Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
Download features.
Download gene features.
GenBank: AF227741.1
FASTA Graphics
LOCUS AF227741 7342 bp mRNA linear ROD 06-JUN-2000 DEFINITION Rattus norvegicus protein kinase WNK1 (WNK1) mRNA, complete cds. ACCESSION AF227741 VERSION AF227741.1 KEYWORDS . SOURCE Rattus norvegicus (Norway rat) ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. REFERENCE 1 (bases 1 to 7342) AUTHORS Xu,B., English,J.M., Wilsbacher,J.L., Stippec,S., Goldsmith,E.J. and Cobb,M.H. TITLE WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II JOURNAL J. Biol. Chem. 275 (22), 16795-16801 (2000) PUBMED 10828064 REFERENCE 2 (bases 1 to 7342) AUTHORS Xu,B.-e., English,J.M. and Cobb,M.H. TITLE Direct Submission JOURNAL Submitted (21-JAN-2000) Pharmacology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9041, USA FEATURES Location/Qualifiers source 1..7342 /organism="Rattus norvegicus" /mol_type="mRNA" /db_xref="taxon:10116" gene 1..7342 /gene="WNK1" CDS 166..6546 /gene="WNK1" /codon_start=1 /product="protein kinase WNK1" /protein_id="AAF74258.1" /translation="MSDGTAEKQSGTPGFLSPPAPVPKNGSSSDSSVGEKLGAAVADS GIGRTEEYRRRRHTMDKDSRGAAATTTPTEHRFFRRSVICDSNATALELPGLPLSIPQ PSVPAVVPQSAPPEPHREETLTATVASQVSQQPSAAASPGEQAVVGSATATVPSSTSK DRPVSQPSLVGSKEEPPPSRSGSGSGGASAKEPQEERNQQQDDIEELETKAVGMSNDG RFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQ HPNIVRFYDSWESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKG LQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLKRASFAKSVIGTPEFMAP EMYEEKYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKVAIP EVKEIIEGCIRQNKDERYSIKDLLNHAFFQEETGVRVELAEEDDGEKIAIKLWLRIED IKKLKGKYKDNEAIEFSFDLERDVPEDVAQEMVESGYVCEGDHKTMAKAIKDRVSLIK RKREQRQLVREEQEKRKQEESSFKQQNEQQASVSQAGIQPLSVASTGIPTAPTTSASV STQVEPEEPEADQHQQLQYQQPSISVLSDGTVDSGQGSSVFTESRVSSQQTVSYGSQH EQAHSIGTAPGHTVSSIQAQSQPHGVYPPSSMAQGQNQGQPSSSLAGVLSSQPVQHPQ QQGIQPTVPPQQAVQYSLPQAASSSEGTVQPVSQPQVSAGTQSSTQGVSQAAPPEQTP ITQSQPTQPVPLVSSVDSAHSDVASGMSDGNENAPSSSGRHEGRTTKRHYRKSVRSRS RHEKTSRPKLRILNVSNKGDRVVECQLETHNRKMVTFKFDLDGDNPEEIATIMVNNDF ILAIERESFVAQVREIIEKADEMLSEDVSVEPEGDQGLESLQGKDDYGFPGSQKLEGE FKQPIAVSSMPQQIGVPTSSLTQVVHSAGRRFIVSPVPESRLRESKIFTSEIPDPVAA STSQGPGMNLSHSASSLSLQQAFSELKHGQMTEGPNTAPPNFNHPGPTFSPFLTSIAG VQTVAASTPSVSVPITSSPLNDISTSVMQSEGALPTDKGIGGVTTSTGVVASGGLTTL SVSETPTLSSAVSSSTAPAVVTVSTTSQPVQAFTSGSIASSTGSFPSGTFSTTTGTTV SSVAVPNAKPPTVLLQQVAGNTAGVAIVTSVSTTTPFPAMASQPSLPLGSSTSAPTLA ETVVVSAHSLDKASHSSTAGLGLSFCAPSSSSSSGTAVSSSVSQPGIVHPLVISSAIA STPVLPQPAVPTSTPLLPQVPNIPPLVQPVANVPAVQQTLIHSQPQPALLPNQPHTHC PEMDADTQSKAPGIDDIKTLEEKLRSLFSEHSSSGTQHASVSLETPLVVETVTPGIPT TAVAPSKLMTSTTSTCLPPTNLPLGTAGMPVMPVGTPGQVSTPGTHASAPASTATGAK PGTTPPKPSLTKTVVPPVGTELSAGTVPCEQLPPFPGPSLIQTQQPLEDLDAQLRRTL SPETIPVTPAVGPLSTMSSTAVTEAGSQPQKDGTEVHVTASSSGAGVVKMGRFQVSVT MDDAQKERKNRSEDTKSVHFESSTSESSVLSSSSPESTLVKPEPNGITVSGISLDVPD STHRTPTPEAKSETGQPTKVGRFQVTTTANKVGRFSVSRTEDKVTELKKEGPVTSPFR DSEQTVIPAAIPKKEKPELAEPSHLNGPSSDLEAAFLSRGGEDGSGSPHSPPHLCSKS LPIQTLSQSLSNSFNSSYMSSDNESDIEDEDLRLELRRLREKHLKEIQDLQSRQKHEI ESLYTKLGKVPPAVIIPPAAPLSGRRRRPTKSKGSKSSRSSSLGNKSPQLSGNLSGQS GTSVLNPQQTLHPPGNTPETGHNQLLQPLKPSPSSDNLYSAFTSDGAISIPSLSAPGQ GTSSTNTVGGTVSSQAAQAQPPAMTSSRKGTFTDDLHKLVDNWARDAMNLSGRRGSKG HMNYEGPGMARKFSAPGQLCISMTSNMGGSTPISAASATSLGHFTKSMCPPQQYGFPA APFGTQWSGTGGPAPQPLGQFQPVGTTSLQNFNISNLQKSISNPPSSNLRTT" ORIGIN 1 gcgtcgccct cggggcgcct tgtcagtgct gagtgggagt cgtccggtgg ctccgagccc 61 gccgtaggag cgctgcccag cacttcttgg tggcttctcc gggccaccct tttccctttt 121 cattcataaa tccgagcccg cattcttcac tccaccggac caaccatgtc tgacggcacc 181 gcagagaagc agagcggcac tcctggcttc ctttcgcctc cggctccagt ccccaagaat 241 ggctcaagct ccgattcttc cgtgggcgag aaactggggg ccgcggtcgc cgactccgga 301 attggcagga cagaggaata ccggcgccgc cggcacacta tggacaagga cagtcgtggg 361 gcggccgcca ccactacccc cacggagcac cgatttttcc gccgaagcgt catctgcgac 421 tccaatgcca cggcgttgga gctgccgggc ctccctctct ctatccctca acctagtgta 481 cccgcagtgg tgcctcagag tgctccaccc gagcctcaca gagaggaaac tttgacggcc 541 accgttgctt cccaggtgtc tcagcaaccc tcggctgctg cctcccctgg ggaacaagcc 601 gttgtaggct cggccaccgc gaccgtcccc agcagtacca gcaaagaccg cccggtgtcc 661 cagcccagcc tcgtgggtag caaagaggag ccgccgccgt ccagaagtgg aagtggcagc 721 ggtggtgcca gtgccaaaga gccgcaggag gaaaggaacc agcaacagga tgatatcgaa 781 gagctggaga ccaaggcagt gggaatgtcc aatgacggtc gctttctcaa atttgacatc 841 gaaatcggca gaggctcctt taagacggtc tacaaaggtc tggacaccga aaccactgtg 901 gaagtcgcct ggtgtgaatt gcaggatcga aagttaacaa aatctgaaag gcagagattc 961 aaagaagaag ctgaaatgct aaagggtctt caacatccta acattgttcg attctatgat 1021 tcctgggaat ccacagtaaa agggaaaaaa tgcattgttt tagtgactga actaatgaca 1081 tctggaacac ttaaaacgta cttaaaaagg tttaaagtga tgaaaatcaa agttttaaga 1141 agctggtgtc ggcaaatcct taaaggactt caatttctcc atacacgaac tcccccgatt 1201 attcaccggg atcttaaatg tgacaacatc tttatcactg gtcctaccgg ctcagtcaag 1261 atcggagacc ttggtctggc aactctaaag cgggcttctt ttgccaagag tgtgataggt 1321 accccagagt ttatggctcc tgagatgtat gaggagaagt acgatgaatc cgttgatgtt 1381 tatgcttttg ggatgtgcat gcttgagatg gctacgtctg aatatccata ctcagagtgc 1441 caaaatgctg ctcagatcta ccgtcgagtg accagtggag tgaagccagc cagttttgac 1501 aaagtagcaa ttcctgaagt gaaggaaatt attgaaggat gtatccgaca aaacaaagat 1561 gaaagatatt ccatcaaaga ccttttgaac catgcctttt tccaggagga aacaggggta 1621 cgggtagaat tagcagaaga agatgatgga gaaaagatag ctatcaaatt atggctacgt 1681 attgaagata ttaagaaatt aaagggaaaa tacaaagaca atgaagctat tgagttttcc 1741 tttgacttgg agagggatgt accagaagat gttgctcaag aaatggtcga gtctggttat 1801 gtctgtgaag gtgatcacaa gaccatggct aaagctatca aagatagggt atcattaatt 1861 aagagaaaac gagagcagcg gcagttggtt cgagaagagc aagaaaaaag aaaacaagaa 1921 gagagcagtt tcaaacagca gaatgaacaa caagcaagtg tttcccaggc aggaatccag 1981 ccactctctg ttgctagcac tggcataccc actgctccca ccacatccgc ttcagtttct 2041 actcaagtag agcctgaaga acccgaggca gatcagcatc aacagctgca gtatcagcaa 2101 cctagtatat ctgtgttgtc tgatggaaca gttgacagtg gtcaaggatc atctgtattc 2161 acagaatcca gagtgagcag ccaacagact gtttcctatg gctcccaaca tgagcaggca 2221 cattctattg gcacagcacc aggacataca gtttctagta tccaagcaca atctcagccc 2281 catggggtgt atccaccctc aagtatggca caggggcaga accagggcca gccatcaagt 2341 agtttagcag gggttctatc ttcacaaccc gtccaacatc ctcagcagca gggaatacag 2401 ccgactgtac ctcctcaaca ggcagtacag tattcacttc cacaggcagc gtcttccagt 2461 gaaggcactg tccagccagt gagtcagcct caagtgtcag ctggaacaca gagtagtaca 2521 cagggagtct ctcaggctgc tcctccagaa caaactccaa taacacagtc acaacctact 2581 caacctgttc cattggtttc ctctgtggac agtgcccatt cagatgttgc ttctggtatg 2641 agtgatggca atgagaatgc tccttcatcc agcgggaggc atgaagggag gacgacaaaa 2701 cgtcattatc gaaaatctgt aagaagtcgt tctcgtcatg aaaagacttc tcgcccgaaa 2761 ctgaggattt taaatgtttc aaataaagga gaccgagtag tagaatgtca attggagact 2821 cataatcgga aaatggttac atttaaattt gacctagatg gcgacaaccc tgaagagata 2881 gcaacaatta tggtgaacaa tgactttatt ctagccatag agagagagtc ttttgtggct 2941 caagtgcggg aaattattga aaaggctgat gaaatgttaa gcgaggatgt cagtgtggag 3001 cctgagggtg accagggatt ggagagtcta caaggaaagg atgactatgg ctttccaggt 3061 tctcagaaat tagaaggaga gttcaagcaa ccaattgctg tatcttccat gccacaacaa 3121 ataggtgttc ctaccagttc tttaacacaa gttgttcatt ctgctggaag acgatttata 3181 gtgagtccag ttccagaaag tcgattacga gaatcaaaaa ttttcaccag tgaaatacca 3241 gatccagttg cggcctctac atctcagggc cctggaatga acttatctca ctccgcttca 3301 tcccttagtc tccagcaggc tttttctgaa ctgaaacatg gtcagatgac tgaaggaccc 3361 aatacagcac ctccaaattt taatcaccca ggaccaacat tttctccctt tttgactagc 3421 attgctggtg tccaaactgt agcagcatcc acaccatcag tatcagtccc tataacaagc 3481 agccctctta atgacatttc cacatcagtg atgcagtcag agggtgcact gcccactgac 3541 aaaggcattg ggggagttac caccagcaca ggtgtggtag cttcaggtgg tctcaccaca 3601 ttgtctgtgt ctgagacacc aacactttcc agtgcagttt caagttctac agcgcctgca 3661 gttgtcacag tgtctacaac atcccaacca gttcaggctt tcacatctgg gagcattgct 3721 tctagtacag gcagttttcc ttctggaaca ttttccacaa ctacaggtac cacagtgagt 3781 agtgtagctg tcccaaatgc taagcctcca actgtattac tgcaacaggt agcaggtaat 3841 actgctgggg tagccatagt gacatcagtt tctactacca ctccattccc agccatggct 3901 tcacagccat cccttccact tggtagcagc acatctgctc ctacactagc tgaaacagtg 3961 gtggttagtg cacactcact agacaaggca tctcacagta gtacagcagg attgggtttg 4021 tccttttgcg caccgtcctc ttcttcctcc tctggaacag cagtgtctag ttctgtttct 4081 cagcctggta ttgtgcatcc tttggtcatc tcatcagcta tagcttctac acctgtcctc 4141 ccacaaccag cagtacctac ttctacacct ttattacccc aagtacctaa tatcccaccc 4201 ttggtacaac ctgttgctaa tgtgcctgct gtacagcaaa cactcattca tagtcagcct 4261 caaccagctc tacttcccaa ccagcctcac acacactgtc ccgaaatgga tgctgatacc 4321 cagtccaaag ctcctgggat cgatgatata aagactctgg aggaaaagct gagatcgctc 4381 tttagtgagc atagctcatc tggaactcag catgcttctg tctccctgga gacaccctta 4441 gtagtagaga ctgtcacacc gggcatccct accactgctg tagcaccaag taaactcatg 4501 acttccacta caagcacttg cttgccacca accaatttac ccttaggaac agctggcatg 4561 ccagttatgc cagtgggcac acctggtcaa gtttctaccc caggcacaca tgcctcagcc 4621 ccagccagca ccgcaacagg agcaaaacct ggaacaactc ccccaaagcc atctttaact 4681 aagactgtgg tgccgccagt gggtactgag ctttcggctg gtactgtacc ctgtgagcag 4741 ctgccacctt ttcccggacc gtctctaatt cagacccagc aacccctaga agatcttgat 4801 gctcagttga gaagaacact tagtccagag actattccag tgacacccgc agttggtcct 4861 ttgtctacga tgtcttcaac ggcagttaca gaagcaggaa gtcaacctca gaaggatggc 4921 acagaagttc atgtcacagc aagtagctca ggagctggtg ttgttaagat ggggagattt 4981 caggtttcag ttacaatgga tgatgcccag aaagagcgta aaaataggtc agaagataca 5041 aagtcggttc attttgaatc tagtacatca gagtcatcag ttctttcaag tagtagtcca 5101 gagagtaccc tggtaaagcc agagcctaat ggaattactg tttctggcat ctccttagat 5161 gtgccagaca gtacccatag aacaccgacc ccagaagcaa agtcagaaac aggacagcct 5221 accaaggttg gacgttttca ggtgacaact acagccaaca aagtgggtcg tttctctgtt 5281 tcaagaactg aggacaaggt cacagagctc aaaaaagagg gaccagtgac ctctcctttc 5341 agagattcag aacaaactgt tattcctgct gcgataccaa agaaggagaa gcctgagctg 5401 gcagaacctt cccatctgaa tgggccatct tcagacttgg aggctgcctt tctaagtagg 5461 ggtggagagg atggatcagg tagtcctcac tctccccctc acctgtgttc aaagagcctt 5521 cccatccaga ctctaagtca aagccttagt aattcattca actcctctta catgagtagt 5581 gacaatgagt ccgacattga agatgaagac ttaaggttag aactgcgacg actacgggaa 5641 aaacatctta aagagattca ggacctgcag agtcgccaga agcatgaaat tgaatctttg 5701 tataccaaac tgggcaaggt tccccctgct gtcattattc ccccagctgc tcctctgtca 5761 gggagaagaa ggaggcctac taaaagcaaa ggcagcaagt ccagtcgcag cagctcattg 5821 ggcaacaaaa gccctcagct ttcaggtaac ctgtctggtc agagtggaac ttcagtctta 5881 aacccccaac agaccctcca tcccccaggc aataccccag agactggaca caaccagctg 5941 ttacagcctc ttaagccatc tccctccagt gacaacctct attcagcctt taccagtgat 6001 ggtgccattt caataccaag cctttctgct ccaggtcaag ggaccagcag cacaaacacc 6061 gttggaggaa cagtgagtag ccaggctgcc caggctcagc ctcctgccat gacttccagt 6121 aggaagggca cattcacaga tgacctgcac aagttggtag acaactgggc ccgagatgcc 6181 atgaatcttt caggcaggag aggcagcaaa ggacacatga attatgaggg ccctggaatg 6241 gcaaggaagt tctctgctcc tgggcagctg tgcatttcca tgacctcaaa catgggtggc 6301 tctaccccca tctctgcagc atctgctacc tctctaggtc acttcaccaa gtccatgtgc 6361 cccccacagc agtatggttt tccagctgcc ccattcggca ctcagtggag tggaacaggt 6421 ggtccagcac cacagccact tggtcagttc caacctgtag gaaccacatc cttgcaaaat 6481 ttcaacatca gcaatttgca gaagtccatc agcaaccccc caagttccaa cctacggacc 6541 acctagtcag cagcaaggat gttaactgag tagatctggg ggcaggaaat ggaatggtga 6601 tggggtgggg ggtggggaaa tagcctatat actaactact agtgctgcat ttaactggtt 6661 atttcttgcc agaagggaat gtttttaata ccattttgag ccctcagaat ggagaaccac 6721 cctccttctc catttgttgg agttaaaaaa gaaggaaaga agagctttct ggtggagggg 6781 ctgcctgaga ctgcttttct gtttttgtac ccaccagtaa ggcctagggg ctagaagaga 6841 gccttgttac cagaaagcct catgtaagcc aaatcccata tgtatctgaa gtgggtagag 6901 ctcttaattt tgacatgtgc ccccgaaact ccttattccc tcaacagtgc acaccttaag 6961 acaaaaaggt tctctcccac tcggatccct acccccactt ttttttttcc ttttacaacc 7021 tagtgaaaaa caccagggga ctggggttgc aaccctttct tatataggtc attaatgctt 7081 taagcaaaag attagcagct ttgactgcag cattagcaat tagggaaaac aatgacgttc 7141 cctgcggaca tgttaacttt gccatcagtt ttgatgtgga aacactgtga tatataaatg 7201 ttgttggaca acattagttt taagagtaaa atttgaaagg tttaaaaggt tcacacacaa 7261 agctagctct gtcctttcct tattaagaca ctttaacttt ttcctttgta tttccattgt 7321 attagataaa taaatgtgaa tg //
Whole sequence Selected region from: to:
All features Gene, RNA, and CDS features only
Show sequence Show reverse complement Show gap features
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on