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Homo sapiens phosphodiesterase 4D interacting protein (PDE4DIP), transcript variant 17, mRNA

NCBI Reference Sequence: NM_001395298.1

FASTA Graphics 

LOCUS       NM_001395298            8551 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens phosphodiesterase 4D interacting protein (PDE4DIP),
            transcript variant 17, mRNA.
ACCESSION   NM_001395298 XM_011510175
VERSION     NM_001395298.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8551)
  AUTHORS   Pan,R., Dai,J., Liang,W., Wang,H., Ye,L., Ye,S., Lin,Z., Huang,S.,
            Xiong,Y., Zhang,L., Lu,L., Wang,O., Shen,X., Liao,W. and Lu,X.
  TITLE     PDE4DIP contributes to colorectal cancer growth and chemoresistance
            through modulation of the NF1/RAS signaling axis
  JOURNAL   Cell Death Dis 14 (6), 373 (2023)
   PUBMED   37355626
  REMARK    GeneRIF: PDE4DIP contributes to colorectal cancer growth and
            chemoresistance through modulation of the NF1/RAS signaling axis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8551)
  AUTHORS   Zhou,Y., Liu,Y., Gupta,S., Paramo,M.I., Hou,Y., Mao,C., Luo,Y.,
            Judd,J., Wierbowski,S., Bertolotti,M., Nerkar,M., Jehi,L.,
            Drayman,N., Nicolaescu,V., Gula,H., Tay,S., Randall,G., Wang,P.,
            Lis,J.T., Feschotte,C., Erzurum,S.C., Cheng,F. and Yu,H.
  TITLE     A comprehensive SARS-CoV-2-human protein-protein interactome
            reveals COVID-19 pathobiology and potential host therapeutic
            targets
  JOURNAL   Nat Biotechnol 41 (1), 128-139 (2023)
   PUBMED   36217030
REFERENCE   3  (bases 1 to 8551)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 8551)
  AUTHORS   Abou Ziki,M.D., Bhat,N., Neogi,A., Driscoll,T.P., Ugwu,N., Liu,Y.,
            Smith,E., Abboud,J.M., Chouairi,S., Schwartz,M.A., Akar,J.G. and
            Mani,A.
  TITLE     Epistatic interaction of PDE4DIP and DES mutations in familial
            atrial fibrillation with slow conduction
  JOURNAL   Hum Mutat 42 (10), 1279-1293 (2021)
   PUBMED   34289528
  REMARK    GeneRIF: Epistatic interaction of PDE4DIP and DES mutations in
            familial atrial fibrillation with slow conduction.
REFERENCE   5  (bases 1 to 8551)
  AUTHORS   Peng,H., Zhang,J., Ya,A., Ma,W., Villa,S., Sukenik,S. and Ge,X.
  TITLE     Myomegalin regulates Hedgehog pathway by controlling PDE4D at the
            centrosome
  JOURNAL   Mol Biol Cell 32 (19), 1807-1817 (2021)
   PUBMED   34260267
  REMARK    GeneRIF: Myomegalin regulates Hedgehog pathway by controlling PDE4D
            at the centrosome.
REFERENCE   6  (bases 1 to 8551)
  AUTHORS   Shimada,H., Kuboshima,M., Shiratori,T., Nabeya,Y., Takeuchi,A.,
            Takagi,H., Nomura,F., Takiguchi,M., Ochiai,T. and Hiwasa,T.
  TITLE     Serum anti-myomegalin antibodies in patients with esophageal
            squamous cell carcinoma
  JOURNAL   Int J Oncol 30 (1), 97-103 (2007)
   PUBMED   17143517
  REMARK    GeneRIF: MMGL-antibody is significantly with a favorable prognosis.
            Consequently, MMGL-anatibodies may be a useful tumor marker to
            diagnose and establish a prognosis in patients with esophageal
            squamous cell carcinoma.
REFERENCE   7  (bases 1 to 8551)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   8  (bases 1 to 8551)
  AUTHORS   Soejima,H., Kawamoto,S., Akai,J., Miyoshi,O., Arai,Y., Morohka,T.,
            Matsuo,S., Niikawa,N., Kimura,A., Okubo,K. and Mukai,T.
  TITLE     Isolation of novel heart-specific genes using the BodyMap database
  JOURNAL   Genomics 74 (1), 115-120 (2001)
   PUBMED   11374908
REFERENCE   9  (bases 1 to 8551)
  AUTHORS   Verde,I., Pahlke,G., Salanova,M., Zhang,G., Wang,S., Coletti,D.,
            Onuffer,J., Jin,S.L. and Conti,M.
  TITLE     Myomegalin is a novel protein of the golgi/centrosome that
            interacts with a cyclic nucleotide phosphodiesterase
  JOURNAL   J Biol Chem 276 (14), 11189-11198 (2001)
   PUBMED   11134006
REFERENCE   10 (bases 1 to 8551)
  AUTHORS   Lanfranchi,G., Muraro,T., Caldara,F., Pacchioni,B., Pallavicini,A.,
            Pandolfo,D., Toppo,S., Trevisan,S., Scarso,S. and Valle,G.
  TITLE     Identification of 4370 expressed sequence tags from a
            3'-end-specific cDNA library of human skeletal muscle by DNA
            sequencing and filter hybridization
  JOURNAL   Genome Res 6 (1), 35-42 (1996)
   PUBMED   8681137
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC245389.1, AC239802.3 and
            AC239804.2.
            
            On Jun 22, 2021 this sequence version replaced XM_011510175.2.
            
            Summary: The protein encoded by this gene serves to anchor
            phosphodiesterase 4D to the Golgi/centrosome region of the cell.
            Defects in this gene may be a cause of myeloproliferative disorder
            (MBD) associated with eosinophilia. Several transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Aug 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-304               AC245389.1         187910-188213
            305-360             AC245389.1         242726-242781
            361-512             AC239802.3         161541-161692       c
            513-623             AC239802.3         140269-140379       c
            624-700             AC239802.3         100890-100966       c
            701-824             AC239802.3         98240-98363         c
            825-1000            AC239802.3         97875-98050         c
            1001-1118           AC239802.3         92299-92416         c
            1119-1250           AC239802.3         69378-69509         c
            1251-1370           AC239802.3         68207-68326         c
            1371-1463           AC239802.3         67875-67967         c
            1464-1676           AC239802.3         67523-67735         c
            1677-1835           AC239802.3         64521-64679         c
            1836-1949           AC239802.3         63507-63620         c
            1950-2087           AC239802.3         63187-63324         c
            2088-2267           AC239802.3         62258-62437         c
            2268-2462           AC239802.3         61133-61327         c
            2463-2627           AC239802.3         57819-57983         c
            2628-2709           AC239802.3         57571-57652         c
            2710-2801           AC239802.3         55558-55649         c
            2802-2918           AC239802.3         52110-52226         c
            2919-3056           AC239802.3         51748-51885         c
            3057-3169           AC239802.3         50314-50426         c
            3170-3297           AC239802.3         48766-48893         c
            3298-3386           AC239802.3         38190-38278         c
            3387-3619           AC239802.3         31788-32020         c
            3620-4055           AC239802.3         28137-28572         c
            4056-4248           AC239802.3         27121-27313         c
            4249-4365           AC239802.3         26433-26549         c
            4366-4894           AC239802.3         24726-25254         c
            4895-5130           AC239802.3         22727-22962         c
            5131-5182           AC239802.3         21668-21719         c
            5183-5406           AC239802.3         20372-20595         c
            5407-5559           AC239802.3         19568-19720         c
            5560-5745           AC239802.3         17387-17572         c
            5746-5997           AC239802.3         13613-13864         c
            5998-6129           AC239802.3         12284-12415         c
            6130-6249           AC239802.3         11502-11621         c
            6250-6439           AC239802.3         9827-10016          c
            6440-6564           AC239802.3         9010-9134           c
            6565-6804           AC239802.3         5479-5718           c
            6805-6921           AC239802.3         3332-3448           c
            6922-7148           AC239802.3         2536-2762           c
            7149-7292           AC239802.3         1460-1603           c
            7293-7431           AC239802.3         238-376             c
            7432-7478           AC239804.2         84522-84568
            7479-8551           AC239804.2         86234-87306
FEATURES             Location/Qualifiers
     source          1..8551
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.2"
     gene            1..8551
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /note="phosphodiesterase 4D interacting protein"
                     /db_xref="GeneID:9659"
                     /db_xref="HGNC:HGNC:15580"
                     /db_xref="MIM:608117"
     exon            1..304
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..7520
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /note="isoform 17 is encoded by transcript variant 17;
                     myomegalin; cardiomyopathy-associated protein 2"
                     /codon_start=1
                     /product="myomegalin isoform 17"
                     /protein_id="NP_001382227.1"
                     /db_xref="CCDS:CCDS91041.1"
                     /db_xref="GeneID:9659"
                     /db_xref="HGNC:HGNC:15580"
                     /db_xref="MIM:608117"
                     /translation="MKGTDSGSCCRRRCDFGCCCRASRRAHYTPYRSGDATRTPQSPR
                     QTPSRERRRPEPAGSWAAAAEEEEAAAAATPWMRDYFAEDDGEMVPRTSHTAAFLSDT
                     KDRGPPVQSQIWRSGEKVPFVQTYSLRAFEKPPQVQTQALRDFEKHLNDLKKENFSLK
                     LRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNS
                     QNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAARMAALVEAEKECNLE
                     LSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQERLVEQLSREKQ
                     QLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATN
                     KILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAK
                     LREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLAD
                     AKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEI
                     RTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVA
                     LERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKG
                     LEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLC
                     KLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQA
                     AAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGRLGKQTDQGSMQ
                     IPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGLEKELSNAKEELELMAKKERESQMELS
                     ALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVL
                     LLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAH
                     PESSERDRTLQVELEGAQVLRSRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTST
                     EFTDSIEEEAAHHSHQQLVKVALEKSLATVETQNPSFSPPSPMGGDSNRCLQEEMLHL
                     RAEFHQHLEEKRKAEEELKELKAQIEEAGFSSVSHIRNTMLSLCLENAELKEQMGEAM
                     SDGWEIEEDKEKGEVMVETVVTKEGLSESSLQAEFRKLQGKLKNAHNIINLLKEQLVL
                     SSKEGNSKLTPELLVHLTSTIERINTELVGSPGKHQHQEEGNVTVRPFPRPQSLDLGA
                     TFTVDAHQLDNQSQPRDPGPQSAFSLPGSTQHLRSQLSQCKQRYQDLQEKLLLSEATV
                     FAQANELEKYRVMLSESLVKQDSKQIQVDLQDLGYETCGRSENEAEREETTSPECEEH
                     NSLKEMVLMEGLCSEQGRRGSTLASSSERKPLENQLGKQEEFRVYGKSENILVLRKDI
                     KDLKAQLQNANKVIQNLKSRVRSLSVTSDYSSSLERPRKLRAVGTLEGSSPHSVPDED
                     EGWLSDGTGAFYSPGLQAKKDLESLIQRVSQLEAQLPKNGLEEKLAEELRSASWPGKY
                     DSLIQDQARELSYLRQKIREGRGICYLITRHAKDTVKSFEDLLRSNDIDYYLGQSFRE
                     QLAQGSQLTERLTSKLSTKDHKSEKDQAGLEPLALRLSRELQEKEKVIEVLQAKLDAR
                     SLTPSSSHALSDSHRSPSSTSFLSDELEACSDMDIVSEYTHYEEKKASPSHSDSIHHS
                     SHSAVLSSKPSSTSASQGAKAESNSNPISLPTPQNTPKEANQAHSGFHFHSIPKLASL
                     PQAPLPSAPSSFLPFSPTGPLLLGCCETPVVSLAEAQQELQMLQKQLGESASTVPPAS
                     TATLLSNDLEADSSYYLNSAQPHSPPRGTIELGRILEPGYLGSSGKWDVMRPQKGSVS
                     GDLSSGSSVYQLNSKPTGADLLEEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTA
                     RGRGSTSNFYSQGLESIPQLCNENRVLREDNRRLQAQLSHVSREHSQETESLREALLS
                     SRSHLQELEKELEHQKVERQQLLEDLREKQQEVLHFREERLSLQENDSRLQHKLVLLQ
                     QQCEEKQQLFESLQSELQIYEALYGNSKKGLKAYSLDACHQIPLSSDLSHLVAEVRAL
                     RGQLEQSIQGNNCLRLQLQQQLESGAGKASLSPSSINQNFPASTDPGNKQLLLQDSAV
                     SPPVRDVGMNSPALVFPSSASSTPGSETPIINRANGLGLDTSPVMKTPPKLEGDATDG
                     SFANKHGRHVIGHIDDYSALRQQIAEGKLLVKKIVSLVRSACSFPGLEAQGTEVLGSK
                     GIHELRSSTSALHHALEESASLLTMFWRAALPSTHIPVLPGKVGESTERELLELRTKV
                     SKQERLLQSTTEHLKNANQQKESMEQFIVSQLTRTHDVLKKARTNLEVKSLRALPCTP
                     AL"
     exon            305..360
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            361..512
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            513..623
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            624..700
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            701..824
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            825..1000
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1118
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1250
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1370
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1463
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1676
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1835
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..1949
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..2087
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..2267
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            2268..2462
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            2463..2627
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            2628..2709
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            2710..2801
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            2802..2918
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            2919..3056
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            3057..3169
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            3170..3297
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            3298..3386
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            3387..3619
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            3620..4055
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            4056..4248
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            4249..4365
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            4366..4894
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            4895..5130
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            5131..5182
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            5183..5406
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            5407..5559
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            5560..5745
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            5746..5997
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            5998..6129
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            6130..6249
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            6250..6439
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            6440..6564
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            6565..6804
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            6805..6921
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            6922..7148
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            7149..7292
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            7293..7431
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            7432..7478
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     exon            7479..8551
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8532..8537
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /note="hexamer: AATAAA"
     polyA_site      8551
                     /gene="PDE4DIP"
                     /gene_synonym="CMYA2; MMGL"
                     /note="major polyA site"
ORIGIN      
        1 agtcccggaa aacaccagga aaacaagcag gaaccgtagc taggactggg gtggccaggc
       61 ccaggaaatc catgaagggc acagacagcg ggtcctgctg ccgccgccga tgcgactttg
      121 gctgctgctg tcgcgcgtcc cgccgggctc actacacgcc ttaccggtcc ggggacgcga
      181 cgcgaacccc tcagtcccca cggcagaccc cgagccggga aagacggcgc ccggagccag
      241 ccgggagctg ggcagcagcg gccgaggagg aagaagcagc tgcggcggcc acaccctgga
      301 tgagagatta ttttgcagag gatgatgggg agatggtacc cagaacgagt cacacagcag
      361 cttttcttag tgacactaaa gatcgaggcc ctccagtgca gtcacagatc tggagaagtg
      421 gtgaaaaggt cccgtttgtg cagacatatt ccttgagagc atttgagaaa ccccctcagg
      481 tacagaccca ggctcttcga gactttgaga agcacctcaa tgacctgaag aaggagaact
      541 tcagcctcaa gctgcgcatc tacttcctgg aggagcgcat gcaacagaag tatgaggcca
      601 gccgggagga catctacaag cggaacattg agctgaaggt tgaagtggag agcttgaaac
      661 gagaactcca ggacaagaaa cagcatctgg ataaaacatg ggctgatgtg gagaatctca
      721 acagtcagaa tgaagctgag ctccgacgcc agtttgagga gcgacagcag gagacggagc
      781 atgtttatga gctcttggag aataagatcc agcttctgca ggaggaatcc aggctagcaa
      841 agaatgaagc tgcgcggatg gcagctctgg tggaagcaga gaaggagtgt aacctggagc
      901 tctcagagaa actgaaggga gtcaccaaaa actgggaaga tgtaccagga gaccaggtca
      961 agcccgacca atacactgag gccctggccc agagggacaa gagaattgaa gaactgaatc
     1021 agagcctggc tgcccaggag aggcttgtag aacagctatc tcgggagaaa caacaactgc
     1081 tacatctgtt ggaggagcca actagcatgg aagtgcagcc catgactgaa gagttgctga
     1141 aacaacaaaa gctgaattca catgagacca ctataactca gcagtctgta tctgattccc
     1201 acttggcaga actccaggaa aaaatccagc aaacagaggc caccaacaag attcttcaag
     1261 agaaacttaa tgaaatgagc tatgaactaa agtgtgctca ggagtcgtct caaaagcaag
     1321 atggtacaat tcagaacctc aaggaaactc tgaaaagcag ggaacgtgag actgaggagt
     1381 tgtaccaggt aattgaaggt caaaatgaca caatggcaaa gcttcgagaa atgctgcacc
     1441 aaagccagct tggacaactt cacagctcag agggtacttc tccagctcag caacaggtag
     1501 ctctgcttga tcttcagagt gctttattct gcagccaact tgaaatacag aagctccaga
     1561 gggtggtacg acagaaagag cgccaactgg ctgatgccaa acaatgtgtg caatttgtag
     1621 aggctgcagc acacgagagt gaacagcaga aagaggcttc ttggaaacat aaccaggaat
     1681 tgcgaaaagc cttgcagcag ctacaagaag aattgcagaa taagagccaa cagcttcgtg
     1741 cctgggaggc tgaaaaatac aatgagattc gaacccagga acaaaacatc cagcacctaa
     1801 accatagtct gagtcacaag gagcagttgc ttcaggaatt tcgggagctc ctacagtatc
     1861 gagataactc agacaaaacc cttgaagcaa atgaaatgtt gcttgagaaa cttcgccagc
     1921 gaatacatga taaagctgtt gctctggagc gggctataga tgaaaaattc tctgctctag
     1981 aagagaaaga aaaagaactg cgccagcttc gtcttgctgt gagagagcga gatcatgact
     2041 tagagagact gcgcgatgtc ctctcctcca atgaagctac tatgcaaagt atggagagtc
     2101 tcctgagggc caaaggcctg gaagtggaac agttatctac tacctgtcaa aacctccagt
     2161 ggctgaaaga agaaatggaa accaaattta gccgttggca gaaggaacaa gagagtatca
     2221 ttcagcagtt acagacgtct cttcatgata ggaacaaaga agtggaggat cttagtgcaa
     2281 cactgctctg caaacttgga ccagggcaga gtgagatagc agaggagctg tgccagcgtc
     2341 tacagcgaaa ggaaaggatg ctgcaggacc ttctaagtga tcgaaataaa caagtgctgg
     2401 aacatgaaat ggagattcaa ggcctgcttc agtctgtgag caccagggag caggaaagcc
     2461 aagctgctgc agagaagttg gtgcaagcct taatggaaag aaattcagaa ttacaggccc
     2521 tgcgccaata tttaggaggg agagactccc tgatgtccca agcacccatc tctaaccaac
     2581 aagctgaagt tacccccact ggccgtcttg gaaaacagac tgatcaaggt tcaatgcaga
     2641 taccttccag agatgatagc acttcattga ctgccaaaga ggatgtcagc atacccagat
     2701 ccacattagg agacttggac acagttgcag ggctggaaaa agaactgagt aatgccaaag
     2761 aggaacttga actcatggct aaaaaagaaa gagaaagtca gatggaactt tctgctctac
     2821 agtccatgat ggctgtgcag gaagaagagc tgcaggtgca ggctgctgat atggagtctc
     2881 tgaccaggaa catacagatt aaagaagatc tcataaagga cctgcaaatg caactggttg
     2941 atcctgaaga cataccagct atggaacgcc tgacccagga agtcttactt cttcgggaaa
     3001 aagttgcttc agtagaatcc cagggtcaag aaatttcagg aaaccgaaga caacagttgc
     3061 tgctgatgct agaaggacta gtagatgaac ggagtcggct caatgaggcc ttacaagcag
     3121 agagacagct ctatagcagt ctggtgaagt tccatgccca tccagagagc tctgagagag
     3181 accgaactct gcaggtggaa ctggaagggg ctcaggtgtt acgcagtcgg ctagaagaag
     3241 ttcttggaag aagcttggag cgcttaaaca ggctggagac cctggccgcc attggaggtg
     3301 cagctgcagg ggatgacacc gaagatacaa gcactgagtt cactgacagt attgaggagg
     3361 aggctgcaca ccatagtcac cagcaacttg tcaaggtggc tttggagaaa agtctggcaa
     3421 ctgtggagac ccagaaccca tctttttccc ctccttctcc gatgggaggg gacagtaaca
     3481 ggtgtcttca ggaagaaatg ctccacctga gggctgagtt ccaccagcac ttagaagaga
     3541 agaggaaagc tgaggaggaa ctgaaggagc taaaggctca aattgaggaa gcaggattct
     3601 cctcagtgtc ccacatcagg aacaccatgc tgagcctttg ccttgagaat gcggagctga
     3661 aagagcagat gggagaagca atgtctgatg gatgggagat cgaggaagac aaggagaagg
     3721 gcgaggtgat ggttgagact gtggtaacca aagagggtct gagtgagagt agccttcagg
     3781 ctgagttcag aaagctccag ggaaaactga agaatgccca caatatcatc aacctcctca
     3841 aagaacaact tgtgctgagt agcaaggaag ggaatagtaa acttactcca gagctccttg
     3901 tgcatctgac cagcaccatt gaaagaataa acacagaact ggttggttcc cctgggaagc
     3961 accaacacca agaggagggg aatgtgactg tgaggccttt ccccagaccc cagagccttg
     4021 accttggggc taccttcaca gtggatgccc accaattgga taaccagtcc cagcctcgtg
     4081 accctgggcc tcagtcagcg tttagcctac cagggtccac ccagcacctg cgctcccagc
     4141 tgtcacaatg caaacaacgc tatcaagatc tccaggagaa gctgctgcta tcagaagcca
     4201 ctgtctttgc tcaggctaac gagctggaga aatacagagt tatgcttagt gaatccttgg
     4261 tgaagcagga cagcaagcag atccaggtgg acctccagga cctgggctat gagacttgtg
     4321 gccgaagcga gaatgaggct gaacgggagg aaaccaccag tcctgagtgt gaggagcaca
     4381 acagcctcaa ggaaatggtc ctgatggagg ggctgtgctc tgagcaggga cgccggggct
     4441 caacactggc tagttcctct gagaggaagc ccttggagaa ccagctaggg aagcaggaag
     4501 agttccgggt atatggaaag tcagaaaaca tcttggtcct acgaaaggac atcaaagatc
     4561 tgaaggccca gctgcagaat gccaacaagg tcattcaaaa cctcaagagc cgggtccggt
     4621 ccctctcagt tacaagtgat tattcgtcta gtctggaaag accccggaag ctgagagctg
     4681 ttggcacctt ggaggggtct tcacctcata gtgtccctga tgaggatgag gggtggctgt
     4741 ctgatggcac tggggctttc tactctccag ggcttcaggc caaaaaggac ctggagagtc
     4801 tcatccagag agtatcccag ctggaggccc agctcccaaa aaatggacta gaagagaagc
     4861 tggctgagga gctgagatca gcctcgtggc ctgggaaata tgattccctg attcaggatc
     4921 aggcccggga actgtcttac ctacggcaaa aaatacgaga agggagaggt atttgttatc
     4981 ttatcacccg gcatgcaaaa gatacagtaa aatcttttga ggatctccta aggagcaatg
     5041 acattgacta ctacctggga cagagcttcc gggagcaact cgcccaggga agccagctga
     5101 cagagaggct caccagcaaa ctcagcacca aggatcataa aagtgagaaa gatcaagctg
     5161 gacttgagcc actggccctc aggctcagca gggagctgca ggagaaggag aaagtgattg
     5221 aagtcctgca ggccaagctg gatgctcggt ccctcacacc ctccagcagc catgccttgt
     5281 ctgactccca ccgctctccc agcagcacct ctttcctgtc tgatgaactg gaagcctgct
     5341 ctgacatgga catagtcagc gagtacacac actatgaaga gaagaaagct tctcccagtc
     5401 actcagattc catccatcat tcgagtcatt ctgctgtgtt gtcttctaaa ccatcatcaa
     5461 ccagtgcatc tcagggggct aaggccgaat ccaacagcaa ccccatcagc ttgccaactc
     5521 cccagaatac ccccaaggag gccaaccagg cccattcagg ctttcatttt cactccatac
     5581 ccaagctggc tagccttcct caggcaccat tgccctcagc tccatccagc ttcctgcctt
     5641 tcagccccac tggccctctc ctccttggct gctgtgagac accagtggtc tccttggctg
     5701 aggctcagca ggagctacag atgctgcaga agcagttggg agaaagtgcc agcactgttc
     5761 ctcctgcttc cacagctaca ttgctgagca acgacttgga agccgactct tcctactacc
     5821 tcaactctgc ccagcctcac tctcctccaa ggggcaccat agaactggga agaatcctag
     5881 agcctgggta cctgggcagc agtggcaagt gggatgtgat gaggcctcag aaagggagtg
     5941 tatctgggga cctatcctca ggctcctctg tgtaccagct taactccaaa cccacagggg
     6001 ctgacctgct ggaagagcat cttggtgaaa tccggaacct gcgccagcgc ctggaggaat
     6061 ccatctgcat caatgaccgc ctacgggagc aactggaaca ccggctgacc tctactgctc
     6121 gtggaagggg atccacttct aacttctaca gtcagggcct ggagtccata cctcagctct
     6181 gcaatgagaa cagagtcctc agggaagaca atcgaagact tcaggctcaa ctgagtcatg
     6241 tttccagaga gcactcccag gaaacagaaa gcctgaggga ggctctgctg tcctctcgat
     6301 cccaccttca agagctggaa aaggagctgg agcaccagaa ggtggaaagg cagcagcttt
     6361 tggaagactt gagggagaag cagcaagagg tcttgcattt cagggaggaa cgtctttccc
     6421 tccaggaaaa cgactccaga ctgcagcaca agctggttct cctgcagcaa cagtgtgaag
     6481 agaaacagca gctctttgag tccctccagt cagagctaca aatctacgag gcactttatg
     6541 gcaattccaa gaaggggctg aaagcttaca gcctggatgc ctgtcaccaa atccctttga
     6601 gcagtgacct gagccacctg gtggcagagg tacgagctct gagagggcag ctggagcaga
     6661 gcattcaggg gaacaattgt ctgcgactgc agctgcaaca gcagctggag agcggtgctg
     6721 gcaaagccag cctcagcccc tcctccatta accagaactt cccagccagc actgaccctg
     6781 gaaacaagca gctgctcctc caagattcag ctgtgtcccc tccagtccgg gatgttggta
     6841 tgaattcccc agctctggtc ttccccagct ctgcttcctc tactcctggc tcagaaacgc
     6901 ccataatcaa cagagcaaat ggcttgggtt tggatacttc tccagtaatg aagacccctc
     6961 ccaagctaga gggtgatgct actgatggct cctttgccaa taagcatggc cgccatgtca
     7021 ttggccacat tgatgactac agtgccctaa gacagcagat tgcggagggc aagctgctgg
     7081 tcaaaaagat agtgtctctt gtgagatcag cgtgcagctt ccctggcctt gaagcccaag
     7141 gcacagaggt gctaggcagc aaaggtattc atgagcttcg gagcagcacc agtgccctgc
     7201 accatgccct agaggagtca gcttccctcc tcaccatgtt ctggagagcg gccctgccaa
     7261 gcacccacat ccctgtgctg cctggcaaag tgggagaatc aacagaaagg gaacttctgg
     7321 aactgagaac caaagtatcc aaacaggagc gactccttca gagcacaact gagcatctga
     7381 agaacgccaa ccagcagaag gagagcatgg agcagttcat cgtcagccag ctaaccagaa
     7441 cacatgatgt tttaaagaag gcaaggacta acttagaggt gaaatcccta agggctctgc
     7501 catgtactcc agccttgtga cccttgcctt ccaggaacca tgcaagaagc gcagccacca
     7561 gaagtcctta aaacagcagg aaaggtgggc ctgtccccct tttgtgcagc tacctatctg
     7621 ctgaggagca tctgggcctc attcctccaa gtccacggga gggtccagaa gagggagtca
     7681 gagatgtatc ctggtggagc tgggagaaag gcagaaagcc tttctgacgg ctatggaata
     7741 cgattagcca aggtccactt ggcccagcac taagaaaaag atgcgtagtt tgcacagaag
     7801 gttttgtgat cctgcctctc aacagcccca gcagcttggg aactagcaag agcacatttc
     7861 ttgcctcatc agctgtcctg agatggaaaa ctcagtgaat ataggaccct gattccgatg
     7921 aaaggggcac gtggtcccaa tgctggagct cctctggcag gttctaaaag cacactactg
     7981 agcagcggtg ccctgccgga cactgctggc gggggctcag tgagcactac tcacagatcc
     8041 acacctgacc ctgttgggtc gagtcaggct gggccttggt ctgcactgta gcacctgtgt
     8101 tctttgagtt cacatcatga atgtggtgac ttcccagata ccatctcagg cttaacctag
     8161 cacatcctat ttcttttctt ctatgatatc caaattggac tgacctcact tcaaagttgc
     8221 tgtcccattt tgtcacccta tcttatctcg gggaaattgc agactgatgg ccagaccaac
     8281 tctgttgaaa ttcttgcata gagcaaacct gtgctcattt ttaagtggca tgggagaggc
     8341 cccaagccta gtaaagccta gtctgtgtct tcacagtgct ggtagaatgt gtttgtgtgt
     8401 ataaatatat gatatagatt tatatatgtt gctaacgcca tatattgaag gccaacataa
     8461 ctggtggaca gggtgggtga cagaaaatga aagtcttttt ggtgattgtt aaagcaaaat
     8521 gtgtataaag aaataaatag tttttctttc a
//
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