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Pseudomonas aeruginosa PAO1, complete genome

NCBI Reference Sequence: NC_002516.2

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LOCUS       NC_002516               1329 bp    DNA     linear   CON 24-JAN-2019
DEFINITION  Pseudomonas aeruginosa PAO1, complete genome.
ACCESSION   NC_002516 REGION: 4683697..4685025
VERSION     NC_002516.2
DBLINK      BioProject: PRJNA57945
            Assembly: GCF_000006765.1
KEYWORDS    RefSeq.
SOURCE      Pseudomonas aeruginosa PAO1
  ORGANISM  Pseudomonas aeruginosa PAO1
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Pseudomonadales; Pseudomonadaceae; Pseudomonas.
REFERENCE   1  (bases 1 to 1329)
  AUTHORS   Winsor,G.L., Van Rossum,T., Lo,R., Khaira,B., Whiteside,M.D.,
            Hancock,R.E. and Brinkman,F.S.
  TITLE     Pseudomonas Genome Database: facilitating user-friendly,
            comprehensive comparisons of microbial genomes
  JOURNAL   Nucleic acids Res. 37 (DATABASE ISSUE), D483-D488 (2009)
   PUBMED   18978025
REFERENCE   2  (bases 1 to 1329)
  AUTHORS   Cirz,R.T., O'Neill,B.M., Hammond,J.A., Head,S.R. and Romesberg,F.E.
  TITLE     Defining the Pseudomonas aeruginosa SOS response and its role in
            the global response to the antibiotic ciprofloxacin
  JOURNAL   J. Bacteriol. 188 (20), 7101-7110 (2006)
   PUBMED   17015649
REFERENCE   3  (bases 1 to 1329)
  AUTHORS   Palmer,K.L., Mashburn,L.M., Singh,P.K. and Whiteley,M.
  TITLE     Cystic fibrosis sputum supports growth and cues key aspects of
            Pseudomonas aeruginosa physiology
  JOURNAL   J. Bacteriol. 187 (15), 5267-5277 (2005)
   PUBMED   16030221
REFERENCE   4  (bases 1 to 1329)
  AUTHORS   Salunkhe,P., Smart,C.H., Morgan,J.A., Panagea,S., Walshaw,M.J.,
            Hart,C.A., Geffers,R., Tummler,B. and Winstanley,C.
  TITLE     A cystic fibrosis epidemic strain of Pseudomonas aeruginosa
            displays enhanced virulence and antimicrobial resistance
  JOURNAL   J. Bacteriol. 187 (14), 4908-4920 (2005)
   PUBMED   15995206
REFERENCE   5  (bases 1 to 1329)
  AUTHORS   Filiatrault,M.J., Wagner,V.E., Bushnell,D., Haidaris,C.G.,
            Iglewski,B.H. and Passador,L.
  TITLE     Effect of anaerobiosis and nitrate on gene expression in
            Pseudomonas aeruginosa
  JOURNAL   Infect. Immun. 73 (6), 3764-3772 (2005)
   PUBMED   15908409
REFERENCE   6  (bases 1 to 1329)
  AUTHORS   Rasmussen,T.B., Bjarnsholt,T., Skindersoe,M.E., Hentzer,M.,
            Kristoffersen,P., Kote,M., Nielsen,J., Eberl,L. and Givskov,M.
  TITLE     Screening for quorum-sensing inhibitors (QSI) by use of a novel
            genetic system, the QSI selector
  JOURNAL   J. Bacteriol. 187 (5), 1799-1814 (2005)
   PUBMED   15716452
REFERENCE   7  (bases 1 to 1329)
  AUTHORS   Winsor,G.L., Lo,R., Sui,S.J., Ung,K.S., Huang,S., Cheng,D.,
            Ching,W.K., Hancock,R.E. and Brinkman,F.S.
  TITLE     Pseudomonas aeruginosa Genome Database and PseudoCap: facilitating
            community-based, continually updated, genome annotation
  JOURNAL   Nucleic acids Res. 33 (DATABASE ISSUE), D338-D343 (2005)
   PUBMED   15608211
REFERENCE   8  (bases 1 to 1329)
  AUTHORS   Wagner,V.E., Bushnell,D., Passador,L., Brooks,A.I. and
            Iglewski,B.H.
  TITLE     Microarray analysis of Pseudomonas aeruginosa quorum-sensing
            regulons: effects of growth phase and environment
  JOURNAL   J. Bacteriol. 185 (7), 2080-2095 (2003)
   PUBMED   12644477
REFERENCE   9  (bases 1 to 1329)
  AUTHORS   Schuster,M., Lostroh,C.P., Ogi,T. and Greenberg,E.P.
  TITLE     Identification, timing, and signal specificity of Pseudomonas
            aeruginosa quorum-controlled genes: a transcriptome analysis
  JOURNAL   J. Bacteriol. 185 (7), 2066-2079 (2003)
   PUBMED   12644476
REFERENCE   10 (bases 1 to 1329)
  AUTHORS   Stover,C.K., Pham,X.Q., Erwin,A.L., Mizoguchi,S.D., Warrener,P.,
            Hickey,M.J., Brinkman,F.S., Hufnagle,W.O., Kowalik,D.J., Lagrou,M.,
            Garber,R.L., Goltry,L., Tolentino,E., Westbrock-Wadman,S., Yuan,Y.,
            Brody,L.L., Coulter,S.N., Folger,K.R., Kas,A., Larbig,K., Lim,R.,
            Smith,K., Spencer,D., Wong,G.K., Wu,Z., Paulsen,I.T., Reizer,J.,
            Saier,M.H., Hancock,R.E., Lory,S. and Olson,M.V.
  TITLE     Complete genome sequence of Pseudomonas aeruginosa PA01, an
            opportunistic pathogen
  JOURNAL   Nature 406 (6799), 959-964 (2000)
   PUBMED   10984043
REFERENCE   11 (bases 1 to 1329)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-OCT-2010) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   12 (bases 1 to 1329)
  AUTHORS   Winsor,G.L., Hancock,R.E. and Brinkman,F.S.
  CONSRTM   Pseudomonas aeruginosa Community Annotation Project (PseudoCap)
  TITLE     Direct Submission
  JOURNAL   Submitted (08-SEP-2010) Department of Molecular Biology and
            Biochemisry, Simon Fraser University, 8888 University Dr., Burnaby,
            British Columbia V5A 1S6, Canada
  REMARK    protein update by submitter
REFERENCE   13 (bases 1 to 1329)
  AUTHORS   Winsor,G.L., Hancock,R.E. and Brinkman,F.S.
  CONSRTM   Pseudomonas aeruginosa Community Annotation Project (PseudoCap)
  TITLE     Direct Submission
  JOURNAL   Submitted (02-OCT-2008) Department of Molecular Biology and
            Biochemisry, Simon Fraser University, 8888 University Dr., Burnaby,
            British Columbia V5A 1S6, Canada
  REMARK    protein update by submitter
REFERENCE   14 (bases 1 to 1329)
  AUTHORS   Winsor,G.L., Hancock,R.E. and Brinkman,F.S.
  CONSRTM   Pseudomonas aeruginosa Community Annotation Project (PseudoCap)
  TITLE     Direct Submission
  JOURNAL   Submitted (05-JUL-2006) Department of Molecular Biology and
            Biochemisry, Simon Fraser University, 8888 University Dr., Burnaby,
            British Columbia V5A 1S6, Canada
  REMARK    Sequence update by submitter
REFERENCE   15 (bases 1 to 1329)
  AUTHORS   Ung,K.S., Hancock,R.E. and Brinkman,F.S.
  CONSRTM   Pseudomonas aeruginosa Community Annotation Project (PseudoCap)
  TITLE     Direct Submission
  JOURNAL   Submitted (04-FEB-2003) Department of Molecular Biology and
            Biochemistry, Simon Fraser University, 8888 University Dr.,
            Burnaby, British Columbia V5A 1S6, Canada
REFERENCE   16 (bases 1 to 1329)
  AUTHORS   Stover,C.K., Pham,X.-Q.T., Erwin,A.L., Mizoguchi,S.D., Warrener,P.,
            Hickey,M.J., Brinkman,F.S.L., Hufnagle,W.O., Kowalik,D.J.,
            Lagrou,M., Garber,R.L., Goltry,L., Tolentino,E.,
            Westbrock-Wadman,S., Yuan,Y., Brody,L.L., Coulter,S.N.,
            Folger,K.R., Kas,A., Larbig,K., Lim,R.M., Smith,K.A., Spencer,D.H.,
            Wong,G.K.-S., Wu,Z., Paulsen,I.T., Reizer,J., Saier,M.H.,
            Hancock,R.E.W., Lory,S. and Olson,M.V.
  CONSRTM   Pseudomonas aeruginosa Community Annotation Project (PseudoCap)
  TITLE     Direct Submission
  JOURNAL   Submitted (16-MAY-2000) Department of Medicine and Genetics,
            University of Washington Genome Center, University Of Washington,
            Box 352145, Seattle, WA 98195, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence is identical to AE004091.
            
            On Jul 24, 2006 this sequence version replaced NC_002516.1.
            RefSeq Category: Reference Genome
                        FGS: First Genome sequenced
                        MOD: Model Organism
                        UPR: UniProt Genome
            -----------------------------------------------------------------
            This represents the Sept 08, 2010 version of the continually
            updated, reviewed, Pseudomonas aeruginosa PAO1 genome annotation
            from PseudoCap (see http://www.pseudomonas.com for the latest
            updates and links to alternate annotations). This update includes
            updated base pair coordinates and new features. PseudoCap is
            coordinated by Fiona S.L. Brinkman (Simon Fraser University,
            Canada) and Robert E.W. Hancock (University of British Columbia,
            Canada) with database development by Geoff Winsor (Simon Fraser
            University). We welcome submission through
            www.pseudomonas.com of any proposed changes.
            'protein name confidence' is used to rate our confidence of the
            accuracy of the protein name.
            class 1: Function experimentally demonstrated in P. aeruginosa.
            class 2: Function of highly similar gene experimentally
            demonstrated in another organism (and gene context consistent in
            terms of pathways its involved in, if known).
            class 3: Function proposed based on presence of conserved amino
            acid motif, structural feature or limited sequence similarity to an
            experimentally studied gene.
            class 4: Homologs of previously reported genes of unknown function,
            or no similarity to any previously reported sequences.
            ------------------------------------------------------------------.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1329
                     /organism="Pseudomonas aeruginosa PAO1"
                     /mol_type="genomic DNA"
                     /strain="PAO1"
                     /db_xref="taxon:208964"
     gene            1..1329
                     /locus_tag="PA4187"
                     /db_xref="GeneID:880334"
     CDS             1..1329
                     /locus_tag="PA4187"
                     /note="'Product name confidence: class 3 (Function
                     proposed based on presence of conserved amino acid motif,
                     structural feature or limited sequence similarity to an
                     experimentally studied gene)'"
                     /codon_start=1
                     /transl_table=11
                     /product="major facilitator superfamily transporter"
                     /protein_id="NP_252876.1"
                     /db_xref="GeneID:880334"
                     /translation="MTNPTTSIEDVPLNAFHRLLTLRSGGGSFVDGYVLSIIGVAMLQ
                     MTAALQLSSFWQGMIAASALVGIFFGGFLGGWLTDRLGRRRLFFVGPSLFVLASLAQY
                     GVDSAAALFVLRFLIGVAVGIEYPVATALLVEFLPKKYRGPRLATLTILWFAGAAFAY
                     LVGDLILRSGGEDAWRLVLASTAAIGAVLFLLRIGTPESPRWLLSKGRDADAERVIRQ
                     VYGEAFSLENLPEQALERKVTIWHLLYAGYGKRMLFVTLFWTCSVIPVFAVYAFAPKV
                     LLALNLKGDWASYGSVAITLLFVIGCIIATRLINRIGRRCMLLHSFLWSGLALLGLGV
                     FHAGSEATILGLFGAYALFIGGAQVLQLVYPNELFPTEIRAFAVGVGTSLSRVGAAVG
                     TYLVPLSLETLGTAQTMYAAALVTLLGLLVTWALAPETRSLNLQQAASLT"
ORIGIN      
        1 atgacaaatc ctacgacctc gatcgaagac gtacccctca acgccttcca ccggctgttg
       61 accctgcgct ccggcggcgg ctccttcgtc gacggctacg tgctgagcat catcggcgtg
      121 gcgatgctgc agatgaccgc ggcattgcaa ctgagcagtt tctggcaggg catgatcgcc
      181 gcctcggcgc tggtcggcat cttcttcggc ggtttcctcg gcggctggct gaccgaccgc
      241 ctgggccgcc gcaggctgtt cttcgtcggc cccagcctgt tcgtcctcgc ttccctggcg
      301 cagtacgggg tcgactcggc ggcggcgctg ttcgtcctgc gcttcctgat cggcgtggcg
      361 gtgggcatcg agtacccggt cgccaccgcc ttgctggtgg agttcttgcc gaagaagtat
      421 cgcggaccgc gcctggccac cctgaccatc ctctggttcg ccggcgccgc cttcgcctac
      481 ctggtcggcg acctgatcct gcgcagcggc ggcgaggacg cctggcgcct ggtactggcc
      541 agcaccgcgg cgatcggtgc cgtgctgttc ctgctacgca tcggcacccc cgagtcgccg
      601 cgctggctgc tgagcaaggg ccgcgacgcg gacgcagaac gggtcatccg ccaggtctac
      661 ggagaagcct tctcgctgga gaacctgccc gaacaggcgc tggaacggaa ggtcaccatc
      721 tggcacctgc tctacgccgg ctacggcaag cgcatgctct tcgtcaccct gttctggacc
      781 tgctcggtga tccccgtgtt cgccgtctac gccttcgcgc ccaaggtgct gctggcgctg
      841 aacctgaagg gcgactgggc ctcctacggt tcggtggcga tcaccctgct gttcgtcatc
      901 ggctgcatca tcgccacccg cctgatcaac cgcatcggcc ggcgctgcat gctgctgcac
      961 agcttcctct ggtccggcct ggcgctgctc gggctgggcg tcttccacgc cggctcggag
     1021 gcgaccatcc tcggcctgtt cggtgcctac gcgctgttca tcggcggcgc ccaggtgctg
     1081 caactggtct acccgaacga actgttcccc accgagatcc gcgccttcgc ggtcggcgtc
     1141 ggcacctcgt tatcgcgcgt cggcgccgcg gtgggcacct acctggtgcc gctttccctg
     1201 gaaaccctgg gtaccgccca gaccatgtac gccgccgcgc tggtgaccct gctcgggctg
     1261 ctcgtgacct gggccctggc gccggaaacc cgttcgctga acctgcagca ggcggcttcg
     1321 ctcacctga
//
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