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Homo sapiens ubiquitin specific peptidase 47 (USP47), transcript variant 8, mRNA

NCBI Reference Sequence: NM_001372095.1

FASTA Graphics 

LOCUS       NM_001372095           10275 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens ubiquitin specific peptidase 47 (USP47), transcript
            variant 8, mRNA.
ACCESSION   NM_001372095
VERSION     NM_001372095.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10275)
  AUTHORS   Lei,H., Xu,H., Yang,L., Wang,Y., Zhang,Y. and Wu,Y.
  TITLE     USP47 stabilizes YBX1 to promote the progression of acute myeloid
            leukemia
  JOURNAL   Oncogene 43 (7), 539-542 (2024)
   PUBMED   38104157
  REMARK    GeneRIF: USP47 stabilizes YBX1 to promote the progression of acute
            myeloid leukemia.
REFERENCE   2  (bases 1 to 10275)
  AUTHORS   Wang,A., Huang,H., Shi,J.H., Yu,X., Ding,R., Zhang,Y., Han,Q.,
            Ni,Z.Y., Li,X., Zhao,R. and Zou,Q.
  TITLE     USP47 inhibits m6A-dependent c-Myc translation to maintain
            regulatory T cell metabolic and functional homeostasis
  JOURNAL   J Clin Invest 133 (23), e169365 (2023)
   PUBMED   37788092
  REMARK    GeneRIF: USP47 inhibits m6A-dependent c-Myc translation to maintain
            regulatory T cell metabolic and functional homeostasis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 10275)
  AUTHORS   Shin,S.C., Park,J., Kim,K.H., Yoon,J.M., Cho,J., Ha,B.H., Oh,Y.,
            Choo,H., Song,E.J. and Kim,E.E.
  TITLE     Structural and functional characterization of USP47 reveals a hot
            spot for inhibitor design
  JOURNAL   Commun Biol 6 (1), 970 (2023)
   PUBMED   37740002
  REMARK    GeneRIF: Structural and functional characterization of USP47
            reveals a hot spot for inhibitor design.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 10275)
  AUTHORS   Chen,H.Y., Tang,R.C., Liang,J.W., Zhao,W., Yu,S.S., Yao,R.R.,
            Xu,R., Zhang,A., Geng,S., Sun,X.Y., Ge,Q. and Zhang,J.
  TITLE     Deubiquitinase USP47 attenuates virus-induced type I interferon
            signaling
  JOURNAL   Int Immunopharmacol 118, 110040 (2023)
   PUBMED   37001379
  REMARK    GeneRIF: Deubiquitinase USP47 attenuates virus-induced type I
            interferon signaling.
REFERENCE   5  (bases 1 to 10275)
  AUTHORS   Kassel,S., Hanson,A.J., Benchabane,H., Saito-Diaz,K., Cabel,C.R.,
            Goldsmith,L., Taha,M., Kanuganti,A., Ng,V.H., Xu,G., Ye,F.,
            Picker,J., Port,F., Boutros,M., Weiss,V.L., Robbins,D.J.,
            Thorne,C.A., Ahmed,Y. and Lee,E.
  TITLE     USP47 deubiquitylates Groucho/TLE to promote Wnt-beta-catenin
            signaling
  JOURNAL   Sci Signal 16 (771), eabn8372 (2023)
   PUBMED   36749823
  REMARK    GeneRIF: USP47 deubiquitylates Groucho/TLE to promote
            Wnt-beta-catenin signaling.
REFERENCE   6  (bases 1 to 10275)
  AUTHORS   Yang,S.W., Oh,K.H., Park,E., Chang,H.M., Park,J.M., Seong,M.W.,
            Ka,S.H., Song,W.K., Park,D.E., Baas,P.W., Jeon,Y.J. and Chung,C.H.
  TITLE     USP47 and C terminus of Hsp70-interacting protein (CHIP)
            antagonistically regulate katanin-p60-mediated axonal growth
  JOURNAL   J Neurosci 33 (31), 12728-12738 (2013)
   PUBMED   23904609
  REMARK    GeneRIF: The results of this study indicated that USP47 plays a
            crucial role in the control of axonal growth during neuronal
            development by antagonizing CHIP-mediated katanin-p60 degradation.
REFERENCE   7  (bases 1 to 10275)
  AUTHORS   Parsons,J.L., Dianova,I.I., Khoronenkova,S.V., Edelmann,M.J.,
            Kessler,B.M. and Dianov,G.L.
  TITLE     USP47 is a deubiquitylating enzyme that regulates base excision
            repair by controlling steady-state levels of DNA polymerase beta
  JOURNAL   Mol Cell 41 (5), 609-615 (2011)
   PUBMED   21362556
  REMARK    GeneRIF: USP47 has a role in regulating DNA repair and maintaining
            genome integrity
REFERENCE   8  (bases 1 to 10275)
  AUTHORS   Peschiaroli,A., Skaar,J.R., Pagano,M. and Melino,G.
  TITLE     The ubiquitin-specific protease USP47 is a novel beta-TRCP
            interactor regulating cell survival
  JOURNAL   Oncogene 29 (9), 1384-1393 (2010)
   PUBMED   19966869
  REMARK    GeneRIF: USP47, a novel beta-Trcp interactor, regulates cell growth
            and survival, potentially providing a novel target for anticancer
            therapies.
REFERENCE   9  (bases 1 to 10275)
  AUTHORS   Quesada,V., Diaz-Perales,A., Gutierrez-Fernandez,A., Garabaya,C.,
            Cal,S. and Lopez-Otin,C.
  TITLE     Cloning and enzymatic analysis of 22 novel human ubiquitin-specific
            proteases
  JOURNAL   Biochem Biophys Res Commun 314 (1), 54-62 (2004)
   PUBMED   14715245
REFERENCE   10 (bases 1 to 10275)
  AUTHORS   Puente,X.S., Sanchez,L.M., Overall,C.M. and Lopez-Otin,C.
  TITLE     Human and mouse proteases: a comparative genomic approach
  JOURNAL   Nat Rev Genet 4 (7), 544-558 (2003)
   PUBMED   12838346
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104383.4 and AC124276.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.150309.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-253               AC104383.4         64816-65068
            254-477             AC104383.4         93344-93567
            478-537             AC104383.4         96644-96703
            538-741             AC104383.4         103021-103224
            742-855             AC104383.4         107311-107424
            856-994             AC104383.4         114812-114950
            995-1091            AC124276.5         194177-194273       c
            1092-1237           AC124276.5         189010-189155       c
            1238-1317           AC124276.5         188528-188607       c
            1318-1467           AC124276.5         186322-186471       c
            1468-1563           AC124276.5         171619-171714       c
            1564-1716           AC124276.5         171376-171528       c
            1717-1884           AC124276.5         168979-169146       c
            1885-2016           AC124276.5         162305-162436       c
            2017-2093           AC124276.5         161750-161826       c
            2094-2149           AC124276.5         161119-161174       c
            2150-2262           AC124276.5         158754-158866       c
            2263-2367           AC124276.5         157935-158039       c
            2368-2575           AC124276.5         155360-155567       c
            2576-2688           AC124276.5         153498-153610       c
            2689-2808           AC124276.5         151322-151441       c
            2809-3586           AC124276.5         148758-149535       c
            3587-3762           AC124276.5         143750-143925       c
            3763-3843           AC124276.5         143312-143392       c
            3844-3959           AC124276.5         141866-141981       c
            3960-4078           AC124276.5         141388-141506       c
            4079-4209           AC124276.5         138999-139129       c
            4210-4257           AC124276.5         136926-136973       c
            4258-4388           AC124276.5         136706-136836       c
            4389-10275          AC124276.5         129983-135869       c
FEATURES             Location/Qualifiers
     source          1..10275
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.3"
     gene            1..10275
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /note="ubiquitin specific peptidase 47"
                     /db_xref="GeneID:55031"
                     /db_xref="HGNC:HGNC:20076"
                     /db_xref="MIM:614460"
     exon            1..253
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /inference="alignment:Splign:2.1.0"
     exon            254..477
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    427..429
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /note="upstream in-frame stop codon"
     exon            478..537
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /inference="alignment:Splign:2.1.0"
     CDS             517..4563
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /EC_number="3.4.19.12"
                     /note="isoform g is encoded by transcript variant 8;
                     ubiquitin carboxyl-terminal hydrolase 47; ubiquitin
                     thioesterase 47; deubiquitinating enzyme 47;
                     ubiquitin-specific-processing protease 47; ubiquitin
                     thiolesterase 47; Trf (TATA binding protein-related
                     factor)-proximal homolog"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 47 isoform
                     g"
                     /protein_id="NP_001359024.1"
                     /db_xref="GeneID:55031"
                     /db_xref="HGNC:HGNC:20076"
                     /db_xref="MIM:614460"
                     /translation="MKKKFLQIENAAEEPRVLCIIQDTTNSKTVNERITLNLPASTPV
                     RKLFEDVANKVGYINGTFDLVWGNGINTADMAPLDHTSDKSLLDANFEPGKKNFLHLT
                     DKDGEQPQILLEDSSAGEDSVHDRFIGPLPREGSGGSTSDYVSQSYSYSSILNKSETG
                     YVGLVNQAMTCYLNSLLQTLFMTPEFRNALYKWEFEESEEDPVTSIPYQLQRLFVLLQ
                     TSKKRAIETTDVTRSFGWDSSEAWQQHDVQELCRVMFDALEQKWKQTEQADLINELYQ
                     GKLKDYVRCLECGYEGWRIDTYLDIPLVIRPYGSSQAFASVEEALHAFIQPEILDGPN
                     QYFCERCKKKCDARKGLRFLHFPYLLTLQLKRFDFDYTTMHRIKLNDRMTFPEELDMS
                     TFIDVEDEKSPQTESCTDSGAENEGSCHSDQMSNDFSNDDGVDEGICLETNSGTEKIS
                     KSGLEKNSLIYELFSVMVHSGSAAGGHYYACIKSFSDEQWYSFNDQHVSRITQEDIKK
                     THGGSSGSRGYYSSAFASSTNAYMLIYRLKDPARNAKFLEVDEYPEHIKNLVQKEREL
                     EEQEKRQREIERNTCKIKLFCLHPTKQVMMENKLEVHKDKTLKEAVEMAYKMMDLEEV
                     IPLDCCRLVKYDEFHDYLERSYEGEEDTPMGLLLGGVKSTYMFDLLLETRKPDQVFQS
                     YKPGVMVKVHVVDLKAESVAAPITVRAYLNQTVTEFKQLISKAIHLPAETMRIVLERC
                     YNDLRLLSVSSKTLKAEGFFRSNKVFVESSETLDYQMAFADSHLWKLLDRHANTIRLF
                     VLLPEQSPVSYSKRTAYQKAGGDSGNVDDDCERVKGPVGSLKSVEAILEESTEKLKSL
                     SLQQQQDGDNGDSSKSTETSDFENIESPLNERDSSASVDNRELEQHIQTSDPENFQSE
                     ERSDSDVNNDRSTSSVDSDILSSSHSSDTLCNADNAQIPLANGLDSHSITSSRRTKAN
                     EGKKETWDTAEEDSGTDSEYDESGKSRGEMQYMYFKAEPYAADEGSGEGHKWLMVHVD
                     KRITLAAFKQHLEPFVGVLSSHFKVFRVYASNQEFESVRLNETLSSFSDDNKITIRLG
                     RALKKGEYRVKVYQLLVNEQEPCKFLLDAVFAKGMTVRQSKEELIPQLREQCGLELSI
                     DRFRLRKKTWKNPGTVFLDYHIYEEDINISSNWEVFLEVLDGVEKMKSMSQLAVLSRR
                     WKPSEMKLDPFQEVVLESSSVDELREKLSEISGIPLDDIEFAKGRGTFPCDISVLDIH
                     QDLDWNPKVSTLNVWPLYICDDGAVIFYRDKTEELMELTDEQRNELMKKESSRLQKTG
                     HRVTYSPRKEKALKIYLDGAPNKDLTQD"
     exon            538..741
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /inference="alignment:Splign:2.1.0"
     exon            742..855
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /inference="alignment:Splign:2.1.0"
     exon            856..994
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1091
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1237
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1317
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1467
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1563
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1716
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1884
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..2016
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /inference="alignment:Splign:2.1.0"
     exon            2017..2093
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /inference="alignment:Splign:2.1.0"
     exon            2094..2149
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /inference="alignment:Splign:2.1.0"
     exon            2150..2262
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /inference="alignment:Splign:2.1.0"
     exon            2263..2367
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /inference="alignment:Splign:2.1.0"
     exon            2368..2575
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /inference="alignment:Splign:2.1.0"
     exon            2576..2688
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /inference="alignment:Splign:2.1.0"
     exon            2689..2808
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /inference="alignment:Splign:2.1.0"
     exon            2809..3586
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /inference="alignment:Splign:2.1.0"
     exon            3587..3762
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /inference="alignment:Splign:2.1.0"
     exon            3763..3843
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /inference="alignment:Splign:2.1.0"
     exon            3844..3959
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /inference="alignment:Splign:2.1.0"
     exon            3960..4078
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /inference="alignment:Splign:2.1.0"
     exon            4079..4209
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /inference="alignment:Splign:2.1.0"
     exon            4210..4257
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /inference="alignment:Splign:2.1.0"
     exon            4258..4388
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /inference="alignment:Splign:2.1.0"
     exon            4389..10275
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4937..4942
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /note="hexamer: AATAAA"
     polyA_site      4958
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /note="major polyA site"
     regulatory      5304..5309
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /note="hexamer: AATAAA"
     polyA_site      5333
                     /gene="USP47"
                     /gene_synonym="TRFP"
     regulatory      5884..5889
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /note="hexamer: AATAAA"
     polyA_site      5903
                     /gene="USP47"
                     /gene_synonym="TRFP"
     regulatory      7519..7524
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /note="hexamer: AATAAA"
     polyA_site      7542
                     /gene="USP47"
                     /gene_synonym="TRFP"
     regulatory      7693..7698
                     /regulatory_class="polyA_signal_sequence"
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /note="hexamer: AATAAA"
     polyA_site      7713
                     /gene="USP47"
                     /gene_synonym="TRFP"
ORIGIN      
        1 gacgaaggcg gctgtggtag cggcggcggc ggcggcggag ccctgggtcg gtgtctgcgc
       61 gctggtgtct gaggcccagg ctgaggcctc cgctattgct ggagcgcagg cggcggagag
      121 gatgactgcc gctgccattc tctcttgagc tagcgagccg ccgccaccct ccaccctccc
      181 ccggcagggc ggagaggagc ggccggagtc agcgatggtg cccggcgagg agaaccaact
      241 ggtcccgaaa gagaactgtc tttagctatt ccttcctgta gggtagttcc actggatgca
      301 aattctttga gttttccttc atctgagaat gtcttgaatt ccacttgatt attaaagcaa
      361 ttcctgggtc gttcttgaag ggcatttctg ctggttattg gattctggtt tgacggttat
      421 tttttgtaag cacctgaaaa atactgtgcc acttccttct ggcctccgtg gtttctggat
      481 gtgttttgga gatgcagaca aaatatcttt gatgaaatga agaagaaatt tttacagata
      541 gaaaatgctg ctgaagaacc tagagtctta tgtattatac aagatactac taattcaaag
      601 acagtgaatg aacggatcac tttaaattta ccagcatcta ctccagtcag aaagctcttt
      661 gaagatgtgg ccaacaaagt aggctacata aatggaacct ttgacttggt gtggggaaat
      721 ggaatcaata ctgctgatat ggcaccactg gatcatacca gtgacaagtc acttctcgac
      781 gctaattttg agccaggaaa gaagaacttt ctgcatttga cagataaaga tggtgaacaa
      841 cctcaaatac tgctggagga ttccagtgct ggggaagaca gtgttcatga caggtttata
      901 ggtccgcttc caagagaagg ttctgggggt tctaccagtg attatgtcag ccaaagctac
      961 tcctactcat ctattttgaa taaatcagaa actggatatg tgggactagt aaaccaagca
     1021 atgacttgct atttgaatag ccttttgcaa acacttttta tgactcctga atttaggaat
     1081 gcattatata agtgggaatt tgaagaatct gaagaagatc cagtgacaag tattccatac
     1141 caacttcaaa ggctttttgt tttgttacaa accagcaaaa agagagcaat tgaaaccaca
     1201 gatgttacaa ggagctttgg atgggatagt agtgaggctt ggcagcagca tgatgtacaa
     1261 gaactatgca gagtcatgtt tgatgctttg gaacagaaat ggaagcaaac agaacaggct
     1321 gatcttataa atgagctata tcaaggcaag ctgaaggact acgtgagatg tctggaatgt
     1381 ggttatgagg gctggcgaat cgacacatat cttgatattc cattggtcat ccgaccttat
     1441 gggtccagcc aagcatttgc tagtgtggaa gaagcattgc atgcatttat tcagccagag
     1501 attctggatg gcccaaatca gtatttttgt gaacgttgta agaagaagtg tgatgcacgg
     1561 aagggccttc ggtttttgca ttttccttat ctgctgacct tacagctgaa aagattcgat
     1621 tttgattata caaccatgca taggattaaa ctgaatgatc gaatgacatt tcccgaggaa
     1681 ctagatatga gtacttttat tgatgttgaa gatgagaaat ctcctcagac tgaaagttgc
     1741 actgacagtg gagcagaaaa tgaaggtagt tgtcacagtg atcagatgag caacgatttc
     1801 tccaatgatg atggtgttga tgaaggaatc tgtcttgaaa ccaatagtgg aactgaaaag
     1861 atctcaaaat ctggacttga aaagaattcc ttgatctatg aacttttctc tgttatggtt
     1921 cattctggga gcgctgctgg tggtcattat tatgcatgta taaagtcatt cagtgatgag
     1981 cagtggtaca gcttcaatga tcaacatgtc agcaggataa cacaagagga cattaagaaa
     2041 acacatggtg gatcttcagg aagcagagga tattattcta gtgctttcgc aagttccaca
     2101 aatgcatata tgctgatcta tagactgaag gatccagcca gaaatgcaaa atttctagaa
     2161 gtggatgaat acccagaaca tattaaaaac ttggtgcaga aagagagaga gttggaagaa
     2221 caagaaaaga gacaacgaga aattgagcgc aatacatgca agataaaatt attctgtttg
     2281 catcctacaa aacaagtaat gatggaaaat aaattggagg ttcataagga taagacatta
     2341 aaggaagcag tagaaatggc ttataagatg atggatttag aagaggtaat acccctggat
     2401 tgctgtcgcc ttgttaaata tgatgagttt catgattatc tagaacggtc atatgaagga
     2461 gaagaagata caccaatggg gcttctacta ggtggcgtca agtcaacata tatgtttgat
     2521 ctgctgttgg agacgagaaa gcctgatcag gttttccaat cttataaacc tggagtgatg
     2581 gtgaaagttc atgttgttga tctaaaggca gaatctgtag ctgctcctat aactgttcgt
     2641 gcttacttaa atcagacagt tacagaattc aaacaactga tttcaaaggc catccattta
     2701 cctgctgaaa caatgagaat agtgctggaa cgctgctaca atgatttgcg tcttctcagt
     2761 gtctccagta aaaccctgaa agctgaagga ttttttagaa gtaacaaggt gtttgttgaa
     2821 agctccgaga ctttggatta ccagatggcc tttgcagact ctcatttatg gaaactcctg
     2881 gatcggcatg caaatacaat cagattattt gttttgctac ctgaacaatc cccagtatct
     2941 tattccaaaa ggacagcata ccagaaagct ggaggcgatt ctggtaatgt ggatgatgac
     3001 tgtgaaagag tcaaaggacc tgtaggaagc ctaaagtctg tggaagctat tctagaagaa
     3061 agcactgaaa aactcaaaag cttgtcactg cagcaacagc aggatggaga taatggggac
     3121 agcagcaaaa gtactgagac aagtgacttt gaaaacatcg aatcacctct caatgagagg
     3181 gactcttcag catcagtgga taatagagaa cttgaacagc atattcagac ttctgatcca
     3241 gaaaattttc agtctgaaga acgatcagac tcagatgtga ataatgacag gagtacaagt
     3301 tcagtggaca gtgatattct tagctccagt catagcagtg atactttgtg caatgcagac
     3361 aatgctcaga tccctttggc taatggactt gactctcaca gtatcacaag tagtagaaga
     3421 acgaaagcaa atgaagggaa aaaagaaaca tgggatacag cagaagaaga ctctggaact
     3481 gatagtgaat atgatgagag tggcaagagt aggggagaaa tgcagtacat gtatttcaaa
     3541 gctgaacctt atgctgcaga tgaaggttct ggggaaggac ataaatggtt gatggtgcat
     3601 gttgataaaa gaattactct ggcagctttc aaacaacatt tagagccctt tgttggagtt
     3661 ttgtcctctc acttcaaggt ctttcgagtg tatgccagca atcaagagtt tgagagcgtc
     3721 cggctgaatg agacactttc atcattttct gatgacaata agattacaat tagactgggg
     3781 agagcactta aaaaaggaga atacagagtt aaagtatacc agcttttggt caatgaacaa
     3841 gagccatgca agtttctgct agatgctgtg tttgctaaag gaatgactgt acggcaatca
     3901 aaagaggaat taattcctca gctcagggag caatgtggtt tagagctcag tattgacagg
     3961 tttcgtctaa ggaaaaaaac atggaagaat cctggcactg tctttttgga ttatcatatt
     4021 tatgaagaag atattaatat ttccagcaac tgggaggttt tccttgaagt tcttgatggg
     4081 gtagagaaga tgaagtccat gtcacagctt gcagttttgt caagacggtg gaagccttca
     4141 gagatgaagt tggatccctt ccaggaggtt gtattggaaa gcagtagtgt ggacgaattg
     4201 cgagagaagc ttagtgaaat cagtgggatt cctttggatg atattgaatt tgctaagggt
     4261 agaggaacat ttccctgtga tatttctgtc cttgatattc atcaggattt agactggaat
     4321 cctaaagttt ctaccctgaa tgtctggcct ctttatatct gtgatgatgg tgcggtcata
     4381 ttttataggg ataaaacaga agaattaatg gaattgacag atgagcaaag aaatgaactg
     4441 atgaaaaaag aaagcagtcg actccagaag actggacatc gtgtaacata ctcacctcgt
     4501 aaagagaaag cactaaaaat atatctggat ggagcaccaa ataaagatct gactcaagac
     4561 tgactctgat agtgtagcat tttccctggg ggagttttgg ttttaattag atggttcact
     4621 accactgggt agtgccattt tggccggaca tggttggggt aacccagtga caccagcact
     4681 gattggactg ccctacacca atcagaagct cagtgcccaa tgggccactg ttttgactcg
     4741 gaatcatgtt gtgcactata gtcaaatgta ctgtaaagtg aaaagggatg tgcaaaaaaa
     4801 taaaaaaaaa caacaaaaaa agctaacctt ctattagaaa aggggacagg ggaatgagta
     4861 aacttctttt attgcggaca aatgtgcaca tagccgctag taaaactagc ctcaaacagg
     4921 atgctcatag cttaataata aaagctgtgc aaaggccatg aatgaatgaa ttttctgttt
     4981 atttcactga tgcacacatt acctcattga caattcagaa gtaaatccaa cgtgtgttga
     5041 ctcttggaaa gcagcaaaaa caggagctga agaaaagaaa ttcttggaac cagccgtaac
     5101 ccagtaagga attgtgaagt tgtgttttta ttttgtttca ttttttgcag agtattaaga
     5161 acattattct ggaacatcag aacgtttccc ttagaccgat cccagcaggt ggcagctcag
     5221 attgctgcag tgttgtaatt ataactgatt gtacttaagt tatggatgta gagaatatgt
     5281 ttcattcatt tattcagcat gtaaataaaa ttgatcctgt tgagttatca taattgcagt
     5341 tcaactatct gccatgatta ttcttttcac gtatcattca ttctgtacat ttgtgtacat
     5401 tgagaagtat agcaatctat gtaaatgtaa tcctcagtga ggttcctcag tgctaggtcc
     5461 cataggattg tcgttgccct tgttaatgag gtttctctgt tcagcggctt caattttttt
     5521 ctctttgtac atctagtttt gaagatttac ttcaagtttg aatcttctag aatgcttgta
     5581 agtccagttt taatttttag agtcaatttg tagttacatg tagtttaact tttgggaaac
     5641 gtcttaacat tgttctgaat aaacttgcta atgaggtcag gtcatggtac agactgatgc
     5701 agtcaacatg atttcattgc agagtttatt agtatcagca agtttttgct ttgctaaata
     5761 aaagtactca atgaacacaa ttctacataa attttgacat accatctaat ttataaaaat
     5821 caataaaaaa ggttttggta aaactttttc atgccagatg ctgtttacaa caatgaacat
     5881 gccaataaaa catttgttca ttctgttgtg ttattttagt cattaaactt ctgtggatga
     5941 agaatctggg ttaagaatag atttgtcatc tttaaatatg acattttgta atgtgtattg
     6001 gatatctcat ttctatgata aaggtatatt tacagtaaag ttctcataag agaaatgaaa
     6061 agctgtgtta atatctaact ttggggaacc ctgtcagtat ttcagatccg atttttaccc
     6121 tttttttctt ataagaaaga taaaattaga aaatactgtt agcaaatgtg gctctgccat
     6181 ttgaatataa tcaccgagaa ttccatgtct taaaagtctc ctggaatcca caatgaaaaa
     6241 aaaaatcttt tctaaggtat ttttctggct aatttttatt tgaagaaagc tatagcattt
     6301 agcgaaattt gactgaagta atgttctgag tttgcattag tgggattggt gatgttctca
     6361 gaagaaaatt ggaaacactt gtgatgaatt gtctttcaga tcacttagat tttctgatgt
     6421 aagaggacag ctgtttggtt ctgatacagg cctgcttact tgggatgtag ggttagtaaa
     6481 tggggtttct gctttaaagg actgacttgc tatcacacaa aagaggcaga cttgtaaaca
     6541 caatgggctt tggagtttgg tctgattggg tttggtttag tattcctatg agcgtaaatg
     6601 gtaaaattct tctgataccc actctttaga ctgtgccttc tgctctgttc tttgttttat
     6661 gtttaactgc tgtttctaat tgcaggtgta ttacagatac aaataagagt aaagaaaata
     6721 tatttcatta tagaaaagaa aaaattaaaa gcttcttgct tttcagtgcc tgatagagtg
     6781 aaaacacaaa gttgcacttt aataatttca ataaaagcta atctgtgtca gcctccctct
     6841 gcttcagaga gtcaggtgag catccataac ctaacaggca gagccctagc gatgtggatc
     6901 aagtttcctg agcccggggg cggtggagcc tcatgatctc ttatcttttg aggctgaggc
     6961 aggtcacatg caacaaattg tgaccctgct ccccacaagt catgcaaagg ttttgaagag
     7021 cttttaccgt ggggcagatg aacttgtgtc aaccatgcac accctgtgag aaccaagtac
     7081 ctgtgtttct aaggcgggca ctcaaggtga ggggtgcatt ctggccaaag aaacaaaagc
     7141 tgtggtttca ggaccatgcc gtgtgtagct gatctgtacg ggacgtgtat gtaaggaaga
     7201 gcaatcatga tagataagaa cagtgtgtga agcagccttc acactagagt gtttggtcat
     7261 ctcttataat gtaagggaag gtactttaaa attctgggaa gatgcgatga actcatgtcc
     7321 cagtcagaaa ataatccaat gaaataagca ttggttgcca ggccacagtt aggaattgta
     7381 ttgtgataca tctagaggcc aagagagcag gagagagcta ccaacttaca ctgtggttta
     7441 agctaaatga ccgcacagca tcatagcatt gcagtgttgt tactaaatct ggaagtgacc
     7501 tgtgaatgta tggaatacaa taaagtcttt tattctggtt catttgctag tacttccttt
     7561 ttgattggat actgtagttc ttcctctgga ttttattttg ttcagcgtca aggccctaat
     7621 tttgcaaatg tagtctaaac cacattacgt ggactagagg atactctgaa ttagcaagtt
     7681 ttttgtttgc tgaataaaac tattccatct taacaattct gtgtaatttt tgaaaaacat
     7741 caacattttg gtcactagta gtcaaaatct tataaggcca tatgtcctga aaggcaaaac
     7801 tctgtgtatg tgcgatttac cagggagata gtaggacagt ttttatgagg gtttcaaagg
     7861 agttcatggc ccaaatgaag cttgtggcca cctaggttta gtgtacatga aattggaaga
     7921 tgcttcttga ttgtagttcc catggggaag agggaggctg tgatcatttg gttagataca
     7981 gcattaattg tcacaacttg actttcagaa acaagaatac tgcacaaact caagcatgca
     8041 ttggagcatg tgttactatt tagaaaagag tgcagccatc agtaggtcaa gctaggaggg
     8101 caaaagagag ttgagaggaa tgctctgccc cttccccatc acagcactgc ccctttccac
     8161 ctcctcacca gctcacctgt acaagagaat tgatctcaac tgagtgtcag ctcaccaggt
     8221 cagaaattgt tattggaccc taaaaccttg cctcacaggt gggcaccaag ctccccttcc
     8281 ctctgctttc catgtttccc acctgccctc tccccacctg ttttcagcct cttttataat
     8341 gcttaagtaa cctgcttgaa gagtataatt tatggagata aaaatactca atgcttacat
     8401 ttttttcata actgtgccaa ttgttttgtc aaatgcagtt acccactggg cagtgggctt
     8461 atcaagtgct cagtgcaatc ctgtgacttt taagtcattt tgcattatta agacaatctt
     8521 atcttaaagt tcagtggttt cattcaaagc tcccctgaac ctccatagtg cctccaagat
     8581 gtgctgtccc tgccaactcc tgcaccagct tgactggtgg tggaagaggc caggaagagc
     8641 ggggggaaga catgtgctaa ccacttctta gcaatgaggc tggtaaggtt actgtcccct
     8701 tgtgcctggt cactagtaac ttttttgtag acatgaaggt agatgccctg caggtcctat
     8761 cagcaaagga cccaactcct aacagcattg gtgctccctc atgaaatttg acagtgtctt
     8821 gccagcctcc tgctggcaga cacttctctg cagtgaatac cactatccca tgctgcacta
     8881 gtccctacca agtcttcaac cctcaatttg atcttccatg agtgtctcaa aaagttcccc
     8941 tcagaagttt cagccaaggg aataaaatct aacctctcct ccctcaacgg agtgtcaggg
     9001 aggggaagaa tctgttttcc aaacaccaca atctcccaaa aggggatttc accctccctt
     9061 ggtcatcttt atacagggca attgtgctgc tgctgctgag gtggccactt tcagcaagcc
     9121 ctgtgtgcag gggcctagct gcatttagaa accaagcata gctatcaaaa agtaatctcc
     9181 aaatagttga attgcatttc ttgagtatct ggagaggatg tgcagaccac aggaatacct
     9241 aatgcctttt ttctcttcct gtctttgtcc ctcacactac agcaggcccc tcccttccct
     9301 cttcaacctc atcctccctc cccacaggcc cagagaacca gttgggcttt gttctcctgc
     9361 aggctatggt tcatcatgca aatagctcct gtgtcagaaa tgctttttgg cttcaaataa
     9421 cagaaaagct aacaccagct ttatcaataa taatatcggt ggtttactta aggtgtccag
     9481 agatggtgga gaacaggatt ggtttcctcc tcaatgtcaa ggactcaaag actctttctg
     9541 tggtagggcc acatcctaaa ccctgtatcc tgtgattatt tacctgacag ggcaaaagag
     9601 attttgcaga tgcaattaag gttaaggacc ttgacgtggg aagattgtga ttatttacct
     9661 gacagggcaa aagagatttt gcagatgcaa ttaaggttaa ggaccttgac gtgggaagat
     9721 tattctggat tatctaggtg ggcgcaattt gatcacatgg gtccccagaa gtggagaacc
     9781 tttcccacct gtagaaagcc agagagctgg cacctgagaa ggacagaact gtcattgcag
     9841 gatttgaaga tgaaggggcc catgagccaa ggaatgccag tgacctatag aggctaaaaa
     9901 acagcaagga aatggactct ccccagagcc tccagaggaa tgcagccctg ttgatcacat
     9961 gatcaccaga tggctgcccc agagccaaat gtcgcttcct gagcaccata ctcaaaggca
    10021 ggggaagtgg atggagggca ggagctccat tcttgtttgc cactctcctt ttgtcaattg
    10081 ggaaaaaatt ccagaaactc tgggagccct ccccttacat ttcctgggtc atggggccag
    10141 ccctagctgc tggagggact gagaacagct gttgagcagt ttacctgacg gcatctgcca
    10201 tggcttggca ggaactctgg ctttgggaga gagcagcagc aaggtattca agcaccacct
    10261 ccacccagcc cctcc
//
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