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Homo sapiens elongin A2 (ELOA2), mRNA

NCBI Reference Sequence: NM_016427.2

FASTA Graphics 

LOCUS       NM_016427               3062 bp    mRNA    linear   PRI 23-JUL-2020
DEFINITION  Homo sapiens elongin A2 (ELOA2), mRNA.
ACCESSION   NM_016427
VERSION     NM_016427.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3062)
  AUTHORS   Luck K, Kim DK, Lambourne L, Spirohn K, Begg BE, Bian W, Brignall
            R, Cafarelli T, Campos-Laborie FJ, Charloteaux B, Choi D, Cote AG,
            Daley M, Deimling S, Desbuleux A, Dricot A, Gebbia M, Hardy MF,
            Kishore N, Knapp JJ, Kovacs IA, Lemmens I, Mee MW, Mellor JC,
            Pollis C, Pons C, Richardson AD, Schlabach S, Teeking B, Yadav A,
            Babor M, Balcha D, Basha O, Bowman-Colin C, Chin SF, Choi SG,
            Colabella C, Coppin G, D'Amata C, De Ridder D, De Rouck S,
            Duran-Frigola M, Ennajdaoui H, Goebels F, Goehring L, Gopal A,
            Haddad G, Hatchi E, Helmy M, Jacob Y, Kassa Y, Landini S, Li R, van
            Lieshout N, MacWilliams A, Markey D, Paulson JN, Rangarajan S,
            Rasla J, Rayhan A, Rolland T, San-Miguel A, Shen Y, Sheykhkarimli
            D, Sheynkman GM, Simonovsky E, Tasan M, Tejeda A, Tropepe V,
            Twizere JC, Wang Y, Weatheritt RJ, Weile J, Xia Y, Yang X,
            Yeger-Lotem E, Zhong Q, Aloy P, Bader GD, De Las Rivas J, Gaudet S,
            Hao T, Rak J, Tavernier J, Hill DE, Vidal M, Roth FP and Calderwood
            MA.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3062)
  AUTHORS   Lim J, Hao T, Shaw C, Patel AJ, Szabo G, Rual JF, Fisk CJ, Li N,
            Smolyar A, Hill DE, Barabasi AL, Vidal M and Zoghbi HY.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   3  (bases 1 to 3062)
  AUTHORS   Aso T, Yamazaki K, Amimoto K, Kuroiwa A, Higashi H, Matsuda Y,
            Kitajima S and Hatakeyama M.
  TITLE     Identification and characterization of Elongin A2, a new member of
            the Elongin family of transcription elongation factors,
            specifically expressed in the testis
  JOURNAL   J. Biol. Chem. 275 (9), 6546-6552 (2000)
   PUBMED   10692460
REFERENCE   4  (bases 1 to 3062)
  AUTHORS   Aso T, Lane WS, Conaway JW and Conaway RC.
  TITLE     Elongin (SIII): a multisubunit regulator of elongation by RNA
            polymerase II
  JOURNAL   Science 269 (5229), 1439-1443 (1995)
   PUBMED   7660129
REFERENCE   5  (bases 1 to 3062)
  AUTHORS   Bradsher JN, Jackson KW, Conaway RC and Conaway JW.
  TITLE     RNA polymerase II transcription factor SIII. I. Identification,
            purification, and properties
  JOURNAL   J. Biol. Chem. 268 (34), 25587-25593 (1993)
   PUBMED   8244996
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC036022.1 and AB030834.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            [WARNING] On Aug 13, 2020 this sequence was replaced by
            NM_016427.3.
            
            On Mar 15, 2004 this sequence version replaced NM_016427.1.
            
            Summary: This gene encodes the transcriptionally active subunit of
            the SIII (or elongin) transcription elongation factor complex,
            which also includes two regulatory subunits, elongins B and C. This
            complex acts to increase the rate of RNA chain elongation by RNA
            polymerase II by suppressing transient pausing of the polymerase at
            many sites along the DNA template. Whereas a related protein with
            similar function, elongin A, is ubiquitously expressed, the encoded
            protein is specifically expressed in the testis, suggesting it may
            have a role in spermatogenesis. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC036022.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-400               BC036022.1         5-404
            401-472             AB030834.1         162-233
            473-1719            BC036022.1         477-1723
            1720-2903           AB030834.1         1481-2664
            2904-3062           BC036022.1         2908-3066
FEATURES             Location/Qualifiers
     source          1..3062
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q21.1"
     gene            1..3062
                     /gene="ELOA2"
                     /gene_synonym="HsT832; TCEB3B; TCEB3L"
                     /note="elongin A2"
                     /db_xref="GeneID:51224"
                     /db_xref="HGNC:HGNC:30771"
                     /db_xref="MIM:609522"
     exon            1..3046
                     /gene="ELOA2"
                     /gene_synonym="HsT832; TCEB3B; TCEB3L"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    45..47
                     /gene="ELOA2"
                     /gene_synonym="HsT832; TCEB3B; TCEB3L"
                     /note="upstream in-frame stop codon"
     CDS             354..2615
                     /gene="ELOA2"
                     /gene_synonym="HsT832; TCEB3B; TCEB3L"
                     /note="transcription elongation factor (SIII) elongin A2
                     elongin A2; RNA polymerase II transcription factor SIII
                     subunit A2; transcription elongation factor B polypeptide
                     3B; transcription elongation factor B subunit 3B"
                     /codon_start=1
                     /product="elongin-A2"
                     /protein_id="NP_057511.2"
                     /db_xref="CCDS:CCDS11932.1"
                     /db_xref="GeneID:51224"
                     /db_xref="HGNC:HGNC:30771"
                     /db_xref="MIM:609522"
                     /translation="MAAGSTTLHAVEKLQVRLATKTEPKKLEKYLQKLSALPMTADIL
                     AETGIRKTVKRLRKHQHVGDFARDLAARWKKLVLVDRNTRPGPQDPEESASRQRFGEA
                     LQDQEKAWGFPENATAPRSPSHSPEHRRTARRTPPGQQRPHPRSHSREPRAERKCPRI
                     APADSGRYRASPTRTAPLRMPEGPEPAAPGKQPGRGHTHAAQGGPLLCPGCQGQPQGK
                     AVVSHSKGHKSSRQEKRPLCAQGDWHSPTLIREKSCGACLREETPRMPSWASARDRQP
                     SDFKTDKEGGQAGSGQRVPALEEAPDSHQKRPQHSHSNKKRPSLDGRDPGNGTHGLSP
                     EEKEQLSNDRETQEGKPPTAHLDRTSVSSLSEVEEVDMAEEFEQPTLSCEKYLTYDQL
                     RKQKKKTGKSATTALGDKQRKANESKGTRESWDSAKKLPPVQESQSERLQAAGADSAG
                     PKTVPSHVFSELWDLSEAWMQANYDPLSDSDSMTSQAKPEALSSPKFREEAAFPGRRV
                     NAKMPVYSGSRPACQLQVPTLRQQCAQVLRNNPDALSDVGEVPYWVLEPVLEGWRPDQ
                     LYRRKKDNHALVRETDELRRNHCFQDFKEEKPQENKTWREQYLRLPDAPEQRLRVMTT
                     NIRSARGNNPNGREAKMICFKSVAKTPYDTSRRQEKSAGDADPENGEIKPASKPAGSS
                     HTPSSQSSSGGGRDSSSSILRWLPEKRANPCLSSSNEHAAPAAKTRKQAAKKVAPLMA
                     KAIRDYKRRFSRR"
     misc_feature    1851..2330
                     /gene="ELOA2"
                     /gene_synonym="HsT832; TCEB3B; TCEB3L"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8IYF1.2);
                     Region: Activation domain. /evidence=ECO:0000250"
     misc_feature    1935..1964
                     /gene="ELOA2"
                     /gene_synonym="HsT832; TCEB3B; TCEB3L"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8IYF1.2);
                     Region: BC-box. /evidence=ECO:0000250|UniProtKB:Q63187"
     misc_feature    1935..1964
                     /gene="ELOA2"
                     /gene_synonym="HsT832; TCEB3B; TCEB3L"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8IYF1.2);
                     Region: Interacting with Elongin BC complex.
                     /evidence=ECO:0000250"
     polyA_site      2921
                     /gene="ELOA2"
                     /gene_synonym="HsT832; TCEB3B; TCEB3L"
     polyA_site      3046
                     /gene="ELOA2"
                     /gene_synonym="HsT832; TCEB3B; TCEB3L"
ORIGIN      
        1 gggtcagggc tagagccgtg agtgtcagcc tgggatgggc tacataaggc ccagctctgg
       61 caccagagct tcattctttg ttgcacagca aactgcagag gtcactccag gctgtggctc
      121 cacatcccga ggaacaaaag cgggcctgct cagctgtctg caaggacggc cgttccagac
      181 caagtggcct gctgctccga ggacccagct cgctccaggc tgtgactcca catcccgagg
      241 tcgctgcctg gcgaccgggc agcgaggacc ggccacccca gacttcctgt cccgcagccc
      301 caaagacaga gctgcgaccg ccgggacagc gacgcctgca cagctctggt gagatggcgg
      361 cagggtccac tacgctgcac gcagtggaga agctgcaggt gcgtctggcc actaagacgg
      421 agccgaaaaa gctagagaaa tatttgcaga aactctccgc cttgcccatg acggcagaca
      481 tcctggcgga gactggaatc agaaagacgg tgaagcgcct gcggaagcac cagcacgtgg
      541 gcgactttgc cagagactta gcggcccggt ggaagaagct ggtgctcgtg gaccgaaaca
      601 cccggcctgg cccacaggac cctgaggaga gcgcttcccg acagcgcttc ggggaggctc
      661 ttcaggacca ggaaaaggcc tggggcttcc cagaaaacgc gacggccccc aggagcccat
      721 ctcacagccc tgagcacaga cggacagcac gcagaacacc tccggggcaa cagagacctc
      781 acccgaggtc tcacagtcgc gagcccagag ctgagagaaa gtgccccaga atagccccag
      841 ctgattccgg ccgctatcgg gcctctccaa cgcgcacagc tcccctccgg atgcccgagg
      901 gccctgagcc cgctgcgccc gggaagcaac ccggaagagg ccacactcac gcggctcagg
      961 gcgggcctct gctgtgtcca ggctgccagg gccaacccca ggggaaagcc gttgtgagcc
     1021 acagcaaggg gcacaaatcg tctcgccagg aaaaacgccc cttgtgtgcc cagggagatt
     1081 ggcactcccc tactttgatc agggagaaat catgcggggc ctgcttaaga gaggaaaccc
     1141 caaggatgcc ctcctgggca agtgccaggg acaggcagcc ttcggacttc aagacagaca
     1201 aggaaggggg gcaagctggc agcggccagc gtgtccctgc cttggaggag gctccagaca
     1261 gtcaccagaa gaggcctcag cacagtcact cgaacaagaa gaggcccagt ctagacggcc
     1321 gggacccagg aaatgggaca cacggcctgt cgcccgagga gaaagagcag ctttccaacg
     1381 accgagagac tcaagagggg aagccaccga ctgctcattt ggacagaacg tccgtgagct
     1441 ccctctctga ggtggaggag gtagatatgg ctgaggaatt cgagcagccc actctgtcat
     1501 gtgaaaaata cctcacctac gatcagttgc ggaagcaaaa gaaaaagact ggaaaatctg
     1561 ccaccactgc acttggagat aaacaaagga aagcaaacga atccaagggc actcgtgagt
     1621 cctgggattc ggctaagaaa ttgcctcctg tccaggaaag ccagtcagag aggctgcagg
     1681 cggccggcgc tgattccgcc gggccgaaaa cggtgcccag ccatgtcttc tcagagctct
     1741 gggacctctc agaggcctgg atgcaggcca actacgatcc gctttcggat tctgactcca
     1801 tgacctccca ggcaaagcca gaagcactct cttcaccaaa gttccgggag gaagctgctt
     1861 tccctggacg cagagtgaat gctaagatgc cggtgtactc gggctccagg cctgcctgcc
     1921 agctccaggt gccgacgctg cgccagcagt gtgcccaggt gcttagaaac aatccggacg
     1981 ccctcagcga cgtgggagag gtcccctact gggttcttga acctgttctg gaagggtgga
     2041 ggcccgatca gctgtatcgc agaaagaaag acaatcacgc actcgttaga gagacagacg
     2101 aattacggag gaatcattgt ttccaggact tcaaggaaga aaagccacag gaaaacaaaa
     2161 cttggaggga gcagtacctg cggcttccgg acgccccaga gcagcggctg agagtaatga
     2221 caacgaatat ccgatctgca cgtggaaaca accccaacgg cagagaggca aagatgatct
     2281 gtttcaaatc tgtggccaag acgccttatg atacttcaag gaggcaagag aagtctgcag
     2341 gagacgctga ccccgaaaat ggggagatca agccagcctc caagcccgcg ggaagcagcc
     2401 acactccctc cagccagagc agcagcggcg gtggcagaga cagcagcagc agcatccttc
     2461 gctggctccc tgagaagcgg gccaacccct gcctgagcag cagcaatgag cacgcggcgc
     2521 ccgcggccaa aacccggaaa caggctgcca agaaagtggc cccgctgatg gccaaggcaa
     2581 ttcgagacta caagagaaga ttctcccgac gataaactca ggacttgcct tgcagataaa
     2641 atctgggggg atttttgcat tggcaaagtc aatgcgggtt ggggaacgaa acttccaatg
     2701 gacaccagaa cctttaactt ggtgcaaagt tgagcctttg aattctgcag gtgtcatgtg
     2761 ctggccctgt gattttgcct cccacaccca gccactacct cccagcttgg agaacacctc
     2821 agaattcaga agatatgaac gcattgggaa caattctatt ttggatgttc actgataatt
     2881 tttaaaaaca ccctagttgt aatcataaat aaggaaaaag atgtgagatt tcctttttcc
     2941 tttctttttt ttttcgaaat caagtagata agaacttctt agacaaaaac acacaagcca
     3001 ttagttgaca ctgataactc cgaatacata aaatgtttgc tgttgcaaaa aaaaaaaaaa
     3061 aa
//
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