LOCUS NM_016427 3062 bp mRNA linear PRI 23-JUL-2020
DEFINITION Homo sapiens elongin A2 (ELOA2), mRNA.
ACCESSION NM_016427
VERSION NM_016427.2
KEYWORDS RefSeq; RefSeq Select.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3062)
AUTHORS Luck K, Kim DK, Lambourne L, Spirohn K, Begg BE, Bian W, Brignall
R, Cafarelli T, Campos-Laborie FJ, Charloteaux B, Choi D, Cote AG,
Daley M, Deimling S, Desbuleux A, Dricot A, Gebbia M, Hardy MF,
Kishore N, Knapp JJ, Kovacs IA, Lemmens I, Mee MW, Mellor JC,
Pollis C, Pons C, Richardson AD, Schlabach S, Teeking B, Yadav A,
Babor M, Balcha D, Basha O, Bowman-Colin C, Chin SF, Choi SG,
Colabella C, Coppin G, D'Amata C, De Ridder D, De Rouck S,
Duran-Frigola M, Ennajdaoui H, Goebels F, Goehring L, Gopal A,
Haddad G, Hatchi E, Helmy M, Jacob Y, Kassa Y, Landini S, Li R, van
Lieshout N, MacWilliams A, Markey D, Paulson JN, Rangarajan S,
Rasla J, Rayhan A, Rolland T, San-Miguel A, Shen Y, Sheykhkarimli
D, Sheynkman GM, Simonovsky E, Tasan M, Tejeda A, Tropepe V,
Twizere JC, Wang Y, Weatheritt RJ, Weile J, Xia Y, Yang X,
Yeger-Lotem E, Zhong Q, Aloy P, Bader GD, De Las Rivas J, Gaudet S,
Hao T, Rak J, Tavernier J, Hill DE, Vidal M, Roth FP and Calderwood
MA.
TITLE A reference map of the human binary protein interactome
JOURNAL Nature 580 (7803), 402-408 (2020)
PUBMED 32296183
REFERENCE 2 (bases 1 to 3062)
AUTHORS Lim J, Hao T, Shaw C, Patel AJ, Szabo G, Rual JF, Fisk CJ, Li N,
Smolyar A, Hill DE, Barabasi AL, Vidal M and Zoghbi HY.
TITLE A protein-protein interaction network for human inherited ataxias
and disorders of Purkinje cell degeneration
JOURNAL Cell 125 (4), 801-814 (2006)
PUBMED 16713569
REFERENCE 3 (bases 1 to 3062)
AUTHORS Aso T, Yamazaki K, Amimoto K, Kuroiwa A, Higashi H, Matsuda Y,
Kitajima S and Hatakeyama M.
TITLE Identification and characterization of Elongin A2, a new member of
the Elongin family of transcription elongation factors,
specifically expressed in the testis
JOURNAL J. Biol. Chem. 275 (9), 6546-6552 (2000)
PUBMED 10692460
REFERENCE 4 (bases 1 to 3062)
AUTHORS Aso T, Lane WS, Conaway JW and Conaway RC.
TITLE Elongin (SIII): a multisubunit regulator of elongation by RNA
polymerase II
JOURNAL Science 269 (5229), 1439-1443 (1995)
PUBMED 7660129
REFERENCE 5 (bases 1 to 3062)
AUTHORS Bradsher JN, Jackson KW, Conaway RC and Conaway JW.
TITLE RNA polymerase II transcription factor SIII. I. Identification,
purification, and properties
JOURNAL J. Biol. Chem. 268 (34), 25587-25593 (1993)
PUBMED 8244996
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BC036022.1 and AB030834.1.
This sequence is a reference standard in the RefSeqGene project.
[WARNING] On Aug 13, 2020 this sequence was replaced by
NM_016427.3.
On Mar 15, 2004 this sequence version replaced NM_016427.1.
Summary: This gene encodes the transcriptionally active subunit of
the SIII (or elongin) transcription elongation factor complex,
which also includes two regulatory subunits, elongins B and C. This
complex acts to increase the rate of RNA chain elongation by RNA
polymerase II by suppressing transient pausing of the polymerase at
many sites along the DNA template. Whereas a related protein with
similar function, elongin A, is ubiquitously expressed, the encoded
protein is specifically expressed in the testis, suggesting it may
have a role in spermatogenesis. [provided by RefSeq, Jul 2008].
##Evidence-Data-START##
Transcript is intronless :: BC036022.1 [ECO:0000345]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on single protein-coding transcript
##RefSeq-Attributes-END##
COMPLETENESS: full length.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-400 BC036022.1 5-404
401-472 AB030834.1 162-233
473-1719 BC036022.1 477-1723
1720-2903 AB030834.1 1481-2664
2904-3062 BC036022.1 2908-3066
FEATURES Location/Qualifiers
source 1..3062
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="18"
/map="18q21.1"
gene 1..3062
/gene="ELOA2"
/gene_synonym="HsT832; TCEB3B; TCEB3L"
/note="elongin A2"
/db_xref="GeneID:51224"
/db_xref="HGNC:HGNC:30771"
/db_xref="MIM:609522"
exon 1..3046
/gene="ELOA2"
/gene_synonym="HsT832; TCEB3B; TCEB3L"
/inference="alignment:Splign:2.1.0"
misc_feature 45..47
/gene="ELOA2"
/gene_synonym="HsT832; TCEB3B; TCEB3L"
/note="upstream in-frame stop codon"
CDS 354..2615
/gene="ELOA2"
/gene_synonym="HsT832; TCEB3B; TCEB3L"
/note="transcription elongation factor (SIII) elongin A2
elongin A2; RNA polymerase II transcription factor SIII
subunit A2; transcription elongation factor B polypeptide
3B; transcription elongation factor B subunit 3B"
/codon_start=1
/product="elongin-A2"
/protein_id="NP_057511.2"
/db_xref="CCDS:CCDS11932.1"
/db_xref="GeneID:51224"
/db_xref="HGNC:HGNC:30771"
/db_xref="MIM:609522"
/translation="MAAGSTTLHAVEKLQVRLATKTEPKKLEKYLQKLSALPMTADIL
AETGIRKTVKRLRKHQHVGDFARDLAARWKKLVLVDRNTRPGPQDPEESASRQRFGEA
LQDQEKAWGFPENATAPRSPSHSPEHRRTARRTPPGQQRPHPRSHSREPRAERKCPRI
APADSGRYRASPTRTAPLRMPEGPEPAAPGKQPGRGHTHAAQGGPLLCPGCQGQPQGK
AVVSHSKGHKSSRQEKRPLCAQGDWHSPTLIREKSCGACLREETPRMPSWASARDRQP
SDFKTDKEGGQAGSGQRVPALEEAPDSHQKRPQHSHSNKKRPSLDGRDPGNGTHGLSP
EEKEQLSNDRETQEGKPPTAHLDRTSVSSLSEVEEVDMAEEFEQPTLSCEKYLTYDQL
RKQKKKTGKSATTALGDKQRKANESKGTRESWDSAKKLPPVQESQSERLQAAGADSAG
PKTVPSHVFSELWDLSEAWMQANYDPLSDSDSMTSQAKPEALSSPKFREEAAFPGRRV
NAKMPVYSGSRPACQLQVPTLRQQCAQVLRNNPDALSDVGEVPYWVLEPVLEGWRPDQ
LYRRKKDNHALVRETDELRRNHCFQDFKEEKPQENKTWREQYLRLPDAPEQRLRVMTT
NIRSARGNNPNGREAKMICFKSVAKTPYDTSRRQEKSAGDADPENGEIKPASKPAGSS
HTPSSQSSSGGGRDSSSSILRWLPEKRANPCLSSSNEHAAPAAKTRKQAAKKVAPLMA
KAIRDYKRRFSRR"
misc_feature 1851..2330
/gene="ELOA2"
/gene_synonym="HsT832; TCEB3B; TCEB3L"
/note="propagated from UniProtKB/Swiss-Prot (Q8IYF1.2);
Region: Activation domain. /evidence=ECO:0000250"
misc_feature 1935..1964
/gene="ELOA2"
/gene_synonym="HsT832; TCEB3B; TCEB3L"
/note="propagated from UniProtKB/Swiss-Prot (Q8IYF1.2);
Region: BC-box. /evidence=ECO:0000250|UniProtKB:Q63187"
misc_feature 1935..1964
/gene="ELOA2"
/gene_synonym="HsT832; TCEB3B; TCEB3L"
/note="propagated from UniProtKB/Swiss-Prot (Q8IYF1.2);
Region: Interacting with Elongin BC complex.
/evidence=ECO:0000250"
polyA_site 2921
/gene="ELOA2"
/gene_synonym="HsT832; TCEB3B; TCEB3L"
polyA_site 3046
/gene="ELOA2"
/gene_synonym="HsT832; TCEB3B; TCEB3L"
ORIGIN
1 gggtcagggc tagagccgtg agtgtcagcc tgggatgggc tacataaggc ccagctctgg
61 caccagagct tcattctttg ttgcacagca aactgcagag gtcactccag gctgtggctc
121 cacatcccga ggaacaaaag cgggcctgct cagctgtctg caaggacggc cgttccagac
181 caagtggcct gctgctccga ggacccagct cgctccaggc tgtgactcca catcccgagg
241 tcgctgcctg gcgaccgggc agcgaggacc ggccacccca gacttcctgt cccgcagccc
301 caaagacaga gctgcgaccg ccgggacagc gacgcctgca cagctctggt gagatggcgg
361 cagggtccac tacgctgcac gcagtggaga agctgcaggt gcgtctggcc actaagacgg
421 agccgaaaaa gctagagaaa tatttgcaga aactctccgc cttgcccatg acggcagaca
481 tcctggcgga gactggaatc agaaagacgg tgaagcgcct gcggaagcac cagcacgtgg
541 gcgactttgc cagagactta gcggcccggt ggaagaagct ggtgctcgtg gaccgaaaca
601 cccggcctgg cccacaggac cctgaggaga gcgcttcccg acagcgcttc ggggaggctc
661 ttcaggacca ggaaaaggcc tggggcttcc cagaaaacgc gacggccccc aggagcccat
721 ctcacagccc tgagcacaga cggacagcac gcagaacacc tccggggcaa cagagacctc
781 acccgaggtc tcacagtcgc gagcccagag ctgagagaaa gtgccccaga atagccccag
841 ctgattccgg ccgctatcgg gcctctccaa cgcgcacagc tcccctccgg atgcccgagg
901 gccctgagcc cgctgcgccc gggaagcaac ccggaagagg ccacactcac gcggctcagg
961 gcgggcctct gctgtgtcca ggctgccagg gccaacccca ggggaaagcc gttgtgagcc
1021 acagcaaggg gcacaaatcg tctcgccagg aaaaacgccc cttgtgtgcc cagggagatt
1081 ggcactcccc tactttgatc agggagaaat catgcggggc ctgcttaaga gaggaaaccc
1141 caaggatgcc ctcctgggca agtgccaggg acaggcagcc ttcggacttc aagacagaca
1201 aggaaggggg gcaagctggc agcggccagc gtgtccctgc cttggaggag gctccagaca
1261 gtcaccagaa gaggcctcag cacagtcact cgaacaagaa gaggcccagt ctagacggcc
1321 gggacccagg aaatgggaca cacggcctgt cgcccgagga gaaagagcag ctttccaacg
1381 accgagagac tcaagagggg aagccaccga ctgctcattt ggacagaacg tccgtgagct
1441 ccctctctga ggtggaggag gtagatatgg ctgaggaatt cgagcagccc actctgtcat
1501 gtgaaaaata cctcacctac gatcagttgc ggaagcaaaa gaaaaagact ggaaaatctg
1561 ccaccactgc acttggagat aaacaaagga aagcaaacga atccaagggc actcgtgagt
1621 cctgggattc ggctaagaaa ttgcctcctg tccaggaaag ccagtcagag aggctgcagg
1681 cggccggcgc tgattccgcc gggccgaaaa cggtgcccag ccatgtcttc tcagagctct
1741 gggacctctc agaggcctgg atgcaggcca actacgatcc gctttcggat tctgactcca
1801 tgacctccca ggcaaagcca gaagcactct cttcaccaaa gttccgggag gaagctgctt
1861 tccctggacg cagagtgaat gctaagatgc cggtgtactc gggctccagg cctgcctgcc
1921 agctccaggt gccgacgctg cgccagcagt gtgcccaggt gcttagaaac aatccggacg
1981 ccctcagcga cgtgggagag gtcccctact gggttcttga acctgttctg gaagggtgga
2041 ggcccgatca gctgtatcgc agaaagaaag acaatcacgc actcgttaga gagacagacg
2101 aattacggag gaatcattgt ttccaggact tcaaggaaga aaagccacag gaaaacaaaa
2161 cttggaggga gcagtacctg cggcttccgg acgccccaga gcagcggctg agagtaatga
2221 caacgaatat ccgatctgca cgtggaaaca accccaacgg cagagaggca aagatgatct
2281 gtttcaaatc tgtggccaag acgccttatg atacttcaag gaggcaagag aagtctgcag
2341 gagacgctga ccccgaaaat ggggagatca agccagcctc caagcccgcg ggaagcagcc
2401 acactccctc cagccagagc agcagcggcg gtggcagaga cagcagcagc agcatccttc
2461 gctggctccc tgagaagcgg gccaacccct gcctgagcag cagcaatgag cacgcggcgc
2521 ccgcggccaa aacccggaaa caggctgcca agaaagtggc cccgctgatg gccaaggcaa
2581 ttcgagacta caagagaaga ttctcccgac gataaactca ggacttgcct tgcagataaa
2641 atctgggggg atttttgcat tggcaaagtc aatgcgggtt ggggaacgaa acttccaatg
2701 gacaccagaa cctttaactt ggtgcaaagt tgagcctttg aattctgcag gtgtcatgtg
2761 ctggccctgt gattttgcct cccacaccca gccactacct cccagcttgg agaacacctc
2821 agaattcaga agatatgaac gcattgggaa caattctatt ttggatgttc actgataatt
2881 tttaaaaaca ccctagttgt aatcataaat aaggaaaaag atgtgagatt tcctttttcc
2941 tttctttttt ttttcgaaat caagtagata agaacttctt agacaaaaac acacaagcca
3001 ttagttgaca ctgataactc cgaatacata aaatgtttgc tgttgcaaaa aaaaaaaaaa
3061 aa
//