LOCUS NM_001109903 2874 bp mRNA linear PRI 07-APR-2024
DEFINITION Homo sapiens ring finger protein, transmembrane 2 (RNFT2),
transcript variant 1, mRNA.
ACCESSION NM_001109903
VERSION NM_001109903.2
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2874)
AUTHORS Sasahara,M., Kanda,M., Shimizu,D., Tanaka,C., Inokawa,Y.,
Hattori,N., Hayashi,M., Nakayama,G. and Kodera,Y.
TITLE Tissue RNFT2 Expression Levels Are Associated With Peritoneal
Recurrence and Poor Prognosis in Gastric Cancer
JOURNAL Anticancer Res 41 (2), 609-617 (2021)
PUBMED 33517265
REMARK GeneRIF: Tissue RNFT2 Expression Levels Are Associated With
Peritoneal Recurrence and Poor Prognosis in Gastric Cancer.
REFERENCE 2 (bases 1 to 2874)
AUTHORS Tong,Y., Lear,T.B., Evankovich,J., Chen,Y., Londino,J.D.,
Myerburg,M.M., Zhang,Y., Popescu,I.D., McDyer,J.F., McVerry,B.J.,
Lockwood,K.C., Jurczak,M.J., Liu,Y. and Chen,B.B.
TITLE The RNFT2/IL-3Ralpha axis regulates IL-3 signaling and innate
immunity
JOURNAL JCI Insight 5 (3), 133652 (2020)
PUBMED 31990690
REMARK GeneRIF: The RNFT2/IL-3Ralpha axis regulates IL-3 signaling and
innate immunity.
Publication Status: Online-Only
REFERENCE 3 (bases 1 to 2874)
AUTHORS Kamboh,M.I., Barmada,M.M., Demirci,F.Y., Minster,R.L.,
Carrasquillo,M.M., Pankratz,V.S., Younkin,S.G., Saykin,A.J.,
Sweet,R.A., Feingold,E., DeKosky,S.T. and Lopez,O.L.
CONSRTM Alzheimer's Disease Neuroimaging Initiative
TITLE Genome-wide association analysis of age-at-onset in Alzheimer's
disease
JOURNAL Mol Psychiatry 17 (12), 1340-1346 (2012)
PUBMED 22005931
REFERENCE 4 (bases 1 to 2874)
AUTHORS Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
Gibbs,R.A. and Butte,N.F.
TITLE Novel genetic loci identified for the pathophysiology of childhood
obesity in the Hispanic population
JOURNAL PLoS One 7 (12), e51954 (2012)
PUBMED 23251661
REFERENCE 5 (bases 1 to 2874)
AUTHORS Scherer,S.E., Muzny,D.M., Buhay,C.J., Chen,R., Cree,A., Ding,Y.,
Dugan-Rocha,S., Gill,R., Gunaratne,P., Harris,R.A., Hawes,A.C.,
Hernandez,J., Hodgson,A.V., Hume,J., Jackson,A., Khan,Z.M.,
Kovar-Smith,C., Lewis,L.R., Lozado,R.J., Metzker,M.L.,
Milosavljevic,A., Miner,G.R., Montgomery,K.T., Morgan,M.B.,
Nazareth,L.V., Scott,G., Sodergren,E., Song,X.Z., Steffen,D.,
Lovering,R.C., Wheeler,D.A., Worley,K.C., Yuan,Y., Zhang,Z.,
Adams,C.Q., Ansari-Lari,M.A., Ayele,M., Brown,M.J., Chen,G.,
Chen,Z., Clerc-Blankenburg,K.P., Davis,C., Delgado,O., Dinh,H.H.,
Draper,H., Gonzalez-Garay,M.L., Havlak,P., Jackson,L.R.,
Jacob,L.S., Kelly,S.H., Li,L., Li,Z., Liu,J., Liu,W., Lu,J.,
Maheshwari,M., Nguyen,B.V., Okwuonu,G.O., Pasternak,S., Perez,L.M.,
Plopper,F.J., Santibanez,J., Shen,H., Tabor,P.E., Verduzco,D.,
Waldron,L., Wang,Q., Williams,G.A., Zhang,J., Zhou,J., Allen,C.C.,
Amin,A.G., Anyalebechi,V., Bailey,M., Barbaria,J.A., Bimage,K.E.,
Bryant,N.P., Burch,P.E., Burkett,C.E., Burrell,K.L., Calderon,E.,
Cardenas,V., Carter,K., Casias,K., Cavazos,I., Cavazos,S.R.,
Ceasar,H., Chacko,J., Chan,S.N., Chavez,D., Christopoulos,C.,
Chu,J., Cockrell,R., Cox,C.D., Dang,M., Dathorne,S.R., David,R.,
Davis,C.M., Davy-Carroll,L., Deshazo,D.R., Donlin,J.E., D'Souza,L.,
Eaves,K.A., Simons,R., Emery-Cohen,A.J., Escotto,M., Flagg,N.,
Forbes,L.D., Gabisi,A.M., Garza,M., Hamilton,C., Henderson,N.,
Hernandez,O., Hines,S., Hogues,M.E., Huang,M., Idlebird,D.G.,
Johnson,R., Jolivet,A., Jones,S., Kagan,R., King,L.M., Leal,B.,
Lebow,H., Lee,S., LeVan,J.M., Lewis,L.C., London,P.,
Lorensuhewa,L.M., Loulseged,H., Lovett,D.A., Lucier,A.,
Lucier,R.L., Ma,J., Madu,R.C., Mapua,P., Martindale,A.D.,
Martinez,E., Massey,E., Mawhiney,S., Meador,M.G., Mendez,S.,
Mercado,C., Mercado,I.C., Merritt,C.E., Miner,Z.L., Minja,E.,
Mitchell,T., Mohabbat,F., Mohabbat,K., Montgomery,B., Moore,N.,
Morris,S., Munidasa,M., Ngo,R.N., Nguyen,N.B., Nickerson,E.,
Nwaokelemeh,O.O., Nwokenkwo,S., Obregon,M., Oguh,M., Oragunye,N.,
Oviedo,R.J., Parish,B.J., Parker,D.N., Parrish,J., Parks,K.L.,
Paul,H.A., Payton,B.A., Perez,A., Perrin,W., Pickens,A.,
Primus,E.L., Pu,L.L., Puazo,M., Quiles,M.M., Quiroz,J.B.,
Rabata,D., Reeves,K., Ruiz,S.J., Shao,H., Sisson,I., Sonaike,T.,
Sorelle,R.P., Sutton,A.E., Svatek,A.F., Svetz,L.A., Tamerisa,K.S.,
Taylor,T.R., Teague,B., Thomas,N., Thorn,R.D., Trejos,Z.Y.,
Trevino,B.K., Ukegbu,O.N., Urban,J.B., Vasquez,L.I., Vera,V.A.,
Villasana,D.M., Wang,L., Ward-Moore,S., Warren,J.T., Wei,X.,
White,F., Williamson,A.L., Wleczyk,R., Wooden,H.S., Wooden,S.H.,
Yen,J., Yoon,L., Yoon,V., Zorrilla,S.E., Nelson,D.,
Kucherlapati,R., Weinstock,G. and Gibbs,R.A.
CONSRTM Baylor College of Medicine Human Genome Sequencing Center Sequence
Production Team
TITLE The finished DNA sequence of human chromosome 12
JOURNAL Nature 440 (7082), 346-351 (2006)
PUBMED 16541075
REFERENCE 6 (bases 1 to 2874)
AUTHORS Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
TITLE The secreted protein discovery initiative (SPDI), a large-scale
effort to identify novel human secreted and transmembrane proteins:
a bioinformatics assessment
JOURNAL Genome Res 13 (10), 2265-2270 (2003)
PUBMED 12975309
REMARK Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BG719293.1, BQ676121.1, AK093164.1, AC083806.16 and CA432422.1.
On Aug 13, 2020 this sequence version replaced NM_001109903.1.
Transcript Variant: This variant (1) represents the longer
transcript and encodes the longer isoform (1).
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data because no single transcript was available
for the full length of the gene. The extent of this transcript is
supported by transcript alignments and orthologous data.
##Evidence-Data-START##
Transcript exon combination :: SRR18074969.1399567.1,
SRR14038194.2007844.1 [ECO:0000332]
RNAseq introns :: mixed sample support SAMEA1965299,
SAMEA1966682 [ECO:0006172]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-402 BG719293.1 30-431
403-889 BQ676121.1 98-584
890-1592 AK093164.1 715-1417
1593-2235 AC083806.16 109121-109763 c
2236-2874 CA432422.1 17-655 c
FEATURES Location/Qualifiers
source 1..2874
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="12"
/map="12q24.22"
gene 1..2874
/gene="RNFT2"
/gene_synonym="TMEM118"
/note="ring finger protein, transmembrane 2"
/db_xref="GeneID:84900"
/db_xref="HGNC:HGNC:25905"
/db_xref="MIM:620254"
exon 1..56
/gene="RNFT2"
/gene_synonym="TMEM118"
/inference="alignment:Splign:2.1.0"
exon 57..233
/gene="RNFT2"
/gene_synonym="TMEM118"
/inference="alignment:Splign:2.1.0"
misc_feature 156..158
/gene="RNFT2"
/gene_synonym="TMEM118"
/note="upstream in-frame stop codon"
CDS 210..1544
/gene="RNFT2"
/gene_synonym="TMEM118"
/note="isoform 1 is encoded by transcript variant 1;
transmembrane protein 118; RING finger and transmembrane
domain-containing protein 2; E3 ubiquitin-protein ligase
RNFT2"
/codon_start=1
/product="E3 ubiquitin-protein ligase RNFT2 isoform 1"
/protein_id="NP_001103373.1"
/db_xref="CCDS:CCDS44987.1"
/db_xref="GeneID:84900"
/db_xref="HGNC:HGNC:25905"
/db_xref="MIM:620254"
/translation="MWLFTVNQVLRKMQRRHSSNTDNIPPERNRSQALSSEASVDEGG
VFESLKAEAASPPALFSGLSGSLPTSSFPSSLVLGSSAGGGDVFIQMPASREEGGGRG
EGGAYHHRQPHHHFHHGGHRGGSLLQHVGGDHRGHSEEGGDEQPGTPAPALSELKAVI
CWLQKGLPFILILLAKLCFQHKLGIAVCIGMASTFAYANSTLREQVSLKEKRSVLVIL
WILAFLAGNTLYVLYTFSSQQLYNSLIFLKPNLEMLDFFDLLWIVGIADFVLKYITIA
LKCLIVALPKIILAVKSKGKFYLVIEELSQLFRSLVPIQLWYKYIMGDDSSNSYFLGG
VLIVLYSLCKSFDICGRVGGVRKALKLLCTSQNYGVRATGQQCTEAGDICAICQAEFR
EPLILLCQHVFCEECLCLWLDRERTCPLCRSVAVDTLRCWKDGATSAHFQVY"
misc_feature 246..332
/gene="RNFT2"
/gene_synonym="TMEM118"
/note="propagated from UniProtKB/Swiss-Prot (Q96EX2.2);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 483..656
/gene="RNFT2"
/gene_synonym="TMEM118"
/note="propagated from UniProtKB/Swiss-Prot (Q96EX2.2);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 753..815
/gene="RNFT2"
/gene_synonym="TMEM118"
/note="propagated from UniProtKB/Swiss-Prot (Q96EX2.2);
transmembrane region"
misc_feature 852..914
/gene="RNFT2"
/gene_synonym="TMEM118"
/note="propagated from UniProtKB/Swiss-Prot (Q96EX2.2);
transmembrane region"
misc_feature 975..1037
/gene="RNFT2"
/gene_synonym="TMEM118"
/note="propagated from UniProtKB/Swiss-Prot (Q96EX2.2);
transmembrane region"
misc_feature 1197..1259
/gene="RNFT2"
/gene_synonym="TMEM118"
/note="propagated from UniProtKB/Swiss-Prot (Q96EX2.2);
transmembrane region"
exon 234..292
/gene="RNFT2"
/gene_synonym="TMEM118"
/inference="alignment:Splign:2.1.0"
exon 293..759
/gene="RNFT2"
/gene_synonym="TMEM118"
/inference="alignment:Splign:2.1.0"
exon 760..836
/gene="RNFT2"
/gene_synonym="TMEM118"
/inference="alignment:Splign:2.1.0"
exon 837..937
/gene="RNFT2"
/gene_synonym="TMEM118"
/inference="alignment:Splign:2.1.0"
exon 938..1091
/gene="RNFT2"
/gene_synonym="TMEM118"
/inference="alignment:Splign:2.1.0"
exon 1092..1241
/gene="RNFT2"
/gene_synonym="TMEM118"
/inference="alignment:Splign:2.1.0"
exon 1242..1307
/gene="RNFT2"
/gene_synonym="TMEM118"
/inference="alignment:Splign:2.1.0"
exon 1308..1409
/gene="RNFT2"
/gene_synonym="TMEM118"
/inference="alignment:Splign:2.1.0"
exon 1410..1580
/gene="RNFT2"
/gene_synonym="TMEM118"
/inference="alignment:Splign:2.1.0"
exon 1581..2874
/gene="RNFT2"
/gene_synonym="TMEM118"
/inference="alignment:Splign:2.1.0"
regulatory 2165..2170
/regulatory_class="polyA_signal_sequence"
/gene="RNFT2"
/gene_synonym="TMEM118"
/note="hexamer: AACAAA"
polyA_site 2188
/gene="RNFT2"
/gene_synonym="TMEM118"
/note="major polyA site"
regulatory 2851..2856
/regulatory_class="polyA_signal_sequence"
/gene="RNFT2"
/gene_synonym="TMEM118"
/note="hexamer: AATAAA"
polyA_site 2874
/gene="RNFT2"
/gene_synonym="TMEM118"
/note="major polyA site"
ORIGIN
1 gattggcttg gctggacctg aatgatgcgg ctgtgattgc tgaattgtct gggcaggttt
61 ggagtctctg gcaagctccc ctgactgtgc atccctctgg agacgaagag gagggggagg
121 cctgtcctct ctgggatcca ttggtcacat ccccctgagg attcccgaat gcctacctcc
181 agtgtcgtca acatggagtt ctgaagtcca tgtggctctt cacagtgaat caggtgttaa
241 ggaagatgca gagacgccac agcagcaaca cggataacat tccacctgaa agaaaccgca
301 gccaggcgct cagctccgag gcgagtgtgg atgaaggtgg cgtctttgag agtctgaagg
361 cagaggcagc ctccccacca gcgctcttct cgggcttatc aggcagcctc cccaccagct
421 cgttcccctc cagcctggtg ctgggctcct cggctggcgg cggggacgtg ttcatccaga
481 tgcccgcgtc cagggaggaa ggagggggcc ggggcgaggg gggcgcctac caccaccgcc
541 agccccacca ccatttccac catggcggcc accgcggggg ctccctgctg cagcacgtgg
601 gtggggacca ccgggggcac tcggaggagg gaggcgacga gcagcctggg acgcccgccc
661 ccgccctgtc cgagctgaag gctgtgatct gctggctcca gaaaggactc cccttcatcc
721 tgatcctcct ggccaaactg tgctttcagc ataagctcgg cattgctgtg tgcatcggga
781 tggccagcac cttcgcctat gccaactcca cgcttcgaga acaggtctca ctgaaggaga
841 agaggtcagt gctggtcatc ttgtggatcc tggcctttct ggcggggaac accctctatg
901 tgctttatac attcagctcc cagcagctgt acaacagcct catattcctg aagcccaacc
961 tggagatgct ggacttcttt gacctgctat ggattgtggg gatcgcagac tttgttctga
1021 agtacatcac catcgccctc aagtgcctca tcgtggccct gcccaagatc atcctggctg
1081 tcaagtccaa gggaaagttc tatctggtca tcgaggagct gagccagctg ttccgatccc
1141 ttgtccccat ccagctgtgg tacaaataca tcatgggtga cgactcctcc aacagctact
1201 tcctgggcgg ggtcctgatc gttctctaca gcctctgcaa gtccttcgac atctgtggac
1261 gtgtgggcgg agttaggaaa gccctgaagc ttctctgtac ctctcagaac tatggagtcc
1321 gagccaccgg gcagcagtgc acagaagctg gtgacatctg cgccatctgt caggccgagt
1381 tccgagagcc tctgattctc ctgtgccagc acgtgttctg tgaggagtgc ctctgcctgt
1441 ggctggaccg tgagcgcacc tgcccgctct gccgctcggt cgccgtggac accctgcgct
1501 gctggaagga cggcgccacg tccgcacact tccaggtgta ctaggaccga acactgagga
1561 cacccagaag gacgccaagg attcaggaca tttgcccctg tgtgccacca aaccaggact
1621 ttccccttgg cttggcatcc ctggctctct cctggtaccc agcaagacgt ctgttccagg
1681 gcagtgtagc atctttcaag ctccgttact atggcgatgg ccatgatgtt acaatcccac
1741 ttgcctgaat aatcaagtgg gaaggggaag cagagggaaa tggggccatg tgaatgcagc
1801 tgctctgttc tccctaccct gaggaaaaac caaagggaag caacaggaac ttctgcaact
1861 ggtttttatc ggaaagatca tcctgcctgc agatgctgtt gaaggggcac aagaaattgg
1921 agctggagaa gattgatgaa agtgcaggtg tgtaaggaaa tagaacagtc tgctgggagt
1981 cagacctgga attctgattc caaactcttt attactttgg gaagtcactc agcctccctg
2041 tagccatctc cagggtgacg gaacccagtg tattacctgc tggaaccaag gaaactaaca
2101 atgtaggtta ctagtgaata ccccaatggt ttctccaatt atgcccatgc caccaaaaca
2161 ataaaacaaa attctctaac actgcaaaga gtgagccatg cctgttaaca ctgtaaagaa
2221 tgtaacatgt gggggacaca caggggcaga tgggatggtt tagtttagga ttttattagt
2281 gcatgcccta ccctctgggg gaacgtccca tctgaggttt tcttctcggt ggggggattt
2341 aacttctgtc ctagggaaaa cagtgtctga tgaggagtgt ttccaacaca ggctacatga
2401 attcccctat accagtgcga aagcagccag gagtccccgt tggaaaagaa caatgccact
2461 ctcttttatg tatcttggtt ctgcaactca tttgttgtaa gtagggttaa tcgagtatca
2521 ggttcacagt atcctgccct tattatttta tgattcactg actcaagttc cacgaagtcc
2581 ttagaaatgg acctcttcat gtaaaatatc ttgagaataa taaatgtgag ggaataagaa
2641 aggcaagctt tggacacaga tatgataggt gcatcagctt cggaagagaa gaatgatgtg
2701 cagagtgtta ggaagacatc cgggctgctg agactcggga ttagaagaaa gagaggtaaa
2761 taaagtgggt cctggaatct tttaggactt ctgctgtagg acaaacagct gcctttggtg
2821 ttttaatgtc tcccaaagta cccttcagcc aataaatacc atctgttggt gcaa
//