LOCUS NM_001243043 4336 bp mRNA linear ROD 17-DEC-2022
DEFINITION Mus musculus adaptor protein complex AP-1, beta 1 subunit (Ap1b1),
transcript variant 1, mRNA.
ACCESSION NM_001243043
VERSION NM_001243043.1
KEYWORDS RefSeq.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (bases 1 to 4336)
AUTHORS Zhang X, Wang Z, Xu Q, Chen Y, Liu W, Zhong T, Li H, Quan C, Zhang
L and Cui CP.
TITLE Splicing factor Srsf5 deletion disrupts alternative splicing and
causes noncompaction of ventricular myocardium
JOURNAL iScience 24 (10), 103097 (2021)
PUBMED 34622152
REMARK Publication Status: Online-Only
REFERENCE 2 (bases 1 to 4336)
AUTHORS San Agustin JT, Klena N, Granath K, Panigrahy A, Stewart E, Devine
W, Strittmatter L, Jonassen JA, Liu X, Lo CW and Pazour GJ.
TITLE Genetic link between renal birth defects and congenital heart
disease
JOURNAL Nat Commun 7, 11103 (2016)
PUBMED 27002738
REMARK Erratum:[Nat Commun. 2016 Jun 08;7:11910. PMID: 27273704]
Publication Status: Online-Only
REFERENCE 3 (bases 1 to 4336)
AUTHORS Folsch H.
TITLE Role of the epithelial cell-specific clathrin adaptor complex AP-1B
in cell polarity
JOURNAL Cell Logist 5 (2), e1074331 (2015)
PUBMED 27057418
REMARK Review article
Publication Status: Online-Only
REFERENCE 4 (bases 1 to 4336)
AUTHORS Li Y, Klena NT, Gabriel GC, Liu X, Kim AJ, Lemke K, Chen Y,
Chatterjee B, Devine W, Damerla RR, Chang C, Yagi H, San Agustin
JT, Thahir M, Anderton S, Lawhead C, Vescovi A, Pratt H, Morgan J,
Haynes L, Smith CL, Eppig JT, Reinholdt L, Francis R, Leatherbury
L, Ganapathiraju MK, Tobita K, Pazour GJ and Lo CW.
TITLE Global genetic analysis in mice unveils central role for cilia in
congenital heart disease
JOURNAL Nature 521 (7553), 520-524 (2015)
PUBMED 25807483
REFERENCE 5 (bases 1 to 4336)
AUTHORS Tomanek RJ, Yu Q and Lo CW.
TITLE Coronary anomalies in mice with congenital heart defects
JOURNAL Anat Rec (Hoboken) 298 (2), 408-417 (2015)
PUBMED 25266175
REFERENCE 6 (bases 1 to 4336)
AUTHORS Nakagawa T, Setou M, Seog D, Ogasawara K, Dohmae N, Takio K and
Hirokawa N.
TITLE A novel motor, KIF13A, transports mannose-6-phosphate receptor to
plasma membrane through direct interaction with AP-1 complex
JOURNAL Cell 103 (4), 569-581 (2000)
PUBMED 11106728
REFERENCE 7 (bases 1 to 4336)
AUTHORS Takatsu H, Sakurai M, Shin HW, Murakami K and Nakayama K.
TITLE Identification and characterization of novel clathrin
adaptor-related proteins
JOURNAL J Biol Chem 273 (38), 24693-24700 (1998)
PUBMED 9733768
REFERENCE 8 (bases 1 to 4336)
AUTHORS Odorizzi G, Cowles CR and Emr SD.
TITLE The AP-3 complex: a coat of many colours
JOURNAL Trends Cell Biol 8 (7), 282-288 (1998)
PUBMED 9714600
REMARK Review article
REFERENCE 9 (bases 1 to 4336)
AUTHORS Seroussi E, Pan HQ, Kedra D, Roe BA and Dumanski JP.
TITLE Characterization of the human NIPSNAP1 gene from 22q12: a member of
a novel gene family
JOURNAL Gene 212 (1), 13-20 (1998)
PUBMED 9661659
REFERENCE 10 (bases 1 to 4336)
AUTHORS Guilbaud C, Peyrard M, Fransson I, Clifton SW, Roe BA, Carter NP
and Dumanski JP.
TITLE Characterization of the mouse beta-prime adaptin gene; cDNA
sequence, genomic structure, and chromosomal localization
JOURNAL Mamm Genome 8 (9), 651-656 (1997)
PUBMED 9271666
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AK034140.1, CA315828.1 and BP765289.1.
[WARNING] On Mar 2, 2023 this sequence was replaced by
NM_001243043.2.
Transcript Variant: This variant (1) represents the longest variant
and encodes the longest isoform (1).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK034140.1, SRR1660821.58520.1
[ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMN00849384, SAMN01164131
[ECO:0000348]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-301 AK034140.1 2-302
302-316 AK034140.1 304-318
317-1308 AK034140.1 320-1311
1309-1654 CA315828.1 332-677
1655-4250 AK034140.1 1658-4253
4251-4336 BP765289.1 1-86 c
FEATURES Location/Qualifiers
source 1..4336
/organism="Mus musculus"
/mol_type="mRNA"
/strain="C57BL/6"
/db_xref="taxon:10090"
/chromosome="11"
/map="11"
gene 1..4336
/gene="Ap1b1"
/gene_synonym="Adtb1; b2b1660Clo"
/note="adaptor protein complex AP-1, beta 1 subunit"
/db_xref="GeneID:11764"
/db_xref="MGI:MGI:1096368"
exon 1..425
/gene="Ap1b1"
/gene_synonym="Adtb1; b2b1660Clo"
/inference="alignment:Splign:2.1.0"
exon 426..488
/gene="Ap1b1"
/gene_synonym="Adtb1; b2b1660Clo"
/inference="alignment:Splign:2.1.0"
misc_feature 440..442
/gene="Ap1b1"
/gene_synonym="Adtb1; b2b1660Clo"
/note="upstream in-frame stop codon"
CDS 452..3313
/gene="Ap1b1"
/gene_synonym="Adtb1; b2b1660Clo"
/note="isoform 1 is encoded by transcript variant 1;
beta-adaptin 1; golgi adaptor HA1/AP1 adaptin beta
subunit; adaptor protein complex AP-1 subunit beta-1;
clathrin assembly protein complex 1 beta large chain;
adaptor-related protein complex AP-1, beta 1 subunit;
beta-prime adaptin"
/codon_start=1
/product="AP-1 complex subunit beta-1 isoform 1"
/protein_id="NP_001229972.1"
/db_xref="GeneID:11764"
/db_xref="MGI:MGI:1096368"
/translation="MTDSKYFTTTKKGEIFELKAELNSDKKEKKKEAVKKVIASMTVG
KDVSALFPDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDPNPLI
RALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQLVEDQG
FLDTLKDLISDSNPMVVANAVAALSEIAESHPSSNLLDLNPQSINKLLTALNECTEWG
QIFILDCLANYMPKDDREAQSICERVTPRLSHANSAVVLSAVKVLMKFMEMLSKDLDY
YATLLKKLAPPLVTLLSAEPELQYVALRNINLIVQKRPEILKHEMKVFFVKYNDPIYV
KLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCV
STLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESVIATLCENLDSLDEPEARAAMIW
IVGEYAERIDNADELLESFLEGFHDESTQVQLQLLTAIVKLFLKKPTETQELVQQVLS
LATQDSDNPDLRDRGYIYWRLLSTDPVAAKEVVLAEKPLISEETDLIEPTLLDELICY
IGTLASVYHKPPNAFVEGGRGVVHKSLPPRTASSESTESPETAPAGAPAGDQPDVIPA
QGDLLGDLLNLDLGPPVSGPPLAASSVQMGAVDLLGGGLDSLMGDESEGIGDSNFGAP
SASVAAAPAPARLGAPISSGLSDLFDLTSGVGTLSGSYVAPKAVWLPAMKAKGLEISG
TFTRQAGSISMDLQLTNKALQVMTDFAIQFNRNSFGLAPAAPLQVHVPLSPNQTVEIS
LPLNTVGSVLKMEPLNNLQVAVKNNIDVFYFSTLYPLHVLFVEDGKMDRQMFLATWKD
IANENEAQFQIRDCPLNTEAASNKLQSSNIFTVAKRNVEGQDMLYQSLKLTNGIWVLA
ELRIQPGNPSFTDLELSLKCRAPEVSQHVYQAYETILKN"
misc_feature 1403..1405
/gene="Ap1b1"
/gene_synonym="Adtb1; b2b1660Clo"
/note="N6-acetyllysine.
/evidence=ECO:0000250|UniProtKB:Q10567; propagated from
UniProtKB/Swiss-Prot (O35643.2); acetylation site"
misc_feature 2201..2314
/gene="Ap1b1"
/gene_synonym="Adtb1; b2b1660Clo"
/note="propagated from UniProtKB/Swiss-Prot (O35643.2);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
exon 489..594
/gene="Ap1b1"
/gene_synonym="Adtb1; b2b1660Clo"
/inference="alignment:Splign:2.1.0"
exon 595..730
/gene="Ap1b1"
/gene_synonym="Adtb1; b2b1660Clo"
/inference="alignment:Splign:2.1.0"
exon 731..976
/gene="Ap1b1"
/gene_synonym="Adtb1; b2b1660Clo"
/inference="alignment:Splign:2.1.0"
exon 977..1167
/gene="Ap1b1"
/gene_synonym="Adtb1; b2b1660Clo"
/inference="alignment:Splign:2.1.0"
exon 1168..1389
/gene="Ap1b1"
/gene_synonym="Adtb1; b2b1660Clo"
/inference="alignment:Splign:2.1.0"
exon 1390..1510
/gene="Ap1b1"
/gene_synonym="Adtb1; b2b1660Clo"
/inference="alignment:Splign:2.1.0"
exon 1511..1606
/gene="Ap1b1"
/gene_synonym="Adtb1; b2b1660Clo"
/inference="alignment:Splign:2.1.0"
exon 1607..1722
/gene="Ap1b1"
/gene_synonym="Adtb1; b2b1660Clo"
/inference="alignment:Splign:2.1.0"
exon 1723..1888
/gene="Ap1b1"
/gene_synonym="Adtb1; b2b1660Clo"
/inference="alignment:Splign:2.1.0"
exon 1889..1987
/gene="Ap1b1"
/gene_synonym="Adtb1; b2b1660Clo"
/inference="alignment:Splign:2.1.0"
exon 1988..2247
/gene="Ap1b1"
/gene_synonym="Adtb1; b2b1660Clo"
/inference="alignment:Splign:2.1.0"
exon 2248..2449
/gene="Ap1b1"
/gene_synonym="Adtb1; b2b1660Clo"
/inference="alignment:Splign:2.1.0"
exon 2450..2470
/gene="Ap1b1"
/gene_synonym="Adtb1; b2b1660Clo"
/inference="alignment:Splign:2.1.0"
exon 2471..2626
/gene="Ap1b1"
/gene_synonym="Adtb1; b2b1660Clo"
/inference="alignment:Splign:2.1.0"
exon 2627..2772
/gene="Ap1b1"
/gene_synonym="Adtb1; b2b1660Clo"
/inference="alignment:Splign:2.1.0"
exon 2773..2902
/gene="Ap1b1"
/gene_synonym="Adtb1; b2b1660Clo"
/inference="alignment:Splign:2.1.0"
exon 2903..2987
/gene="Ap1b1"
/gene_synonym="Adtb1; b2b1660Clo"
/inference="alignment:Splign:2.1.0"
exon 2988..3074
/gene="Ap1b1"
/gene_synonym="Adtb1; b2b1660Clo"
/inference="alignment:Splign:2.1.0"
exon 3075..3229
/gene="Ap1b1"
/gene_synonym="Adtb1; b2b1660Clo"
/inference="alignment:Splign:2.1.0"
exon 3230..3238
/gene="Ap1b1"
/gene_synonym="Adtb1; b2b1660Clo"
/inference="alignment:Splign:2.1.0"
exon 3239..4315
/gene="Ap1b1"
/gene_synonym="Adtb1; b2b1660Clo"
/inference="alignment:Splign:2.1.0"
ORIGIN
1 ggcgcggccg gcttgctgct gccgcagcgc cgccgcctcg ccctccaggc tgcggttgtg
61 cgcctcgagc tgcctcacct tgtcgatgta gcccgcgaag cggtcgttca gagcctgcag
121 ctgctccttc tcgctgcgcg ccgccaccgc cgccaccacg cagccctctg ggccgttgct
181 tagggtgtct agcgagtcgg tgctcgaggc ggcgccgcgg aagcggctgg gtgaggcgga
241 cacggagctc acggacgtcc gcgcccacga gtggaagccg ctggaggagc cggccgcgga
301 gcgcgtgccg cccgggcctg ccttgcggct cagcgagtag tgcaggctgc cgcctccgtg
361 cagcggcgcg aacggggcgc ccagcagcgc atcggcgctg ccgaagctca tcatggccgg
421 agcagagtct ggccacagat aaaggaccaa aatgactgac tcaaaatact tcaccacaac
481 caagaaaggg gagatctttg agctgaaggc agagcttaac agtgacaaga aggagaagaa
541 gaaggaggca gtgaagaaag tgattgcatc aatgactgtg ggcaaagatg tcagtgctct
601 cttccctgat gtggtgaact gcatgcagac agacaacctg gagctaaaga agctggtgta
661 cctgtacttg atgaactatg ccaagagtca gcctgacatg gccattatgg ctgtcaacac
721 ctttgtgaag gactgtgagg accccaatcc tctcatccgg gccctggctg tgaggactat
781 gggctgcatc cgagttgaca agattacaga gtacttgtgt gaaccactcc ggaagtgcct
841 gaaggatgaa gacccatatg tgcgcaagac agcggctgtg tgtgtggcca agctccatga
901 catcaatgcc cagctggtag aagaccaggg cttcctggac acgcttaaag acctcatctc
961 agactctaac cccatggtgg tagcgaatgc agtggctgcc ctgtcagaga tcgctgagtc
1021 tcaccccagt agcaacctgc ttgacttgaa cccacagtct atcaacaagc tgctgacagc
1081 ccttaatgag tgcactgaat ggggccagat cttcattctg gactgtctgg ccaactacat
1141 gcccaaggat gaccgtgagg cccagagcat ctgtgagcgg gtcactccta gactctccca
1201 tgccaactct gctgtggtgc tgtctgcggt gaaggtgctg atgaagttca tggagatgct
1261 gtccaaggac ctggactact atgccacact gctcaagaag ctggcccctc ccctggtcac
1321 actgctgtcc gcagagccag agctgcagta tgtggccctg cgcaacatca atctcattgt
1381 acagaaaagg ccagagatct tgaagcatga aatgaaggtt ttctttgtga agtacaatga
1441 ccccatctac gtgaagctgg agaaactgga cattatgatc cgcctggcct cccaggccaa
1501 cattgcccag gtattggcag aactcaaaga gtatgctaca gaagtagacg tggatttcgt
1561 acggaaggca gtgcgtgcca ttggccgctg tgccatcaag gtggagcaat ctgcagagcg
1621 ctgtgtgagc acattgcttg atctcatcca gaccaaggtc aactatgtgg ttcaggaagc
1681 cattgtggtc attaaggaca tcttccgcaa gtaccccaac aagtatgaga gtgtgatagc
1741 tacactgtgt gagaatctgg actctctgga tgagcctgag gcccgagccg ctatgatctg
1801 gatagtgggc gagtatgccg agcggattga caatgcagac gagctgctcg agagcttcct
1861 ggaaggtttc catgatgaga gcactcaggt ccagctacag ctactgacag ccattgtgaa
1921 actcttcctg aagaagccaa cagagactca ggagctggtg cagcaggtcc tcagtttggc
1981 cactcaggac tcagacaatc cagaccttcg ggaccgtggc tacatctact ggcgcttgct
2041 ctccacggac cctgtagctg ctaaagaggt ggtactggct gagaagcccc tcatctcaga
2101 ggagacagac cttattgagc ctacacttct ggatgaactc atctgctaca ttggcacgct
2161 ggcctctgtc taccacaagc ctcccaacgc ctttgtggag ggtggccggg gagtggtaca
2221 taagagcctg ccaccccgca ctgcctcgag tgagagcaca gagagccctg agacagctcc
2281 tgctggagca cctgctggtg atcagcctga tgtcattcct gcccagggtg acctgttagg
2341 tgacctcctc aacctggacc ttgggccccc agtgagtggc ccacccttag ctgcctcctc
2401 cgtgcaaatg ggagctgtgg atcttcttgg tggtggcctc gacagcctga tgggggatga
2461 gtctgaaggg attggagata gcaactttgg ggcaccttca gcatcagtgg ccgcagcacc
2521 agcaccagcc agacttggag cacccatcag cagtggctta agtgacctct ttgacctgac
2581 cagtggtgtg ggcacccttt caggatccta tgtagctccc aaagcagtct ggctccctgc
2641 catgaaggcc aagggactgg agatctctgg caccttcacc cggcaggctg gctccatctc
2701 tatggacctg cagctgacta acaaggccct gcaggtcatg acagattttg ctatccagtt
2761 caatcgtaac agctttggct tggcccctgc tgcacctctc caggtgcacg taccactcag
2821 ccccaaccag accgtggaga tctccctgcc tcttaacaca gtgggctcag tcttgaagat
2881 ggagcctcta aacaatcttc aggtggctgt gaagaacaac attgacgtct tctacttcag
2941 cactttgtac ccactgcatg tcctcttcgt ggaggatggg aagatggacc ggcagatgtt
3001 cctggccaca tggaaggaca ttgccaacga gaacgaagcc cagttccaga tcagagactg
3061 cccgcttaac acagaggctg cgagcaacaa gctacagagc agtaacattt tcactgtcgc
3121 caagaggaac gtggagggcc aggatatgct ctaccaatct ctgaagttga ccaatggcat
3181 ctgggtgctg gcggagctgc ggatccagcc aggcaacccc agcttcacgg acttggagct
3241 gtccctgaag tgtcgagcac cggaggtgtc ccagcatgta taccaggcct acgagactat
3301 cctcaagaac tgaagccctg tcgcatccac cccagccttc tgccagccca gtcatggaac
3361 cctgcaggtg gcagtacctc ctcctttctt tgaggaaagg ccaggtgggc tcctgaacca
3421 cccaggaggc tcccctgatc ctaactgagg gtctggagca gggccatgtc tcctcccaga
3481 gtgaaatctc agtgcatctc cagtggctgc ttttttctat tgctgttgat gtgggatcaa
3541 aggaaatgga gccagcacag catcagaagc tggacagagg gccacagggt gctcttcctt
3601 ctcttctcct gggtgtgaac atggacccca cccccacccc cagggtccta gcccataatc
3661 cctgcccagt ctcctcagtg agcctgtcct gggtggagtc ctctgggtgc caatattact
3721 gcttgggact ccaagggctg gaagtggtga tgggcagatg tgagcccaga ggagcagcct
3781 gggccagcac catctgcccc atgtaacccc agtcggtgct ctgtggccac ctgcaggtcc
3841 cagagcccag ctgggattat gttctctgtg ccccggaaga tggtcactgc ctacaaaaca
3901 ttcctggtgt cccctctgtg agtccagggc tcttagaaca gaaatagggt aagaggtgga
3961 gcaaggggca gtggacatgc ttctggtgtg aggtcctgtg ggttctccag cagccgctgg
4021 ctcccctggc tcccagtctg tgtgtgtgac agctatcctg tcactgctgt ttgataataa
4081 agagattctg ctttcggcaa tcatgcacat ttcttccctc tacaaactgc ttctggtaac
4141 tggggatgtc tgatcctgca gtaattatat ctaatacata taatgaaata tatattgtat
4201 atttaccctt ttttcaaata agaaagtgaa taaaaacgat gacatcaagt aagttcctgg
4261 ccagtgtgtc aggtggtaag gctcttctgg gcaggagtcc tgcgctgaag ccataaaaaa
4321 aaaaaaaaaa aaaaaa
//