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Homo sapiens ring finger protein, transmembrane 2 (RNFT2), transcript variant 1, mRNA

NCBI Reference Sequence: NM_001109903.2

FASTA Graphics 

LOCUS       NM_001109903            2874 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens ring finger protein, transmembrane 2 (RNFT2),
            transcript variant 1, mRNA.
ACCESSION   NM_001109903
VERSION     NM_001109903.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2874)
  AUTHORS   Sasahara,M., Kanda,M., Shimizu,D., Tanaka,C., Inokawa,Y.,
            Hattori,N., Hayashi,M., Nakayama,G. and Kodera,Y.
  TITLE     Tissue RNFT2 Expression Levels Are Associated With Peritoneal
            Recurrence and Poor Prognosis in Gastric Cancer
  JOURNAL   Anticancer Res 41 (2), 609-617 (2021)
   PUBMED   33517265
  REMARK    GeneRIF: Tissue RNFT2 Expression Levels Are Associated With
            Peritoneal Recurrence and Poor Prognosis in Gastric Cancer.
REFERENCE   2  (bases 1 to 2874)
  AUTHORS   Tong,Y., Lear,T.B., Evankovich,J., Chen,Y., Londino,J.D.,
            Myerburg,M.M., Zhang,Y., Popescu,I.D., McDyer,J.F., McVerry,B.J.,
            Lockwood,K.C., Jurczak,M.J., Liu,Y. and Chen,B.B.
  TITLE     The RNFT2/IL-3Ralpha axis regulates IL-3 signaling and innate
            immunity
  JOURNAL   JCI Insight 5 (3), 133652 (2020)
   PUBMED   31990690
  REMARK    GeneRIF: The RNFT2/IL-3Ralpha axis regulates IL-3 signaling and
            innate immunity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2874)
  AUTHORS   Kamboh,M.I., Barmada,M.M., Demirci,F.Y., Minster,R.L.,
            Carrasquillo,M.M., Pankratz,V.S., Younkin,S.G., Saykin,A.J.,
            Sweet,R.A., Feingold,E., DeKosky,S.T. and Lopez,O.L.
  CONSRTM   Alzheimer's Disease Neuroimaging Initiative
  TITLE     Genome-wide association analysis of age-at-onset in Alzheimer's
            disease
  JOURNAL   Mol Psychiatry 17 (12), 1340-1346 (2012)
   PUBMED   22005931
REFERENCE   4  (bases 1 to 2874)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   5  (bases 1 to 2874)
  AUTHORS   Scherer,S.E., Muzny,D.M., Buhay,C.J., Chen,R., Cree,A., Ding,Y.,
            Dugan-Rocha,S., Gill,R., Gunaratne,P., Harris,R.A., Hawes,A.C.,
            Hernandez,J., Hodgson,A.V., Hume,J., Jackson,A., Khan,Z.M.,
            Kovar-Smith,C., Lewis,L.R., Lozado,R.J., Metzker,M.L.,
            Milosavljevic,A., Miner,G.R., Montgomery,K.T., Morgan,M.B.,
            Nazareth,L.V., Scott,G., Sodergren,E., Song,X.Z., Steffen,D.,
            Lovering,R.C., Wheeler,D.A., Worley,K.C., Yuan,Y., Zhang,Z.,
            Adams,C.Q., Ansari-Lari,M.A., Ayele,M., Brown,M.J., Chen,G.,
            Chen,Z., Clerc-Blankenburg,K.P., Davis,C., Delgado,O., Dinh,H.H.,
            Draper,H., Gonzalez-Garay,M.L., Havlak,P., Jackson,L.R.,
            Jacob,L.S., Kelly,S.H., Li,L., Li,Z., Liu,J., Liu,W., Lu,J.,
            Maheshwari,M., Nguyen,B.V., Okwuonu,G.O., Pasternak,S., Perez,L.M.,
            Plopper,F.J., Santibanez,J., Shen,H., Tabor,P.E., Verduzco,D.,
            Waldron,L., Wang,Q., Williams,G.A., Zhang,J., Zhou,J., Allen,C.C.,
            Amin,A.G., Anyalebechi,V., Bailey,M., Barbaria,J.A., Bimage,K.E.,
            Bryant,N.P., Burch,P.E., Burkett,C.E., Burrell,K.L., Calderon,E.,
            Cardenas,V., Carter,K., Casias,K., Cavazos,I., Cavazos,S.R.,
            Ceasar,H., Chacko,J., Chan,S.N., Chavez,D., Christopoulos,C.,
            Chu,J., Cockrell,R., Cox,C.D., Dang,M., Dathorne,S.R., David,R.,
            Davis,C.M., Davy-Carroll,L., Deshazo,D.R., Donlin,J.E., D'Souza,L.,
            Eaves,K.A., Simons,R., Emery-Cohen,A.J., Escotto,M., Flagg,N.,
            Forbes,L.D., Gabisi,A.M., Garza,M., Hamilton,C., Henderson,N.,
            Hernandez,O., Hines,S., Hogues,M.E., Huang,M., Idlebird,D.G.,
            Johnson,R., Jolivet,A., Jones,S., Kagan,R., King,L.M., Leal,B.,
            Lebow,H., Lee,S., LeVan,J.M., Lewis,L.C., London,P.,
            Lorensuhewa,L.M., Loulseged,H., Lovett,D.A., Lucier,A.,
            Lucier,R.L., Ma,J., Madu,R.C., Mapua,P., Martindale,A.D.,
            Martinez,E., Massey,E., Mawhiney,S., Meador,M.G., Mendez,S.,
            Mercado,C., Mercado,I.C., Merritt,C.E., Miner,Z.L., Minja,E.,
            Mitchell,T., Mohabbat,F., Mohabbat,K., Montgomery,B., Moore,N.,
            Morris,S., Munidasa,M., Ngo,R.N., Nguyen,N.B., Nickerson,E.,
            Nwaokelemeh,O.O., Nwokenkwo,S., Obregon,M., Oguh,M., Oragunye,N.,
            Oviedo,R.J., Parish,B.J., Parker,D.N., Parrish,J., Parks,K.L.,
            Paul,H.A., Payton,B.A., Perez,A., Perrin,W., Pickens,A.,
            Primus,E.L., Pu,L.L., Puazo,M., Quiles,M.M., Quiroz,J.B.,
            Rabata,D., Reeves,K., Ruiz,S.J., Shao,H., Sisson,I., Sonaike,T.,
            Sorelle,R.P., Sutton,A.E., Svatek,A.F., Svetz,L.A., Tamerisa,K.S.,
            Taylor,T.R., Teague,B., Thomas,N., Thorn,R.D., Trejos,Z.Y.,
            Trevino,B.K., Ukegbu,O.N., Urban,J.B., Vasquez,L.I., Vera,V.A.,
            Villasana,D.M., Wang,L., Ward-Moore,S., Warren,J.T., Wei,X.,
            White,F., Williamson,A.L., Wleczyk,R., Wooden,H.S., Wooden,S.H.,
            Yen,J., Yoon,L., Yoon,V., Zorrilla,S.E., Nelson,D.,
            Kucherlapati,R., Weinstock,G. and Gibbs,R.A.
  CONSRTM   Baylor College of Medicine Human Genome Sequencing Center Sequence
            Production Team
  TITLE     The finished DNA sequence of human chromosome 12
  JOURNAL   Nature 440 (7082), 346-351 (2006)
   PUBMED   16541075
REFERENCE   6  (bases 1 to 2874)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG719293.1, BQ676121.1, AK093164.1, AC083806.16 and CA432422.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001109903.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.1399567.1,
                                           SRR14038194.2007844.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-402               BG719293.1         30-431
            403-889             BQ676121.1         98-584
            890-1592            AK093164.1         715-1417
            1593-2235           AC083806.16        109121-109763       c
            2236-2874           CA432422.1         17-655              c
FEATURES             Location/Qualifiers
     source          1..2874
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.22"
     gene            1..2874
                     /gene="RNFT2"
                     /gene_synonym="TMEM118"
                     /note="ring finger protein, transmembrane 2"
                     /db_xref="GeneID:84900"
                     /db_xref="HGNC:HGNC:25905"
                     /db_xref="MIM:620254"
     exon            1..56
                     /gene="RNFT2"
                     /gene_synonym="TMEM118"
                     /inference="alignment:Splign:2.1.0"
     exon            57..233
                     /gene="RNFT2"
                     /gene_synonym="TMEM118"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    156..158
                     /gene="RNFT2"
                     /gene_synonym="TMEM118"
                     /note="upstream in-frame stop codon"
     CDS             210..1544
                     /gene="RNFT2"
                     /gene_synonym="TMEM118"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transmembrane protein 118; RING finger and transmembrane
                     domain-containing protein 2; E3 ubiquitin-protein ligase
                     RNFT2"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNFT2 isoform 1"
                     /protein_id="NP_001103373.1"
                     /db_xref="CCDS:CCDS44987.1"
                     /db_xref="GeneID:84900"
                     /db_xref="HGNC:HGNC:25905"
                     /db_xref="MIM:620254"
                     /translation="MWLFTVNQVLRKMQRRHSSNTDNIPPERNRSQALSSEASVDEGG
                     VFESLKAEAASPPALFSGLSGSLPTSSFPSSLVLGSSAGGGDVFIQMPASREEGGGRG
                     EGGAYHHRQPHHHFHHGGHRGGSLLQHVGGDHRGHSEEGGDEQPGTPAPALSELKAVI
                     CWLQKGLPFILILLAKLCFQHKLGIAVCIGMASTFAYANSTLREQVSLKEKRSVLVIL
                     WILAFLAGNTLYVLYTFSSQQLYNSLIFLKPNLEMLDFFDLLWIVGIADFVLKYITIA
                     LKCLIVALPKIILAVKSKGKFYLVIEELSQLFRSLVPIQLWYKYIMGDDSSNSYFLGG
                     VLIVLYSLCKSFDICGRVGGVRKALKLLCTSQNYGVRATGQQCTEAGDICAICQAEFR
                     EPLILLCQHVFCEECLCLWLDRERTCPLCRSVAVDTLRCWKDGATSAHFQVY"
     misc_feature    246..332
                     /gene="RNFT2"
                     /gene_synonym="TMEM118"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96EX2.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    483..656
                     /gene="RNFT2"
                     /gene_synonym="TMEM118"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96EX2.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    753..815
                     /gene="RNFT2"
                     /gene_synonym="TMEM118"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96EX2.2);
                     transmembrane region"
     misc_feature    852..914
                     /gene="RNFT2"
                     /gene_synonym="TMEM118"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96EX2.2);
                     transmembrane region"
     misc_feature    975..1037
                     /gene="RNFT2"
                     /gene_synonym="TMEM118"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96EX2.2);
                     transmembrane region"
     misc_feature    1197..1259
                     /gene="RNFT2"
                     /gene_synonym="TMEM118"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96EX2.2);
                     transmembrane region"
     exon            234..292
                     /gene="RNFT2"
                     /gene_synonym="TMEM118"
                     /inference="alignment:Splign:2.1.0"
     exon            293..759
                     /gene="RNFT2"
                     /gene_synonym="TMEM118"
                     /inference="alignment:Splign:2.1.0"
     exon            760..836
                     /gene="RNFT2"
                     /gene_synonym="TMEM118"
                     /inference="alignment:Splign:2.1.0"
     exon            837..937
                     /gene="RNFT2"
                     /gene_synonym="TMEM118"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1091
                     /gene="RNFT2"
                     /gene_synonym="TMEM118"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1241
                     /gene="RNFT2"
                     /gene_synonym="TMEM118"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1307
                     /gene="RNFT2"
                     /gene_synonym="TMEM118"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1409
                     /gene="RNFT2"
                     /gene_synonym="TMEM118"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1580
                     /gene="RNFT2"
                     /gene_synonym="TMEM118"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..2874
                     /gene="RNFT2"
                     /gene_synonym="TMEM118"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2165..2170
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNFT2"
                     /gene_synonym="TMEM118"
                     /note="hexamer: AACAAA"
     polyA_site      2188
                     /gene="RNFT2"
                     /gene_synonym="TMEM118"
                     /note="major polyA site"
     regulatory      2851..2856
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RNFT2"
                     /gene_synonym="TMEM118"
                     /note="hexamer: AATAAA"
     polyA_site      2874
                     /gene="RNFT2"
                     /gene_synonym="TMEM118"
                     /note="major polyA site"
ORIGIN      
        1 gattggcttg gctggacctg aatgatgcgg ctgtgattgc tgaattgtct gggcaggttt
       61 ggagtctctg gcaagctccc ctgactgtgc atccctctgg agacgaagag gagggggagg
      121 cctgtcctct ctgggatcca ttggtcacat ccccctgagg attcccgaat gcctacctcc
      181 agtgtcgtca acatggagtt ctgaagtcca tgtggctctt cacagtgaat caggtgttaa
      241 ggaagatgca gagacgccac agcagcaaca cggataacat tccacctgaa agaaaccgca
      301 gccaggcgct cagctccgag gcgagtgtgg atgaaggtgg cgtctttgag agtctgaagg
      361 cagaggcagc ctccccacca gcgctcttct cgggcttatc aggcagcctc cccaccagct
      421 cgttcccctc cagcctggtg ctgggctcct cggctggcgg cggggacgtg ttcatccaga
      481 tgcccgcgtc cagggaggaa ggagggggcc ggggcgaggg gggcgcctac caccaccgcc
      541 agccccacca ccatttccac catggcggcc accgcggggg ctccctgctg cagcacgtgg
      601 gtggggacca ccgggggcac tcggaggagg gaggcgacga gcagcctggg acgcccgccc
      661 ccgccctgtc cgagctgaag gctgtgatct gctggctcca gaaaggactc cccttcatcc
      721 tgatcctcct ggccaaactg tgctttcagc ataagctcgg cattgctgtg tgcatcggga
      781 tggccagcac cttcgcctat gccaactcca cgcttcgaga acaggtctca ctgaaggaga
      841 agaggtcagt gctggtcatc ttgtggatcc tggcctttct ggcggggaac accctctatg
      901 tgctttatac attcagctcc cagcagctgt acaacagcct catattcctg aagcccaacc
      961 tggagatgct ggacttcttt gacctgctat ggattgtggg gatcgcagac tttgttctga
     1021 agtacatcac catcgccctc aagtgcctca tcgtggccct gcccaagatc atcctggctg
     1081 tcaagtccaa gggaaagttc tatctggtca tcgaggagct gagccagctg ttccgatccc
     1141 ttgtccccat ccagctgtgg tacaaataca tcatgggtga cgactcctcc aacagctact
     1201 tcctgggcgg ggtcctgatc gttctctaca gcctctgcaa gtccttcgac atctgtggac
     1261 gtgtgggcgg agttaggaaa gccctgaagc ttctctgtac ctctcagaac tatggagtcc
     1321 gagccaccgg gcagcagtgc acagaagctg gtgacatctg cgccatctgt caggccgagt
     1381 tccgagagcc tctgattctc ctgtgccagc acgtgttctg tgaggagtgc ctctgcctgt
     1441 ggctggaccg tgagcgcacc tgcccgctct gccgctcggt cgccgtggac accctgcgct
     1501 gctggaagga cggcgccacg tccgcacact tccaggtgta ctaggaccga acactgagga
     1561 cacccagaag gacgccaagg attcaggaca tttgcccctg tgtgccacca aaccaggact
     1621 ttccccttgg cttggcatcc ctggctctct cctggtaccc agcaagacgt ctgttccagg
     1681 gcagtgtagc atctttcaag ctccgttact atggcgatgg ccatgatgtt acaatcccac
     1741 ttgcctgaat aatcaagtgg gaaggggaag cagagggaaa tggggccatg tgaatgcagc
     1801 tgctctgttc tccctaccct gaggaaaaac caaagggaag caacaggaac ttctgcaact
     1861 ggtttttatc ggaaagatca tcctgcctgc agatgctgtt gaaggggcac aagaaattgg
     1921 agctggagaa gattgatgaa agtgcaggtg tgtaaggaaa tagaacagtc tgctgggagt
     1981 cagacctgga attctgattc caaactcttt attactttgg gaagtcactc agcctccctg
     2041 tagccatctc cagggtgacg gaacccagtg tattacctgc tggaaccaag gaaactaaca
     2101 atgtaggtta ctagtgaata ccccaatggt ttctccaatt atgcccatgc caccaaaaca
     2161 ataaaacaaa attctctaac actgcaaaga gtgagccatg cctgttaaca ctgtaaagaa
     2221 tgtaacatgt gggggacaca caggggcaga tgggatggtt tagtttagga ttttattagt
     2281 gcatgcccta ccctctgggg gaacgtccca tctgaggttt tcttctcggt ggggggattt
     2341 aacttctgtc ctagggaaaa cagtgtctga tgaggagtgt ttccaacaca ggctacatga
     2401 attcccctat accagtgcga aagcagccag gagtccccgt tggaaaagaa caatgccact
     2461 ctcttttatg tatcttggtt ctgcaactca tttgttgtaa gtagggttaa tcgagtatca
     2521 ggttcacagt atcctgccct tattatttta tgattcactg actcaagttc cacgaagtcc
     2581 ttagaaatgg acctcttcat gtaaaatatc ttgagaataa taaatgtgag ggaataagaa
     2641 aggcaagctt tggacacaga tatgataggt gcatcagctt cggaagagaa gaatgatgtg
     2701 cagagtgtta ggaagacatc cgggctgctg agactcggga ttagaagaaa gagaggtaaa
     2761 taaagtgggt cctggaatct tttaggactt ctgctgtagg acaaacagct gcctttggtg
     2821 ttttaatgtc tcccaaagta cccttcagcc aataaatacc atctgttggt gcaa
//
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