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Homo sapiens NANOG hESC enhancer GRCh37_chr15:81585795-81586313 (LOC127830442) on chromosome 15

NCBI Reference Sequence: NG_131924.1

FASTA Graphics 

LOCUS       NG_131924                519 bp    DNA     linear   CON 08-APR-2023
DEFINITION  Homo sapiens NANOG hESC enhancer GRCh37_chr15:81585795-81586313
            (LOC127830442) on chromosome 15.
ACCESSION   NG_131924 REGION: 101..619
VERSION     NG_131924.1
DBLINK      BioProject: PRJNA343958
KEYWORDS    RefSeq; RefSeqFE.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 519)
  AUTHORS   Barakat TS, Halbritter F, Zhang M, Rendeiro AF, Perenthaler E, Bock
            C and Chambers I.
  TITLE     Functional Dissection of the Enhancer Repertoire in Human Embryonic
            Stem Cells
  JOURNAL   Cell Stem Cell 23 (2), 276-288 (2018)
   PUBMED   30033119
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC103858.2.
            
            Summary: This genomic region was validated as an active enhancer by
            the ChIP-STARR-seq massively parallel reporter assay in naive human
            embryonic stem cells. This enhancer associates with the NANOG
            transcription factor. [provided by RefSeq, Nov 2022].
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-719               AC103858.2         109023-109741
FEATURES             Location/Qualifiers
     source          1..519
                     /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15"
     misc_feature    1..519
                     /standard_name="NANOG hESC enhancer
                     GRCh37_chr15:81585795-81586313"
                     /note="Region: biological region"
                     /db_xref="GeneID:127830442"
     regulatory      1..519
                     /regulatory_class="enhancer"
                     /experiment="EXISTENCE:reporter gene assay evidence
                     [ECO:0000049][PMID:30033119]"
                     /note="NANOG hESC enhancer chr15:81585795-81586313
                     (GRCh37/hg19 assembly coordinates)"
                     /function="activates a minimal SCP1, AML or CMV promoter
                     by ChIP-STARR-seq in naive H9 embryonic stem cells
                     {active_cell/tissue: H9 hESC(naive)}"
                     /db_xref="GeneID:127830442"
ORIGIN      
        1 gcactttggg aggctgagcc gggtggatca tgagctcagg agttcaagac cagcctggcc
       61 aagatggtga aaccctgtct ctactaacaa tacaaaaatt agccgggtat ggtggcaggt
      121 gcctgtaatc ccagctacgc aggaggctga ggcagggaat tgcttaaacc cgggaggagt
      181 ggctccttcc aagggctatt gtgaggatta aaggtaacca cttaaggcaa gtacctgaca
      241 gcatctcagg catattagca ttcattgcca tgatctttcc ccatcaggcc ccttaaagcc
      301 ctcctttcca ccccttgcat aaaaggcaga ctgactgaca gacagctgct gtgtctagaa
      361 ccattttatg cgcaggctaa ccacactgag tactttcatg tacattgtgt caattaaatc
      421 ttacaaccac ctgatggtga gagtcccagt tgtgcaaaga gggaactgag aaactcgctc
      481 aagttcacat tgctagtggg tcacagttac ccactatgc
//
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