Homo sapiens HECT domain E3 ubiquitin protein ligase 4 (HECTD4), trans - Nucleotide

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MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons. [Neuron. 2024]
MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.
Liu Y, Flamier A, Bell GW, Diao AJ, Whitfield TW, Wang HC, Wu Y, Schulte F, Friesen M, Guo R, et al. Neuron. 2024 Jun 19; 112(12):1943-1958.e10. Epub 2024 May 1.
The Weakened Interaction Between HECTD4 and GluN2B in Ischemic Stroke Promotes Calcium Overload and Brain Injury Through a Mechanism Involving the Decrease of GluN2B and MALT1 Ubiquitination. [Mol Neurobiol. 2023]
The Weakened Interaction Between HECTD4 and GluN2B in Ischemic Stroke Promotes Calcium Overload and Brain Injury Through a Mechanism Involving the Decrease of GluN2B and MALT1 Ubiquitination.
Zhang YY, Yang XY, Liu HQ, Zhang Z, Hu CP, Peng J, Luo XJ. Mol Neurobiol. 2023 Mar; 60(3):1563-1579. Epub 2022 Dec 17.
Biallelic variants in HECT E3 paralogs, HECTD4 and UBE3C, encoding ubiquitin ligases cause neurodevelopmental disorders that overlap with Angelman syndrome. [Genet Med. 2023]
Biallelic variants in HECT E3 paralogs, HECTD4 and UBE3C, encoding ubiquitin ligases cause neurodevelopmental disorders that overlap with Angelman syndrome.
Faqeih EA, Alghamdi MA, Almahroos MA, Alharby E, Almuntashri M, Alshangiti AM, Clément P, Calame DG, Qebibo L, Burglen L, et al. Genet Med. 2023 Feb; 25(2):100323. Epub 2022 Nov 19.

RefSeq alternative splicing
See the other reference mRNA sequence splice variant for the HECTD4 gene (NM_001388303.1).
RefSeq protein product
See the reference protein sequence for probable E3 ubiquitin-protein ligase HECTD4 isoform 1 (NP_001103132.4).

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Nucleotide