LOCUS NM_001395298 8551 bp mRNA linear PRI 22-SEP-2024
DEFINITION Homo sapiens phosphodiesterase 4D interacting protein (PDE4DIP),
transcript variant 17, mRNA.
ACCESSION NM_001395298 XM_011510175
VERSION NM_001395298.1
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 8551)
AUTHORS Pan,R., Dai,J., Liang,W., Wang,H., Ye,L., Ye,S., Lin,Z., Huang,S.,
Xiong,Y., Zhang,L., Lu,L., Wang,O., Shen,X., Liao,W. and Lu,X.
TITLE PDE4DIP contributes to colorectal cancer growth and chemoresistance
through modulation of the NF1/RAS signaling axis
JOURNAL Cell Death Dis 14 (6), 373 (2023)
PUBMED 37355626
REMARK GeneRIF: PDE4DIP contributes to colorectal cancer growth and
chemoresistance through modulation of the NF1/RAS signaling axis.
Publication Status: Online-Only
REFERENCE 2 (bases 1 to 8551)
AUTHORS Zhou,Y., Liu,Y., Gupta,S., Paramo,M.I., Hou,Y., Mao,C., Luo,Y.,
Judd,J., Wierbowski,S., Bertolotti,M., Nerkar,M., Jehi,L.,
Drayman,N., Nicolaescu,V., Gula,H., Tay,S., Randall,G., Wang,P.,
Lis,J.T., Feschotte,C., Erzurum,S.C., Cheng,F. and Yu,H.
TITLE A comprehensive SARS-CoV-2-human protein-protein interactome
reveals COVID-19 pathobiology and potential host therapeutic
targets
JOURNAL Nat Biotechnol 41 (1), 128-139 (2023)
PUBMED 36217030
REFERENCE 3 (bases 1 to 8551)
AUTHORS Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
and Leonetti,M.D.
TITLE OpenCell: Endogenous tagging for the cartography of human cellular
organization
JOURNAL Science 375 (6585), eabi6983 (2022)
PUBMED 35271311
REFERENCE 4 (bases 1 to 8551)
AUTHORS Abou Ziki,M.D., Bhat,N., Neogi,A., Driscoll,T.P., Ugwu,N., Liu,Y.,
Smith,E., Abboud,J.M., Chouairi,S., Schwartz,M.A., Akar,J.G. and
Mani,A.
TITLE Epistatic interaction of PDE4DIP and DES mutations in familial
atrial fibrillation with slow conduction
JOURNAL Hum Mutat 42 (10), 1279-1293 (2021)
PUBMED 34289528
REMARK GeneRIF: Epistatic interaction of PDE4DIP and DES mutations in
familial atrial fibrillation with slow conduction.
REFERENCE 5 (bases 1 to 8551)
AUTHORS Peng,H., Zhang,J., Ya,A., Ma,W., Villa,S., Sukenik,S. and Ge,X.
TITLE Myomegalin regulates Hedgehog pathway by controlling PDE4D at the
centrosome
JOURNAL Mol Biol Cell 32 (19), 1807-1817 (2021)
PUBMED 34260267
REMARK GeneRIF: Myomegalin regulates Hedgehog pathway by controlling PDE4D
at the centrosome.
REFERENCE 6 (bases 1 to 8551)
AUTHORS Shimada,H., Kuboshima,M., Shiratori,T., Nabeya,Y., Takeuchi,A.,
Takagi,H., Nomura,F., Takiguchi,M., Ochiai,T. and Hiwasa,T.
TITLE Serum anti-myomegalin antibodies in patients with esophageal
squamous cell carcinoma
JOURNAL Int J Oncol 30 (1), 97-103 (2007)
PUBMED 17143517
REMARK GeneRIF: MMGL-antibody is significantly with a favorable prognosis.
Consequently, MMGL-anatibodies may be a useful tumor marker to
diagnose and establish a prognosis in patients with esophageal
squamous cell carcinoma.
REFERENCE 7 (bases 1 to 8551)
AUTHORS Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
and Zoghbi,H.Y.
TITLE A protein-protein interaction network for human inherited ataxias
and disorders of Purkinje cell degeneration
JOURNAL Cell 125 (4), 801-814 (2006)
PUBMED 16713569
REFERENCE 8 (bases 1 to 8551)
AUTHORS Soejima,H., Kawamoto,S., Akai,J., Miyoshi,O., Arai,Y., Morohka,T.,
Matsuo,S., Niikawa,N., Kimura,A., Okubo,K. and Mukai,T.
TITLE Isolation of novel heart-specific genes using the BodyMap database
JOURNAL Genomics 74 (1), 115-120 (2001)
PUBMED 11374908
REFERENCE 9 (bases 1 to 8551)
AUTHORS Verde,I., Pahlke,G., Salanova,M., Zhang,G., Wang,S., Coletti,D.,
Onuffer,J., Jin,S.L. and Conti,M.
TITLE Myomegalin is a novel protein of the golgi/centrosome that
interacts with a cyclic nucleotide phosphodiesterase
JOURNAL J Biol Chem 276 (14), 11189-11198 (2001)
PUBMED 11134006
REFERENCE 10 (bases 1 to 8551)
AUTHORS Lanfranchi,G., Muraro,T., Caldara,F., Pacchioni,B., Pallavicini,A.,
Pandolfo,D., Toppo,S., Trevisan,S., Scarso,S. and Valle,G.
TITLE Identification of 4370 expressed sequence tags from a
3'-end-specific cDNA library of human skeletal muscle by DNA
sequencing and filter hybridization
JOURNAL Genome Res 6 (1), 35-42 (1996)
PUBMED 8681137
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AC245389.1, AC239802.3 and
AC239804.2.
On Jun 22, 2021 this sequence version replaced XM_011510175.2.
Summary: The protein encoded by this gene serves to anchor
phosphodiesterase 4D to the Golgi/centrosome region of the cell.
Defects in this gene may be a cause of myeloproliferative disorder
(MBD) associated with eosinophilia. Several transcript variants
encoding different isoforms have been found for this gene.
[provided by RefSeq, Aug 2010].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
COMPLETENESS: full length.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-304 AC245389.1 187910-188213
305-360 AC245389.1 242726-242781
361-512 AC239802.3 161541-161692 c
513-623 AC239802.3 140269-140379 c
624-700 AC239802.3 100890-100966 c
701-824 AC239802.3 98240-98363 c
825-1000 AC239802.3 97875-98050 c
1001-1118 AC239802.3 92299-92416 c
1119-1250 AC239802.3 69378-69509 c
1251-1370 AC239802.3 68207-68326 c
1371-1463 AC239802.3 67875-67967 c
1464-1676 AC239802.3 67523-67735 c
1677-1835 AC239802.3 64521-64679 c
1836-1949 AC239802.3 63507-63620 c
1950-2087 AC239802.3 63187-63324 c
2088-2267 AC239802.3 62258-62437 c
2268-2462 AC239802.3 61133-61327 c
2463-2627 AC239802.3 57819-57983 c
2628-2709 AC239802.3 57571-57652 c
2710-2801 AC239802.3 55558-55649 c
2802-2918 AC239802.3 52110-52226 c
2919-3056 AC239802.3 51748-51885 c
3057-3169 AC239802.3 50314-50426 c
3170-3297 AC239802.3 48766-48893 c
3298-3386 AC239802.3 38190-38278 c
3387-3619 AC239802.3 31788-32020 c
3620-4055 AC239802.3 28137-28572 c
4056-4248 AC239802.3 27121-27313 c
4249-4365 AC239802.3 26433-26549 c
4366-4894 AC239802.3 24726-25254 c
4895-5130 AC239802.3 22727-22962 c
5131-5182 AC239802.3 21668-21719 c
5183-5406 AC239802.3 20372-20595 c
5407-5559 AC239802.3 19568-19720 c
5560-5745 AC239802.3 17387-17572 c
5746-5997 AC239802.3 13613-13864 c
5998-6129 AC239802.3 12284-12415 c
6130-6249 AC239802.3 11502-11621 c
6250-6439 AC239802.3 9827-10016 c
6440-6564 AC239802.3 9010-9134 c
6565-6804 AC239802.3 5479-5718 c
6805-6921 AC239802.3 3332-3448 c
6922-7148 AC239802.3 2536-2762 c
7149-7292 AC239802.3 1460-1603 c
7293-7431 AC239802.3 238-376 c
7432-7478 AC239804.2 84522-84568
7479-8551 AC239804.2 86234-87306
FEATURES Location/Qualifiers
source 1..8551
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1q21.2"
gene 1..8551
/gene="PDE4DIP"
/gene_synonym="CMYA2; MMGL"
/note="phosphodiesterase 4D interacting protein"
/db_xref="GeneID:9659"
/db_xref="HGNC:HGNC:15580"
/db_xref="MIM:608117"
exon 1..304
/gene="PDE4DIP"
/gene_synonym="CMYA2; MMGL"
/inference="alignment:Splign:2.1.0"
CDS 72..7520
/gene="PDE4DIP"
/gene_synonym="CMYA2; MMGL"
/note="isoform 17 is encoded by transcript variant 17;
myomegalin; cardiomyopathy-associated protein 2"
/codon_start=1
/product="myomegalin isoform 17"
/protein_id="NP_001382227.1"
/db_xref="CCDS:CCDS91041.1"
/db_xref="GeneID:9659"
/db_xref="HGNC:HGNC:15580"
/db_xref="MIM:608117"
/translation="MKGTDSGSCCRRRCDFGCCCRASRRAHYTPYRSGDATRTPQSPR
QTPSRERRRPEPAGSWAAAAEEEEAAAAATPWMRDYFAEDDGEMVPRTSHTAAFLSDT
KDRGPPVQSQIWRSGEKVPFVQTYSLRAFEKPPQVQTQALRDFEKHLNDLKKENFSLK
LRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNS
QNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAARMAALVEAEKECNLE
LSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQERLVEQLSREKQ
QLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATN
KILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAK
LREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLAD
AKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEI
RTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVA
LERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKG
LEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLC
KLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQA
AAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGRLGKQTDQGSMQ
IPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMELS
ALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVL
LLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAH
PESSERDRTLQVELEGAQVLRSRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTST
EFTDSIEEEAAHHSHQQLVKVALEKSLATVETQNPSFSPPSPMGGDSNRCLQEEMLHL
RAEFHQHLEEKRKAEEELKELKAQIEEAGFSSVSHIRNTMLSLCLENAELKEQMGEAM
SDGWEIEEDKEKGEVMVETVVTKEGLSESSLQAEFRKLQGKLKNAHNIINLLKEQLVL
SSKEGNSKLTPELLVHLTSTIERINTELVGSPGKHQHQEEGNVTVRPFPRPQSLDLGA
TFTVDAHQLDNQSQPRDPGPQSAFSLPGSTQHLRSQLSQCKQRYQDLQEKLLLSEATV
FAQANELEKYRVMLSESLVKQDSKQIQVDLQDLGYETCGRSENEAEREETTSPECEEH
NSLKEMVLMEGLCSEQGRRGSTLASSSERKPLENQLGKQEEFRVYGKSENILVLRKDI
KDLKAQLQNANKVIQNLKSRVRSLSVTSDYSSSLERPRKLRAVGTLEGSSPHSVPDED
EGWLSDGTGAFYSPGLQAKKDLESLIQRVSQLEAQLPKNGLEEKLAEELRSASWPGKY
DSLIQDQARELSYLRQKIREGRGICYLITRHAKDTVKSFEDLLRSNDIDYYLGQSFRE
QLAQGSQLTERLTSKLSTKDHKSEKDQAGLEPLALRLSRELQEKEKVIEVLQAKLDAR
SLTPSSSHALSDSHRSPSSTSFLSDELEACSDMDIVSEYTHYEEKKASPSHSDSIHHS
SHSAVLSSKPSSTSASQGAKAESNSNPISLPTPQNTPKEANQAHSGFHFHSIPKLASL
PQAPLPSAPSSFLPFSPTGPLLLGCCETPVVSLAEAQQELQMLQKQLGESASTVPPAS
TATLLSNDLEADSSYYLNSAQPHSPPRGTIELGRILEPGYLGSSGKWDVMRPQKGSVS
GDLSSGSSVYQLNSKPTGADLLEEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTA
RGRGSTSNFYSQGLESIPQLCNENRVLREDNRRLQAQLSHVSREHSQETESLREALLS
SRSHLQELEKELEHQKVERQQLLEDLREKQQEVLHFREERLSLQENDSRLQHKLVLLQ
QQCEEKQQLFESLQSELQIYEALYGNSKKGLKAYSLDACHQIPLSSDLSHLVAEVRAL
RGQLEQSIQGNNCLRLQLQQQLESGAGKASLSPSSINQNFPASTDPGNKQLLLQDSAV
SPPVRDVGMNSPALVFPSSASSTPGSETPIINRANGLGLDTSPVMKTPPKLEGDATDG
SFANKHGRHVIGHIDDYSALRQQIAEGKLLVKKIVSLVRSACSFPGLEAQGTEVLGSK
GIHELRSSTSALHHALEESASLLTMFWRAALPSTHIPVLPGKVGESTERELLELRTKV
SKQERLLQSTTEHLKNANQQKESMEQFIVSQLTRTHDVLKKARTNLEVKSLRALPCTP
AL"
exon 305..360
/gene="PDE4DIP"
/gene_synonym="CMYA2; MMGL"
/inference="alignment:Splign:2.1.0"
exon 361..512
/gene="PDE4DIP"
/gene_synonym="CMYA2; MMGL"
/inference="alignment:Splign:2.1.0"
exon 513..623
/gene="PDE4DIP"
/gene_synonym="CMYA2; MMGL"
/inference="alignment:Splign:2.1.0"
exon 624..700
/gene="PDE4DIP"
/gene_synonym="CMYA2; MMGL"
/inference="alignment:Splign:2.1.0"
exon 701..824
/gene="PDE4DIP"
/gene_synonym="CMYA2; MMGL"
/inference="alignment:Splign:2.1.0"
exon 825..1000
/gene="PDE4DIP"
/gene_synonym="CMYA2; MMGL"
/inference="alignment:Splign:2.1.0"
exon 1001..1118
/gene="PDE4DIP"
/gene_synonym="CMYA2; MMGL"
/inference="alignment:Splign:2.1.0"
exon 1119..1250
/gene="PDE4DIP"
/gene_synonym="CMYA2; MMGL"
/inference="alignment:Splign:2.1.0"
exon 1251..1370
/gene="PDE4DIP"
/gene_synonym="CMYA2; MMGL"
/inference="alignment:Splign:2.1.0"
exon 1371..1463
/gene="PDE4DIP"
/gene_synonym="CMYA2; MMGL"
/inference="alignment:Splign:2.1.0"
exon 1464..1676
/gene="PDE4DIP"
/gene_synonym="CMYA2; MMGL"
/inference="alignment:Splign:2.1.0"
exon 1677..1835
/gene="PDE4DIP"
/gene_synonym="CMYA2; MMGL"
/inference="alignment:Splign:2.1.0"
exon 1836..1949
/gene="PDE4DIP"
/gene_synonym="CMYA2; MMGL"
/inference="alignment:Splign:2.1.0"
exon 1950..2087
/gene="PDE4DIP"
/gene_synonym="CMYA2; MMGL"
/inference="alignment:Splign:2.1.0"
exon 2088..2267
/gene="PDE4DIP"
/gene_synonym="CMYA2; MMGL"
/inference="alignment:Splign:2.1.0"
exon 2268..2462
/gene="PDE4DIP"
/gene_synonym="CMYA2; MMGL"
/inference="alignment:Splign:2.1.0"
exon 2463..2627
/gene="PDE4DIP"
/gene_synonym="CMYA2; MMGL"
/inference="alignment:Splign:2.1.0"
exon 2628..2709
/gene="PDE4DIP"
/gene_synonym="CMYA2; MMGL"
/inference="alignment:Splign:2.1.0"
exon 2710..2801
/gene="PDE4DIP"
/gene_synonym="CMYA2; MMGL"
/inference="alignment:Splign:2.1.0"
exon 2802..2918
/gene="PDE4DIP"
/gene_synonym="CMYA2; MMGL"
/inference="alignment:Splign:2.1.0"
exon 2919..3056
/gene="PDE4DIP"
/gene_synonym="CMYA2; MMGL"
/inference="alignment:Splign:2.1.0"
exon 3057..3169
/gene="PDE4DIP"
/gene_synonym="CMYA2; MMGL"
/inference="alignment:Splign:2.1.0"
exon 3170..3297
/gene="PDE4DIP"
/gene_synonym="CMYA2; MMGL"
/inference="alignment:Splign:2.1.0"
exon 3298..3386
/gene="PDE4DIP"
/gene_synonym="CMYA2; MMGL"
/inference="alignment:Splign:2.1.0"
exon 3387..3619
/gene="PDE4DIP"
/gene_synonym="CMYA2; MMGL"
/inference="alignment:Splign:2.1.0"
exon 3620..4055
/gene="PDE4DIP"
/gene_synonym="CMYA2; MMGL"
/inference="alignment:Splign:2.1.0"
exon 4056..4248
/gene="PDE4DIP"
/gene_synonym="CMYA2; MMGL"
/inference="alignment:Splign:2.1.0"
exon 4249..4365
/gene="PDE4DIP"
/gene_synonym="CMYA2; MMGL"
/inference="alignment:Splign:2.1.0"
exon 4366..4894
/gene="PDE4DIP"
/gene_synonym="CMYA2; MMGL"
/inference="alignment:Splign:2.1.0"
exon 4895..5130
/gene="PDE4DIP"
/gene_synonym="CMYA2; MMGL"
/inference="alignment:Splign:2.1.0"
exon 5131..5182
/gene="PDE4DIP"
/gene_synonym="CMYA2; MMGL"
/inference="alignment:Splign:2.1.0"
exon 5183..5406
/gene="PDE4DIP"
/gene_synonym="CMYA2; MMGL"
/inference="alignment:Splign:2.1.0"
exon 5407..5559
/gene="PDE4DIP"
/gene_synonym="CMYA2; MMGL"
/inference="alignment:Splign:2.1.0"
exon 5560..5745
/gene="PDE4DIP"
/gene_synonym="CMYA2; MMGL"
/inference="alignment:Splign:2.1.0"
exon 5746..5997
/gene="PDE4DIP"
/gene_synonym="CMYA2; MMGL"
/inference="alignment:Splign:2.1.0"
exon 5998..6129
/gene="PDE4DIP"
/gene_synonym="CMYA2; MMGL"
/inference="alignment:Splign:2.1.0"
exon 6130..6249
/gene="PDE4DIP"
/gene_synonym="CMYA2; MMGL"
/inference="alignment:Splign:2.1.0"
exon 6250..6439
/gene="PDE4DIP"
/gene_synonym="CMYA2; MMGL"
/inference="alignment:Splign:2.1.0"
exon 6440..6564
/gene="PDE4DIP"
/gene_synonym="CMYA2; MMGL"
/inference="alignment:Splign:2.1.0"
exon 6565..6804
/gene="PDE4DIP"
/gene_synonym="CMYA2; MMGL"
/inference="alignment:Splign:2.1.0"
exon 6805..6921
/gene="PDE4DIP"
/gene_synonym="CMYA2; MMGL"
/inference="alignment:Splign:2.1.0"
exon 6922..7148
/gene="PDE4DIP"
/gene_synonym="CMYA2; MMGL"
/inference="alignment:Splign:2.1.0"
exon 7149..7292
/gene="PDE4DIP"
/gene_synonym="CMYA2; MMGL"
/inference="alignment:Splign:2.1.0"
exon 7293..7431
/gene="PDE4DIP"
/gene_synonym="CMYA2; MMGL"
/inference="alignment:Splign:2.1.0"
exon 7432..7478
/gene="PDE4DIP"
/gene_synonym="CMYA2; MMGL"
/inference="alignment:Splign:2.1.0"
exon 7479..8551
/gene="PDE4DIP"
/gene_synonym="CMYA2; MMGL"
/inference="alignment:Splign:2.1.0"
regulatory 8532..8537
/regulatory_class="polyA_signal_sequence"
/gene="PDE4DIP"
/gene_synonym="CMYA2; MMGL"
/note="hexamer: AATAAA"
polyA_site 8551
/gene="PDE4DIP"
/gene_synonym="CMYA2; MMGL"
/note="major polyA site"
ORIGIN
1 agtcccggaa aacaccagga aaacaagcag gaaccgtagc taggactggg gtggccaggc
61 ccaggaaatc catgaagggc acagacagcg ggtcctgctg ccgccgccga tgcgactttg
121 gctgctgctg tcgcgcgtcc cgccgggctc actacacgcc ttaccggtcc ggggacgcga
181 cgcgaacccc tcagtcccca cggcagaccc cgagccggga aagacggcgc ccggagccag
241 ccgggagctg ggcagcagcg gccgaggagg aagaagcagc tgcggcggcc acaccctgga
301 tgagagatta ttttgcagag gatgatgggg agatggtacc cagaacgagt cacacagcag
361 cttttcttag tgacactaaa gatcgaggcc ctccagtgca gtcacagatc tggagaagtg
421 gtgaaaaggt cccgtttgtg cagacatatt ccttgagagc atttgagaaa ccccctcagg
481 tacagaccca ggctcttcga gactttgaga agcacctcaa tgacctgaag aaggagaact
541 tcagcctcaa gctgcgcatc tacttcctgg aggagcgcat gcaacagaag tatgaggcca
601 gccgggagga catctacaag cggaacattg agctgaaggt tgaagtggag agcttgaaac
661 gagaactcca ggacaagaaa cagcatctgg ataaaacatg ggctgatgtg gagaatctca
721 acagtcagaa tgaagctgag ctccgacgcc agtttgagga gcgacagcag gagacggagc
781 atgtttatga gctcttggag aataagatcc agcttctgca ggaggaatcc aggctagcaa
841 agaatgaagc tgcgcggatg gcagctctgg tggaagcaga gaaggagtgt aacctggagc
901 tctcagagaa actgaaggga gtcaccaaaa actgggaaga tgtaccagga gaccaggtca
961 agcccgacca atacactgag gccctggccc agagggacaa gagaattgaa gaactgaatc
1021 agagcctggc tgcccaggag aggcttgtag aacagctatc tcgggagaaa caacaactgc
1081 tacatctgtt ggaggagcca actagcatgg aagtgcagcc catgactgaa gagttgctga
1141 aacaacaaaa gctgaattca catgagacca ctataactca gcagtctgta tctgattccc
1201 acttggcaga actccaggaa aaaatccagc aaacagaggc caccaacaag attcttcaag
1261 agaaacttaa tgaaatgagc tatgaactaa agtgtgctca ggagtcgtct caaaagcaag
1321 atggtacaat tcagaacctc aaggaaactc tgaaaagcag ggaacgtgag actgaggagt
1381 tgtaccaggt aattgaaggt caaaatgaca caatggcaaa gcttcgagaa atgctgcacc
1441 aaagccagct tggacaactt cacagctcag agggtacttc tccagctcag caacaggtag
1501 ctctgcttga tcttcagagt gctttattct gcagccaact tgaaatacag aagctccaga
1561 gggtggtacg acagaaagag cgccaactgg ctgatgccaa acaatgtgtg caatttgtag
1621 aggctgcagc acacgagagt gaacagcaga aagaggcttc ttggaaacat aaccaggaat
1681 tgcgaaaagc cttgcagcag ctacaagaag aattgcagaa taagagccaa cagcttcgtg
1741 cctgggaggc tgaaaaatac aatgagattc gaacccagga acaaaacatc cagcacctaa
1801 accatagtct gagtcacaag gagcagttgc ttcaggaatt tcgggagctc ctacagtatc
1861 gagataactc agacaaaacc cttgaagcaa atgaaatgtt gcttgagaaa cttcgccagc
1921 gaatacatga taaagctgtt gctctggagc gggctataga tgaaaaattc tctgctctag
1981 aagagaaaga aaaagaactg cgccagcttc gtcttgctgt gagagagcga gatcatgact
2041 tagagagact gcgcgatgtc ctctcctcca atgaagctac tatgcaaagt atggagagtc
2101 tcctgagggc caaaggcctg gaagtggaac agttatctac tacctgtcaa aacctccagt
2161 ggctgaaaga agaaatggaa accaaattta gccgttggca gaaggaacaa gagagtatca
2221 ttcagcagtt acagacgtct cttcatgata ggaacaaaga agtggaggat cttagtgcaa
2281 cactgctctg caaacttgga ccagggcaga gtgagatagc agaggagctg tgccagcgtc
2341 tacagcgaaa ggaaaggatg ctgcaggacc ttctaagtga tcgaaataaa caagtgctgg
2401 aacatgaaat ggagattcaa ggcctgcttc agtctgtgag caccagggag caggaaagcc
2461 aagctgctgc agagaagttg gtgcaagcct taatggaaag aaattcagaa ttacaggccc
2521 tgcgccaata tttaggaggg agagactccc tgatgtccca agcacccatc tctaaccaac
2581 aagctgaagt tacccccact ggccgtcttg gaaaacagac tgatcaaggt tcaatgcaga
2641 taccttccag agatgatagc acttcattga ctgccaaaga ggatgtcagc atacccagat
2701 ccacattagg agacttggac acagttgcag ggctggaaaa agaactgagt aatgccaaag
2761 aggaacttga actcatggct aaaaaagaaa gagaaagtca gatggaactt tctgctctac
2821 agtccatgat ggctgtgcag gaagaagagc tgcaggtgca ggctgctgat atggagtctc
2881 tgaccaggaa catacagatt aaagaagatc tcataaagga cctgcaaatg caactggttg
2941 atcctgaaga cataccagct atggaacgcc tgacccagga agtcttactt cttcgggaaa
3001 aagttgcttc agtagaatcc cagggtcaag aaatttcagg aaaccgaaga caacagttgc
3061 tgctgatgct agaaggacta gtagatgaac ggagtcggct caatgaggcc ttacaagcag
3121 agagacagct ctatagcagt ctggtgaagt tccatgccca tccagagagc tctgagagag
3181 accgaactct gcaggtggaa ctggaagggg ctcaggtgtt acgcagtcgg ctagaagaag
3241 ttcttggaag aagcttggag cgcttaaaca ggctggagac cctggccgcc attggaggtg
3301 cagctgcagg ggatgacacc gaagatacaa gcactgagtt cactgacagt attgaggagg
3361 aggctgcaca ccatagtcac cagcaacttg tcaaggtggc tttggagaaa agtctggcaa
3421 ctgtggagac ccagaaccca tctttttccc ctccttctcc gatgggaggg gacagtaaca
3481 ggtgtcttca ggaagaaatg ctccacctga gggctgagtt ccaccagcac ttagaagaga
3541 agaggaaagc tgaggaggaa ctgaaggagc taaaggctca aattgaggaa gcaggattct
3601 cctcagtgtc ccacatcagg aacaccatgc tgagcctttg ccttgagaat gcggagctga
3661 aagagcagat gggagaagca atgtctgatg gatgggagat cgaggaagac aaggagaagg
3721 gcgaggtgat ggttgagact gtggtaacca aagagggtct gagtgagagt agccttcagg
3781 ctgagttcag aaagctccag ggaaaactga agaatgccca caatatcatc aacctcctca
3841 aagaacaact tgtgctgagt agcaaggaag ggaatagtaa acttactcca gagctccttg
3901 tgcatctgac cagcaccatt gaaagaataa acacagaact ggttggttcc cctgggaagc
3961 accaacacca agaggagggg aatgtgactg tgaggccttt ccccagaccc cagagccttg
4021 accttggggc taccttcaca gtggatgccc accaattgga taaccagtcc cagcctcgtg
4081 accctgggcc tcagtcagcg tttagcctac cagggtccac ccagcacctg cgctcccagc
4141 tgtcacaatg caaacaacgc tatcaagatc tccaggagaa gctgctgcta tcagaagcca
4201 ctgtctttgc tcaggctaac gagctggaga aatacagagt tatgcttagt gaatccttgg
4261 tgaagcagga cagcaagcag atccaggtgg acctccagga cctgggctat gagacttgtg
4321 gccgaagcga gaatgaggct gaacgggagg aaaccaccag tcctgagtgt gaggagcaca
4381 acagcctcaa ggaaatggtc ctgatggagg ggctgtgctc tgagcaggga cgccggggct
4441 caacactggc tagttcctct gagaggaagc ccttggagaa ccagctaggg aagcaggaag
4501 agttccgggt atatggaaag tcagaaaaca tcttggtcct acgaaaggac atcaaagatc
4561 tgaaggccca gctgcagaat gccaacaagg tcattcaaaa cctcaagagc cgggtccggt
4621 ccctctcagt tacaagtgat tattcgtcta gtctggaaag accccggaag ctgagagctg
4681 ttggcacctt ggaggggtct tcacctcata gtgtccctga tgaggatgag gggtggctgt
4741 ctgatggcac tggggctttc tactctccag ggcttcaggc caaaaaggac ctggagagtc
4801 tcatccagag agtatcccag ctggaggccc agctcccaaa aaatggacta gaagagaagc
4861 tggctgagga gctgagatca gcctcgtggc ctgggaaata tgattccctg attcaggatc
4921 aggcccggga actgtcttac ctacggcaaa aaatacgaga agggagaggt atttgttatc
4981 ttatcacccg gcatgcaaaa gatacagtaa aatcttttga ggatctccta aggagcaatg
5041 acattgacta ctacctggga cagagcttcc gggagcaact cgcccaggga agccagctga
5101 cagagaggct caccagcaaa ctcagcacca aggatcataa aagtgagaaa gatcaagctg
5161 gacttgagcc actggccctc aggctcagca gggagctgca ggagaaggag aaagtgattg
5221 aagtcctgca ggccaagctg gatgctcggt ccctcacacc ctccagcagc catgccttgt
5281 ctgactccca ccgctctccc agcagcacct ctttcctgtc tgatgaactg gaagcctgct
5341 ctgacatgga catagtcagc gagtacacac actatgaaga gaagaaagct tctcccagtc
5401 actcagattc catccatcat tcgagtcatt ctgctgtgtt gtcttctaaa ccatcatcaa
5461 ccagtgcatc tcagggggct aaggccgaat ccaacagcaa ccccatcagc ttgccaactc
5521 cccagaatac ccccaaggag gccaaccagg cccattcagg ctttcatttt cactccatac
5581 ccaagctggc tagccttcct caggcaccat tgccctcagc tccatccagc ttcctgcctt
5641 tcagccccac tggccctctc ctccttggct gctgtgagac accagtggtc tccttggctg
5701 aggctcagca ggagctacag atgctgcaga agcagttggg agaaagtgcc agcactgttc
5761 ctcctgcttc cacagctaca ttgctgagca acgacttgga agccgactct tcctactacc
5821 tcaactctgc ccagcctcac tctcctccaa ggggcaccat agaactggga agaatcctag
5881 agcctgggta cctgggcagc agtggcaagt gggatgtgat gaggcctcag aaagggagtg
5941 tatctgggga cctatcctca ggctcctctg tgtaccagct taactccaaa cccacagggg
6001 ctgacctgct ggaagagcat cttggtgaaa tccggaacct gcgccagcgc ctggaggaat
6061 ccatctgcat caatgaccgc ctacgggagc aactggaaca ccggctgacc tctactgctc
6121 gtggaagggg atccacttct aacttctaca gtcagggcct ggagtccata cctcagctct
6181 gcaatgagaa cagagtcctc agggaagaca atcgaagact tcaggctcaa ctgagtcatg
6241 tttccagaga gcactcccag gaaacagaaa gcctgaggga ggctctgctg tcctctcgat
6301 cccaccttca agagctggaa aaggagctgg agcaccagaa ggtggaaagg cagcagcttt
6361 tggaagactt gagggagaag cagcaagagg tcttgcattt cagggaggaa cgtctttccc
6421 tccaggaaaa cgactccaga ctgcagcaca agctggttct cctgcagcaa cagtgtgaag
6481 agaaacagca gctctttgag tccctccagt cagagctaca aatctacgag gcactttatg
6541 gcaattccaa gaaggggctg aaagcttaca gcctggatgc ctgtcaccaa atccctttga
6601 gcagtgacct gagccacctg gtggcagagg tacgagctct gagagggcag ctggagcaga
6661 gcattcaggg gaacaattgt ctgcgactgc agctgcaaca gcagctggag agcggtgctg
6721 gcaaagccag cctcagcccc tcctccatta accagaactt cccagccagc actgaccctg
6781 gaaacaagca gctgctcctc caagattcag ctgtgtcccc tccagtccgg gatgttggta
6841 tgaattcccc agctctggtc ttccccagct ctgcttcctc tactcctggc tcagaaacgc
6901 ccataatcaa cagagcaaat ggcttgggtt tggatacttc tccagtaatg aagacccctc
6961 ccaagctaga gggtgatgct actgatggct cctttgccaa taagcatggc cgccatgtca
7021 ttggccacat tgatgactac agtgccctaa gacagcagat tgcggagggc aagctgctgg
7081 tcaaaaagat agtgtctctt gtgagatcag cgtgcagctt ccctggcctt gaagcccaag
7141 gcacagaggt gctaggcagc aaaggtattc atgagcttcg gagcagcacc agtgccctgc
7201 accatgccct agaggagtca gcttccctcc tcaccatgtt ctggagagcg gccctgccaa
7261 gcacccacat ccctgtgctg cctggcaaag tgggagaatc aacagaaagg gaacttctgg
7321 aactgagaac caaagtatcc aaacaggagc gactccttca gagcacaact gagcatctga
7381 agaacgccaa ccagcagaag gagagcatgg agcagttcat cgtcagccag ctaaccagaa
7441 cacatgatgt tttaaagaag gcaaggacta acttagaggt gaaatcccta agggctctgc
7501 catgtactcc agccttgtga cccttgcctt ccaggaacca tgcaagaagc gcagccacca
7561 gaagtcctta aaacagcagg aaaggtgggc ctgtccccct tttgtgcagc tacctatctg
7621 ctgaggagca tctgggcctc attcctccaa gtccacggga gggtccagaa gagggagtca
7681 gagatgtatc ctggtggagc tgggagaaag gcagaaagcc tttctgacgg ctatggaata
7741 cgattagcca aggtccactt ggcccagcac taagaaaaag atgcgtagtt tgcacagaag
7801 gttttgtgat cctgcctctc aacagcccca gcagcttggg aactagcaag agcacatttc
7861 ttgcctcatc agctgtcctg agatggaaaa ctcagtgaat ataggaccct gattccgatg
7921 aaaggggcac gtggtcccaa tgctggagct cctctggcag gttctaaaag cacactactg
7981 agcagcggtg ccctgccgga cactgctggc gggggctcag tgagcactac tcacagatcc
8041 acacctgacc ctgttgggtc gagtcaggct gggccttggt ctgcactgta gcacctgtgt
8101 tctttgagtt cacatcatga atgtggtgac ttcccagata ccatctcagg cttaacctag
8161 cacatcctat ttcttttctt ctatgatatc caaattggac tgacctcact tcaaagttgc
8221 tgtcccattt tgtcacccta tcttatctcg gggaaattgc agactgatgg ccagaccaac
8281 tctgttgaaa ttcttgcata gagcaaacct gtgctcattt ttaagtggca tgggagaggc
8341 cccaagccta gtaaagccta gtctgtgtct tcacagtgct ggtagaatgt gtttgtgtgt
8401 ataaatatat gatatagatt tatatatgtt gctaacgcca tatattgaag gccaacataa
8461 ctggtggaca gggtgggtga cagaaaatga aagtcttttt ggtgattgtt aaagcaaaat
8521 gtgtataaag aaataaatag tttttctttc a
//