LOCUS NM_029020 2940 bp mRNA linear ROD 06-JUN-2024
DEFINITION Mus musculus ATP-binding cassette, sub-family B member 8 (Abcb8),
mRNA; nuclear gene for mitochondrial product.
ACCESSION NM_029020
VERSION NM_029020.3
KEYWORDS RefSeq; RefSeq Select.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (bases 1 to 2940)
AUTHORS Chang,H.C., Shapiro,J.S., Jiang,X., Senyei,G., Sato,T., Geier,J.,
Sawicki,K.T. and Ardehali,H.
TITLE Augmenter of liver regeneration regulates cellular iron homeostasis
by modulating mitochondrial transport of ATP-binding cassette B8
JOURNAL Elife 10, e65158 (2021)
PUBMED 33835027
REMARK GeneRIF: Augmenter of liver regeneration regulates cellular iron
homeostasis by modulating mitochondrial transport of ATP-binding
cassette B8.
Publication Status: Online-Only
REFERENCE 2 (bases 1 to 2940)
AUTHORS Paggio,A., Checchetto,V., Campo,A., Menabo,R., Di Marco,G., Di
Lisa,F., Szabo,I., Rizzuto,R. and De Stefani,D.
TITLE Identification of an ATP-sensitive potassium channel in
mitochondria
JOURNAL Nature 572 (7771), 609-613 (2019)
PUBMED 31435016
REFERENCE 3 (bases 1 to 2940)
AUTHORS Chang,H.C., Wu,R., Shang,M., Sato,T., Chen,C., Shapiro,J.S.,
Liu,T., Thakur,A., Sawicki,K.T., Prasad,S.V. and Ardehali,H.
TITLE Reduction in mitochondrial iron alleviates cardiac damage during
injury
JOURNAL EMBO Mol Med 8 (3), 247-267 (2016)
PUBMED 26896449
REFERENCE 4 (bases 1 to 2940)
AUTHORS Ichikawa,Y., Ghanefar,M., Bayeva,M., Wu,R., Khechaduri,A., Naga
Prasad,S.V., Mutharasan,R.K., Naik,T.J. and Ardehali,H.
TITLE Cardiotoxicity of doxorubicin is mediated through mitochondrial
iron accumulation
JOURNAL J Clin Invest 124 (2), 617-630 (2014)
PUBMED 24382354
REFERENCE 5 (bases 1 to 2940)
AUTHORS Ichikawa,Y., Bayeva,M., Ghanefar,M., Potini,V., Sun,L.,
Mutharasan,R.K., Wu,R., Khechaduri,A., Jairaj Naik,T. and
Ardehali,H.
TITLE Disruption of ATP-binding cassette B8 in mice leads to
cardiomyopathy through a decrease in mitochondrial iron export
JOURNAL Proc Natl Acad Sci U S A 109 (11), 4152-4157 (2012)
PUBMED 22375032
REMARK GeneRIF: These results indicate that ABCB8 is essential for normal
cardiac function, maintenance of mitochondrial iron homeostasis and
maturation of cytosolic Fe/S proteins.
REFERENCE 6 (bases 1 to 2940)
AUTHORS Schriml,L.M. and Dean,M.
TITLE Identification of 18 mouse ABC genes and characterization of the
ABC superfamily in Mus musculus
JOURNAL Genomics 64 (1), 24-31 (2000)
PUBMED 10708515
REFERENCE 7 (bases 1 to 2940)
AUTHORS Wang,C. and Brennan,W.A. Jr.
TITLE Rat skeletal muscle, liver and brain have different fetal and adult
forms of the glucose transporter
JOURNAL Biochim Biophys Acta 946 (1), 11-18 (1988)
PUBMED 3145016
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AC113055.9.
On Aug 16, 2018 this sequence version replaced NM_029020.2.
Sequence Note: The RefSeq transcript and protein were derived from
genomic sequence to make the sequence consistent with the reference
genome assembly. The genomic coordinates used for the transcript
record were based on alignments.
##Evidence-Data-START##
Transcript exon combination :: BC015301.1, AK166704.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMN00849374, SAMN00849375
[ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
gene product(s) localized to mito. :: reported by MitoCarta
RefSeq Select criteria :: based on conservation,
expression, longest protein
##RefSeq-Attributes-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-428 AC113055.9 31469-31896 c
429-738 AC113055.9 25830-26139 c
739-894 AC113055.9 25372-25527 c
895-989 AC113055.9 25201-25295 c
990-1095 AC113055.9 24972-25077 c
1096-1257 AC113055.9 24128-24289 c
1258-1343 AC113055.9 23922-24007 c
1344-1441 AC113055.9 23713-23810 c
1442-1547 AC113055.9 22874-22979 c
1548-1581 AC113055.9 20204-20237 c
1582-1718 AC113055.9 19798-19934 c
1719-1813 AC113055.9 19558-19652 c
1814-1947 AC113055.9 19251-19384 c
1948-2095 AC113055.9 18597-18744 c
2096-2346 AC113055.9 17234-17484 c
2347-2940 AC113055.9 16105-16698 c
FEATURES Location/Qualifiers
source 1..2940
/organism="Mus musculus"
/mol_type="mRNA"
/strain="C57BL/6"
/db_xref="taxon:10090"
/chromosome="5"
/map="5 11.57 cM"
gene 1..2940
/gene="Abcb8"
/gene_synonym="4833412N02Rik; MITOSUR"
/note="ATP-binding cassette, sub-family B member 8"
/db_xref="GeneID:74610"
/db_xref="MGI:MGI:1351667"
exon 1..428
/gene="Abcb8"
/gene_synonym="4833412N02Rik; MITOSUR"
/inference="alignment:Splign:2.1.0"
misc_feature 292..294
/gene="Abcb8"
/gene_synonym="4833412N02Rik; MITOSUR"
/note="upstream in-frame stop codon"
CDS 334..2487
/gene="Abcb8"
/gene_synonym="4833412N02Rik; MITOSUR"
/note="ATP-binding cassette sub-family B member 8,
mitochondrial; mitochondrial sulfonylurea-receptor;
mitochondrial potassium channel ATP-binding subunit;
ATP-binding cassette, sub-family B (MDR/TAP), member 8"
/codon_start=1
/product="mitochondrial potassium channel ATP-binding
subunit precursor"
/protein_id="NP_083296.2"
/db_xref="CCDS:CCDS19118.1"
/db_xref="GeneID:74610"
/db_xref="MGI:MGI:1351667"
/translation="MLVHLFRFGIRGGPVPGWSLQSLRFQTFSAARSSDDRLSSHLLR
TVAQLRVQLRAHLPRAPPASHWSPSAWCWVGGTLVVPAVLWQHPRLCLIALCEAKESP
PAQPTRAPELRFNWKLFWHFLHPHLLALGAAIVLALGAALVNVQIPLLLGQLVEIVAK
YTRDHMGSFVSESRKLSVQLLLLYGVQGLLTFGYLVLLSHIGERMAMDMRKALFSSLL
RQDIAFFDAKKTGQLVSRLTTDVQEFKSSFKLVISQGLRSCTQVIGSLVSLSMLSPRL
TLMLAVVTPALMGVGTLMGSGLRKLSRQCQEQIARATGVADEALGNVRTVRAFAMEKR
EEERYQAELESCCCKAEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQQLKGGD
LMSFLVASQTVQRSMASLSVLFGQVVRGLSAGARVFEYMALSPVIPLTGGYCIPNKDI
RGSITFQNVTFSYPCRPGFNVLKDFTLKLPSGKIVALVGQSGGGKTTVASLLERFYDP
EAGSVTLDGHDLRTLNPSWLRGQVIGFISQEPVLFATTIMENIRFGKLDASDEEVYTA
AREANAHEFISSFPDGYSTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSAL
DAESERVVQEALDRASAGRTVLVIAHRLSTVRAAHSIIVMANGQVCEAGTHEELLKKG
GLYSELIRRQTLDASLTSTPPAEKPEDPKSCQSKA"
transit_peptide 334..408
/gene="Abcb8"
/gene_synonym="4833412N02Rik; MITOSUR"
/note="Mitochondrion. /evidence=ECO:0000255; propagated
from UniProtKB/Swiss-Prot (Q9CXJ4.1)"
mat_peptide 409..2484
/gene="Abcb8"
/gene_synonym="4833412N02Rik; MITOSUR"
/product="Mitochondrial potassium channel ATP-binding
subunit. /evidence=ECO:0000255. /id=PRO_0000356233"
/note="propagated from UniProtKB/Swiss-Prot (Q9CXJ4.1)"
misc_feature 712..774
/gene="Abcb8"
/gene_synonym="4833412N02Rik; MITOSUR"
/note="propagated from UniProtKB/Swiss-Prot (Q9CXJ4.1);
transmembrane region"
misc_feature 865..927
/gene="Abcb8"
/gene_synonym="4833412N02Rik; MITOSUR"
/note="propagated from UniProtKB/Swiss-Prot (Q9CXJ4.1);
transmembrane region"
misc_feature 1165..1227
/gene="Abcb8"
/gene_synonym="4833412N02Rik; MITOSUR"
/note="propagated from UniProtKB/Swiss-Prot (Q9CXJ4.1);
transmembrane region"
misc_feature 1426..1488
/gene="Abcb8"
/gene_synonym="4833412N02Rik; MITOSUR"
/note="propagated from UniProtKB/Swiss-Prot (Q9CXJ4.1);
transmembrane region"
misc_feature 2416..2484
/gene="Abcb8"
/gene_synonym="4833412N02Rik; MITOSUR"
/note="propagated from UniProtKB/Swiss-Prot (Q9CXJ4.1);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
exon 429..738
/gene="Abcb8"
/gene_synonym="4833412N02Rik; MITOSUR"
/inference="alignment:Splign:2.1.0"
exon 739..894
/gene="Abcb8"
/gene_synonym="4833412N02Rik; MITOSUR"
/inference="alignment:Splign:2.1.0"
exon 895..989
/gene="Abcb8"
/gene_synonym="4833412N02Rik; MITOSUR"
/inference="alignment:Splign:2.1.0"
exon 990..1095
/gene="Abcb8"
/gene_synonym="4833412N02Rik; MITOSUR"
/inference="alignment:Splign:2.1.0"
exon 1096..1257
/gene="Abcb8"
/gene_synonym="4833412N02Rik; MITOSUR"
/inference="alignment:Splign:2.1.0"
exon 1258..1343
/gene="Abcb8"
/gene_synonym="4833412N02Rik; MITOSUR"
/inference="alignment:Splign:2.1.0"
exon 1344..1441
/gene="Abcb8"
/gene_synonym="4833412N02Rik; MITOSUR"
/inference="alignment:Splign:2.1.0"
exon 1442..1547
/gene="Abcb8"
/gene_synonym="4833412N02Rik; MITOSUR"
/inference="alignment:Splign:2.1.0"
exon 1548..1581
/gene="Abcb8"
/gene_synonym="4833412N02Rik; MITOSUR"
/inference="alignment:Splign:2.1.0"
exon 1582..1718
/gene="Abcb8"
/gene_synonym="4833412N02Rik; MITOSUR"
/inference="alignment:Splign:2.1.0"
exon 1719..1813
/gene="Abcb8"
/gene_synonym="4833412N02Rik; MITOSUR"
/inference="alignment:Splign:2.1.0"
exon 1814..1947
/gene="Abcb8"
/gene_synonym="4833412N02Rik; MITOSUR"
/inference="alignment:Splign:2.1.0"
exon 1948..2095
/gene="Abcb8"
/gene_synonym="4833412N02Rik; MITOSUR"
/inference="alignment:Splign:2.1.0"
exon 2096..2346
/gene="Abcb8"
/gene_synonym="4833412N02Rik; MITOSUR"
/inference="alignment:Splign:2.1.0"
exon 2347..2940
/gene="Abcb8"
/gene_synonym="4833412N02Rik; MITOSUR"
/inference="alignment:Splign:2.1.0"
regulatory 2897..2902
/regulatory_class="polyA_signal_sequence"
/gene="Abcb8"
/gene_synonym="4833412N02Rik; MITOSUR"
/note="hexamer: AACAAA"
polyA_site 2910
/gene="Abcb8"
/gene_synonym="4833412N02Rik; MITOSUR"
/note="major polyA site"
regulatory 2915..2920
/regulatory_class="polyA_signal_sequence"
/gene="Abcb8"
/gene_synonym="4833412N02Rik; MITOSUR"
/note="hexamer: AATAAA"
polyA_site 2916
/gene="Abcb8"
/gene_synonym="4833412N02Rik; MITOSUR"
/note="major polyA site"
polyA_site 2940
/gene="Abcb8"
/gene_synonym="4833412N02Rik; MITOSUR"
/note="major polyA site"
ORIGIN
1 ggagcataga gattgtctgg aacaactcta gagaaagggc tcaaggtcag aagcgccagg
61 acgtcctcta atgtgagaat gaacgtcgca caacctctga cccgcacctg acttcaggcc
121 actgagcaaa tagctagagc tgcttctgct cggtcccgcc tacagccaac attttatcca
181 atcacagctt gcagcaagac tgatgtgtct tttctccaat catcgctgag aatgggaagg
241 ggttgtcggg atggggccat agcgaacatg gaaccctcgg taggataagt gtgagattgc
301 cgttgctggc tgcccctatc ttattgcctc aacatgttgg tgcacttatt tcggttcgga
361 atccggggtg gcccagttcc aggatggtcg ctacaatccc tgcgcttcca gacgttctct
421 gccgccaggt cctcagatga ccggctcagc tcacacctcc tgcggactgt agcccagctc
481 cgtgtacagc tccgggctca cctccctcga gccccaccag cttcccactg gagcccctct
541 gcctggtgtt gggttggggg gaccttggtg gtccctgcag tcctgtggca gcatccacgc
601 ctctgcctta tagcactatg tgaggccaaa gagtcccctc ctgcccagcc cacacgtgcc
661 ccagagctgc gctttaattg gaagctcttc tggcatttcc ttcaccccca cctgctggcc
721 ttgggggcag ccattgtgct ggccttaggt gcggcactag tgaatgtgca gatccccttg
781 ctcctgggcc agctggtgga gattgtcgcc aagtacacga gggaccacat ggggagtttc
841 gtgtctgagt cccgtaagct cagcgtccag ctgctcctac tgtacggtgt tcagggactg
901 ctgacctttg gatacctagt gctgctgtcc cacattggtg agcgcatggc catggacatg
961 cggaaagccc ttttcagctc cctgctccgg caagacattg ctttctttga tgccaaaaag
1021 acagggcagc tagtgagtcg cttgactact gatgtgcaag aattcaagtc atccttcaag
1081 cttgtcatct cccagggact gcgcagctgc acccaggtga ttggtagcct ggtgtccctg
1141 tctatgctgt cccctcgcct taccctgatg ctggctgtcg tcacacccgc cctcatggga
1201 gtgggcaccc tgatgggctc aggcctccga aagctgtctc gccagtgtca ggagcagatt
1261 gccagggcaa caggtgtagc agatgaggcc cttggcaatg ttcggactgt gcgggccttc
1321 gcgatggaga agagggagga ggaacgctat caagcagaac tggagtcatg ctgctgtaaa
1381 gcagaagaac tgggcagggg catcgccttg ttccaagggc tctccaacat cgctttcaac
1441 tgtatggtct tgggcaccct gttcattggg ggctcccttg tggctggaca gcagctgaaa
1501 gggggagacc tcatgtcctt cctggtggct tcccagacag tacagaggtc tatggccagc
1561 ctctctgtcc tgtttggtca ggtggtacgt gggctgagtg cgggagcccg agtcttcgaa
1621 tacatggccc tgagccctgt catcccattg accgggggct actgcatccc caacaaggac
1681 attcgtggtt ccatcacctt ccaaaatgtc accttcagct acccctgcag acctggcttc
1741 aatgtgctca aggacttcac cctgaagctg ccctctggca agattgtggc tcttgtgggc
1801 cagtctgggg gaggaaagac cacagttgcc tccttgctgg aacgcttcta tgaccctgaa
1861 gctggctcgg tgacgttgga tgggcatgac ctgcgaactc tcaacccctc ctggctccgg
1921 ggccaggtca taggtttcat cagccaggag ccagtcctgt ttgcaacaac catcatggag
1981 aatatccgat ttgggaagct ggatgcttcc gatgaagagg tgtacacagc tgcacgagaa
2041 gccaatgccc acgagttcat cagcagcttc cccgatggct acagcactgt ggttggtgag
2101 cggggcacaa ccttgtctgg tggccagaag cagcgcctag ccatcgcacg tgccctcatc
2161 aagcagccca cagtgctgat cctggacgag gccaccagtg cgctagatgc agaatccgag
2221 agggtggtac aggaggccct ggaccgggcc agtgctggcc gcaccgtgtt ggtcattgcc
2281 caccggctta gtactgtccg tgcagcccac tccatcattg tcatggccaa tggccaagtc
2341 tgtgaggctg ggacccacga agaactcctt aaaaaaggcg ggctctattc agagcttatc
2401 cggagacaaa ccctggacgc ctcactgacc tcaacccctc ctgcagagaa gcctgaagac
2461 cccaaaagct gccagtccaa agcctgagag gccccctggg gtcaggtcac tgcaagacat
2521 cagtctgagg ctggagctct gctggggaca gagcccttgg aaggccagtg tgctggagtg
2581 tggcctgcac tactgccccc ttaaaggagc tgggctcaac agctggggtg ggaaatggct
2641 ctccgcccac ctgctctgac catcctgact cagctctgtg gtcacgggat gtacacagtg
2701 agacagagtc cctggacacc tctgcttgac cctctcaggc tggcctggtt ctgcccaaca
2761 ctcagttgtt tgggccctca ctccaggaga ctggccaggc ctggtagaat gggttgtaat
2821 cccagcactt gggagacaga agtgggaggg tcaagagttc aaggccatcc tgggctaaat
2881 agtgagaccc tctctcaaca aaaagaaaaa cctaaataaa gaggaaaaat tttcaaagag
//