Homo sapiens sphingomyelin phosphodiesterase, acid-like 3A, mRNA (cDNA - Nucleotide

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SMPDL3A is a cGAMP-degrading enzyme induced by LXR-mediated lipid metabolism to restrict cGAS-STING DNA sensing. [Immunity. 2023]
SMPDL3A is a cGAMP-degrading enzyme induced by LXR-mediated lipid metabolism to restrict cGAS-STING DNA sensing.
Hou Y, Wang Z, Liu P, Wei X, Zhang Z, Fan S, Zhang L, Han F, Song Y, Chu L, et al. Immunity. 2023 Nov 14; 56(11):2492-2507.e10. Epub 2023 Oct 26.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. [Cell. 2021]
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Huttlin EL, Bruckner RJ, Navarrete-Perea J, Cannon JR, Baltier K, Gebreab F, Gygi MP, Thornock A, Zarraga G, Tam S, et al. Cell. 2021 May 27; 184(11):3022-3040.e28. Epub 2021 May 6.
Ligand-dependent and -independent regulation of human hepatic sphingomyelin phosphodiesterase acid-like 3A expression by pregnane X receptor and crosstalk with liver X receptor. [Biochem Pharmacol. 2017]
Ligand-dependent and -independent regulation of human hepatic sphingomyelin phosphodiesterase acid-like 3A expression by pregnane X receptor and crosstalk with liver X receptor.
Jeske J, Bitter A, Thasler WE, Weiss TS, Schwab M, Burk O. Biochem Pharmacol. 2017 Jul 15; 136:122-135. Epub 2017 Apr 13.

RefSeq alternative splicing
See 2 reference mRNA sequence splice variants for the SMPDL3A gene.

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Nucleotide