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Homo sapiens tetratricopeptide repeat domain 3 (TTC3), transcript variant 1, mRNA

NCBI Reference Sequence: NM_003316.3

FASTA Graphics 

LOCUS       NM_003316               9021 bp    mRNA    linear   PRI 13-MAY-2017
DEFINITION  Homo sapiens tetratricopeptide repeat domain 3 (TTC3), transcript
            variant 1, mRNA.
ACCESSION   NM_003316
VERSION     NM_003316.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9021)
  AUTHORS   Liu F, Wollstein A, Hysi PG, Ankra-Badu GA, Spector TD, Park D, Zhu
            G, Larsson M, Duffy DL, Montgomery GW, Mackey DA, Walsh S, Lao O,
            Hofman A, Rivadeneira F, Vingerling JR, Uitterlinden AG, Martin NG,
            Hammond CJ and Kayser M.
  TITLE     Digital quantification of human eye color highlights genetic
            association of three new loci
  JOURNAL   PLoS Genet. 6 (5), E1000934 (2010)
   PUBMED   20463881
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9021)
  AUTHORS   Suizu F, Hiramuki Y, Okumura F, Matsuda M, Okumura AJ, Hirata N,
            Narita M, Kohno T, Yokota J, Bohgaki M, Obuse C, Hatakeyama S,
            Obata T and Noguchi M.
  TITLE     The E3 ligase TTC3 facilitates ubiquitination and degradation of
            phosphorylated Akt
  JOURNAL   Dev. Cell 17 (6), 800-810 (2009)
   PUBMED   20059950
  REMARK    GeneRIF: Interaction between TTC3 and Akt may contribute to the
            clinical symptoms of Down syndrome.
REFERENCE   3  (bases 1 to 9021)
  AUTHORS   Berto G, Camera P, Fusco C, Imarisio S, Ambrogio C, Chiarle R,
            Silengo L and Di Cunto F.
  TITLE     The Down syndrome critical region protein TTC3 inhibits neuronal
            differentiation via RhoA and Citron kinase
  JOURNAL   J. Cell. Sci. 120 (PT 11), 1859-1867 (2007)
   PUBMED   17488780
  REMARK    GeneRIF: These results suggest that the TTC3-RhoA-CIT-K pathway
            could be a crucial determinant of in vivo neuronal development,
            whose hyperactivity may result in detrimental effects on the normal
            differentiation program.
REFERENCE   4  (bases 1 to 9021)
  AUTHORS   Rachidi M, Lopes C, Gassanova S, Sinet PM, Vekemans M, Attie T,
            Delezoide AL and Delabar JM.
  TITLE     Regional and cellular specificity of the expression of TPRD, the
            tetratricopeptide Down syndrome gene, during human embryonic
            development
  JOURNAL   Mech. Dev. 93 (1-2), 189-193 (2000)
   PUBMED   10781955
REFERENCE   5  (bases 1 to 9021)
  AUTHORS   Dahmane N, Ghezala GA, Gosset P, Chamoun Z, Dufresne-Zacharia MC,
            Lopes C, Rabatel N, Gassanova-Maugenre S, Chettouh Z, Abramowski V,
            Fayet E, Yaspo ML, Korn B, Blouin JL, Lehrach H, Poutska A,
            Antonarakis SE, Sinet PM, Creau N and Delabar JM.
  TITLE     Transcriptional map of the 2.5-Mb CBR-ERG region of chromosome 21
            involved in Down syndrome
  JOURNAL   Genomics 48 (1), 12-23 (1998)
   PUBMED   9503011
REFERENCE   6  (bases 1 to 9021)
  AUTHORS   Eki T, Abe M, Naitou M, Sasanuma SI, Nohata J, Kawashima K, Ahmad
            I, Hanaoka F and Murakami Y.
  TITLE     Cloning and characterization of novel gene, DCRR1, expressed from
            Down's syndrome critical region of human chromosome 21q22.2
  JOURNAL   DNA Seq. 7 (3-4), 153-164 (1997)
   PUBMED   9254009
REFERENCE   7  (bases 1 to 9021)
  AUTHORS   Tsukahara F, Hattori M, Muraki T and Sakaki Y.
  TITLE     Identification and cloning of a novel cDNA belonging to
            tetratricopeptide repeat gene family from Down syndrome-critical
            region 21q22.2
  JOURNAL   J. Biochem. 120 (4), 820-827 (1996)
   PUBMED   8947847
REFERENCE   8  (bases 1 to 9021)
  AUTHORS   Ohira M, Ootsuyama A, Suzuki E, Ichikawa H, Seki N, Nagase T,
            Nomura N and Ohki M.
  TITLE     Identification of a novel human gene containing the
            tetratricopeptide repeat domain from the Down syndrome region of
            chromosome 21
  JOURNAL   DNA Res. 3 (1), 9-16 (1996)
   PUBMED   8724848
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            D83077.1, D83327.1, D84296.1, BQ893819.1 and CA420000.1.
            
            [WARNING] On Aug 1, 2017 this sequence was replaced by NM_003316.4.
            
            On Jul 2, 2004 this sequence version replaced NM_003316.2.
            
            Transcript Variant: This variant (1) differs in the 5' UTR and has
            multiple coding region differences compared to variant 3. These
            differences cause translation initiation at a downstream AUG and
            result in an isoform (1) with a shorter N-terminus compared to
            isoform 3. Variants 1 and 2 encode the same isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: D83077.1, SRR1660803.96350.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3150              D83077.1           1-3150
            3151-3914           D83327.1           1503-2266
            3915-6646           D84296.1           2326-5057
            6647-7246           BQ893819.1         206-805
            7247-8995           D84296.1           5658-7406
            8996-9021           CA420000.1         1-26                c
FEATURES             Location/Qualifiers
     source          1..9021
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.13"
     gene            1..9021
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /note="tetratricopeptide repeat domain 3"
                     /db_xref="GeneID:7267"
                     /db_xref="HGNC:HGNC:12393"
                     /db_xref="MIM:602259"
     misc_feature    1349..1351
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /note="upstream in-frame stop codon"
     CDS             1397..7474
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1; TPR
                     repeat protein D; E3 ubiquitin-protein ligase TTC3; TPR
                     repeat protein 3; RING finger protein 105;
                     tetratricopeptide repeat protein 3; RING-type E3 ubiquitin
                     transferase TTC3"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TTC3 isoform 1"
                     /protein_id="NP_003307.3"
                     /db_xref="CCDS:CCDS13651.1"
                     /db_xref="GeneID:7267"
                     /db_xref="HGNC:HGNC:12393"
                     /db_xref="MIM:602259"
                     /translation="MDNFAEGDFTVADYALLEDCPHVDDCVFAAEFMSNDYVRVTQLY
                     CDGVGVQYKDYIQSERNLEFDICSIWCSKPISVLQDYCDAIKINIFWPLLFQHQNSSV
                     ISRLHPCVDANNSRASEINLKKLQHLELMEDIVDLAKKVANDSFLIGGLLRIGCKIEN
                     KILAMEEALNWIKYAGDVTILTKLGSIDNCWPMLSIFFTEYKYHITKIVMEDCNLLEE
                     LKTQSCMDCIEEGELMKMKGNEEFSKERFDIAIIYYTRAIEYRPENYLLYGNRALCFL
                     RTGQFRNALGDGKRATILKNTWPKGHYRYCDALSMLGEYDWALQANIKAQKLCKNDPE
                     GIKDLIQQHVKLQKQIEDLQGRTANKDPIKAFYENRAYTPRSLSAPIFTTSLNFVEKE
                     RDFRKINHEMANGGNQNLKVADEALKVDDCDCHPEFSPPSSQPPKHKGKQKSRNNESE
                     KFSSSSPLTLPADLKNILEKQFSKSSRAAHQDFANIMKMLRSLIQDGYMALLEQRCRS
                     AAQAFTELLNGLDPQKIKQLNLAMINYVLVVYGLAISLLGIGQPEELSEAENQFKRII
                     EHYPSEGLDCLAYCGIGKVYLKKNRFLEALNHFEKARTLIYRLPGVLTWPTSNVIIEE
                     SQPQKIKMLLEKFVEECKFPPVPDAICCYQKCHGYSKIQIYITDPDFKGFIRISCCQY
                     CKIEFHMNCWKKLKTTTFNDKIDKDFLQGICLTPDCEGVISKIIIFSSGGEVKCEFEH
                     KVIKEKVPPRPILKQKCSSLEKLRLKEDKKLKRKIQKKEAKKLAQERMEEDLRESNPP
                     KNEEQKETVDNVQRCQFLDDRILQCIKQYADKIKSGIQNTAMLLKELLSWKVLSTEDY
                     TTCFSSRNFLNEAVDYVIRHLIQENNRVKTRIFLHVLSELKEVEPKLAAWIQKLNSFG
                     LDATGTFFSRYGASLKLLDFSIMTFLWNEKYGHKLDSIEGKQLDYFSEPASLKEARCL
                     IWLLEEHRDKFPALHSALDEFFDIMDSRCTVLRKQDSGEAPFSSTKVKNKSKKKKPKD
                     SKPMLVGSGTTSVTSNNEIITSSEDHSNRNSDSAGPFAVPDHLRQDVEEFEALYDQHS
                     NEYVVRNKKLWDMNPKQKCSTLYDYFSQFLEEHGPLDMSNKMFSAEYEFFPEETRQIL
                     EKAGGLKPFLLGCPRFVVIDNCIALKKVASRLKKKRKKKNIKTKVEEISKAGEYVRVK
                     LQLNPAAREFKPDVKSKPVSDSSSAPAFENVKPKPVSANSPKPACEDVKAKPVSDNSS
                     RQVSEDGQPKGVSSNSPKPGSEDANYKRVSCNSPKPVLEDVKPTYWAQSHLVTGYCTY
                     LPFQRFDITQTPPAYINVLPGLPQYTSIYTPLASLSPEYQLPRSVPVVPSFVANDRAD
                     KNAAAYFEGHHLNAENVAGHQIASETQILEGSLGISVKSHCSTGDAHTVLSESNRNDE
                     HCGNSNNKCEVIPESTSAVTNIPHVQMVAIQVSWNIIHQEVNTEPYNPFEERQGEISR
                     IEKEHQVLQDQLQEVYENYEQIKLKGLEETRDLEEKLKRHLEENKISKTELDWFLQDL
                     EREIKKWQQEKKEIQERLKSLKKKIKKVSNASEMYTQKNDGKEKEHELHLDQSLEISN
                     TLTNEKMKIEEYIKKGKEDYEESHQRAVAAEVSVLENWKESEVYKLQIMESQAEAFLK
                     KLGLISRDPAAYPDMESDIRSWELFLSNVTKEIEKAKSQFEEQIKAIKNGSRLSELSK
                     VQISELSFPACNTVHPELLPESSGDDGQGLVTSASDVTGNHAALHRDPSVFSAGDSPG
                     EAPSALLPGPPPGQPEATQLTGPKRAGQAALSERSPVADRKQPVPPGRAARSSQSPKK
                     PFNSIIEHLSVVFPCYNSTELAGFIKKVRSKNKNSLSGLSIDEIVQRVTEHILDEQKK
                     KKPNPGKDKRTYEPSSATPVTRSSQGSPSVVVAPSPKTKGQKAEDVPVRIALGASSCE
                     ICHEVFKSKNVRVLKCGHKYHKGCFKQWLKGQSACPACQGRDLLTEESPSGRGWPSQN
                     QELPSCSSR"
     misc_feature    2087..2188
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P53804.2);
                     Region: TPR 1"
     misc_feature    2192..2290
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P53804.2);
                     Region: TPR 2"
     misc_feature    2528..2530
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine, by PKB/AKT2.
                     {ECO:0000269|PubMed:20059950}; propagated from
                     UniProtKB/Swiss-Prot (P53804.2); phosphorylation site"
     misc_feature    3002..3112
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P53804.2);
                     Region: TPR 3"
     misc_feature    3122..3223
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P53804.2);
                     Region: TPR 4"
     misc_feature    4421..4423
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000250|UniProtKB:O88196};
                     propagated from UniProtKB/Swiss-Prot (P53804.2);
                     phosphorylation site"
     misc_feature    4577..4579
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000250|UniProtKB:O88196};
                     propagated from UniProtKB/Swiss-Prot (P53804.2);
                     phosphorylation site"
     regulatory      8983..8988
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
     polyA_site      9004
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
                     /experiment="experimental evidence, no additional details
                     recorded"
     polyA_site      9007
                     /gene="TTC3"
                     /gene_synonym="DCRR1; RNF105; TPRDIII"
ORIGIN      
        1 cctaaagaaa agtattaagt aaatagcagt acagatggca aatggattgc acaatatatc
       61 ctctggatcc atagtgaccc tgcagagata aacctgtgat ggtcaaacaa tgtgaaaact
      121 gctgtcagag acatgggcag ggtgctcttg tttacagaga agaggtgcaa aaatcaactt
      181 gatggtagtg ggaagatcag gaaatgcttc ctgaaattga gtattaagaa ctaatagaca
      241 ttaggtggtt gcagaataag ttttgtttag gaaggacaag cagttgggta tgactggctt
      301 ctaggttgtg tgttgtggag tgactgggga taaaagcagg agcaagatca caaaaggtct
      361 tctatgctta tattagggaa gttggacttt attctcaagc tgaagggaag ctgttgcatg
      421 gttttaagca gtaaagtgat atgatcagag ttttagagga tgccaagatt gaaggcaagt
      481 ctgaccagtt aggagactgc ttgttaaatt agttcagagg agaaacagtg aaggcagtgg
      541 cactgggcat gaagaagtat atgtgtgcta attttagatt tcttagggaa gcagaaatga
      601 caagagttag tggtccattg gacagaaata ttgaaggaga ctggggagtc taggttgact
      661 cccagggttt aggtttgggc agtaaaatga catgtagaac aattaactga taaacagcat
      721 acagaaagag gaaagaactt catttcatat gtttgttttt gaggaaaaga tgtttgtttt
      781 tgaacttcct gattcagagg ggcttgtggg acatcttggt taagatcctg tagtagttct
      841 agtagggtct agaagtcaag agatacaacc ccgcctggaa ggatttggga gtcttcagca
      901 tttggaattt tggaagccat tgtttactgc agtgcatatg agataattta aactggtaca
      961 tagataaaca cttgaaaaaa ttttaataga taggaattta atgtgtatga gaaacataac
     1021 ttgcacatct aacctttgat aatcatggac attatcactt aggccaagtg agctcaataa
     1081 aagggaaata ttaactaaaa atatatgtga tacatggaaa tggcaaaaat cacggtgaag
     1141 ctatgcaaac gatgcaagtt cagaaagtgc tgtgttaagt catgggtgtg gtggataaat
     1201 tcacccaagg agagagtaag agtgagaaga aaagagagtt gacattgggt ggcggggaat
     1261 ggagaagaag aacccatgaa ggaaactgag gaagagcagc cagacgaata ggaggaaaac
     1321 caggagaaga tggtctttgg agtccaaatg aagagttctg aggaggaagt ggtccacagc
     1381 gtcaaacttg tgcaccatgg acaattttgc tgagggagat ttcactgtgg cggattatgc
     1441 cttgttagaa gattgccctc acgtggatga ttgtgtcttt gctgctgaat ttatgagcaa
     1501 tgattatgtt cgtgtgactc agctttactg tgatggggtg ggtgtgcaat ataaagatta
     1561 tatccaaagt gagaggaatt tggaatttga catctgcagt atatggtgta gtaaaccaat
     1621 ttctgtcctg caagattatt gcgatgccat taaaataaac atcttctggc cacttctgtt
     1681 tcaacatcaa aacagttccg taatatcacg attgcatccc tgtgtggacg ccaacaattc
     1741 acgtgcttct gagataaatt tgaagaaact acaacatctt gagttgatgg aagatattgt
     1801 ggatttggca aagaaagttg ctaatgattc attccttatt ggaggcttat tgagaattgg
     1861 ttgtaaaata gaaaataaaa tcttggcaat ggaagaagct ctgaattgga taaaatatgc
     1921 aggcgatgta acaattctaa ctaaattagg atcaattgac aattgttggc ctatgttaag
     1981 tattttcttt actgaataca agtaccacat aactaaaatt gtaatggaag actgcaattt
     2041 gcttgaagaa cttaaaactc aaagttgtat ggattgtata gaggaaggag aactaatgaa
     2101 aatgaaagga aatgaagagt tttccaaaga aagatttgat atagctatta tctattacac
     2161 cagagccatt gaatatagac ctgaaaacta ccttctttat ggtaaccgag ctctttgttt
     2221 tcttcgtact ggacagttta gaaatgcact cggtgatgga aagagagcca ctattctgaa
     2281 gaacacttgg ccaaagggtc attatcgtta ttgtgatgct ctttctatgc tgggggaata
     2341 tgactgggcc ctgcaagcaa acataaaagc tcaaaaactc tgtaaaaatg accctgaggg
     2401 aatcaaggat ctaattcagc agcatgtaaa gttacaaaaa caaatagaag acctacaagg
     2461 tcgaacagca aataaggatc caattaaagc cttttatgaa aacagggcct acacacctag
     2521 gagtttatca gcacctatat ttactacttc acttaacttt gtggagaagg aaagagattt
     2581 cagaaaaatt aatcacgaaa tggccaacgg tggtaatcag aatctaaagg tggcggatga
     2641 ggcgttgaag gtagatgatt gtgactgtca tcctgaattt tcaccaccat caagtcagcc
     2701 tccaaaacat aaaggaaaac aaaaatctcg aaacaatgaa tcagaaaagt tcagttctag
     2761 ttcaccattg actttaccag cagatttgaa gaacatcttg gagaaacagt tttctaaatc
     2821 ttccagagct gcacaccagg attttgctaa tataatgaaa atgctgagaa gcttaattca
     2881 agatggctat atggccttat tggagcagcg ttgccgcagc gctgcacagg cctttacaga
     2941 gttgctgaac ggtttagatc ctcaaaaaat aaagcaattg aacctggcca tgattaacta
     3001 tgttttggtc gtctatggac ttgccatttc tctccttgga ataggacagc ctgaggaatt
     3061 atctgaagcc gaaaaccagt ttaagaggat tattgaacac taccccagtg agggccttga
     3121 ttgcttggcc tactgtggaa ttggaaaagt atatttgaaa aaaaacagat ttctagaagc
     3181 tctcaatcac tttgagaaag caagaacctt gatttatcgt cttcctggag tgttaacttg
     3241 gcccacgagt aatgtgatta ttgaagagtc tcagccacaa aaaataaaga tgctgttaga
     3301 gaaatttgtt gaagaatgca agttccctcc agtgccagat gccatttgtt gctatcagaa
     3361 gtgccatgga tattctaaga tccagatata cataactgat ccagacttta agggttttat
     3421 acgcatcagc tgttgccagt actgtaaaat agaatttcac atgaattgct ggaagaagtt
     3481 aaaaactaca acctttaatg ataaaattga caaggatttt ctacaaggaa tatgtcttac
     3541 ccctgactgt gaaggtgtca tttctaagat tatcatcttc agcagtggtg gtgaagttaa
     3601 atgtgaattt gaacacaagg tcataaaaga aaaggttcct ccaagaccta ttctgaaaca
     3661 gaaatgttct agcctagaga aactaagact gaaagaagac aaaaaattga agagaaagat
     3721 ccaaaaaaaa gaagcaaaaa agttagcaca agaaagaatg gaggaggact taagagaaag
     3781 taatccaccc aaaaatgaag agcagaaaga aactgtagac aatgttcagc gttgtcagtt
     3841 ccttgatgac agaattctac agtgtataaa gcagtatgct gacaagatta aatccggcat
     3901 acagaataca gccatgcttc tcaaagaatt gctttcttgg aaagttttga gcacagaaga
     3961 ctatacaacc tgtttttcta gcagaaattt tctaaatgaa gcagtggact atgttattcg
     4021 ccacttgatt caagaaaata acagagtaaa gacaagaata tttctgcatg ttttgagtga
     4081 gcttaaagaa gtggagccca aattagccgc ctggatccaa aaacttaata gctttggctt
     4141 agatgccaca ggaactttct tttctcgtta tggagcatct cttaaactgc ttgattttag
     4201 tatcatgact ttcctctgga atgagaaata tggtcacaaa ctagactcta tagaaggaaa
     4261 gcaacttgat tatttctctg agccagcatc attgaaggaa gcccgttgtt taatatggct
     4321 gctagaagaa cacagagaca agttcccagc attgcatagt gctttagatg aattctttga
     4381 tataatggac agccgctgta ctgtgttaag gaaacaagat agtggtgaag caccgtttag
     4441 ttcaaccaag gtgaaaaaca aaagcaagaa aaagaagcca aaggattcaa agcctatgtt
     4501 agttgggtct ggaacaactt cagtaacttc aaataatgag atcatcactt caagtgaaga
     4561 ccatagcaat cgaaattcag attctgcagg cccatttgca gtgcctgacc atcttcggca
     4621 agatgtagaa gaattcgaag ctctctatga ccaacacagt aacgaatatg ttgtccgcaa
     4681 taagaagcta tgggacatga acccaaaaca aaaatgttca actctatatg attacttctc
     4741 tcagtttttg gaggaacatg gtcccttgga catgagtaac aagatgttct ctgcagaata
     4801 tgagtttttc ccagaagaaa ctcgacagat actagaaaaa gcaggaggtt taaaaccttt
     4861 tctcttggga tgccctcgtt ttgttgtgat tgacaactgt attgcactga agaaggttgc
     4921 atcacggctc aagaaaaaaa ggaagaagaa aaacattaaa acaaaagtag aagaaatttc
     4981 aaaagcaggg gagtatgtac gagttaaact acaactgaat ccagctgcta gggaatttaa
     5041 accagatgta aagtctaaac cagtgtcaga ttcatcttca gcaccagctt ttgaaaatgt
     5101 gaaacccaaa cctgtgtctg caaattctcc caagccagct tgtgaagatg tgaaggccaa
     5161 accagtatcc gacaattctt ctagacaagt ttctgaggat gggcaaccca aaggggtctc
     5221 ttctaattct cctaaaccag gctctgagga tgcaaattac aagcgagtct cctgtaattc
     5281 ccccaaaccg gttcttgagg atgtgaaacc aacttattgg gctcaatccc atttggtcac
     5341 aggatactgt acgtatcttc ctttccagag atttgatatc acccagacac cgccagcata
     5401 cataaacgtg ttaccaggtt tgccccagta caccagcata tatacaccct tggccagcct
     5461 ttctcctgaa tatcagctac caagatcagt accagtggtg ccgtcttttg tagccaatga
     5521 cagagcagat aaaaatgctg ctgcctattt tgagggtcat catttgaatg ctgagaatgt
     5581 tgctggtcac cagattgcct ctgaaacaca gatccttgag ggctctttgg gaatatctgt
     5641 aaagtcacac tgcagcacag gtgatgctca tacagtcctg agtgagtcta acagaaatga
     5701 tgagcactgt ggaaattcta acaacaaatg tgaagtaatt ccagaaagca ccagtgcagt
     5761 aacaaacatt ccacacgtgc agatggttgc catacaggta tcttggaaca taatacacca
     5821 agaagtcaat actgagccat ataatccttt tgaggaacga caaggggaaa tttcacggat
     5881 tgaaaaggag caccaagtat tacaagacca acttcaagaa gtgtatgaaa attatgagca
     5941 gataaaactt aagggcttag aagagaccag ggacctggaa gagaagttga aaaggcactt
     6001 agaagaaaac aagatctcaa agacggaatt agattggttc cttcaagatt tggaaagaga
     6061 aattaaaaaa tggcaacagg aaaaaaaaga aatccaagaa agactaaaat cactgaagaa
     6121 gaaaattaaa aaggtttcaa atgccagtga aatgtatacc cagaaaaatg atggaaagga
     6181 aaaggaacat gaattacatc tggatcagtc ccttgaaatc agcaacacac ttacaaatga
     6241 gaaaatgaaa atagaagagt atataaagaa agggaaagag gattatgaag agagtcatca
     6301 gagagctgtg gctgcagagg tatccgtact tgaaaactgg aaggagagtg aagtgtataa
     6361 gctacagatc atggagtcac aagcagaagc ctttctgaag aagctggggc tgattagccg
     6421 tgatcctgca gcatatcctg acatggagtc tgatatacgt tcatgggaat tgtttctttc
     6481 taatgttaca aaagaaattg agaaagcaaa gtctcagttt gaagaacaaa ttaaggcaat
     6541 taaaaatggt tctcggctca gtgaactttc taaagtgcag atttctgagc tttcatttcc
     6601 tgcctgtaac acggttcatc ccgagttact ccctgagtct tcaggcgacg atggccaagg
     6661 gcttgtgact tctgcaagcg acgtgactgg aaaccacgca gcacttcaca gggatcctag
     6721 tgtgttctct gctggtgatt ccccagggga ggctccttct gcgctgttgc cagggccacc
     6781 ccctggtcag cctgaagcca ctcagctgac agggccaaaa cgggctggcc aggcagctct
     6841 gtcagaacga agccctgtgg ctgatcggaa gcagcctgtt cctccaggac gtgctgcgcg
     6901 ttcaagccag tctccaaaaa agccgttcaa tagtattatt gagcacctgt cagtggtatt
     6961 cccatgttac aacagcactg agcttgctgg ttttattaaa aaagtgcgaa gcaaaaacaa
     7021 gaactcactc tcaggattga gtattgatga aattgtccaa agagtgacag aacacattct
     7081 agatgaacag aaaaagaaaa agccaaaccc aggaaaggac aagaggactt atgagcccag
     7141 ctctgccacc cccgtgacca ggtcctccca gggctcaccc tcggtggttg ttgcaccatc
     7201 acccaaaacc aaggggcaga aagcagaaga tgtccctgtg aggattgcac tgggtgcaag
     7261 ttcctgtgaa atatgccacg aggtgttcaa atcaaaaaac gtgcgtgtgc tcaaatgtgg
     7321 gcacaagtat cacaaagggt gctttaagca gtggcttaaa gggcagagcg cttgcccggc
     7381 ctgccagggt cgtgatctcc tgacagaaga gtcaccttct ggaagaggct ggcccagtca
     7441 gaatcaggag ctgccttcct gctcttctag gtagtcacac ttcactaaag tgtcatccac
     7501 cagtgtgttg aatccgaaga atgacaattt tctaccactg gtgtaaaaaa caaacatttg
     7561 aagacccttg tgcattgtgt gtcacaaagc taaatacatg gaaatcgtta atatcgctga
     7621 tattaagtaa tttccccact ctgagtgaat actttgatga ttgccaacag tggctaataa
     7681 aatgacggct accacactca tgggtcactg gggctgcgca gggctctttg aggtgggtgg
     7741 cttcttttgg aaagtactat gaacgtctcg aagcagtatt ctagtgataa gaattcttaa
     7801 catagccaag cgccccacgt ttgttcccca cgtttgttcc ccttttctgt ttgaaaaacc
     7861 tgttctggta gctccacaag agagatgata ctgacttttt aaatttttta caagagtctg
     7921 tattcctgat atgcctatat ttttcctcaa agattctgca ttttaaggat gggcataagc
     7981 aaactatatt ttaataattt atagttaatg ttaaaatatt ggctgattta gaccaaaaga
     8041 ttcaaatctc ctctttgtga aatcccatct gcatttgatt ttttattatt ttatgttccc
     8101 ccgttagatt gttttaagtg tttgcttttc atcttttata gatgtaatct gattttcaaa
     8161 aatcattaac actttttaat tagtatcgac taagactttt tccccctgga atcgaggctg
     8221 tgtgtccgtc atcccagccc ccggttggag cctgctcttt gaactccgct gccttcctta
     8281 gcagcttctg tcctcttctg tgagtcagtc agcgagtgct tgggatccgc atccagccgt
     8341 gctgagcaca caacaggctg tgtgtggaaa tggccaccac cattctcctt ccccacccca
     8401 ccacaaaaag agaagctgtg tctttagaca accctgaggt atctgtgtta caatcgttct
     8461 gtgtttgata tttgtgtaaa gtatgcatgc agtcttgtac tgtgacctaa gaacaaaact
     8521 gtaactgcat tagaaaccat gaaaaaatta gatattgttt tgtgactttt agacagtggt
     8581 aaatatagaa ccatgaattc tggtcacatt ccatttctct ccaacatgaa ggatcaaaaa
     8641 atgtttttca atgtgttctt tgttccactg gaaacttaga gtcatgagtt tatgagctga
     8701 tttggtcacc ttcctctgcc tttgttcact gtgagttctg atgtcttagt gacttagttc
     8761 ttagaagctc acgccttagt ttgaaacaga ttctccacgg tggtccccaa aacactgtct
     8821 gcatatccat aagaattgag cgctatgggt gttaacgtgc atgaggatca gtttgcagca
     8881 gcaagtacaa aaggagaaga ggaacatccg ttgaatgagt gtgttttgta cataacttca
     8941 gatacttgtg aacatgcctt atatttgtcc aacaactgtc agaataaaga acattctaaa
     9001 atgagaaaaa aaaaaaaaaa a
//
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