LOCUS NM_007407 6262 bp mRNA linear ROD 11-SEP-2024
DEFINITION Mus musculus adenylate cyclase activating polypeptide 1 receptor 1
(Adcyap1r1), transcript variant 1, mRNA.
ACCESSION NM_007407
VERSION NM_007407.4
KEYWORDS RefSeq; RefSeq Select.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (bases 1 to 6262)
AUTHORS Diao,M., Tao,Y., Liu,Q., Huang,L., Li,H. and Lin,X.
TITLE Rac1 promotes the lipopolysaccharide-induced inflammatory response
and contraction-associated proteins (CAPs) expression in mouse
uterine smooth muscle cells
JOURNAL Reprod Biol 24 (3), 100896 (2024)
PUBMED 38833837
REMARK GeneRIF: Rac1 promotes the lipopolysaccharide-induced inflammatory
response and contraction-associated proteins (CAPs) expression in
mouse uterine smooth muscle cells.
REFERENCE 2 (bases 1 to 6262)
AUTHORS Son,H., Zhang,Y., Shannonhouse,J., Gomez,R. and Kim,Y.S.
TITLE PACAP38/mast-cell-specific receptor axis mediates repetitive
stress-induced headache in mice
JOURNAL J Headache Pain 25 (1), 87 (2024)
PUBMED 38802819
REMARK Publication Status: Online-Only
REFERENCE 3 (bases 1 to 6262)
AUTHORS Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
Jackson,S.P. and Balmus,G.
CONSRTM Sanger Mouse Genetics Project
TITLE Genetic determinants of micronucleus formation in vivo
JOURNAL Nature 627 (8002), 130-136 (2024)
PUBMED 38355793
REFERENCE 4 (bases 1 to 6262)
AUTHORS Yavas,E., Zhuravka,I. and Fanselow,M.S.
TITLE PAC1 receptor modulation of freezing and flight behavior in
periaqueductal gray
JOURNAL Genes Brain Behav 22 (6), e12873 (2023)
PUBMED 37983568
REMARK GeneRIF: PAC1 receptor modulation of freezing and flight behavior
in periaqueductal gray.
REFERENCE 5 (bases 1 to 6262)
AUTHORS Zhao,X., Wang,N., Li,Z. and Li,L.
TITLE Knockdown of PAC1 improved inflammatory pain in mice by regulating
the RAGE/TLR4/NF-kappaB signaling pathway
JOURNAL Brain Res Bull 197, 49-56 (2023)
PUBMED 36967091
REMARK GeneRIF: Knockdown of PAC1 improved inflammatory pain in mice by
regulating the RAGE/TLR4/NF-kappaB signaling pathway.
REFERENCE 6 (bases 1 to 6262)
AUTHORS Sheward,W.J., Lutz,E.M. and Harmar,A.J.
TITLE Expression of pituitary adenylate cyclase activating polypeptide
receptors in the early mouse embryo as assessed by reverse
transcription polymerase chain reaction and in situ hybridisation
JOURNAL Neurosci Lett 216 (1), 45-48 (1996)
PUBMED 8892388
REFERENCE 7 (bases 1 to 6262)
AUTHORS Pantaloni,C., Brabet,P., Bilanges,B., Dumuis,A., Houssami,S.,
Spengler,D., Bockaert,J. and Journot,L.
TITLE Alternative splicing in the N-terminal extracellular domain of the
pituitary adenylate cyclase-activating polypeptide (PACAP) receptor
modulates receptor selectivity and relative potencies of PACAP-27
and PACAP-38 in phospholipase C activation
JOURNAL J Biol Chem 271 (36), 22146-22151 (1996)
PUBMED 8703026
REFERENCE 8 (bases 1 to 6262)
AUTHORS Hashimoto,H., Yamamoto,K., Hagigara,N., Ogawa,N., Nishino,A.,
Aino,H., Nogi,H., Imanishi,K., Matsuda,T. and Baba,A.
TITLE cDNA cloning of a mouse pituitary adenylate cyclase-activating
polypeptide receptor
JOURNAL Biochim Biophys Acta 1281 (2), 129-133 (1996)
PUBMED 8664310
REFERENCE 9 (bases 1 to 6262)
AUTHORS Aino,H., Hashimoto,H., Ogawa,N., Nishino,A., Yamamoto,K., Nogi,H.,
Nagata,S. and Baba,A.
TITLE Structure of the gene encoding the mouse pituitary adenylate
cyclase-activating polypeptide receptor
JOURNAL Gene 164 (2), 301-304 (1995)
PUBMED 7590347
REFERENCE 10 (bases 1 to 6262)
AUTHORS Spengler,D., Waeber,C., Pantaloni,C., Holsboer,F., Bockaert,J.,
Seeburg,P.H. and Journot,L.
TITLE Differential signal transduction by five splice variants of the
PACAP receptor
JOURNAL Nature 365 (6442), 170-175 (1993)
PUBMED 8396727
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BY286680.1, AK083108.1, CA320747.1, BC067039.1 and AI843743.1.
On Nov 6, 2013 this sequence version replaced NM_007407.3.
Transcript Variant: This variant (1) represents the longer
transcript and encodes the longer isoform (1).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK042820.1, AK083108.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMN00849374, SAMN00849375
[ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on conservation, expression
##RefSeq-Attributes-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-2 BY286680.1 2-3
3-871 AK083108.1 1-869
872-3460 AK083108.1 871-3459
3461-3996 CA320747.1 146-681
3997-6238 BC067039.1 3846-6087
6239-6262 AI843743.1 1-24 c
FEATURES Location/Qualifiers
source 1..6262
/organism="Mus musculus"
/mol_type="mRNA"
/strain="C57BL/6"
/db_xref="taxon:10090"
/chromosome="6"
/map="6 27.38 cM"
gene 1..6262
/gene="Adcyap1r1"
/gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
/note="adenylate cyclase activating polypeptide 1 receptor
1"
/db_xref="GeneID:11517"
/db_xref="MGI:MGI:108449"
exon 1..391
/gene="Adcyap1r1"
/gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
/inference="alignment:Splign:2.1.0"
exon 392..521
/gene="Adcyap1r1"
/gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
/inference="alignment:Splign:2.1.0"
misc_feature 420..422
/gene="Adcyap1r1"
/gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
/note="upstream in-frame stop codon"
CDS 471..1961
/gene="Adcyap1r1"
/gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
/note="isoform 1 precursor is encoded by transcript
variant 1; pituitary adenylate cyclase-activating
polypeptide type I receptor; PACAP type I receptor"
/codon_start=1
/product="pituitary adenylate cyclase-activating
polypeptide type I receptor isoform 1 precursor"
/protein_id="NP_031433.3"
/db_xref="CCDS:CCDS20167.1"
/db_xref="GeneID:11517"
/db_xref="MGI:MGI:108449"
/translation="MARTLQLSLTALLLLPMAIAMHSDCIFKKEQAMCLERIQRANDL
MGLNESSPGCPGMWDNITCWKPAQIGEMVLVSCPEVFRIFNPDQVWMTETIGDSGFAD
SNSLEITDMGVVGRNCTEDGWSEPFPHYFDACGFDDYEPESGDQDYYYLSVKALYTVG
YSTSLVTLTTAMVILCRFRKLHCTRNFIHMNLFVSFMLRAISVFIKDWILYAEQDSSH
CFVSTVECKAVMVFFHYCVVSNYFWLFIEGLYLFTLLVETFFPERRYFYWYTIIGWGT
PTVCVTVWAVLRLYFDDAGCWDMNDSTALWWVIKGPVVGSIMVNFVLFIGIIIILVQK
LQSPDMGGNESSIYFSCVQKCYCKPQRAQQHSCKMSELSTITLRLARSTLLLIPLFGI
HYTVFAFSPENVSKRERLVFELGLGSFQGFVVAVLYCFLNGEVQAEIKRKWRSWKVNR
YFTMDFKHRHPSLASSGVNGGTQLSILSKSSSQLRMSSLPADNLAT"
sig_peptide 471..530
/gene="Adcyap1r1"
/gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
/inference="COORDINATES: ab initio prediction:SignalP:6.0"
mat_peptide 531..1958
/gene="Adcyap1r1"
/gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
/product="Pituitary adenylate cyclase-activating
polypeptide type I receptor. /id=PRO_0000012842"
/note="propagated from UniProtKB/Swiss-Prot (P70205.1)"
misc_feature 612..614
/gene="Adcyap1r1"
/gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (P70205.1); glycosylation site"
misc_feature 648..650
/gene="Adcyap1r1"
/gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (P70205.1); glycosylation site"
misc_feature 819..821
/gene="Adcyap1r1"
/gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (P70205.1); glycosylation site"
misc_feature 843..887
/gene="Adcyap1r1"
/gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
/note="propagated from UniProtKB/Swiss-Prot (P70205.1);
Region: Important for ligand binding and specificity.
/evidence=ECO:0000250"
misc_feature 936..1004
/gene="Adcyap1r1"
/gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
/note="propagated from UniProtKB/Swiss-Prot (P70205.1);
transmembrane region"
misc_feature 1029..1085
/gene="Adcyap1r1"
/gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
/note="propagated from UniProtKB/Swiss-Prot (P70205.1);
transmembrane region"
misc_feature 1152..1229
/gene="Adcyap1r1"
/gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
/note="propagated from UniProtKB/Swiss-Prot (P70205.1);
transmembrane region"
misc_feature 1275..1343
/gene="Adcyap1r1"
/gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
/note="propagated from UniProtKB/Swiss-Prot (P70205.1);
transmembrane region"
misc_feature 1398..1466
/gene="Adcyap1r1"
/gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
/note="propagated from UniProtKB/Swiss-Prot (P70205.1);
transmembrane region"
misc_feature 1605..1667
/gene="Adcyap1r1"
/gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
/note="propagated from UniProtKB/Swiss-Prot (P70205.1);
transmembrane region"
misc_feature 1710..1769
/gene="Adcyap1r1"
/gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
/note="propagated from UniProtKB/Swiss-Prot (P70205.1);
transmembrane region"
misc_feature 1854..1856
/gene="Adcyap1r1"
/gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:21183079; propagated from
UniProtKB/Swiss-Prot (P70205.1); phosphorylation site"
misc_feature 1893..1895
/gene="Adcyap1r1"
/gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:21183079; propagated from
UniProtKB/Swiss-Prot (P70205.1); phosphorylation site"
exon 522..627
/gene="Adcyap1r1"
/gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
/inference="alignment:Splign:2.1.0"
exon 628..735
/gene="Adcyap1r1"
/gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
/inference="alignment:Splign:2.1.0"
exon 736..756
/gene="Adcyap1r1"
/gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
/inference="alignment:Splign:2.1.0"
exon 757..798
/gene="Adcyap1r1"
/gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
/inference="alignment:Splign:2.1.0"
exon 799..908
/gene="Adcyap1r1"
/gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
/inference="alignment:Splign:2.1.0"
exon 909..1006
/gene="Adcyap1r1"
/gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
/inference="alignment:Splign:2.1.0"
exon 1007..1139
/gene="Adcyap1r1"
/gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
/inference="alignment:Splign:2.1.0"
exon 1140..1293
/gene="Adcyap1r1"
/gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
/inference="alignment:Splign:2.1.0"
exon 1294..1354
/gene="Adcyap1r1"
/gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
/inference="alignment:Splign:2.1.0"
exon 1355..1424
/gene="Adcyap1r1"
/gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
/inference="alignment:Splign:2.1.0"
exon 1425..1516
/gene="Adcyap1r1"
/gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
/inference="alignment:Splign:2.1.0"
exon 1517..1600
/gene="Adcyap1r1"
/gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
/inference="alignment:Splign:2.1.0"
exon 1601..1730
/gene="Adcyap1r1"
/gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
/inference="alignment:Splign:2.1.0"
exon 1731..1772
/gene="Adcyap1r1"
/gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
/inference="alignment:Splign:2.1.0"
exon 1773..6245
/gene="Adcyap1r1"
/gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
/inference="alignment:Splign:2.1.0"
regulatory 2956..2961
/regulatory_class="polyA_signal_sequence"
/gene="Adcyap1r1"
/gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
/note="hexamer: ATTACA"
polyA_site 2978
/gene="Adcyap1r1"
/gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
/note="major polyA site"
regulatory 5086..5091
/regulatory_class="polyA_signal_sequence"
/gene="Adcyap1r1"
/gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
/note="hexamer: AATAAA"
polyA_site 5111
/gene="Adcyap1r1"
/gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
/note="major polyA site"
regulatory 6220..6225
/regulatory_class="polyA_signal_sequence"
/gene="Adcyap1r1"
/gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
/note="hexamer: AATAAA"
polyA_site 6240
/gene="Adcyap1r1"
/gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
/note="major polyA site"
ORIGIN
1 gaggtctgcc ggggaggcgg tggtctatcg cctccctcgg ccccgggcct ggctgcgcag
61 cagaggcggc gcctctcccg caggacagag ccggtcgagt ggcacagggt gggctaaagg
121 agacgaggga cgcctcgctc cgattcccga ctgcgactgg ctgcgacttt ggagcagcgc
181 ggtcccttgt gcagtacgca cacaccgcgg cgcagggaca cacagacttg gctgctcgcg
241 gccacacgca ccgagagacc aggctcggcg cgcgctccgc ggcgcacacg ctccagccag
301 tgcggctctg ggcgcggatt cgcgggttgc gcgtcctcct gcaccttcag cccctgcgcc
361 cagcagtccc gaccagcccc gaggccatca gcgctgcatg cacagtggag ggtggtgact
421 gactccccaa ggctgggagc aacagccaga gacagtggct gggaagcacc atggccagaa
481 ccctgcagct ctccctgact gctctcctcc tgctgcctat ggctattgct atgcactctg
541 actgcatctt caagaaggag caagccatgt gcctggagag gatccagagg gccaacgacc
601 tgatgggcct aaatgagtct tccccaggtt gccctggcat gtgggacaat atcacatgtt
661 ggaagcctgc tcaaataggt gagatggtcc ttgtgagctg ccctgaggtc ttccggatct
721 tcaacccgga ccaagtctgg atgacagaaa ccatagggga ttctggcttt gctgatagta
781 attccttgga gatcacagac atgggggtcg tgggccggaa ctgcactgag gatggctggt
841 cggagccctt cccccattac ttcgatgctt gtgggtttga tgactatgag cccgagtctg
901 gggatcagga ttattactac ctgtcggtga aggccctcta cacagtcggc tacagcacct
961 ccctcgtcac cctcaccact gccatggtca tcttgtgccg cttccggaag ctgcactgta
1021 cccgtaactt catccacatg aacctgtttg tatccttcat gctgagagct atctctgtct
1081 tcatcaaaga ctggatcttg tatgccgagc aggacagcag tcattgcttc gtttccaccg
1141 tggaatgcaa agctgtcatg gttttctttc actactgcgt ggtgtccaac tacttctggc
1201 tgttcattga aggcctatac ctctttacac tgctggtgga gaccttcttc cctgagagga
1261 gatatttcta ctggtatacc atcattggct gggggacacc tactgtgtgt gtaactgtgt
1321 gggctgtgct gaggctctac tttgatgatg cgggatgctg ggatatgaat gacagcacag
1381 ctctgtggtg ggtgatcaaa ggccctgtag ttggctctat aatggttaac tttgtgcttt
1441 tcatcggcat catcatcatc cttgtgcaga agctgcagtc cccagacatg ggaggcaatg
1501 agtcgagcat ctacttcagc tgcgtgcaga aatgctactg caagccacag cgggctcagc
1561 agcactcttg caagatgtca gaactatcca ccattactct acggctggcc cgctccaccc
1621 tgctgctcat cccactcttt ggaatccact acacagtatt tgccttctct ccagagaacg
1681 tcagcaagag ggaaagactt gtgtttgagc ttgggctggg ctccttccag ggctttgtgg
1741 tggctgtact ctactgcttc ctgaatgggg aggtacaggc agagattaag aggaaatgga
1801 ggagctggaa ggtgaaccgt tacttcacta tggacttcaa gcaccggcat ccatccctgg
1861 ccagcagtgg agtgaacggg ggcacccagc tgtccatcct gagcaagagc agctcccagc
1921 tccgcatgtc cagcctcccg gccgacaact tggccacctg agccctgtct cccttcttct
1981 tctgcacagg ctggggctgc gggccagtgc ctgcgcatgt ttgtgcctct cccctctcct
2041 tgggcaggcc ctgggtagga agctgggctc ctcctcaaag gggaagagag agatagggta
2101 taggctgata ttgcccctcc tgtttgggtc ccatctactg tggtccactg agcccaattt
2161 gatatgtaaa tacacctcaa atttggaaag ttgccccatc tctccccccc aacccatgcc
2221 cctgctcacc tctgccaggt cccagcttga cctactgggt caaggccagc ctcggtgatg
2281 gcctgatccc aggtacaagg ccttgtgaac tgagtttgaa acatgcctgc tttggagaga
2341 ctggggcagt gaacacccca gcagcctttc agcaaattgg ctttggacat ggacccttct
2401 cagcctgtac caagtactgc agctcagtgt catgagcatc ctttggagca ggtcaacctg
2461 aggctccttt ggcttacatc taagttgtcc aggtgctcag ctcctgtgtg cctggatgat
2521 gagagggctc tagggctctt tcagtcagag acttacattg aggtggggtg agggtcagag
2581 aaagttctgg tgcttttcct gtgctctaag agctgagagc cagaaatgca gattcaattt
2641 ggaaggagat gggatagctg aagaacttac cacgtccatg actgtgccct gactcaagac
2701 cgtatcatgt ggtggcttta tttctacact tcttgcccac catggatggc ctgaagaagc
2761 tgttctccag ccacaacaac cacagaaagc ccctcgctct cccctctctg ttttcccatt
2821 aatcaaagcc atgtctagaa tgggccagcc accttgcagt aaaatcaatg agttctgaag
2881 caaccttcaa ttttcataag ccaagtcttg ggtccaggga actccacagt gctcccaccc
2941 ccaccccctc tactgattac aaggaatcct acatgccatc ttcagcctgg actcaattac
3001 taaactcgga tttgtctgca agactttctc cacgtgccct tgacattgga atcacttgtg
3061 gggcctccta gggtgtttgg aggtgatatg gtgtctatca tgtgcatagg cagaagctgc
3121 tggtagaggg agtggtggct ttctagtgcc catcttggct ctccagctgc aagttgcaca
3181 gccataacct aagactttaa aataaggcca cacccagatt tgggaaggta gagggggaaa
3241 aaaagtagtg ccatggggcc acggggccca gcttattccg tgtagatgct tgtttttgtc
3301 cctgcctccg aggaacttgt tcatgattgt gctctgaact gcatggggag tgtggggtgc
3361 tgccttgctc gctgttatat taagtagaag gagttttagg atattcgaga cagtgcttct
3421 ggaggagcca ttggaaagac tggagaagat tctaatggat aggatttaga gatgtgttct
3481 gtgttcttga ccagtgaagt atgctcttgg gtctttggca aagctggaaa gagaaagggc
3541 ctccttgttc tttcccagaa acattcagtg gcttggacca acccctgagt atatacattg
3601 gctctttccc ccctgtacct tatctctccc ctccatcccc tcccctgttc tgagaaccag
3661 gttatcagcc aaacaagaat cagttgatcc ccttgcactt tggacacttc aatggagcct
3721 gagctgctta gaagccttgg ttcaggattc cagctgggtt catgactgtg aacacaatgt
3781 gccctgtgct gggccacagc ttccttgttt atgaagtgag gtggtttcta gtgcttttcc
3841 aggttctgcc ttagttaaaa actaaggcag gtaaacagag atgaatcctt gtgaaaagca
3901 tctaaggggt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgcgtgcat
3961 gtgtgtatta agagggatga catcctgttt attttcccat ttggatgcca catggtatcc
4021 aaagctggta gagcagctat catgcctcag gccatggaca tttgaatggg agcctcaggc
4081 atgatgtgca gaaatagcct tctacaccag gcagggacag gttgcctgtg gccccctcaa
4141 tctgaggtgc accccttggg ctatggaccc cattcccttg ccatcacccc cgccagtggg
4201 tctgcttcac tgtggaagga gaaactgtga ctttctggtt gcattactgc aaaacagcaa
4261 aaaccgaata acccgagccc tgctgctttc tgagccctgg gcctgtgtcc tcctagaact
4321 tccaggttcc cgttgctttg tttttctgtc tgaaggaatc tttttcttag tcttgtgagc
4381 agatgtacct gaaggattct gctgttccat gagggtctgg ctctcaggct gtaggcagtg
4441 atggggcagc acaaggctgg ataaatccct tccctattga ccttcttaca tagtgcaagc
4501 aataagactt attgatctgt gtgtatccca gtgttcctct ggggttctgt ctaaacacca
4561 accatcttct cttggaatgg gccccaggca aggcttgcag caatatagcc tggacccaga
4621 aaagggaaaa cgataaggaa attctgtctg gtaggtgcaa agggcttcat ggatttggaa
4681 acctggaggc aggaacatag cagatttaag gggtacccag ctgtggaagg tcattcctga
4741 gaagtggggg cttgttttat gaaaccttaa aggccaaacg gactgtccca ttttggggat
4801 caggacatcc ctgtccttat ctcctgtcat agctgtccaa ctgcagggta aggagcaagt
4861 tgtgaggaaa ggtcctcaga acatgggatt ccacatgagg aatccttagg ctgccaggaa
4921 gccagagggg tttagaggtg ctcagctttg agccccagta tgcactatgc ttaagctctg
4981 acgactcttg cgtgcagcga ggaggtcctc cctgacatgc tcagcatccc gcagtgattc
5041 ctctcatagc tctgggatgg ggcttggtta gggtgtcgtg atggaaataa acctgaacct
5101 gttgcccagt accagggcct ctgctgtttg gtcttcactc tctcttcctt ggagggaaag
5161 ctacaagaga ctctcttttt aattccttga gtaccctttg ccccacttcc aagagaggac
5221 agcaagtccc ctgacactgc aaatttcatt tgagcctagg gagctgggaa aacagttggg
5281 cctagtctgt ttttgaattg cattgcattg agttgtaccg gtattgcaca gccctgcgtg
5341 tgagccagat gtaacactcc aagcagctgt gaaatgcaat gttccttttg caggagtggc
5401 tgtacctgca gaaagcccag gggtccacag tacagtgcag gagaagcagc tgagttggcc
5461 tggtctaagg atacccccta gcaaacttgg ccctctccat ctgttctggg actctatact
5521 tccctaacct ggatccctgc tctgcaatga ggtggccgtg gttacaccat catctaccct
5581 ctagctaggg atgaggtgga ggtaaaatgc tccctgtgag tttgcaagct ctgaaaacaa
5641 caccgctgtg tgctcattct tagagtgaag accctgaaag gtatcccttt gcagcctgtc
5701 tcctgttttg agccctttag gggtaactca tttgtaaaac caccagcctg agctcaagga
5761 tgaggccaca gggctctggt ggacttcaaa tcccagcttt accgtcatca ctgttcagtt
5821 ttcttcgaag gtacggatga ggagaaatct tctatgagca actccgtgct gtctgcctag
5881 gaatccttca gtggtatggg acactcctca agtgagccaa atgcccgttc tttctccctt
5941 ccttgaactc caggtcctgt gctgtgtctg tactcagcca tgtgtgtttt gtctgctgtc
6001 tgtcttctga ggcttagcat ctgtcagggc tggggttggt tcagcccttg gtactccaga
6061 tgtggttcca ggctcccttg tgggagctgg accggtctgg gtttaatctc ccacaataaa
6121 gataaacccc acggacctca ctgctactgc tgcctccatt aacgctgtgc tcacacattg
6181 tctgggattt taaggatgtc aaactgctgt agatgactca ataaatgtct tatcgttttt
6241 cttggaaaaa aaaaaaaaaa aa
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