LOCUS BC104871 3212 bp mRNA linear PRI 21-JUL-2006
DEFINITION Homo sapiens klotho beta, mRNA (cDNA clone MGC:132531
IMAGE:8143874), complete cds.
ACCESSION BC104871
VERSION BC104871.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3212)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 3212)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (13-SEP-2005) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Mike Brownstein, NIMH
cDNA Library Preparation: British Columbia Cancer Research Center
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Genome Sequence Centre,
BC Cancer Agency, Vancouver, BC, Canada
info@bcgsc.bc.ca
Martin Hirst, Thomas Zeng, Ryan Morin, Michelle Moksa, Johnson
Pang, Diana Mah, Jing Wang, Kieth Fichter, Eric Chuah, Allen
Delaney, Rob Kirkpatrick, Agnes Baross, Sarah Barber, Mabel
Brown-John, Steve S. Chand, William Chow, Ryan Babakaiff, Dave
Wong, Corey Matsuo, Jaclyn Beland, Susan Gibson, Luis delRio, Ruth
Featherstone, Malachi Griffith, Obi Griffith, Ran Guin, Nancy Liao,
Kim MacDonald, Mike R. Mayo, Josh Moran, Diana Palmquist, JR
Santos, Duane Smailus, Jeff Stott, Miranda Tsai, George Yang,
Jacquie Schein, Asim Siddiqui,Steven Jones, Rob Holt, Marco Marra.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRCB Plate: 3 Row: e Column: 24.
FEATURES Location/Qualifiers
source 1..3212
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:132531 IMAGE:8143874"
/tissue_type="Liver, PCR rescued clones"
/clone_lib="NIH_MGC_291"
/note="Vector: pCR4-TOPO with reversed insert; Clone
identification sequence tag: GAAAGCCC"
gene 1..3212
/gene="KLB"
/db_xref="GeneID:152831"
/db_xref="HGNC:HGNC:15527"
CDS 22..3156
/gene="KLB"
/codon_start=1
/product="klotho beta"
/protein_id="AAI04872.1"
/db_xref="GeneID:152831"
/db_xref="HGNC:HGNC:15527"
/translation="MKPGCAAGSPGNEWIFFSTDEITTRYRNTMSNGGLQRSVILSAL
ILLRAVTGFSGDGRAIWSKNPNFTPVNESQLFLYDTFPKNFFWGIGTGALQVEGSWKK
DGKGPSIWDHFIHTHLKNVSSTNGSSDSYIFLEKDLSALDFIGVSFYQFSISWPRLFP
DGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWDLPLALQEKYGGWKNDTIIDIF
NDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAPGEKGNLAAVYTVGHNLIKA
HSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIFKCQQSMVSVLGWFANPI
HGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFAFSFGPNNFKPLNTMAKMGQNV
SLNLREALNWIKLEYNNPRILIAENGWFTDSRVKTEDTTAIYMMKNFLSQVLQAIRLD
EIRVFGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIRENGF
SLKESTPDVQGQFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEG
VRLKTRPAQCTDFVNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYR
CVVSEGLKLGISAMVTLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELG
DLVKLWITINEPNRLSDIYNRSGNDTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSL
SLHADWAEPANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGL
SSSALPRLTEAERRLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRL
SSPTRLAVIPWGVRKLLRWVRRNYGDMDIYITASGIDDQALEDDRLRKYYLGKYLQEV
LKAYLIDKVRIKGYYAFKLAEEKSKPRFGFFTSDFKAKSSIQFYNKVISSRGFPFENS
SSRCSQTQENTECTVCLFLVQKKPLIFLGCCFFSTLVLLLSIAIFQRQKRRKFWKAKN
LQHIPLKKGKRVVS"
ORIGIN
1 cagtccagca gttggtggca aatgaagcca ggctgtgcgg caggatctcc agggaatgaa
61 tggattttct tcagcactga tgaaataacc acacgctata ggaatacaat gtccaacggg
121 ggattgcaaa gatctgtcat cctgtcagca cttattctgc tacgagctgt tactggattc
181 tctggagatg gaagagctat atggtctaaa aatcctaatt ttactccggt aaatgaaagt
241 cagctgtttc tctatgacac tttccctaaa aactttttct ggggtattgg gactggagca
301 ttgcaagtgg aagggagttg gaagaaggat ggaaaaggac cttctatatg ggatcatttc
361 atccacacac accttaaaaa tgtcagcagc acgaatggtt ccagtgacag ttatattttt
421 ctggaaaaag acttatcagc cctggatttt ataggagttt ctttttatca attttcaatt
481 tcctggccaa ggcttttccc cgatggaata gtaacagttg ccaacgcaaa aggtctgcag
541 tactacagta ctcttctgga cgctctagtg cttagaaaca ttgaacctat agttacttta
601 taccactggg atttgccttt ggcactacaa gaaaaatatg gggggtggaa aaatgatacc
661 ataatagata tcttcaatga ctatgccaca tactgtttcc agatgtttgg ggaccgtgtc
721 aaatattgga ttacaattca caacccatat ctagtggctt ggcatgggta tgggacaggt
781 atgcatgccc ctggagagaa gggaaattta gcagctgtct acactgtggg acacaacttg
841 atcaaggctc actcgaaagt ttggcataac tacaacacac atttccgccc acatcagaag
901 ggttggttat cgatcacgtt gggatctcat tggatcgagc caaaccggtc ggaaaacacg
961 atggatatat tcaaatgtca acaatccatg gtttctgtgc ttggatggtt tgccaaccct
1021 atccatgggg atggcgacta tccagagggg atgagaaaga agttgttctc cgttctaccc
1081 attttctctg aagcagagaa gcatgagatg agaggcacag ctgatttctt tgccttttct
1141 tttggaccca acaacttcaa gcccctaaac accatggcta aaatgggaca aaatgtttca
1201 cttaatttaa gagaagcgct gaactggatt aaactggaat acaacaaccc tcgaatcttg
1261 attgctgaga atggctggtt cacagacagt cgtgtgaaaa cagaagacac cacggccatc
1321 tacatgatga agaatttcct cagccaggtg cttcaagcaa taaggttaga tgaaatacga
1381 gtgtttggtt atactgcctg gtctctcctg gatggctttg aatggcagga tgcttacacc
1441 atccgccgag gattatttta tgtggatttt aacagtaaac agaaagagcg gaaacctaag
1501 tcttcagcac actactacaa acagatcata cgagaaaatg gtttttcttt aaaagagtcc
1561 acgccagatg tgcagggcca gtttccctgt gacttctcct ggggtgtcac tgaatctgtt
1621 cttaagcccg agtctgtggc ttcgtcccca cagttcagcg atcctcatct gtacgtgtgg
1681 aacgccactg gcaacagact gttgcaccga gtggaagggg tgaggctgaa aacacgaccc
1741 gctcaatgca cagattttgt aaacatcaaa aaacaacttg agatgttggc aagaatgaaa
1801 gtcacccact accggtttgc tctggattgg gcctcggtcc ttcccactgg caacctgtcc
1861 gcggtgaacc gacaggccct gaggtactac aggtgcgtgg tcagtgaggg gctgaagctt
1921 ggcatctccg cgatggtcac cctgtattat ccgacccacg cccacctagg cctccccgag
1981 cctctgttgc atgccgacgg gtggctgaac ccatcgacgg ccgaggcctt ccaggcctac
2041 gctgggctgt gcttccagga gctgggggac ctggtgaagc tctggatcac catcaacgag
2101 cctaaccggc taagtgacat ctacaaccgc tctggcaacg acacctacgg ggcggcgcac
2161 aacctgctgg tggcccacgc cctggcctgg cgcctctacg accggcagtt caggccctca
2221 cagcgcgggg ccgtgtcgct gtcgctgcac gcggactggg cggaacccgc caacccctat
2281 gctgactcgc actggagggc ggccgagcgc ttcctgcagt tcgagatcgc ctggttcgcc
2341 gagccgctct tcaagaccgg ggactacccc gcggccatga gggaatacat tgcctccaag
2401 caccgacggg ggctttccag ctcggccctg ccgcgcctca ccgaggccga aaggaggctg
2461 ctcaagggca cggtcgactt ctgcgcgctc aaccacttca ccactaggtt cgtgatgcac
2521 gagcagctgg ccggcagccg ctacgactcg gacagggaca tccagtttct gcaggacatc
2581 acccgcctga gctcccccac gcgcctggct gtgattccct ggggggtgcg caagctgctg
2641 cggtgggtcc ggaggaacta cggcgacatg gacatttaca tcaccgccag tggcatcgac
2701 gaccaggctc tggaggatga ccggctccgg aagtactacc tagggaagta ccttcaggag
2761 gtgctgaaag catacctgat tgataaagtc agaatcaaag gctattatgc attcaaactg
2821 gctgaagaga aatctaaacc cagatttgga ttcttcacat ctgattttaa agctaaatcc
2881 tcaatacaat tttacaacaa agtgatcagc agcaggggct tcccttttga gaacagtagt
2941 tctagatgca gtcagaccca agaaaataca gagtgcactg tctgcttatt ccttgtgcag
3001 aagaaaccac tgatattcct gggttgttgc ttcttctcca ccctggttct actcttatca
3061 attgccattt ttcaaaggca gaagagaaga aagttttgga aagcaaaaaa cttacaacac
3121 ataccattaa agaaaggcaa gagagttgtt agctaaactg atctgtctgc atgatagaca
3181 gtttaaaaat tcatcccagt tccatatgct gg
//