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NCBI Reference Sequence: NM_174899.5
FASTA Graphics
LOCUS NM_174899 2813 bp mRNA linear PRI 02-APR-2024 DEFINITION Homo sapiens F-box protein 36 (FBXO36), mRNA. ACCESSION NM_174899 VERSION NM_174899.5 KEYWORDS RefSeq; MANE Select. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2813) AUTHORS Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and Harper,J.W. TITLE Systematic analysis and nomenclature of mammalian F-box proteins JOURNAL Genes Dev 18 (21), 2573-2580 (2004) PUBMED 15520277 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC017869.1, BC033935.1, AK123085.1, AC009973.10 and BM997950.1. On Nov 22, 2018 this sequence version replaced NM_174899.4. Summary: Members of the F-box protein family, such as FBXO36, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.52603.1, SRR1660809.214853.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000283946.8/ ENSP00000283946.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-216 BC017869.1 13-228 217-268 BC033935.1 222-273 269-1309 AK123085.1 586-1626 1310-2737 AC009973.10 197621-199048 2738-2803 BM997950.1 18-83 c 2804-2813 AC009973.10 199115-199124 FEATURES Location/Qualifiers source 1..2813 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="2" /map="2q36.3" gene 1..2813 /gene="FBXO36" /gene_synonym="Fbx36" /note="F-box protein 36" /db_xref="GeneID:130888" /db_xref="HGNC:HGNC:27020" /db_xref="MIM:609105" exon 1..107 /gene="FBXO36" /gene_synonym="Fbx36" /inference="alignment:Splign:2.1.0" CDS 12..578 /gene="FBXO36" /gene_synonym="Fbx36" /codon_start=1 /product="F-box only protein 36" /protein_id="NP_777559.3" /db_xref="CCDS:CCDS2472.1" /db_xref="GeneID:130888" /db_xref="HGNC:HGNC:27020" /db_xref="MIM:609105" /translation="MASWLPETLFETVGQGPPPSKDYYQLLVTRSQVIFRWWKISLRS EYRSTKPGEAKETHEDFLENSHLQGQTALIFGARILDYVINLCKGKFDFLERLSDDLL LTIISYLDLEDIARLCQTSHRFAKLCMSDKLWEQIVQSTCDTITPDVRALAEDTGWRQ LFFTNKLQLQRQLRKRKQKYGNLREKQP" exon 108..216 /gene="FBXO36" /gene_synonym="Fbx36" /inference="alignment:Splign:2.1.0" exon 217..389 /gene="FBXO36" /gene_synonym="Fbx36" /inference="alignment:Splign:2.1.0" exon 390..2813 /gene="FBXO36" /gene_synonym="Fbx36" /inference="alignment:Splign:2.1.0" regulatory 2783..2788 /regulatory_class="polyA_signal_sequence" /gene="FBXO36" /gene_synonym="Fbx36" /note="hexamer: ATTAAA" polyA_site 2813 /gene="FBXO36" /gene_synonym="Fbx36" /note="major polyA site" ORIGIN 1 ggcgtcccaa gatggcgtcg tggctgccgg agactctctt tgaaactgta ggacaaggcc 61 cgccgcctag caaagactat taccagttac tggtcacccg gtctcaggta atctttagat 121 ggtggaagat ctctctaagg agtgagtatc gatcaacaaa acctggagaa gcaaaagaaa 181 cccatgaaga cttcctagag aattcacatc ttcaaggtca aactgcctta atatttggtg 241 caagaatatt agactatgtc atcaatttgt gcaaaggtaa atttgacttc cttgaacggc 301 tctcagacga tttgctcctg actatcattt cttatctgga tcttgaagat attgccaggc 361 tttgtcaaac atcacacaga tttgcaaagc tgtgcatgtc tgataaactg tgggaacaga 421 tagtccagtc gacctgcgac accatcactc ctgacgtgag ggccctggcg gaggacacag 481 gctggagaca gctgttcttc accaacaagc tccagctcca gcggcagctc cgcaagagga 541 aacaaaaata tggaaacctg agagaaaagc aaccttaggc acacattttc ctaccagcag 601 ggagctcagg catggctgtg tttctcttca gtgtccaaat ctcttctgtc tccttttctt 661 aagaactaag aggttttgtt gatgcgtgga gccatttgaa actcgtaggg gatttgcaca 721 caaatgcagc agagtctggc tccccagtgc cttgctagag tcaccgtcat tctgaggtca 781 aatcatggcc cgaggacaag ggctgtaaga cagggagccc cataggccat catcatcctt 841 atcccacacc cattataaaa gaggtttcta ttgtatataa acaaacaata aatgattatt 901 agcaggtttt tattagacat ctattttatc taggcattag aaagggtaat ggggcttttg 961 aattttttcc tggcattgtg tcgtctgcgt ccagccatga agctggtggc tgagtgtccc 1021 caccaggaac tgtgaagggc acgtaccacg ggaggcactc agggtgggtg cagctgcctt 1081 cccaactttg ttctgctaag tccatattca gggccctatc cttgtgagcc caggatgcca 1141 gggtccatcc ccgcatgtag acagcttccg acctggtgct ggagcatgac tggagaagtg 1201 caggcatcct gcttgcggac cttgctcaaa gtacaacttc ccaggactac ttcacattgt 1261 taaataaacc tataaacatt tcttttcttt tctttttttt tttttttttg tattttcttt 1321 ttagtagagg tggagtttcg ccatgtaggc caggctggtc ttgaactcct gacctcaagt 1381 gatctacctg ctctggcttc caaagtgctg ggattacagg catgagccac tatgtctggc 1441 taaaacctat aaacatttct tagagaaatg ctgttcccca aaggaatgtg aacagctacc 1501 acttttaaca aggatattta agaaaacaga ctatgagtta actaagtaaa aatgtaaata 1561 tggtttgcat gctgttaaca tggcagaggg gtaaaaagaa tacagtcctg gggagaaagg 1621 tcacttcact gagaaggctt acttaaaaat gtttttctcc ctgcactttc atgattatta 1681 agtaccccta gaaaatgaac tcatagcagc aaataatcta atgactcctt ttaggttaca 1741 gagcaaagta gctttctact tccacatcac attataatat agccttataa tttcttcttt 1801 cctgcaacct tcactttcct acctaggaaa actcacctcc ggtgccagag aaacttccca 1861 ggatgcacta gggccctgtg aacaatacag aagttgtgga ctctggctct ttgtcccacc 1921 taagtccttc cagaagggct ctacagcatg gcttagtgac attaaaaaaa aaaactgaac 1981 ccatgttaat atcaaacaag attttaatct tcattcacac acccttaaaa cccagtcacg 2041 gggctccccg gtgccagttt gagaccgtca acctagccct ctctgcttct cattgctgga 2101 ggtacacaca gtcaaaagtt ttccgtgact gtgaaatcca gtgcaatctg cttcccagca 2161 gatgaggagc ctgacgtggt tatgtctgga tttagtccaa gaacagagca aagctttaat 2221 tgtcaagaga cccaggcctc attctccact taggagagtt tgctagggca ggtacaggta 2281 aaggtaacca gcaggcagct gagagcaaga aggcacgtgc tctgcagagc tctagctgcc 2341 ttggctctcc ctgagctccc agacttcact catggcctaa ttttcaatga cagaacgtag 2401 gttttatcgt gaggatgcag acacaaccac aattacgtat gtcaacataa cttcataaat 2461 atgtaactgt aacttattgg taacatcagt gcaagatgat taaagcttca tgtgtagtat 2521 tttatcaaca aacagattct gaaagcttat ggacatgcgc aatagttgat tcagcttcaa 2581 tcaataagaa cataaatatg gcaatttgaa aacactatgt atatacctac tcacatatat 2641 attatactta cgatatatac ttatatgtag tatataataa tattacatat aaaaatgtta 2701 taaaaataaa tgctaaagta aataaaaaaa gagccattaa tatgttaact attgttaaat 2761 aatagctaaa ataatacaga ttattaaatt attttaatac ttacttgcca taa //
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