LOCUS NM_024099 1818 bp mRNA linear PRI 22-SEP-2024
DEFINITION Homo sapiens LBH domain containing 1 (LBHD1), transcript variant 2,
mRNA.
ACCESSION NM_024099
VERSION NM_024099.5
KEYWORDS RefSeq; MANE Select.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1818)
AUTHORS Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
TITLE A reference map of the human binary protein interactome
JOURNAL Nature 580 (7803), 402-408 (2020)
PUBMED 32296183
REFERENCE 2 (bases 1 to 1818)
AUTHORS Michel,A.M., Choudhury,K.R., Firth,A.E., Ingolia,N.T., Atkins,J.F.
and Baranov,P.V.
TITLE Observation of dually decoded regions of the human genome using
ribosome profiling data
JOURNAL Genome Res 22 (11), 2219-2229 (2012)
PUBMED 22593554
REFERENCE 3 (bases 1 to 1818)
AUTHORS Oyama,M., Kozuka-Hata,H., Suzuki,Y., Semba,K., Yamamoto,T. and
Sugano,S.
TITLE Diversity of translation start sites may define increased
complexity of the human short ORFeome
JOURNAL Mol Cell Proteomics 6 (6), 1000-1006 (2007)
PUBMED 17317662
REFERENCE 4 (bases 1 to 1818)
AUTHORS Weber,M.J.
TITLE Mammalian small nucleolar RNAs are mobile genetic elements
JOURNAL PLoS Genet 2 (12), e205 (2006)
PUBMED 17154719
REMARK Erratum:[PLoS Genet. 2007 Feb;3(2):e36]
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AP001458.6.
On Apr 28, 2021 this sequence version replaced NM_024099.4.
Summary: This gene shares three exons in common with another gene,
chromosome 11 open reading frame 98 (GeneID:102288414), but the
encoded protein uses a reading frame that is different from that of
the chromosome 11 open reading frame 98 gene. [provided by RefSeq,
Nov 2017].
Transcript Variant: This variant (2) lacks an alternate in-frame
segment compared to variant 1. The resulting isoform (b) has the
same N- and C-termini but is shorter compared to isoform a.
Variants 2, 3, and 8-10 all encode the same isoform (b).
##Evidence-Data-START##
Transcript exon combination :: BC001434.2, SRR14038192.2864228.1
[ECO:0000332]
RNAseq introns :: mixed sample support SAMEA1965299,
SAMEA1966682 [ECO:0006172]
##Evidence-Data-END##
##RefSeq-Attributes-START##
MANE Ensembl match :: ENST00000354588.8/ ENSP00000346600.3
RefSeq Select criteria :: based on manual assertion, expression
##RefSeq-Attributes-END##
COMPLETENESS: full length.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-704 AP001458.6 78831-79534 c
705-864 AP001458.6 77149-77308 c
865-1027 AP001458.6 76908-77070 c
1028-1252 AP001458.6 74790-75014 c
1253-1377 AP001458.6 72116-72240 c
1378-1475 AP001458.6 70503-70600 c
1476-1818 AP001458.6 70084-70426 c
FEATURES Location/Qualifiers
source 1..1818
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="11"
/map="11q12.3"
gene 1..1818
/gene="LBHD1"
/gene_synonym="C11orf48"
/note="LBH domain containing 1"
/db_xref="GeneID:79081"
/db_xref="HGNC:HGNC:28351"
exon 1..704
/gene="LBHD1"
/gene_synonym="C11orf48"
/inference="alignment:Splign:2.1.0"
misc_feature 652..654
/gene="LBHD1"
/gene_synonym="C11orf48"
/note="upstream in-frame stop codon"
exon 705..864
/gene="LBHD1"
/gene_synonym="C11orf48"
/inference="alignment:Splign:2.1.0"
CDS 715..1506
/gene="LBHD1"
/gene_synonym="C11orf48"
/note="isoform b is encoded by transcript variant 2; LBH
domain-containing protein 1"
/codon_start=1
/product="LBH domain-containing protein 1 isoform b"
/protein_id="NP_077004.2"
/db_xref="CCDS:CCDS8028.1"
/db_xref="GeneID:79081"
/db_xref="HGNC:HGNC:28351"
/translation="MALVPGRSKEDGLWTRNSPGSSQHPESPRLPNPLWDRGKIGKVE
GHQHIQDFSQKSHLPSIVVESSEVNEESGDLHLPHEELLLLTDGEEEDAEAFFQDQSE
EPGWAWSPQDPRSPLRTFNAGLSWGQDQDEEDACWILEDTACLEATNHCPFWDSTGSR
VCRSGFVEYSHLLPPNSFEGAEEEAVQTPAGVESGAASEAPGGRGCDRPRADHAAPPQ
EAGVQCTCQHYTVREEAQKTPPADPACPEREDSHGSGSPFKASQD"
exon 865..1027
/gene="LBHD1"
/gene_synonym="C11orf48"
/inference="alignment:Splign:2.1.0"
exon 1028..1252
/gene="LBHD1"
/gene_synonym="C11orf48"
/inference="alignment:Splign:2.1.0"
exon 1253..1377
/gene="LBHD1"
/gene_synonym="C11orf48"
/inference="alignment:Splign:2.1.0"
exon 1378..1475
/gene="LBHD1"
/gene_synonym="C11orf48"
/inference="alignment:Splign:2.1.0"
exon 1476..1818
/gene="LBHD1"
/gene_synonym="C11orf48"
/inference="alignment:Splign:2.1.0"
regulatory 1798..1803
/regulatory_class="polyA_signal_sequence"
/gene="LBHD1"
/gene_synonym="C11orf48"
/note="hexamer: AATAAA"
polyA_site 1818
/gene="LBHD1"
/gene_synonym="C11orf48"
/note="major polyA site"
ORIGIN
1 aaacgtgctc acccgacggc agctcacagg accccggaga gtcctggcat ggtatctcgg
61 tccggactct ccgctgggcc cacgaaggag aaaggctgcc tcggattcct gcgcccaagc
121 caaggtccgg cgcccacgga ggcaagtccg gtctcacggt gacctcccgc cggcgccgcc
181 ttcgccgcca accatccagt tcttcctcca ggccacgttc tcctgcgtgg tcgctgcctc
241 ctgcagagtg gccagcaata gctgctgggt cctggccgcc tcctccctgc tccttgggtc
301 ctgcagtggc atctcctgag ggcaggaagg ggagttcgca ggagctccag tccggggctc
361 tccacccgcc cacccttcct cgggactacc agttgcttct acctttagca tttcctgctt
421 ccgccgctct cccggggtca cgataacgag gagcgcgtag cccacgccag cccctgcgcc
481 cagcattgcg actgagatca gcattttccg caaggaatcc atggccgcct gcacagccag
541 cggagcgccc acgggagctc cccgcagccg caagctgttg ccgcgcggtc tcactacccc
601 ttggcgcagg ctagagcgcc ctatagcaga aaccatagat aagcggccgg ctagagagga
661 cctgctcgag gaaacgtttg gaatccggag cgcttggatc tcagaatcac caccatggcc
721 cttgtgccag ggagaagcaa ggaggatggg ctttggacta gaaatagccc aggctcctcc
781 cagcatccag aaagtcccag gctgcccaac cctctctggg acagaggaaa aattggcaag
841 gttgaaggtc accagcacat tcaggatttc tctcaaaagt cccatctgcc gtctattgtg
901 gtggaatcca gtgaggtgaa tgaagagagt ggggatctcc atttgcccca tgaggagctg
961 ctgctgctca ctgatggtga ggaagaggat gctgaggcct tcttccaaga ccaaagtgaa
1021 gagccaggct gggcttggag cccacaggac cctagaagtc ctttaagaac atttaacgct
1081 ggactcagct gggggcagga ccaggatgaa gaagatgctt gttggattct tgaggacaca
1141 gcatgtctgg aagccaccaa ccactgtccc ttctgggact caacaggctc ccgtgtttgt
1201 agaagtggct ttgtggaata ttcccatctc ctgcctccta atagctttga gggagctgaa
1261 gaagaagctg ttcaaacgcc ggcgggtgtt gaatcgggag cggcgtctga ggcaccgggt
1321 ggtcggggct gtgatagacc aagggctgat cacgcggcac cacctcaaga agcgggcgtc
1381 cagtgcacgt gccaacatta cactgtcagg gaagaagcgc agaaaactcc tccagcagat
1441 ccggcttgcc cagaaagaga agacagccat ggaagtggaa gccccttcaa agccagccag
1501 gactagtgaa ccacagctca aaaggcaaaa gaagacaaaa gccccccagg atgtagaaat
1561 gaaggacctt gaagatgaga gctaaacctc ttccactaga agattctcaa ctggagccag
1621 ccttcagact cagtggttgt ttcagaggac tttgacaaaa gcaaggcccc ttttcactct
1681 ccagatttcc tcctacctaa tggcctactg acctccccta gagggatgtc tttgggaggg
1741 aagaaggtac agaagaaaga ttggagaagg gcctctctag cagtcaactc catttgtaat
1801 aaagccctag cactctga
//