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Rattus norvegicus protein kinase WNK1 (WNK1) mRNA, complete cds

GenBank: AF227741.1

FASTA Graphics 

LOCUS       AF227741                7342 bp    mRNA    linear   ROD 06-JUN-2000
DEFINITION  Rattus norvegicus protein kinase WNK1 (WNK1) mRNA, complete cds.
ACCESSION   AF227741
VERSION     AF227741.1
KEYWORDS    .
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7342)
  AUTHORS   Xu,B., English,J.M., Wilsbacher,J.L., Stippec,S., Goldsmith,E.J.
            and Cobb,M.H.
  TITLE     WNK1, a novel mammalian serine/threonine protein kinase lacking the
            catalytic lysine in subdomain II
  JOURNAL   J. Biol. Chem. 275 (22), 16795-16801 (2000)
   PUBMED   10828064
REFERENCE   2  (bases 1 to 7342)
  AUTHORS   Xu,B.-e., English,J.M. and Cobb,M.H.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-JAN-2000) Pharmacology, The University of Texas
            Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX
            75390-9041, USA
FEATURES             Location/Qualifiers
     source          1..7342
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
     gene            1..7342
                     /gene="WNK1"
     CDS             166..6546
                     /gene="WNK1"
                     /codon_start=1
                     /product="protein kinase WNK1"
                     /protein_id="AAF74258.1"
                     /translation="MSDGTAEKQSGTPGFLSPPAPVPKNGSSSDSSVGEKLGAAVADS
                     GIGRTEEYRRRRHTMDKDSRGAAATTTPTEHRFFRRSVICDSNATALELPGLPLSIPQ
                     PSVPAVVPQSAPPEPHREETLTATVASQVSQQPSAAASPGEQAVVGSATATVPSSTSK
                     DRPVSQPSLVGSKEEPPPSRSGSGSGGASAKEPQEERNQQQDDIEELETKAVGMSNDG
                     RFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQ
                     HPNIVRFYDSWESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKG
                     LQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLKRASFAKSVIGTPEFMAP
                     EMYEEKYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKVAIP
                     EVKEIIEGCIRQNKDERYSIKDLLNHAFFQEETGVRVELAEEDDGEKIAIKLWLRIED
                     IKKLKGKYKDNEAIEFSFDLERDVPEDVAQEMVESGYVCEGDHKTMAKAIKDRVSLIK
                     RKREQRQLVREEQEKRKQEESSFKQQNEQQASVSQAGIQPLSVASTGIPTAPTTSASV
                     STQVEPEEPEADQHQQLQYQQPSISVLSDGTVDSGQGSSVFTESRVSSQQTVSYGSQH
                     EQAHSIGTAPGHTVSSIQAQSQPHGVYPPSSMAQGQNQGQPSSSLAGVLSSQPVQHPQ
                     QQGIQPTVPPQQAVQYSLPQAASSSEGTVQPVSQPQVSAGTQSSTQGVSQAAPPEQTP
                     ITQSQPTQPVPLVSSVDSAHSDVASGMSDGNENAPSSSGRHEGRTTKRHYRKSVRSRS
                     RHEKTSRPKLRILNVSNKGDRVVECQLETHNRKMVTFKFDLDGDNPEEIATIMVNNDF
                     ILAIERESFVAQVREIIEKADEMLSEDVSVEPEGDQGLESLQGKDDYGFPGSQKLEGE
                     FKQPIAVSSMPQQIGVPTSSLTQVVHSAGRRFIVSPVPESRLRESKIFTSEIPDPVAA
                     STSQGPGMNLSHSASSLSLQQAFSELKHGQMTEGPNTAPPNFNHPGPTFSPFLTSIAG
                     VQTVAASTPSVSVPITSSPLNDISTSVMQSEGALPTDKGIGGVTTSTGVVASGGLTTL
                     SVSETPTLSSAVSSSTAPAVVTVSTTSQPVQAFTSGSIASSTGSFPSGTFSTTTGTTV
                     SSVAVPNAKPPTVLLQQVAGNTAGVAIVTSVSTTTPFPAMASQPSLPLGSSTSAPTLA
                     ETVVVSAHSLDKASHSSTAGLGLSFCAPSSSSSSGTAVSSSVSQPGIVHPLVISSAIA
                     STPVLPQPAVPTSTPLLPQVPNIPPLVQPVANVPAVQQTLIHSQPQPALLPNQPHTHC
                     PEMDADTQSKAPGIDDIKTLEEKLRSLFSEHSSSGTQHASVSLETPLVVETVTPGIPT
                     TAVAPSKLMTSTTSTCLPPTNLPLGTAGMPVMPVGTPGQVSTPGTHASAPASTATGAK
                     PGTTPPKPSLTKTVVPPVGTELSAGTVPCEQLPPFPGPSLIQTQQPLEDLDAQLRRTL
                     SPETIPVTPAVGPLSTMSSTAVTEAGSQPQKDGTEVHVTASSSGAGVVKMGRFQVSVT
                     MDDAQKERKNRSEDTKSVHFESSTSESSVLSSSSPESTLVKPEPNGITVSGISLDVPD
                     STHRTPTPEAKSETGQPTKVGRFQVTTTANKVGRFSVSRTEDKVTELKKEGPVTSPFR
                     DSEQTVIPAAIPKKEKPELAEPSHLNGPSSDLEAAFLSRGGEDGSGSPHSPPHLCSKS
                     LPIQTLSQSLSNSFNSSYMSSDNESDIEDEDLRLELRRLREKHLKEIQDLQSRQKHEI
                     ESLYTKLGKVPPAVIIPPAAPLSGRRRRPTKSKGSKSSRSSSLGNKSPQLSGNLSGQS
                     GTSVLNPQQTLHPPGNTPETGHNQLLQPLKPSPSSDNLYSAFTSDGAISIPSLSAPGQ
                     GTSSTNTVGGTVSSQAAQAQPPAMTSSRKGTFTDDLHKLVDNWARDAMNLSGRRGSKG
                     HMNYEGPGMARKFSAPGQLCISMTSNMGGSTPISAASATSLGHFTKSMCPPQQYGFPA
                     APFGTQWSGTGGPAPQPLGQFQPVGTTSLQNFNISNLQKSISNPPSSNLRTT"
ORIGIN      
        1 gcgtcgccct cggggcgcct tgtcagtgct gagtgggagt cgtccggtgg ctccgagccc
       61 gccgtaggag cgctgcccag cacttcttgg tggcttctcc gggccaccct tttccctttt
      121 cattcataaa tccgagcccg cattcttcac tccaccggac caaccatgtc tgacggcacc
      181 gcagagaagc agagcggcac tcctggcttc ctttcgcctc cggctccagt ccccaagaat
      241 ggctcaagct ccgattcttc cgtgggcgag aaactggggg ccgcggtcgc cgactccgga
      301 attggcagga cagaggaata ccggcgccgc cggcacacta tggacaagga cagtcgtggg
      361 gcggccgcca ccactacccc cacggagcac cgatttttcc gccgaagcgt catctgcgac
      421 tccaatgcca cggcgttgga gctgccgggc ctccctctct ctatccctca acctagtgta
      481 cccgcagtgg tgcctcagag tgctccaccc gagcctcaca gagaggaaac tttgacggcc
      541 accgttgctt cccaggtgtc tcagcaaccc tcggctgctg cctcccctgg ggaacaagcc
      601 gttgtaggct cggccaccgc gaccgtcccc agcagtacca gcaaagaccg cccggtgtcc
      661 cagcccagcc tcgtgggtag caaagaggag ccgccgccgt ccagaagtgg aagtggcagc
      721 ggtggtgcca gtgccaaaga gccgcaggag gaaaggaacc agcaacagga tgatatcgaa
      781 gagctggaga ccaaggcagt gggaatgtcc aatgacggtc gctttctcaa atttgacatc
      841 gaaatcggca gaggctcctt taagacggtc tacaaaggtc tggacaccga aaccactgtg
      901 gaagtcgcct ggtgtgaatt gcaggatcga aagttaacaa aatctgaaag gcagagattc
      961 aaagaagaag ctgaaatgct aaagggtctt caacatccta acattgttcg attctatgat
     1021 tcctgggaat ccacagtaaa agggaaaaaa tgcattgttt tagtgactga actaatgaca
     1081 tctggaacac ttaaaacgta cttaaaaagg tttaaagtga tgaaaatcaa agttttaaga
     1141 agctggtgtc ggcaaatcct taaaggactt caatttctcc atacacgaac tcccccgatt
     1201 attcaccggg atcttaaatg tgacaacatc tttatcactg gtcctaccgg ctcagtcaag
     1261 atcggagacc ttggtctggc aactctaaag cgggcttctt ttgccaagag tgtgataggt
     1321 accccagagt ttatggctcc tgagatgtat gaggagaagt acgatgaatc cgttgatgtt
     1381 tatgcttttg ggatgtgcat gcttgagatg gctacgtctg aatatccata ctcagagtgc
     1441 caaaatgctg ctcagatcta ccgtcgagtg accagtggag tgaagccagc cagttttgac
     1501 aaagtagcaa ttcctgaagt gaaggaaatt attgaaggat gtatccgaca aaacaaagat
     1561 gaaagatatt ccatcaaaga ccttttgaac catgcctttt tccaggagga aacaggggta
     1621 cgggtagaat tagcagaaga agatgatgga gaaaagatag ctatcaaatt atggctacgt
     1681 attgaagata ttaagaaatt aaagggaaaa tacaaagaca atgaagctat tgagttttcc
     1741 tttgacttgg agagggatgt accagaagat gttgctcaag aaatggtcga gtctggttat
     1801 gtctgtgaag gtgatcacaa gaccatggct aaagctatca aagatagggt atcattaatt
     1861 aagagaaaac gagagcagcg gcagttggtt cgagaagagc aagaaaaaag aaaacaagaa
     1921 gagagcagtt tcaaacagca gaatgaacaa caagcaagtg tttcccaggc aggaatccag
     1981 ccactctctg ttgctagcac tggcataccc actgctccca ccacatccgc ttcagtttct
     2041 actcaagtag agcctgaaga acccgaggca gatcagcatc aacagctgca gtatcagcaa
     2101 cctagtatat ctgtgttgtc tgatggaaca gttgacagtg gtcaaggatc atctgtattc
     2161 acagaatcca gagtgagcag ccaacagact gtttcctatg gctcccaaca tgagcaggca
     2221 cattctattg gcacagcacc aggacataca gtttctagta tccaagcaca atctcagccc
     2281 catggggtgt atccaccctc aagtatggca caggggcaga accagggcca gccatcaagt
     2341 agtttagcag gggttctatc ttcacaaccc gtccaacatc ctcagcagca gggaatacag
     2401 ccgactgtac ctcctcaaca ggcagtacag tattcacttc cacaggcagc gtcttccagt
     2461 gaaggcactg tccagccagt gagtcagcct caagtgtcag ctggaacaca gagtagtaca
     2521 cagggagtct ctcaggctgc tcctccagaa caaactccaa taacacagtc acaacctact
     2581 caacctgttc cattggtttc ctctgtggac agtgcccatt cagatgttgc ttctggtatg
     2641 agtgatggca atgagaatgc tccttcatcc agcgggaggc atgaagggag gacgacaaaa
     2701 cgtcattatc gaaaatctgt aagaagtcgt tctcgtcatg aaaagacttc tcgcccgaaa
     2761 ctgaggattt taaatgtttc aaataaagga gaccgagtag tagaatgtca attggagact
     2821 cataatcgga aaatggttac atttaaattt gacctagatg gcgacaaccc tgaagagata
     2881 gcaacaatta tggtgaacaa tgactttatt ctagccatag agagagagtc ttttgtggct
     2941 caagtgcggg aaattattga aaaggctgat gaaatgttaa gcgaggatgt cagtgtggag
     3001 cctgagggtg accagggatt ggagagtcta caaggaaagg atgactatgg ctttccaggt
     3061 tctcagaaat tagaaggaga gttcaagcaa ccaattgctg tatcttccat gccacaacaa
     3121 ataggtgttc ctaccagttc tttaacacaa gttgttcatt ctgctggaag acgatttata
     3181 gtgagtccag ttccagaaag tcgattacga gaatcaaaaa ttttcaccag tgaaatacca
     3241 gatccagttg cggcctctac atctcagggc cctggaatga acttatctca ctccgcttca
     3301 tcccttagtc tccagcaggc tttttctgaa ctgaaacatg gtcagatgac tgaaggaccc
     3361 aatacagcac ctccaaattt taatcaccca ggaccaacat tttctccctt tttgactagc
     3421 attgctggtg tccaaactgt agcagcatcc acaccatcag tatcagtccc tataacaagc
     3481 agccctctta atgacatttc cacatcagtg atgcagtcag agggtgcact gcccactgac
     3541 aaaggcattg ggggagttac caccagcaca ggtgtggtag cttcaggtgg tctcaccaca
     3601 ttgtctgtgt ctgagacacc aacactttcc agtgcagttt caagttctac agcgcctgca
     3661 gttgtcacag tgtctacaac atcccaacca gttcaggctt tcacatctgg gagcattgct
     3721 tctagtacag gcagttttcc ttctggaaca ttttccacaa ctacaggtac cacagtgagt
     3781 agtgtagctg tcccaaatgc taagcctcca actgtattac tgcaacaggt agcaggtaat
     3841 actgctgggg tagccatagt gacatcagtt tctactacca ctccattccc agccatggct
     3901 tcacagccat cccttccact tggtagcagc acatctgctc ctacactagc tgaaacagtg
     3961 gtggttagtg cacactcact agacaaggca tctcacagta gtacagcagg attgggtttg
     4021 tccttttgcg caccgtcctc ttcttcctcc tctggaacag cagtgtctag ttctgtttct
     4081 cagcctggta ttgtgcatcc tttggtcatc tcatcagcta tagcttctac acctgtcctc
     4141 ccacaaccag cagtacctac ttctacacct ttattacccc aagtacctaa tatcccaccc
     4201 ttggtacaac ctgttgctaa tgtgcctgct gtacagcaaa cactcattca tagtcagcct
     4261 caaccagctc tacttcccaa ccagcctcac acacactgtc ccgaaatgga tgctgatacc
     4321 cagtccaaag ctcctgggat cgatgatata aagactctgg aggaaaagct gagatcgctc
     4381 tttagtgagc atagctcatc tggaactcag catgcttctg tctccctgga gacaccctta
     4441 gtagtagaga ctgtcacacc gggcatccct accactgctg tagcaccaag taaactcatg
     4501 acttccacta caagcacttg cttgccacca accaatttac ccttaggaac agctggcatg
     4561 ccagttatgc cagtgggcac acctggtcaa gtttctaccc caggcacaca tgcctcagcc
     4621 ccagccagca ccgcaacagg agcaaaacct ggaacaactc ccccaaagcc atctttaact
     4681 aagactgtgg tgccgccagt gggtactgag ctttcggctg gtactgtacc ctgtgagcag
     4741 ctgccacctt ttcccggacc gtctctaatt cagacccagc aacccctaga agatcttgat
     4801 gctcagttga gaagaacact tagtccagag actattccag tgacacccgc agttggtcct
     4861 ttgtctacga tgtcttcaac ggcagttaca gaagcaggaa gtcaacctca gaaggatggc
     4921 acagaagttc atgtcacagc aagtagctca ggagctggtg ttgttaagat ggggagattt
     4981 caggtttcag ttacaatgga tgatgcccag aaagagcgta aaaataggtc agaagataca
     5041 aagtcggttc attttgaatc tagtacatca gagtcatcag ttctttcaag tagtagtcca
     5101 gagagtaccc tggtaaagcc agagcctaat ggaattactg tttctggcat ctccttagat
     5161 gtgccagaca gtacccatag aacaccgacc ccagaagcaa agtcagaaac aggacagcct
     5221 accaaggttg gacgttttca ggtgacaact acagccaaca aagtgggtcg tttctctgtt
     5281 tcaagaactg aggacaaggt cacagagctc aaaaaagagg gaccagtgac ctctcctttc
     5341 agagattcag aacaaactgt tattcctgct gcgataccaa agaaggagaa gcctgagctg
     5401 gcagaacctt cccatctgaa tgggccatct tcagacttgg aggctgcctt tctaagtagg
     5461 ggtggagagg atggatcagg tagtcctcac tctccccctc acctgtgttc aaagagcctt
     5521 cccatccaga ctctaagtca aagccttagt aattcattca actcctctta catgagtagt
     5581 gacaatgagt ccgacattga agatgaagac ttaaggttag aactgcgacg actacgggaa
     5641 aaacatctta aagagattca ggacctgcag agtcgccaga agcatgaaat tgaatctttg
     5701 tataccaaac tgggcaaggt tccccctgct gtcattattc ccccagctgc tcctctgtca
     5761 gggagaagaa ggaggcctac taaaagcaaa ggcagcaagt ccagtcgcag cagctcattg
     5821 ggcaacaaaa gccctcagct ttcaggtaac ctgtctggtc agagtggaac ttcagtctta
     5881 aacccccaac agaccctcca tcccccaggc aataccccag agactggaca caaccagctg
     5941 ttacagcctc ttaagccatc tccctccagt gacaacctct attcagcctt taccagtgat
     6001 ggtgccattt caataccaag cctttctgct ccaggtcaag ggaccagcag cacaaacacc
     6061 gttggaggaa cagtgagtag ccaggctgcc caggctcagc ctcctgccat gacttccagt
     6121 aggaagggca cattcacaga tgacctgcac aagttggtag acaactgggc ccgagatgcc
     6181 atgaatcttt caggcaggag aggcagcaaa ggacacatga attatgaggg ccctggaatg
     6241 gcaaggaagt tctctgctcc tgggcagctg tgcatttcca tgacctcaaa catgggtggc
     6301 tctaccccca tctctgcagc atctgctacc tctctaggtc acttcaccaa gtccatgtgc
     6361 cccccacagc agtatggttt tccagctgcc ccattcggca ctcagtggag tggaacaggt
     6421 ggtccagcac cacagccact tggtcagttc caacctgtag gaaccacatc cttgcaaaat
     6481 ttcaacatca gcaatttgca gaagtccatc agcaaccccc caagttccaa cctacggacc
     6541 acctagtcag cagcaaggat gttaactgag tagatctggg ggcaggaaat ggaatggtga
     6601 tggggtgggg ggtggggaaa tagcctatat actaactact agtgctgcat ttaactggtt
     6661 atttcttgcc agaagggaat gtttttaata ccattttgag ccctcagaat ggagaaccac
     6721 cctccttctc catttgttgg agttaaaaaa gaaggaaaga agagctttct ggtggagggg
     6781 ctgcctgaga ctgcttttct gtttttgtac ccaccagtaa ggcctagggg ctagaagaga
     6841 gccttgttac cagaaagcct catgtaagcc aaatcccata tgtatctgaa gtgggtagag
     6901 ctcttaattt tgacatgtgc ccccgaaact ccttattccc tcaacagtgc acaccttaag
     6961 acaaaaaggt tctctcccac tcggatccct acccccactt ttttttttcc ttttacaacc
     7021 tagtgaaaaa caccagggga ctggggttgc aaccctttct tatataggtc attaatgctt
     7081 taagcaaaag attagcagct ttgactgcag cattagcaat tagggaaaac aatgacgttc
     7141 cctgcggaca tgttaacttt gccatcagtt ttgatgtgga aacactgtga tatataaatg
     7201 ttgttggaca acattagttt taagagtaaa atttgaaagg tttaaaaggt tcacacacaa
     7261 agctagctct gtcctttcct tattaagaca ctttaacttt ttcctttgta tttccattgt
     7321 attagataaa taaatgtgaa tg
//
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