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Homo sapiens zinc finger protein 106 (ZNF106), transcript variant 1, mRNA

NCBI Reference Sequence: NM_022473.2

FASTA Graphics 

LOCUS       NM_022473              10890 bp    mRNA    linear   PRI 06-AUG-2019
DEFINITION  Homo sapiens zinc finger protein 106 (ZNF106), transcript variant
            1, mRNA.
ACCESSION   NM_022473
VERSION     NM_022473.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10890)
  AUTHORS   Contreras-Martos S, Piai A, Kosol S, Varadi M, Bekesi A, Lebrun P,
            Volkov AN, Gevaert K, Pierattelli R, Felli IC and Tompa P.
  TITLE     Linking functions: an additional role for an intrinsically
            disordered linker domain in the transcriptional coactivator CBP
  JOURNAL   Sci Rep 7 (1), 4676 (2017)
   PUBMED   28680062
  REMARK    GeneRIF: Study identified ZFP106 as a novel substrate for
            CBP-mediated acetylation, and showed that the fully disordered
            isolated ID3 in CREBBP transiently interacts with an IDR of ZFP106
            in a fashion that both IDR regions are maintained.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10890)
  AUTHORS   Grasberger H, Ye H, Mashima H and Bell GI.
  TITLE     Dual promoter structure of ZFP106: regulation by myogenin and
            nuclear respiratory factor-1
  JOURNAL   Gene 344, 143-159 (2005)
   PUBMED   15656981
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK091929.1, AF205632.1 and AI658947.1.
            
            [WARNING] On Apr 21, 2020 this sequence was replaced by
            NM_022473.3.
            
            On Sep 27, 2013 this sequence version replaced NM_022473.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF205632.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                AK091929.1         1-35
            36-10495            AF205632.1         9-10468
            10496-10890         AI658947.1         1-395               c
FEATURES             Location/Qualifiers
     source          1..10890
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.1"
     gene            1..10890
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /note="zinc finger protein 106"
                     /db_xref="GeneID:64397"
                     /db_xref="HGNC:HGNC:12886"
     exon            1..610
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    294..296
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /note="upstream in-frame stop codon"
     CDS             363..6014
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /note="isoform 1 is encoded by transcript variant 1;
                     SH3-domain binding protein 3; zinc finger protein 474"
                     /codon_start=1
                     /product="zinc finger protein 106 isoform 1"
                     /protein_id="NP_071918.1"
                     /db_xref="CCDS:CCDS32208.1"
                     /db_xref="GeneID:64397"
                     /db_xref="HGNC:HGNC:12886"
                     /translation="MPVGRIECPSSPSFPRDISHECRVCGVTEVGLSAYAKHISGQLH
                     KDNVDAQEREDDGKGEEEEEDYFDKELIQLIKQRKEQSRQDEPSNSNQEINSDDRRPQ
                     WRREDRIPYQDRESYSQPAWHHRGPPQRDWKWEKDGFNNTRKNSFPHSLRNGGGPRGR
                     SGWHKGVAGGSSTWFHNHSNSGGGWLSNSGAVDWNHNGTGRNSSWLSEGTGGFSSWHM
                     NNSNGNWKSSVRSTNNWNYSGPGDKFQPGRNRNSNCQMEDMTMLWNKKSNKSNKYSHD
                     RYNWQRQENDKLGTVATYRGPSEGFTSDKFPSEGLLDFNFEQLESQTTKQADTATSKV
                     SGKNGSAAREKPRRWTPYPSQKTLDLQSGLKDITGNKSEMIEKPLFDFSLITTGIQEP
                     QTDETRNSPTQKTQKEIHTGSLNHKASSDSAASFEVVRQCPTAEKPEQEHTPNKMPSL
                     KSPLLPCPATKSLSQKQDPKNISKNTKTNFFSPGEHSNPSNKPTVEDNHGPYISKLRS
                     SCPHVLKGNKSTFGSQKQSGDNLNDTLRKAKEVLQCHESLQNPLLSTSKSTRNYAKAS
                     RNVEESEKGSLKIEFQVHALEDESDGETSDTEKHGTKIGTLGSATTELLSGSTRTADE
                     KEEDDRILKTSRELSTSPCNPIVRQKESELQMTSAASPHPGLLLDLKTSLEDAQVDDS
                     IKSHVSYETEGFESASLDAELQKSDISQPSGPLLPELSKLGFPASLQRDLTRHISLKS
                     KTGVHLPEPNLNSARRIRNISGHRKSETEKESGLKPTLRQILNASRRNVNWEQVIQQV
                     TKKKQELGKGLPRFGIEMVPLVQNEQEALDLDGEPDLSSLEGFQWEGVSISSSPGLAR
                     KRSLSESSVIMDRAPSVYSFFSEEGTGKENEPQQMVSPSNSLRAGQSQKATMHLKQEV
                     TPRAASLRTGERAENVATQRRHSAQLSSDHIIPLMHLAKDLNSQERSIPPSENQNSQE
                     SNGEGNCLSSSASSALAISSLADAATDSSCTSGAEQNDGQSIRKKRRATGDGSSPELP
                     SLERKNKRRKIKGKKERSQVDQLLNISLREEELSKSLQCMDNNLLQARAALQTAYVEV
                     QRLLMLKQQITMEMSALRTHRIQILQGLQETYEPSEHPDQVPCSLTRERRNSRSQTSI
                     DAALLPTPFFPLFLEPPSSHVSPSPTGASLQITTSPTFQTHGSVPAPDSSVQIKQEPM
                     SPEQDENVNAVPPSSACNVSKELLEANREISDSCPVYPVITARLSLPESTESFHEPSQ
                     ELKFSVEQRNTRNRENSPSSQSAGLSSINKEGEEPTKGNSGSEACTSSFLRLSFASET
                     PLEKEPHSPADQPEQQAESTLTSAETRGSKKKKKLRKKKSLRAAHVPENSDTEQDVLT
                     VKPVRKVKAGKLIKGGKVTTSTWEDSRTGREQESVRDEPDSDSSLEVLEIPNPQLEVV
                     AIDSSESGEEKPDSPSKKDIWNSTEQNPLETSRSGCDEVSSTSEIGTRYKDGIPVSVA
                     ETQTVISSIKGSKNSSEISSEPGDDDEPTEGSFEGHQAAVNAIQIFGNLLYTCSADKT
                     VRVYNLVSRKCIGVFEGHTSKVNCLLVTQTSGKNAALYTGSSDHTIRCYNVKSRECVE
                     QLQLEDRVLCLHSRWRILYAGLANGTVVTFNIKNNKRLEIFECHGPRAVSCLATAQEG
                     ARKLLVVGSYDCTISVRDARNGLLLRTLEGHSKTILCMKVVNDLVFSGSSDQSVHAHN
                     IHTGELVRIYKGHNHAVTVVNILGKVMVTACLDKFVRVYELQSHDRLQVYGGHKDMIM
                     CMTIHKSMIYTGCYDGSIQAVRLNLMQNYRCWWHGCSLIFGVVDHLKQHLLTDHTNPN
                     FQTLKCRWKNCDAFFTARKGSKQDAAGHIERHAEDDSKIDS"
     misc_feature    1626..1628
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:23186163};
                     propagated from UniProtKB/Swiss-Prot (Q9H2Y7.1);
                     phosphorylation site"
     misc_feature    2130..2132
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:19690332};
                     propagated from UniProtKB/Swiss-Prot (Q9H2Y7.1);
                     phosphorylation site"
     misc_feature    2283..2285
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:23186163};
                     propagated from UniProtKB/Swiss-Prot (Q9H2Y7.1);
                     phosphorylation site"
     misc_feature    2343..2345
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:23186163};
                     propagated from UniProtKB/Swiss-Prot (Q9H2Y7.1);
                     phosphorylation site"
     misc_feature    2937..2939
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:18669648};
                     propagated from UniProtKB/Swiss-Prot (Q9H2Y7.1);
                     phosphorylation site"
     misc_feature    2943..2945
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:18669648,
                     ECO:0000244|PubMed:19690332, ECO:0000244|PubMed:20068231,
                     ECO:0000244|PubMed:23186163}; propagated from
                     UniProtKB/Swiss-Prot (Q9H2Y7.1); phosphorylation site"
     misc_feature    2952..2954
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:18669648,
                     ECO:0000244|PubMed:23186163}; propagated from
                     UniProtKB/Swiss-Prot (Q9H2Y7.1); phosphorylation site"
     misc_feature    3039..3041
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:20068231,
                     ECO:0000244|PubMed:23186163}; propagated from
                     UniProtKB/Swiss-Prot (Q9H2Y7.1); phosphorylation site"
     misc_feature    3171..3173
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:18669648,
                     ECO:0000244|PubMed:23186163}; propagated from
                     UniProtKB/Swiss-Prot (Q9H2Y7.1); phosphorylation site"
     misc_feature    3423..3425
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine. {ECO:0000244|PubMed:18669648,
                     ECO:0000244|PubMed:23186163}; propagated from
                     UniProtKB/Swiss-Prot (Q9H2Y7.1); phosphorylation site"
     misc_feature    3435..3437
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:18669648,
                     ECO:0000244|PubMed:19690332, ECO:0000244|PubMed:20068231,
                     ECO:0000244|PubMed:21406692, ECO:0000244|PubMed:23186163};
                     propagated from UniProtKB/Swiss-Prot (Q9H2Y7.1);
                     phosphorylation site"
     misc_feature    3438..3440
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:18669648,
                     ECO:0000244|PubMed:19690332, ECO:0000244|PubMed:20068231,
                     ECO:0000244|PubMed:21406692, ECO:0000244|PubMed:23186163};
                     propagated from UniProtKB/Swiss-Prot (Q9H2Y7.1);
                     phosphorylation site"
     misc_feature    3453..3455
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:18669648,
                     ECO:0000244|PubMed:21406692}; propagated from
                     UniProtKB/Swiss-Prot (Q9H2Y7.1); phosphorylation site"
     misc_feature    4107..4109
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:23186163};
                     propagated from UniProtKB/Swiss-Prot (Q9H2Y7.1);
                     phosphorylation site"
     misc_feature    4197..4199
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:18669648,
                     ECO:0000244|PubMed:20068231, ECO:0000244|PubMed:21406692,
                     ECO:0000244|PubMed:23186163}; propagated from
                     UniProtKB/Swiss-Prot (Q9H2Y7.1); phosphorylation site"
     misc_feature    4203..4205
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000250|UniProtKB:O88466};
                     propagated from UniProtKB/Swiss-Prot (Q9H2Y7.1);
                     phosphorylation site"
     misc_feature    4212..4214
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:21406692};
                     propagated from UniProtKB/Swiss-Prot (Q9H2Y7.1);
                     phosphorylation site"
     misc_feature    4266..4268
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:21406692,
                     ECO:0000244|PubMed:23186163}; propagated from
                     UniProtKB/Swiss-Prot (Q9H2Y7.1); phosphorylation site"
     misc_feature    4344..4346
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:18669648,
                     ECO:0000244|PubMed:20068231, ECO:0000244|PubMed:21406692,
                     ECO:0000244|PubMed:23186163}; propagated from
                     UniProtKB/Swiss-Prot (Q9H2Y7.1); phosphorylation site"
     misc_feature    4470..4472
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:19690332,
                     ECO:0000244|PubMed:20068231, ECO:0000244|PubMed:21406692,
                     ECO:0000244|PubMed:23186163}; propagated from
                     UniProtKB/Swiss-Prot (Q9H2Y7.1); phosphorylation site"
     misc_feature    4476..4478
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine. {ECO:0000244|PubMed:19690332,
                     ECO:0000244|PubMed:23186163}; propagated from
                     UniProtKB/Swiss-Prot (Q9H2Y7.1); phosphorylation site"
     misc_feature    4764..4766
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:23186163};
                     propagated from UniProtKB/Swiss-Prot (Q9H2Y7.1);
                     phosphorylation site"
     misc_feature    4947..5066
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9H2Y7.1);
                     Region: WD 1"
     misc_feature    5070..5195
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9H2Y7.1);
                     Region: WD 2"
     misc_feature    5322..5447
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9H2Y7.1);
                     Region: WD 3"
     misc_feature    5454..5573
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9H2Y7.1);
                     Region: WD 4"
     misc_feature    5574..5687
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9H2Y7.1);
                     Region: WD 5"
     misc_feature    5694..5807
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9H2Y7.1);
                     Region: WD 6"
     exon            611..2794
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /inference="alignment:Splign:2.1.0"
     exon            2795..3428
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /inference="alignment:Splign:2.1.0"
     exon            3429..3498
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /inference="alignment:Splign:2.1.0"
     exon            3499..3653
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /inference="alignment:Splign:2.1.0"
     exon            3654..3714
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /inference="alignment:Splign:2.1.0"
     exon            3715..4056
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /inference="alignment:Splign:2.1.0"
     exon            4057..4837
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /inference="alignment:Splign:2.1.0"
     exon            4838..4893
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /inference="alignment:Splign:2.1.0"
     exon            4894..5039
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /inference="alignment:Splign:2.1.0"
     exon            5040..5174
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /inference="alignment:Splign:2.1.0"
     exon            5175..5291
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /inference="alignment:Splign:2.1.0"
     exon            5292..5483
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /inference="alignment:Splign:2.1.0"
     exon            5484..5546
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /inference="alignment:Splign:2.1.0"
     exon            5547..5666
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /inference="alignment:Splign:2.1.0"
     exon            5667..5738
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /inference="alignment:Splign:2.1.0"
     exon            5739..5810
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /inference="alignment:Splign:2.1.0"
     exon            5811..5957
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /inference="alignment:Splign:2.1.0"
     exon            5958..10881
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaagattaaa tgtaagcgct gtcaccaggc cttctgagtg cagctggcac catgggtgtg
       61 ctccagagca acttctgctt gctctgagcc ccctgccctg cctccccttt caccatgttt
      121 cctctgacaa gattttaagt acagcaattc aagaagattt ctcctcctaa acgacattta
      181 tctgaagtct attgcctctt gattgctgga aaagaatctt aaaatcattt caaaagtaac
      241 ttataaacaa acttattaaa agtgatgaaa ggagcattga aattaattag cactaatttt
      301 tcactgtgcc aaagtgtgca gtgtccttca gaggaaacaa taacagatct ggtgagtgtg
      361 ccatgccagt ggggagaatt gaatgtccct catctccctc tttccctagg gacattagtc
      421 atgagtgccg agtgtgcggg gtcacagaag tgggtctttc tgcatatgca aagcacattt
      481 ctggccagtt gcacaaagat aacgttgatg cccaggaaag agaagatgat ggaaaaggag
      541 aggaagagga agaagattat tttgacaagg aactcattca gttaataaaa caaaggaaag
      601 aacaaagtcg acaagatgaa ccttccaata gcaaccaaga aataaactct gatgacagac
      661 gaccccaatg gagacgagaa gaccgaattc cttaccaaga cagagagagt tacagtcagc
      721 ctgcatggca tcatcgtgga cctccacagc gggattggaa atgggaaaaa gatggcttta
      781 ataatactag gaaaaacagc tttccacatt ctttgaggaa tggtggtgga ccaagaggac
      841 gttccgggtg gcataagggt gttgcaggag gctcctcgac ttggtttcac aaccatagta
      901 attctggagg tggttggctt tcaaatagtg gagcagtaga ttggaatcat aatggtacag
      961 gaaggaattc cagttggctt tctgaaggaa caggtggctt ttccagttgg catatgaaca
     1021 acagtaacgg aaactggaaa tccagtgtac gtagtacaaa taattggaat tacagtggcc
     1081 ctggagacaa atttcaacca ggcagaaaca gaaattctaa ctgtcaaatg gaagacatga
     1141 ctatgctatg gaacaagaaa tctaataagt caaacaaata cagtcacgac agatataatt
     1201 ggcagcggca agaaaatgac aaacttggta cagttgccac atatagaggt ccttctgaag
     1261 gatttacaag tgataaattt ccttcagaag gcttactcga cttcaatttt gagcagctgg
     1321 aaagccaaac cactaaacaa gcagacactg ctacttccaa agttagtgga aagaatggca
     1381 gtgcggcaag ggaaaagcct cgtcgctgga cgccttaccc ttctcagaag actctggatt
     1441 tacagtcggg attgaaagac atcactggta acaagtcaga aatgatagag aaacctctct
     1501 ttgattttag cttgataact acaggaatac aggagcccca aactgatgaa acacgtaatt
     1561 ccccaacaca gaaaacacaa aaagaaatac atactggatc tcttaatcac aaggcctctt
     1621 ctgattccgc tgcttccttc gaggtggtga gacagtgccc cactgcagaa aaacctgaac
     1681 aagagcatac accaaataaa atgccatcat tgaaatcccc actccttcca tgtccagcca
     1741 ctaaatcatt gtctcaaaag caagatccaa agaatatctc aaaaaacacc aaaacaaatt
     1801 ttttttcccc tggagaacac tcaaatccct cgaacaagcc cactgtggaa gataaccatg
     1861 gtccttacat atccaaactg cgtagttcat gtcctcatgt tttaaaaggg aataaaagta
     1921 catttggctc tcaaaagcaa tctggtgata atttaaatga tactttacga aaggccaaag
     1981 aggtgctaca gtgtcatgag tcattgcaaa atccacttct tagcacttct aaaagtacca
     2041 ggaactatgc aaaagcaagt agaaatgtag aagaatctga aaaagggtct ttgaaaattg
     2101 agtttcaagt gcacgcacta gaagatgaaa gtgatggaga gacatctgac acggaaaagc
     2161 atggaacaaa aattggaacc ctaggttctg caactacaga attgttatct ggcagcactc
     2221 gaactgctga tgagaaagag gaggatgacc gcatcctgaa gacttctaga gagctatcca
     2281 cttccccatg taatcccata gttcgccaga aagaatctga attacaaatg acatctgcag
     2341 ccagtccaca ccctggctta ttgctagact tgaaaacctc tctagaagat gcacaggttg
     2401 atgactctat taaatctcat gtatcttatg aaacagaagg ctttgagagt gctagcttgg
     2461 atgcagagct tcaaaaaagt gacatcagtc agccctcggg ccctctcctg cctgaactaa
     2521 gtaagcttgg ctttcctgcc tcacttcaga gggatctaac ccggcacatt agtttgaaga
     2581 gcaaaactgg agtacacctt cctgagccaa acctcaatag tgcccgccgc attcgcaata
     2641 ttagcggtca ccgaaagagt gagacagaga aggagtctgg gctcaagcca accctacggc
     2701 agattctaaa tgcatctcgg agaaatgtca actgggaaca ggtcattcag caagtaacca
     2761 agaaaaagca agagctgggc aaaggcttac ccaggtttgg catagaaatg gtaccccttg
     2821 ttcaaaatga acaagaagcc ttagatttgg atggggaacc tgatctgtcc agtctagaag
     2881 gattccagtg ggaaggtgtt tccatttcct cgtcccctgg cttggcaaga aagcgaagcc
     2941 tttctgagag cagcgtgatc atggacagag ctccttctgt gtatagcttc ttcagtgagg
     3001 aaggtacagg caaagaaaat gagccccagc agatggtttc acctagtaac tcattgaggg
     3061 ctggacagag ccagaaagca accatgcacc tcaaacaaga agtgacacct cgggctgcct
     3121 ccctccgaac aggtgaaagg gctgaaaatg ttgctaccca aaggcgacat agtgcacaat
     3181 tatcctctga ccatataata cctttgatgc atttggcaaa agacttgaac agccaggaga
     3241 ggtctatacc accgtcagag aatcagaatt cccaggagag taatggagag ggaaactgtc
     3301 tgtcatcaag cgcatcctca gcccttgcga tctccagttt agcggatgca gccacagata
     3361 gtagctgtac ctctggtgct gaacaaaatg atggccaaag tattagaaag aaacgaagag
     3421 ccactggaga tggatcttct cctgaactcc caagtcttga gagaaaaaat aaaagaagga
     3481 aaattaaagg aaaaaaagaa cgttctcagg ttgaccagct gctgaatatt tctttaaggg
     3541 aggaagaact tagtaagtca ttgcagtgca tggataacaa tcttctgcaa gcccgtgcag
     3601 cccttcagac agcttatgtg gaagttcaga ggctacttat gctcaagcag cagataacta
     3661 tggagatgag tgcactgagg acccatagaa tacagattct acagggatta caagaaacat
     3721 atgaaccttc tgagcaccca gaccaggttc cctgtagcct cacacgagaa cgaaggaaca
     3781 gtagatctca aacatccatt gatgccgcac tgctgcccac tccctttttc ccactttttc
     3841 tggagcctcc atcttcccat gtgtctccat cacccaccgg agcctctctt caaataacca
     3901 cgtctcctac tttccaaacc catggcagtg tccctgctcc agactcatca gttcagatta
     3961 aacaagagcc catgtctcct gaacaagatg agaatgtgaa tgctgtgcca ccaagctctg
     4021 cctgcaatgt gtccaaggaa ttactggaag ctaatagaga gatcagtgac agttgtccag
     4081 tttatccagt catcactgct agattgtcct taccagagtc aacagaaagt ttccatgagc
     4141 ctagccaaga actgaagttt tctgtggagc aaagaaatac cagaaacaga gaaaactctc
     4201 cctcttccca atcagctggt ctttctagca taaataaaga aggggaagag ccaaccaaag
     4261 gcaatagtgg gtctgaagcc tgtaccagtt cttttctaag attgtctttt gcttcagaaa
     4321 cccctttgga gaaggaaccc cactctccag ctgaccagcc tgaacaacag gcagaatcca
     4381 ctttgacatc agctgagact aggggaagca agaaaaagaa gaaactccgg aagaagaaaa
     4441 gtctacgggc tgcccatgtt cctgagaata gtgacactga acaggatgtt ttgactgtta
     4501 aacctgtaag gaaagtaaaa gctggaaagt taattaaagg ggggaaagta acaacctcca
     4561 cttgggaaga cagcaggact ggtcgggagc aggagagtgt cagagatgag ccagatagtg
     4621 actcgtctct ggaagtccta gaaattccta atcctcagtt agaagtagta gccattgatt
     4681 cttcagaatc aggagaagag aaaccagaca gcccatctaa aaaggatatt tggaactcta
     4741 cagagcaaaa cccactagaa acgtctcgtt ctgggtgtga tgaagttagc tctaccagtg
     4801 aaattggcac tcgctataaa gatggcatcc ctgtaagtgt ggcagaaact cagactgtga
     4861 tctcctccat aaaaggatca aagaattctt cagaaatatc ttcagagcca ggagatgatg
     4921 atgaacccac agaaggaagc tttgagggac accaagctgc cgtaaatgca attcagatat
     4981 ttgggaactt gctatatacc tgttcagcag ataaaactgt tcgggtttat aatctggtga
     5041 gtcggaaatg tattggtgtc tttgagggtc atacctccaa agttaactgc ctcctggtta
     5101 ctcagacctc cgggaagaat gctgcccttt acaccgggtc cagtgaccat accatccgct
     5161 gctataatgt taagagccga gagtgtgtgg agcagttaca gctggaagac cgggtcctct
     5221 gcctccacag tagatggcga atcctctatg cgggactggc aaatggcact gtggtcacct
     5281 tcaacataaa gaacaacaaa cgacttgaga tctttgaatg ccatggccct cgggcagtca
     5341 gctgtcttgc tacagctcag gaaggtgccc gaaaactgct ggtcgtgggg tcttatgact
     5401 gcacaattag tgtacgcgat gcccggaatg gactgctcct cagaactctg gagggccata
     5461 gcaaaaccat tctttgcatg aaggtggtga atgatctcgt gttcagtggc tccagtgatc
     5521 agtcagtcca tgctcacaac attcacactg gtgagctcgt gcggatctat aaaggtcaca
     5581 atcatgcagt gactgtggtg aatatcctag gaaaagtgat ggtgactgct tgcctggata
     5641 aatttgttcg tgtctatgaa ttacagtctc atgatcgatt acaagtttat ggaggacaca
     5701 aagacatgat tatgtgtatg accatccata aaagcatgat ttacactggc tgttatgatg
     5761 gcagtattca ggccgtgagg cttaatctga tgcagaatta ccgctgttgg tggcatggtt
     5821 gctctctgat atttggcgtt gtagatcatt taaaacaaca cttgctgacc gaccacacta
     5881 atcccaactt ccagactctg aaatgtcgct ggaagaactg cgatgctttt ttcactgcta
     5941 ggaaaggatc caaacaggat gctgcaggac atattgaacg acatgctgaa gatgacagca
     6001 aaattgattc atgaagtttt ttgcctccca cgttgggaag tcattagttg aactattttc
     6061 acattggccc cccacacagg ccactctctt ccctttcttg gtgaagtaag gaaggagaaa
     6121 gtggttacta gccaggcata cccctagcat aagtctgggc agctctatgg gatgataaat
     6181 tacactttta agttcttgct ggaggtttta aatagattta gacaaatgtt aaggaaccat
     6241 acttctctgg gacagcatgg catatagtga tatatgctat ttgcgttctc cagatgttta
     6301 ttgaagatac agatcctaat tggttaccca gtttgaccct aatcatatgt atattttatt
     6361 gatttcagtt tgcaattttt aatttatgtt cttatgatgg tttaaaccta tagtcaggct
     6421 tttaagtaca agtttgttta agtgccagac tttgaggatc agttttaatt tctccatttg
     6481 taatagctgg gtatttaaac tggaagcaaa tagttttctt tcttaacaat tatgtgcagt
     6541 gtgtgtcact gttttcttgc tttatagata gagctggctt taagtgctaa aggacacagt
     6601 agatttttga caaacagtgg ctgctctgct gactatcttt taggaattca ggaagcaaat
     6661 cacatagtga caagtcctta cagacaccac ttctagtaaa tctctgtaaa tgtggataga
     6721 aagctcagtg tgaggcagtg cgtagaccta acgtctacct ttacatctgc tgttgaacct
     6781 gggcactacc tgttacagat cctgtcaggc tgttgaactg gaggtgtacc tttatcttcc
     6841 tttctagtgt ctgaccctgc aagcctaatg ttggtttgaa cccttttggt ttgttcagtt
     6901 gccagcctcc atctctccca ctgtatggcc gtgcctagac cgatggcagc catcgaatat
     6961 tcctctgggc tcacggggtg ttttccaccc ccctgcagca actaagatgg tgggggagag
     7021 ggggttagaa taaagcatct gaatacagtt ttcaggacct caagcagact tcctagagac
     7081 ttgtttctga gacagttctt tgccttcact tccctgctag ctgggaaaga agagtggagc
     7141 agagactctg cctggccact gagaacagcc aaattcacaa accctcagtg gggctttgtt
     7201 tttggatttt ctccggactc atcagtaaac ctgtagaagt gtcgctttcc agccttttgt
     7261 ttctggatcc tcaaaactca gaacgtggcc gggcgtggtg gctcacgcct gtaatcccag
     7321 cactttggga ggctgaggca ggcagatcac ctgaggctag gagttgcaga ccagcctggc
     7381 caacatggca aaaccccgtc tctactaaaa atacaaaaag ccgggcgtgg tgggcgcctg
     7441 taatcccagc tgctcaggag gctgaggcag gagaatcgct tgaacccggg aggcagagat
     7501 tgcagtaagc tgagatcgtg ccactgcact ccagcctggt gacagagtga gactccgtct
     7561 caaaaaaaaa aaaaaaaact cagcttcttc agagagataa aattggggga ggagcccagg
     7621 gccacatacc aagctttggg acatggtgcc tcatgctctc tgggattgca gaccatccag
     7681 gtctgtcttc gcccctgtta gtgcacatat atccactcac atgtcttccc tcaggctatc
     7741 gggcaggggg acttcaccag ggggtttatg gataggcttc aagagggtct gtgagccccc
     7801 agaaattgtg tgtgagactg agtatgtgtt cttttttcca ggaaaggctc cagtggttct
     7861 tacttgatcc aaaaaatgtc aagaattaat ctaggaggcc gggcctggtg gctcacacct
     7921 gtaatcccag ctctttggga ggccgaggcg ggtggatcac tcaaggtcag gcatttgaga
     7981 ccagcctggc caacatagtg aaaccccgtc tctattaaaa atacaaaaat tagctgggtg
     8041 tggtggtatg tgcctgtagt ctcagctact caggaggctg agacaggaga atcacttgaa
     8101 ccctggaggt agaagttgca gtgagccaag atcatactac tgcactccag cctgggcgac
     8161 aagagtgaaa ctccacctca aaaaaaaaaa aaaaagagtt aatctaggag ataatgaatg
     8221 gcctagtact agataatata tggccccaca agctcttgac ttctgtcctt ggggaaagcc
     8281 attttgttaa ccacactagt gagatttaca tgatgcttaa tggagaacag agaagatctt
     8341 gttgcaaaag gtgtattaaa tatttgtgct gtttctgtat gagattgaga agcttttccc
     8401 acctctcacc cctatttcct ataaggatat ccagagaagc caaactgttc tgtgggtttg
     8461 ggaatggtca tttcccggga aaatgcatct ggatcgatga ctaaacctgg cccttttctc
     8521 tgggctgtag tgaagccgca ttttcacgct ggctggcagt gtgctgagag cctcgaatgc
     8581 tctgcggcgt agtgcccttc tgccctgcct gacgatgtat cgaaaagatg agagtgaagg
     8641 agactttgtg cagcaggaaa cgggtaggtg aggtgttggg cagttgtggg aacttctgag
     8701 agtattacag agtggtagaa tcggtaagaa ctctgatttg gacttcgctt tggtggaact
     8761 gtgtgcctat acctgcctgt gtgtgtgcaa gtgtgcaggt tcctttgtat gtatgtgtac
     8821 gtgtgggaac ctgtgtttgt catatttttc ttcatttcac aaaggctttt tttgaagcag
     8881 tggcagtatg cctttgtttc aagaacacat gaaattcttt taacaccaga ttagtgtgtt
     8941 accccaaatg aacggttcta gccctctatt aagaaataaa gggaccataa gcattttggc
     9001 tgcttatggc tgtgtgttac tacttacaag agtcttgaaa attatacaga actttgcctt
     9061 ctttttttaa tgtcttccac aatgttgtga ctgattataa ccctgtttcc cctcagagaa
     9121 gagctatggc tcagggatct gtgttgactc tggcatttag tggctttgtg aaggaaagaa
     9181 accattaaat gacctgacaa aaactgactc atgtctttaa agtagttgaa gccactttta
     9241 gaatgttact ctcggttgct tttgtctaat tctaatggct taaagccaag aaaaccatag
     9301 tataaatctt tttgtgtacc tatgctagtg tttaaatggc agttcgttgt gataaagtat
     9361 cagtcacttc aagttttctg tgaaagtttt taattaggtt aaaaataatt ttggcatacg
     9421 tctctactca gtttataaag cagttccaca ccatgcaaac aaaactctaa cagcaaaggt
     9481 tatcttgacc tgatgttact tgaatctgag agaaagtcat tacttactac tgcactcctg
     9541 cttttgtggg aaaaattttc ttcttcccca gaagagttaa cagttgagtg ttcagctcct
     9601 gacttacctt taatttagag gcaatattat tactgtttaa gtgattattt gcttaacaca
     9661 ggttttattt tgtctttttg ctggtagatt atacaaggga caactttagt gatgaggcat
     9721 gtggatgatt tggtgggagt aggtatatac ttagtggaat ggtttatttt atggaagaga
     9781 attcattgga ggtgagattg aagtatattg tgaagtggga tttgaacagc acatatgctc
     9841 tggtttgctc aaataactgc agtttatgct tacatctaaa ttttgtttct gttacctaaa
     9901 cgggagcttc tagaattacg aaggccatac ctgccacatt tataaaataa tggttttatc
     9961 cctgccccca aatcatcagg ttcctcgggt ttaagagaag tggtctaata gacaggaata
    10021 gaagttgtgg tggaggtgat ttgggataga ctaggtttcc ttatgcaagt ggatatgagc
    10081 tcctcataga aaccagacct actgtattag acagtaacct ctaacctcac ctccaagccc
    10141 aagtatatgg ccctgctggg ttacctggtg actacatttc ccagattcac tctaaattca
    10201 aggtagtgac ccaaataaat tgggaaagga gggggtcaag gaggaaaagc tgttgaaaat
    10261 ctttctccta tttaagagaa atatatgccc tagagctgct ccagcaccct tggtttctga
    10321 tttttttaat attgaatatg gattagaaga atgaaatcag atgacacctg actgcaaaaa
    10381 tgtttataag caaatagcct tcttacattt tggtataaag ctgtgaactt cgtaactttg
    10441 taaagcaaga tataaagcaa atacaagagg aaaataaagt acttttacta attgacggtt
    10501 tactttcgtt accttgtctg catattcacg gccagccctt tccacgttgg cttagcgagg
    10561 aagaaggaaa ctgggtggaa aacacaggat gcctatagat atgccgcagg ccatggtcca
    10621 gagaagttta gcaaacaaac agctgcgttc agggttttgt ccacggtcat gcgacaggtc
    10681 agttagtgag cagaggagct aggatagctc aatctccact ccattattca ggtaaccggc
    10741 ccctcccgtt gtacatgacc catttattct tgatgtcttt tacagcaaca actattcctc
    10801 tgccttcctt ttatgtcttg gaaagtatct gagccattct tatgctcaag aaatagcaat
    10861 aggcatgatt acaaaattca aaaaaaaaaa
//
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