :: BC055506.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA3505370, SAMEA3505372
[ECO:0000348]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..2013
/organism="Danio rerio"
/mol_type="mRNA"
/strain="AB"
/db_xref="taxon:7955"
/chromosome="6"
/map="6"
gene 1..2013
/gene="gmppab"
/gene_synonym="gmppa; zgc:66135"
/note="GDP-mannose pyrophosphorylase Ab"
/db_xref="GeneID:393469"
/db_xref="ZFIN:ZDB-GENE-040426-1550"
exon 1..272
/gene="gmppab"
/gene_synonym="gmppa; zgc:66135"
/inference="alignment:Splign:2.1.0"
misc_feature 227..229
/gene="gmppab"
/gene_synonym="gmppa; zgc:66135"
/note="upstream in-frame stop codon"
CDS 233..1501
/gene="gmppab"
/gene_synonym="gmppa; zgc:66135"
/EC_number="2.7.7.13"
/note="GDP-mannose pyrophosphorylase A-B;
GTP-mannose-1-phosphate guanylyltransferase apha-B;
GTP-mannose-1-phosphate guanylyltransferase alpha-b;
mannose-1-phosphate guanyltransferase alpha-B"
/codon_start=1
/product="mannose-1-phosphate guanylyltransferase
regulatory subunit alpha-B"
/protein_id="NP_956791.1"
/db_xref="GeneID:393469"
/db_xref="ZFIN:ZDB-GENE-040426-1550"
/translation="MLKAIILIGGPQKGTRFRPLSFEVPKPLFPVAGVPMLQHHIEAC
AQVPDMKEIMLIGFYQPNDELNRFIYSAQQEFKIPIRYLQEFAALGTGGGIYHFRDQI
LSGGPAAFFLMNADVCSEFPLLEMLQFHRQHGENHCGVLLGTTANRTQSLNYGCIVEN
HETNEVLHFVEKPSTFVSDIINCGIYLFTPDIFAHIGKVFQRNQQEKIQEELTHGRQM
PEVVRLEQDIFTALAGQKKLFVYKTQHFWSQIKSAGSAIYASRLYLKQYHQTHPERLA
TNQGGTPKITGDVYIHPTANIDPSAVLGPNVSIGKGVTIGGGVRVRESIILHGAVLQD
HCCVLNSIVGWDSTVGKWARVEGTPSDPNPNDPYAKIDSETLFRDGGLTPSITILGCN
VNIPSEVIIRNSIVLPHKDLNRSFKNQIIL"
misc_feature 236..991
/gene="gmppab"
/gene_synonym="gmppa; zgc:66135"
/note="propagated from UniProtKB/Swiss-Prot (Q7SXP8.1);
Region: Substrate-binding domain.
/evidence=ECO:0000250|UniProtKB:Q96IJ6"
misc_feature 1055..1498
/gene="gmppab"
/gene_synonym="gmppa; zgc:66135"
/note="propagated from UniProtKB/Swiss-Prot (Q7SXP8.1);
Region: Hexapeptide repeat domain.
/evidence=ECO:0000250|UniProtKB:Q96IJ6"
misc_feature 1304..1390
/gene="gmppab"
/gene_synonym="gmppa; zgc:66135"
/note="propagated from UniProtKB/Swiss-Prot (Q7SXP8.1);
Region: C-loop. /evidence=ECO:0000250|UniProtKB:Q96IJ6"
exon 273..370
/gene="gmppab"
/gene_synonym="gmppa; zgc:66135"
/inference="alignment:Splign:2.1.0"
exon 371..474
/gene="gmppab"
/gene_synonym="gmppa; zgc:66135"
/inference="alignment:Splign:2.1.0"
exon 475..667
/gene="gmppab"
/gene_synonym="gmppa; zgc:66135"
/inference="alignment:Splign:2.1.0"
exon 668..727
/gene="gmppab"
/gene_synonym="gmppa; zgc:66135"
/inference="alignment:Splign:2.1.0"
exon 728..858
/gene="gmppab"
/gene_synonym="gmppa; zgc:66135"
/inference="alignment:Splign:2.1.0"
exon 859..993
/gene="gmppab"
/gene_synonym="gmppa; zgc:66135"
/inference="alignment:Splign:2.1.0"
exon 994..1091
/gene="gmppab"
/gene_synonym="gmppa; zgc:66135"
/inference="alignment:Splign:2.1.0"
exon 1092..1138
/gene="gmppab"
/gene_synonym="gmppa; zgc:66135"
/inference="alignment:Splign:2.1.0"
exon 1139..1231
/gene="gmppab"
/gene_synonym="gmppa; zgc:66135"
/inference="alignment:Splign:2.1.0"
exon 1232..1400
/gene="gmppab"
/gene_synonym="gmppa; zgc:66135"
/inference="alignment:Splign:2.1.0"
exon 1401..1993
/gene="gmppab"
/gene_synonym="gmppa; zgc:66135"
/inference="alignment:Splign:2.1.0"
ORIGIN
1 actcacttcc gcgttactgt actgaatgga ttttatgaaa ctggtctgtt aaggttaaat
61 tgtactagtt tgggctcgct gttgcgattt tcggaaaagt tagaagaagt gttttataga
121 ctaaacaaaa tgtttaacta gttattttat aaacagacgt gataacaaaa actggacgtg
181 aaataatccg cgaattaaat ttcaattcaa gtgactacat cataactgaa agatgttaaa
241 agcgattatc ctaattgggg gtcctcaaaa aggtaccagg ttccgccccc tgtcatttga
301 ggtgcccaaa cctcttttcc ctgtagcagg agttccaatg ctgcaacatc acattgaagc
361 ctgtgcccaa gttcctgata tgaaggagat catgctaata ggcttttatc agcccaacga
421 tgagctgaac cgcttcattt attctgctca gcaggagttt aaaatcccaa tcaggtacct
481 gcaggagttt gctgctctgg gtacaggtgg tgggatctat cactttcgtg accaaatcct
541 gtccgggggc ccggctgctt ttttcctcat gaatgcagat gtatgctcag agttcccctt
601 gctagaaatg ctccagttcc accgtcagca tggtgaaaat cattgtggag tcctacttgg
661 aactacagca aatcgaacac aatctctgaa ctacggctgc attgtggaaa accatgagac
721 aaatgaggtg ctccattttg tagagaaacc cagtactttt gtaagcgaca tcatcaactg
781 tggcatctat ttgttcaccc cagatatttt tgcccatatt gggaaagttt tccagaggaa
841 ccaacaagag aagatccagg aagagctcac tcatggcagg cagatgccag aggtggttcg
901 gctggaacag gacattttta cagccctagc aggacagaaa aaactctttg tctataaaac
961 acagcacttc tggagtcaga taaagtctgc agggtcagca atatatgcta gtcgcttgta
1021 cctcaaacag tatcatcaga ctcatccgga gagactggcc acaaaccaag gtggaacccc
1081 caaaataaca ggagatgttt atatccatcc tactgcaaac attgatcctt ctgctgtgtt
1141 aggtcctaat gtttccattg gcaaaggggt gacaattgga ggaggtgtaa gagtgaggga
1201 gtccatcatt ttacatggag ccgtgttaca ggaccactgt tgtgtgttga acagtattgt
1261 tggctgggac agcacagtgg ggaagtgggc aagagtggaa ggaactccaa gtgaccctaa
1321 tcccaatgac ccgtatgcca agatagacag tgagactctg ttcagggacg gaggtctgac
1381 cccatccatc accatccttg gctgcaatgt gaatattcca tcagaggtca tcattcgaaa
1441 ctctatcgtc ttgcctcata aagatctcaa caggagcttc aaaaaccaga tcattctcta
1501 aaagacactt ttctcttttc ttgggaataa atattgcaca atgggggatg tagaaagtat
1561 atagtattgt ttatagttta tttttatgta atgtttaggt acttggagaa aatgtgtcta
1621 catatggaag cagattgtat tacagtagta tagtgtaaat tatatggttg aacaactggg
1681 gattttcctg ataaatttca ggattggata ttttgtattt aatgactctg ctgatacacc
1741 agccttacac gcactgacac aacattagat ttgagtgtta atggttttat tcttaataac
1801 aaatgacaca tattatacct gtattgcctt ttccacaaaa tgatgagaga ttaggtcatt
1861 tttgtttgtc tttctttaga aaatgacaaa tttgaaggga catagtgttt ttttgggcag
1921 aaacaaaact tttgttgttg ttgattatcg ctttattctg ttacaacagt ttattaaaat
1981 aatcttaaca caaaaaaaaa aaaaaaaaaa aaa
//