Human GRB2 isoform mRNA

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CCDC6-RET fusion protein regulates Ras/MAPK signaling through the fusion- GRB2-SHC1 signal niche. [Proc Natl Acad Sci U S A. 2024]
CCDC6-RET fusion protein regulates Ras/MAPK signaling through the fusion- GRB2-SHC1 signal niche.
Qiu T, Kong Y, Wei G, Sun K, Wang R, Wang Y, Chen Y, Wang W, Zhang Y, Jiang C, et al. Proc Natl Acad Sci U S A. 2024 Jun 4; 121(23):e2322359121. Epub 2024 May 28.
GRB2 stabilizes RAD51 at reversed replication forks suppressing genomic instability and innate immunity against cancer. [Nat Commun. 2024]
GRB2 stabilizes RAD51 at reversed replication forks suppressing genomic instability and innate immunity against cancer.
Ye Z, Xu S, Shi Y, Cheng X, Zhang Y, Roy S, Namjoshi S, Longo MA, Link TM, Schlacher K, et al. Nat Commun. 2024 Mar 8; 15(1):2132. Epub 2024 Mar 8.
The binding selectivity of the C-terminal SH3 domain of Grb2, but not its folding pathway, is dictated by its contiguous SH2 domain. [J Biol Chem. 2024]
The binding selectivity of the C-terminal SH3 domain of Grb2, but not its folding pathway, is dictated by its contiguous SH2 domain.
Di Felice M, Pagano L, Pennacchietti V, Diop A, Pietrangeli P, Marcocci L, Di Matteo S, Malagrinò F, Toto A, Gianni S. J Biol Chem. 2024 Apr; 300(4):107129. Epub 2024 Mar 1.

RefSeq alternative splicing
See 2 reference mRNA sequence splice variants for the GRB2 gene.

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Nucleotide