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Homo sapiens G protein-coupled receptor 78 (GPR78), transcript variant 2, non-coding RNA

NCBI Reference Sequence: NR_045511.3

FASTA Graphics 

LOCUS       NR_045511               3397 bp    RNA     linear   PRI 17-JUN-2024
DEFINITION  Homo sapiens G protein-coupled receptor 78 (GPR78), transcript
            variant 2, non-coding RNA.
ACCESSION   NR_045511
VERSION     NR_045511.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3397)
  AUTHORS   Tanaka,T., Guimaro,M.C., Nakamura,H., Perez,P., Ji,Y.,
            Michael,D.G., Afione,S.A., Zheng,C., Goldsmith,C., Swaim,W.D.,
            Pedersen,A.M.L. and Chiorini,J.A.
  TITLE     Association of G protein-coupled receptor 78 with salivary
            dysfunction in male Sjogren's patients
  JOURNAL   Oral Dis 30 (3), 1173-1182 (2024)
   PUBMED   36652502
  REMARK    GeneRIF: Association of G protein-coupled receptor 78 with salivary
            dysfunction in male Sjogren's patients.
REFERENCE   2  (bases 1 to 3397)
  AUTHORS   Cai,M.N., Chen,D.M., Xiao,L.X., Li,S.S., Liao,C.H., Li,J.,
            Huang,Z.X., Wang,J.L., Gu,Y.R., Gu,L., Huang,Y.H. and Lian,Y.F.
  TITLE     COLEC10 Induces Endoplasmic Reticulum Stress by Occupying GRP78 and
            Inhibits Hepatocellular Carcinoma
  JOURNAL   Lab Invest 103 (7), 100130 (2023)
   PUBMED   36925047
  REMARK    GeneRIF: COLEC10 Induces Endoplasmic Reticulum Stress by Occupying
            GRP78 and Inhibits Hepatocellular Carcinoma.
REFERENCE   3  (bases 1 to 3397)
  AUTHORS   Deelen,J., Evans,D.S., Arking,D.E., Tesi,N., Nygaard,M., Liu,X.,
            Wojczynski,M.K., Biggs,M.L., van der Spek,A., Atzmon,G., Ware,E.B.,
            Sarnowski,C., Smith,A.V., Seppala,I., Cordell,H.J., Dose,J.,
            Amin,N., Arnold,A.M., Ayers,K.L., Barzilai,N., Becker,E.J.,
            Beekman,M., Blanche,H., Christensen,K., Christiansen,L.,
            Collerton,J.C., Cubaynes,S., Cummings,S.R., Davies,K.,
            Debrabant,B., Deleuze,J.F., Duncan,R., Faul,J.D., Franceschi,C.,
            Galan,P., Gudnason,V., Harris,T.B., Huisman,M., Hurme,M.A.,
            Jagger,C., Jansen,I., Jylha,M., Kahonen,M., Karasik,D.,
            Kardia,S.L.R., Kingston,A., Kirkwood,T.B.L., Launer,L.J.,
            Lehtimaki,T., Lieb,W., Lyytikainen,L.P., Martin-Ruiz,C., Min,J.,
            Nebel,A., Newman,A.B., Nie,C., Nohr,E.A., Orwoll,E.S., Perls,T.T.,
            Province,M.A., Psaty,B.M., Raitakari,O.T., Reinders,M.J.T.,
            Robine,J.M., Rotter,J.I., Sebastiani,P., Smith,J., Sorensen,T.I.A.,
            Taylor,K.D., Uitterlinden,A.G., van der Flier,W., van der Lee,S.J.,
            van Duijn,C.M., van Heemst,D., Vaupel,J.W., Weir,D., Ye,K.,
            Zeng,Y., Zheng,W., Holstege,H., Kiel,D.P., Lunetta,K.L.,
            Slagboom,P.E. and Murabito,J.M.
  TITLE     A meta-analysis of genome-wide association studies identifies
            multiple longevity genes
  JOURNAL   Nat Commun 10 (1), 3669 (2019)
   PUBMED   31413261
  REMARK    GeneRIF: rs7676745, located near GPR78, associates with lower odds
            of surviving to the 90th percentile age. [Meta-analysis]
            Erratum:[Nat Commun. 2021 Apr 23;12(1):2463. doi:
            10.1038/s41467-021-22613-2. PMID: 33893282]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3397)
  AUTHORS   Stan,R.C., Silva,R.L. and de Camargo,M.M.
  TITLE     Human GRP78 affinity towards its signaling partners Ire1alpha and
            PERK is differently modulated by an unfolded protein client
  JOURNAL   Biochem Biophys Res Commun 487 (2), 375-380 (2017)
   PUBMED   28416388
  REMARK    GeneRIF: We reveal distinct binding affinities between the binary
            and ternary complexes thus formed, that suggest a preference for
            the PERK signaling branch under stress, and a predilection for the
            GRP78-UPR sensor complex formation upon stressor removal. These
            results imply a gated UPR mechanism that tunes the overall cellular
            behavior to the accumulation of unfolded proteins.
            Erratum:[Biochem Biophys Res Commun. 2017 Aug 12;490(1):69. doi:
            10.1016/j.bbrc.2017.06.004. PMID: 28601239]
REFERENCE   5  (bases 1 to 3397)
  AUTHORS   Dong,D.D., Zhou,H. and Li,G.
  TITLE     GPR78 promotes lung cancer cell migration and metastasis by
            activation of Galphaq-Rho GTPase pathway
  JOURNAL   BMB Rep 49 (11), 623-628 (2016)
   PUBMED   27697106
  REMARK    GeneRIF: Knockdown of GPR78 in lung cancer cells suppressed cell
            migration and GPR78 modulated the formation of actin stress fibers
            in A549 cells, in a RhoA- and Rac1-dependent manner.
REFERENCE   6  (bases 1 to 3397)
  AUTHORS   Ijuin,T., Hatano,N. and Takenawa,T.
  TITLE     Glucose-regulated protein 78 (GRP78) binds directly to PIP3
            phosphatase SKIP and determines its localization
  JOURNAL   Genes Cells 21 (5), 457-465 (2016)
   PUBMED   26940976
REFERENCE   7  (bases 1 to 3397)
  AUTHORS   Yang,J.F., Cao,J.G., Tian,L. and Liu,F.
  TITLE     5, 7-Dimethoxyflavone sensitizes TRAIL-induced apoptosis through
            DR5 upregulation in hepatocellular carcinoma cells
  JOURNAL   Cancer Chemother Pharmacol 69 (1), 195-206 (2012)
   PUBMED   21660448
REFERENCE   8  (bases 1 to 3397)
  AUTHORS   Jones,P.G., Nawoschik,S.P., Sreekumar,K., Uveges,A.J., Tseng,E.,
            Zhang,L., Johnson,J., He,L., Paulsen,J.E., Bates,B. and Pausch,M.H.
  TITLE     Tissue distribution and functional analyses of the constitutively
            active orphan G protein coupled receptors, GPR26 and GPR78
  JOURNAL   Biochim Biophys Acta 1770 (6), 890-901 (2007)
   PUBMED   17363172
REFERENCE   9  (bases 1 to 3397)
  AUTHORS   Underwood,S.L., Christoforou,A., Thomson,P.A., Wray,N.R.,
            Tenesa,A., Whittaker,J., Adams,R.A., Le Hellard,S., Morris,S.W.,
            Blackwood,D.H., Muir,W.J., Porteous,D.J. and Evans,K.L.
  TITLE     Association analysis of the chromosome 4p-located G protein-coupled
            receptor 78 (GPR78) gene in bipolar affective disorder and
            schizophrenia
  JOURNAL   Mol Psychiatry 11 (4), 384-394 (2006)
   PUBMED   16389273
  REMARK    GeneRIF: Two haplotypes remained significant in both the female
            bipolar affective disorder individuals and in the full sample of
            affected female individuals. Results provide preliminary evidence
            for involvement of GPR78 in susceptibility to BPAD and SCZ.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 3397)
  AUTHORS   Lee,D.K., Nguyen,T., Lynch,K.R., Cheng,R., Vanti,W.B., Arkhitko,O.,
            Lewis,T., Evans,J.F., George,S.R. and O'Dowd,B.F.
  TITLE     Discovery and mapping of ten novel G protein-coupled receptor genes
  JOURNAL   Gene 275 (1), 83-91 (2001)
   PUBMED   11574155
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK307281.1, AC105345.3 and
            BE645298.1.
            
            On Jul 25, 2019 this sequence version replaced NR_045511.2.
            
            Summary: The protein encoded by this gene belongs to the G
            protein-coupled receptor family, which contain 7 transmembrane
            domains and transduce extracellular signals through heterotrimeric
            G proteins. This is an orphan receptor, which displays significant
            level of constitutive activity. Association analysis shows
            preliminary evidence for the involvement of this gene in
            susceptibility to bipolar affective disorder and schizophrenia.
            Alternatively spliced transcript variants have been found for this
            gene. [provided by RefSeq, Nov 2011].
            
            Transcript Variant: This variant (2) contains an alternate 5' exon,
            compared to variant 1. This variant is represented as non-coding
            because it lacks a large portion of the coding region, including
            the translational start codon, found in variant 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK307281.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142853, SAMEA2147975
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-813               AK307281.1         156-968
            814-3360            AC105345.3         135624-138170
            3361-3397           BE645298.1         18-54               c
FEATURES             Location/Qualifiers
     source          1..3397
                     /organism="Homo sapiens"
                     /mol_type="transcribed RNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.1"
     gene            1..3397
                     /gene="GPR78"
                     /note="G protein-coupled receptor 78"
                     /db_xref="GeneID:27201"
                     /db_xref="HGNC:HGNC:4528"
                     /db_xref="MIM:606921"
     misc_RNA        1..3397
                     /gene="GPR78"
                     /product="G protein-coupled receptor 78, transcript
                     variant 2"
                     /db_xref="GeneID:27201"
                     /db_xref="HGNC:HGNC:4528"
                     /db_xref="MIM:606921"
     exon            1..313
                     /gene="GPR78"
                     /inference="alignment:Splign:2.1.0"
     exon            314..427
                     /gene="GPR78"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    420..737
                     /gene="GPR78"
                     /inference="COORDINATES:
                     alignment:Blast2seq::RefSeq|NM_080819.5"
                     /note="predicted ORF does not meet quality criteria for
                     protein coding locus with longer protein data."
                     /db_xref="GeneID:27201"
     exon            428..3397
                     /gene="GPR78"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagccaccag gtcgctccag tttggtgcca gcgcctggag ggagaggcgt ggcgagggct
       61 gtgctgccta ggatccactg agtggctctt gctggcgtgt cagctgcgcg cgaaccaggg
      121 ctgggaggct cggctggagg tgtgaccagg gcagggactg acctggcccg gaacagaagc
      181 gcgcagagtc ccatcctgcc acgccacgag gagagaagaa ggaaagatac agtgttagga
      241 aagagacctc cctcgcccct acgccccgcg cccctgcgcc tcgcttcagc ctcaggacag
      301 tcctgccggg acgtgtgcgg cagcgctgcc tcatccagca gaagcggcgc cgccaccgcg
      361 ccaccaggaa gattggcatt gctattgcga ccttcctcat ctgctttgcc ccgtatgtca
      421 tgaccaggct ggcggagctc gtgcccttcg tcaccgtgaa cgcccagtgg ggcatcctca
      481 gcaagtgcct gacctacagc aaggcggtgg ccgacccgtt cacgtactct ctgctccgcc
      541 ggccgttccg ccaagtcctg gccggcatgg tgcaccggct gctgaagaga accccgcgcc
      601 cagcatccac ccatgacagc tctctggatg tggccggcat ggtgcaccag ctgctgaaga
      661 gaaccccgcg cccagcgtcc acccacaacg gctctgtgga cacagagaat gattcctgcc
      721 tgcagcagac acactgaggg cctggcaggg ctcatcgccc ccaccttcta agaagccctg
      781 tggaaagggc actggccctg ccacagagat gccactgggg acccccagac accagtggct
      841 tgactttgag ctaaggctga agtacaggag gaggaggagg agagggccgg atgtgggtgt
      901 ggacagcagt agtggcggag gagagctcgg ggctgggctg cctggctgct gggtggcccc
      961 gggacagtgg cttttcctct ctgaacctta gcttcctcac ccttgttctg gggtcatggc
     1021 gatgcttcga gacagtgggt agggaagtgc cctgtgtggc atatggtact cgtgggcgtg
     1081 ctataagtga ctgctgttca tgtgggtgag gtggtcactc ttgctcaggg tctgttgtgc
     1141 agcccagatg gacacctgtt tctccaacct ggttattagc attgttccga tttgttctcg
     1201 gcattgccca ggtttgggag ataaatgccg gggcggagtc tggttggggg ctcccagagt
     1261 tcacatctga tagtctgtgg tcaggacctg gcaggcacgg gcagtccctg ggacatgccc
     1321 atctctggaa gcctaggggt ccccagctcc aggcctgtcc gctgtgactg cctgtgtggg
     1381 cacgcagatg gagcctgtct cctgccttcc tttccatggt ttgccagggg tttggcatct
     1441 tgactgcgga agctgtggag tctgtgtgct cagagccttt tctggtgaag atatcatcag
     1501 agcatgtgac ctctgtttcc tccccctgaa ggccaccgct gggcctctgg atcttagaca
     1561 tgagacggtc aagagattga agtagtagcc agggcccagg tgtccagaga gggtggcctg
     1621 ggatggggag ggcccttgct ccccaacagc agtgctgggg gagccaagag aaggtggagc
     1681 atccctgagt agtggtgtgc atcaccccca gtttagtaat cacggggtgc cattccccgg
     1741 tgggagcacc caccatcaat gtcattgaat gtccccatgg gacagtgttg aggacttttg
     1801 tgacatctgt cctatttcac agctcaggga aaggtgcaca gtgcacacgg gcacccggtg
     1861 gagaggtgtg tgtgtgaatg agtgagcgag tgaatgaatg gacacgattc tctcttcagc
     1921 ctctgtcatt gctgttttct tcaaggccca gggccatccc ctgcagaggt agggtgggct
     1981 gcaagacctc aggcccctgc ctcatgggac tctctgatgg gcttcaaccg tgggctcttg
     2041 caggcatgga gcctgtatca tgacacctta cacccaaggc cagcaatgca aggagagtat
     2101 ggacatcaaa ttctttcctt ccagaggctg aattcttcaa agacacacgc ggtcgtcact
     2161 tgctcttggc attaacggtg gagaacccag ctgaggtggc ttcacagatt cttccccaaa
     2221 aacacaggtg ttattattat acttttaaaa aactttttga gacagggtct gactctgttg
     2281 cctaggctag agtgcagtgg tgcaatctca gctcactgca gcctccacct cccatgctca
     2341 agccatcctc ccacctcagc ctcctgagta gttgaggaca caggcacggg acaccatgcc
     2401 tggctaattt ttgtattttt ttttgtagag atggcggtct cactttgttg cccaggctgg
     2461 tcttgaattc ctgagcttaa gtgatcctcc cacctcagcc tcccaaagtg ctgggattac
     2521 aggtgtgagc caccacaccc agccaaaacc aggtgttatt tgctgactca ccaatgcctc
     2581 ccccaaaagg ataaatttaa aggtgtgtat aacccatgaa gtgtaattca aataaaacaa
     2641 attatcgttt ggaataataa caactatagg tatgtggtca ggaagcagtt aaaaacatta
     2701 aaatacagac ctggccagtt caatccaacc caggggttcc aagcaggagg tggggcaggt
     2761 gggcgtcatg ccctgattca cagagggcac aggtgggtgt catgccctgg ttcacagagg
     2821 gcacgtgaac tcgagaccgt gctgcacccc ggtgcccctg tgcttataag ggagggcacg
     2881 tgcacagcag aagcaggttg ttccccattt aaagttctgg agcccaggct gtgagctcct
     2941 tggctgagcc ctctcctgtc cctgggagct ccccaggtgc gaggagcctg ccagccagtg
     3001 gggcctacac tctgtgttat tgcatctccg ccaggctaaa agccttggtc actactttag
     3061 agccactcaa ggaaacgcgt gcaccctgcc ctgctggaag gcaccatggt tagagggagg
     3121 cacactgttt cttagagacg gggactgctt gctgtcatgt ttcgccttcc tcggcagctc
     3181 catggaatgt tctggagcag gcatcttagg gcattccctc cgcacttctc tgccagccca
     3241 tgtggctccc acactgggct atcccttgcc ttaggcttgt ggcctttttt tttttttttt
     3301 ttttaatttg aaaaatattt ttcatgtgca cttaaacgtg ttgtggaatg atgctgggtc
     3361 tcaagaatgc tgtgaatcaa taaacatttt attcaga
//
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