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Mus musculus adaptor protein complex AP-1, beta 1 subunit (Ap1b1), transcript variant 1, mRNA

NCBI Reference Sequence: NM_001243043.1

FASTA Graphics 

LOCUS       NM_001243043            4336 bp    mRNA    linear   ROD 17-DEC-2022
DEFINITION  Mus musculus adaptor protein complex AP-1, beta 1 subunit (Ap1b1),
            transcript variant 1, mRNA.
ACCESSION   NM_001243043
VERSION     NM_001243043.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4336)
  AUTHORS   Zhang X, Wang Z, Xu Q, Chen Y, Liu W, Zhong T, Li H, Quan C, Zhang
            L and Cui CP.
  TITLE     Splicing factor Srsf5 deletion disrupts alternative splicing and
            causes noncompaction of ventricular myocardium
  JOURNAL   iScience 24 (10), 103097 (2021)
   PUBMED   34622152
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4336)
  AUTHORS   San Agustin JT, Klena N, Granath K, Panigrahy A, Stewart E, Devine
            W, Strittmatter L, Jonassen JA, Liu X, Lo CW and Pazour GJ.
  TITLE     Genetic link between renal birth defects and congenital heart
            disease
  JOURNAL   Nat Commun 7, 11103 (2016)
   PUBMED   27002738
  REMARK    Erratum:[Nat Commun. 2016 Jun 08;7:11910. PMID: 27273704]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4336)
  AUTHORS   Folsch H.
  TITLE     Role of the epithelial cell-specific clathrin adaptor complex AP-1B
            in cell polarity
  JOURNAL   Cell Logist 5 (2), e1074331 (2015)
   PUBMED   27057418
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4336)
  AUTHORS   Li Y, Klena NT, Gabriel GC, Liu X, Kim AJ, Lemke K, Chen Y,
            Chatterjee B, Devine W, Damerla RR, Chang C, Yagi H, San Agustin
            JT, Thahir M, Anderton S, Lawhead C, Vescovi A, Pratt H, Morgan J,
            Haynes L, Smith CL, Eppig JT, Reinholdt L, Francis R, Leatherbury
            L, Ganapathiraju MK, Tobita K, Pazour GJ and Lo CW.
  TITLE     Global genetic analysis in mice unveils central role for cilia in
            congenital heart disease
  JOURNAL   Nature 521 (7553), 520-524 (2015)
   PUBMED   25807483
REFERENCE   5  (bases 1 to 4336)
  AUTHORS   Tomanek RJ, Yu Q and Lo CW.
  TITLE     Coronary anomalies in mice with congenital heart defects
  JOURNAL   Anat Rec (Hoboken) 298 (2), 408-417 (2015)
   PUBMED   25266175
REFERENCE   6  (bases 1 to 4336)
  AUTHORS   Nakagawa T, Setou M, Seog D, Ogasawara K, Dohmae N, Takio K and
            Hirokawa N.
  TITLE     A novel motor, KIF13A, transports mannose-6-phosphate receptor to
            plasma membrane through direct interaction with AP-1 complex
  JOURNAL   Cell 103 (4), 569-581 (2000)
   PUBMED   11106728
REFERENCE   7  (bases 1 to 4336)
  AUTHORS   Takatsu H, Sakurai M, Shin HW, Murakami K and Nakayama K.
  TITLE     Identification and characterization of novel clathrin
            adaptor-related proteins
  JOURNAL   J Biol Chem 273 (38), 24693-24700 (1998)
   PUBMED   9733768
REFERENCE   8  (bases 1 to 4336)
  AUTHORS   Odorizzi G, Cowles CR and Emr SD.
  TITLE     The AP-3 complex: a coat of many colours
  JOURNAL   Trends Cell Biol 8 (7), 282-288 (1998)
   PUBMED   9714600
  REMARK    Review article
REFERENCE   9  (bases 1 to 4336)
  AUTHORS   Seroussi E, Pan HQ, Kedra D, Roe BA and Dumanski JP.
  TITLE     Characterization of the human NIPSNAP1 gene from 22q12: a member of
            a novel gene family
  JOURNAL   Gene 212 (1), 13-20 (1998)
   PUBMED   9661659
REFERENCE   10 (bases 1 to 4336)
  AUTHORS   Guilbaud C, Peyrard M, Fransson I, Clifton SW, Roe BA, Carter NP
            and Dumanski JP.
  TITLE     Characterization of the mouse beta-prime adaptin gene; cDNA
            sequence, genomic structure, and chromosomal localization
  JOURNAL   Mamm Genome 8 (9), 651-656 (1997)
   PUBMED   9271666
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK034140.1, CA315828.1 and BP765289.1.
            
            [WARNING] On Mar 2, 2023 this sequence was replaced by
            NM_001243043.2.
            
            Transcript Variant: This variant (1) represents the longest variant
            and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK034140.1, SRR1660821.58520.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-301               AK034140.1         2-302
            302-316             AK034140.1         304-318
            317-1308            AK034140.1         320-1311
            1309-1654           CA315828.1         332-677
            1655-4250           AK034140.1         1658-4253
            4251-4336           BP765289.1         1-86                c
FEATURES             Location/Qualifiers
     source          1..4336
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11"
     gene            1..4336
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1; b2b1660Clo"
                     /note="adaptor protein complex AP-1, beta 1 subunit"
                     /db_xref="GeneID:11764"
                     /db_xref="MGI:MGI:1096368"
     exon            1..425
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1; b2b1660Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            426..488
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1; b2b1660Clo"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    440..442
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1; b2b1660Clo"
                     /note="upstream in-frame stop codon"
     CDS             452..3313
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1; b2b1660Clo"
                     /note="isoform 1 is encoded by transcript variant 1;
                     beta-adaptin 1; golgi adaptor HA1/AP1 adaptin beta
                     subunit; adaptor protein complex AP-1 subunit beta-1;
                     clathrin assembly protein complex 1 beta large chain;
                     adaptor-related protein complex AP-1, beta 1 subunit;
                     beta-prime adaptin"
                     /codon_start=1
                     /product="AP-1 complex subunit beta-1 isoform 1"
                     /protein_id="NP_001229972.1"
                     /db_xref="GeneID:11764"
                     /db_xref="MGI:MGI:1096368"
                     /translation="MTDSKYFTTTKKGEIFELKAELNSDKKEKKKEAVKKVIASMTVG
                     KDVSALFPDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDPNPLI
                     RALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQLVEDQG
                     FLDTLKDLISDSNPMVVANAVAALSEIAESHPSSNLLDLNPQSINKLLTALNECTEWG
                     QIFILDCLANYMPKDDREAQSICERVTPRLSHANSAVVLSAVKVLMKFMEMLSKDLDY
                     YATLLKKLAPPLVTLLSAEPELQYVALRNINLIVQKRPEILKHEMKVFFVKYNDPIYV
                     KLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCV
                     STLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESVIATLCENLDSLDEPEARAAMIW
                     IVGEYAERIDNADELLESFLEGFHDESTQVQLQLLTAIVKLFLKKPTETQELVQQVLS
                     LATQDSDNPDLRDRGYIYWRLLSTDPVAAKEVVLAEKPLISEETDLIEPTLLDELICY
                     IGTLASVYHKPPNAFVEGGRGVVHKSLPPRTASSESTESPETAPAGAPAGDQPDVIPA
                     QGDLLGDLLNLDLGPPVSGPPLAASSVQMGAVDLLGGGLDSLMGDESEGIGDSNFGAP
                     SASVAAAPAPARLGAPISSGLSDLFDLTSGVGTLSGSYVAPKAVWLPAMKAKGLEISG
                     TFTRQAGSISMDLQLTNKALQVMTDFAIQFNRNSFGLAPAAPLQVHVPLSPNQTVEIS
                     LPLNTVGSVLKMEPLNNLQVAVKNNIDVFYFSTLYPLHVLFVEDGKMDRQMFLATWKD
                     IANENEAQFQIRDCPLNTEAASNKLQSSNIFTVAKRNVEGQDMLYQSLKLTNGIWVLA
                     ELRIQPGNPSFTDLELSLKCRAPEVSQHVYQAYETILKN"
     misc_feature    1403..1405
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1; b2b1660Clo"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q10567; propagated from
                     UniProtKB/Swiss-Prot (O35643.2); acetylation site"
     misc_feature    2201..2314
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1; b2b1660Clo"
                     /note="propagated from UniProtKB/Swiss-Prot (O35643.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            489..594
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1; b2b1660Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            595..730
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1; b2b1660Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            731..976
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1; b2b1660Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1167
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1; b2b1660Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1389
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1; b2b1660Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1510
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1; b2b1660Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1606
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1; b2b1660Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1722
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1; b2b1660Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1888
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1; b2b1660Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..1987
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1; b2b1660Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..2247
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1; b2b1660Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            2248..2449
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1; b2b1660Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            2450..2470
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1; b2b1660Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            2471..2626
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1; b2b1660Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            2627..2772
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1; b2b1660Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            2773..2902
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1; b2b1660Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            2903..2987
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1; b2b1660Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            2988..3074
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1; b2b1660Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            3075..3229
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1; b2b1660Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            3230..3238
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1; b2b1660Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            3239..4315
                     /gene="Ap1b1"
                     /gene_synonym="Adtb1; b2b1660Clo"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgcggccg gcttgctgct gccgcagcgc cgccgcctcg ccctccaggc tgcggttgtg
       61 cgcctcgagc tgcctcacct tgtcgatgta gcccgcgaag cggtcgttca gagcctgcag
      121 ctgctccttc tcgctgcgcg ccgccaccgc cgccaccacg cagccctctg ggccgttgct
      181 tagggtgtct agcgagtcgg tgctcgaggc ggcgccgcgg aagcggctgg gtgaggcgga
      241 cacggagctc acggacgtcc gcgcccacga gtggaagccg ctggaggagc cggccgcgga
      301 gcgcgtgccg cccgggcctg ccttgcggct cagcgagtag tgcaggctgc cgcctccgtg
      361 cagcggcgcg aacggggcgc ccagcagcgc atcggcgctg ccgaagctca tcatggccgg
      421 agcagagtct ggccacagat aaaggaccaa aatgactgac tcaaaatact tcaccacaac
      481 caagaaaggg gagatctttg agctgaaggc agagcttaac agtgacaaga aggagaagaa
      541 gaaggaggca gtgaagaaag tgattgcatc aatgactgtg ggcaaagatg tcagtgctct
      601 cttccctgat gtggtgaact gcatgcagac agacaacctg gagctaaaga agctggtgta
      661 cctgtacttg atgaactatg ccaagagtca gcctgacatg gccattatgg ctgtcaacac
      721 ctttgtgaag gactgtgagg accccaatcc tctcatccgg gccctggctg tgaggactat
      781 gggctgcatc cgagttgaca agattacaga gtacttgtgt gaaccactcc ggaagtgcct
      841 gaaggatgaa gacccatatg tgcgcaagac agcggctgtg tgtgtggcca agctccatga
      901 catcaatgcc cagctggtag aagaccaggg cttcctggac acgcttaaag acctcatctc
      961 agactctaac cccatggtgg tagcgaatgc agtggctgcc ctgtcagaga tcgctgagtc
     1021 tcaccccagt agcaacctgc ttgacttgaa cccacagtct atcaacaagc tgctgacagc
     1081 ccttaatgag tgcactgaat ggggccagat cttcattctg gactgtctgg ccaactacat
     1141 gcccaaggat gaccgtgagg cccagagcat ctgtgagcgg gtcactccta gactctccca
     1201 tgccaactct gctgtggtgc tgtctgcggt gaaggtgctg atgaagttca tggagatgct
     1261 gtccaaggac ctggactact atgccacact gctcaagaag ctggcccctc ccctggtcac
     1321 actgctgtcc gcagagccag agctgcagta tgtggccctg cgcaacatca atctcattgt
     1381 acagaaaagg ccagagatct tgaagcatga aatgaaggtt ttctttgtga agtacaatga
     1441 ccccatctac gtgaagctgg agaaactgga cattatgatc cgcctggcct cccaggccaa
     1501 cattgcccag gtattggcag aactcaaaga gtatgctaca gaagtagacg tggatttcgt
     1561 acggaaggca gtgcgtgcca ttggccgctg tgccatcaag gtggagcaat ctgcagagcg
     1621 ctgtgtgagc acattgcttg atctcatcca gaccaaggtc aactatgtgg ttcaggaagc
     1681 cattgtggtc attaaggaca tcttccgcaa gtaccccaac aagtatgaga gtgtgatagc
     1741 tacactgtgt gagaatctgg actctctgga tgagcctgag gcccgagccg ctatgatctg
     1801 gatagtgggc gagtatgccg agcggattga caatgcagac gagctgctcg agagcttcct
     1861 ggaaggtttc catgatgaga gcactcaggt ccagctacag ctactgacag ccattgtgaa
     1921 actcttcctg aagaagccaa cagagactca ggagctggtg cagcaggtcc tcagtttggc
     1981 cactcaggac tcagacaatc cagaccttcg ggaccgtggc tacatctact ggcgcttgct
     2041 ctccacggac cctgtagctg ctaaagaggt ggtactggct gagaagcccc tcatctcaga
     2101 ggagacagac cttattgagc ctacacttct ggatgaactc atctgctaca ttggcacgct
     2161 ggcctctgtc taccacaagc ctcccaacgc ctttgtggag ggtggccggg gagtggtaca
     2221 taagagcctg ccaccccgca ctgcctcgag tgagagcaca gagagccctg agacagctcc
     2281 tgctggagca cctgctggtg atcagcctga tgtcattcct gcccagggtg acctgttagg
     2341 tgacctcctc aacctggacc ttgggccccc agtgagtggc ccacccttag ctgcctcctc
     2401 cgtgcaaatg ggagctgtgg atcttcttgg tggtggcctc gacagcctga tgggggatga
     2461 gtctgaaggg attggagata gcaactttgg ggcaccttca gcatcagtgg ccgcagcacc
     2521 agcaccagcc agacttggag cacccatcag cagtggctta agtgacctct ttgacctgac
     2581 cagtggtgtg ggcacccttt caggatccta tgtagctccc aaagcagtct ggctccctgc
     2641 catgaaggcc aagggactgg agatctctgg caccttcacc cggcaggctg gctccatctc
     2701 tatggacctg cagctgacta acaaggccct gcaggtcatg acagattttg ctatccagtt
     2761 caatcgtaac agctttggct tggcccctgc tgcacctctc caggtgcacg taccactcag
     2821 ccccaaccag accgtggaga tctccctgcc tcttaacaca gtgggctcag tcttgaagat
     2881 ggagcctcta aacaatcttc aggtggctgt gaagaacaac attgacgtct tctacttcag
     2941 cactttgtac ccactgcatg tcctcttcgt ggaggatggg aagatggacc ggcagatgtt
     3001 cctggccaca tggaaggaca ttgccaacga gaacgaagcc cagttccaga tcagagactg
     3061 cccgcttaac acagaggctg cgagcaacaa gctacagagc agtaacattt tcactgtcgc
     3121 caagaggaac gtggagggcc aggatatgct ctaccaatct ctgaagttga ccaatggcat
     3181 ctgggtgctg gcggagctgc ggatccagcc aggcaacccc agcttcacgg acttggagct
     3241 gtccctgaag tgtcgagcac cggaggtgtc ccagcatgta taccaggcct acgagactat
     3301 cctcaagaac tgaagccctg tcgcatccac cccagccttc tgccagccca gtcatggaac
     3361 cctgcaggtg gcagtacctc ctcctttctt tgaggaaagg ccaggtgggc tcctgaacca
     3421 cccaggaggc tcccctgatc ctaactgagg gtctggagca gggccatgtc tcctcccaga
     3481 gtgaaatctc agtgcatctc cagtggctgc ttttttctat tgctgttgat gtgggatcaa
     3541 aggaaatgga gccagcacag catcagaagc tggacagagg gccacagggt gctcttcctt
     3601 ctcttctcct gggtgtgaac atggacccca cccccacccc cagggtccta gcccataatc
     3661 cctgcccagt ctcctcagtg agcctgtcct gggtggagtc ctctgggtgc caatattact
     3721 gcttgggact ccaagggctg gaagtggtga tgggcagatg tgagcccaga ggagcagcct
     3781 gggccagcac catctgcccc atgtaacccc agtcggtgct ctgtggccac ctgcaggtcc
     3841 cagagcccag ctgggattat gttctctgtg ccccggaaga tggtcactgc ctacaaaaca
     3901 ttcctggtgt cccctctgtg agtccagggc tcttagaaca gaaatagggt aagaggtgga
     3961 gcaaggggca gtggacatgc ttctggtgtg aggtcctgtg ggttctccag cagccgctgg
     4021 ctcccctggc tcccagtctg tgtgtgtgac agctatcctg tcactgctgt ttgataataa
     4081 agagattctg ctttcggcaa tcatgcacat ttcttccctc tacaaactgc ttctggtaac
     4141 tggggatgtc tgatcctgca gtaattatat ctaatacata taatgaaata tatattgtat
     4201 atttaccctt ttttcaaata agaaagtgaa taaaaacgat gacatcaagt aagttcctgg
     4261 ccagtgtgtc aggtggtaag gctcttctgg gcaggagtcc tgcgctgaag ccataaaaaa
     4321 aaaaaaaaaa aaaaaa
//
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